Birabresib (BioDeep_00000789172)
代谢物信息卡片
化学式: C25H22ClN5O2S (491.11826620000005)
中文名称: 比拉瑞塞
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NC4=CC=C(C=C4)O)C5=CC=C(C=C5)Cl)C
InChI: InChI=1S/C25H22ClN5O2S/c1-13-14(2)34-25-22(13)23(16-4-6-17(26)7-5-16)28-20(24-30-29-15(3)31(24)25)12-21(33)27-18-8-10-19(32)11-9-18/h4-11,20,32H,12H2,1-3H3,(H,27,33)/t20-/m0/s1
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:191051
- KEGGdrug: D10911
- PubChem: 9936746
- DrugBank: DB15189
- ChEMBL: CHEMBL3581647
- CAS: 202590-98-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Narayanan Balaji, Murugan Chinnapattu, Abhishek Dixit, Promod Sahu, Suresh P S, Ramesh Mullangi. Validation of an enantioselective LC-MS/MS method to quantify enantiomers of (±)-OTX015 in mice plasma: Lack of in vivo inversion of (-)-OTX015 to its antipode.
Biomedical chromatography : BMC.
2017 Apr; 31(4):. doi:
10.1002/bmc.3853. [PMID: 27632936] - Eugenio Gaudio, Chiara Tarantelli, Maurilio Ponzoni, Elodie Odore, Keyvan Rezai, Elena Bernasconi, Luciano Cascione, Andrea Rinaldi, Anastasios Stathis, Eugenia Riveiro, Esteban Cvitkovic, Emanuele Zucca, Francesco Bertoni. Bromodomain inhibitor OTX015 (MK-8628) combined with targeted agents shows strong in vivo antitumor activity in lymphoma.
Oncotarget.
2016 Sep; 7(36):58142-58147. doi:
10.18632/oncotarget.10983. [PMID: 27494885] - Sandy Amorim, Anastasios Stathis, Mary Gleeson, Sunil Iyengar, Valeria Magarotto, Xavier Leleu, Franck Morschhauser, Lionel Karlin, Florence Broussais, Keyvan Rezai, Patrice Herait, Carmen Kahatt, François Lokiec, Gilles Salles, Thierry Facon, Antonio Palumbo, David Cunningham, Emanuele Zucca, Catherine Thieblemont. Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study.
The Lancet. Haematology.
2016 Apr; 3(4):e196-204. doi:
10.1016/s2352-3026(16)00021-1. [PMID: 27063978] - Céline Berthon, Emmanuel Raffoux, Xavier Thomas, Norbert Vey, Carlos Gomez-Roca, Karen Yee, David Christopher Taussig, Keyvan Rezai, Christophe Roumier, Patrice Herait, Carmen Kahatt, Bruno Quesnel, Mauricette Michallet, Christian Recher, François Lokiec, Claude Preudhomme, Hervé Dombret. Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 study.
The Lancet. Haematology.
2016 Apr; 3(4):e186-95. doi:
10.1016/s2352-3026(15)00247-1. [PMID: 27063977] - Elodie Odore, François Lokiec, Esteban Cvitkovic, Mohamed Bekradda, Patrice Herait, Fabrice Bourdel, Carmen Kahatt, Emmanuel Raffoux, Anastasios Stathis, Catherine Thieblemont, Bruno Quesnel, David Cunningham, Maria E Riveiro, Keyvan Rezaï. Phase I Population Pharmacokinetic Assessment of the Oral Bromodomain Inhibitor OTX015 in Patients with Haematologic Malignancies.
Clinical pharmacokinetics.
2016 Mar; 55(3):397-405. doi:
10.1007/s40262-015-0327-6. [PMID: 26341814] - M J Crabbe, R E Childs, W G Bardsley. Time-dependent inhibition of diamine oxidase by carbonyl-group reagents and urea.
European journal of biochemistry.
1975 Dec; 60(2):325-33. doi:
10.1111/j.1432-1033.1975.tb21007.x. [PMID: 1269]