Tubacin (BioDeep_00000789160)
代谢物信息卡片
化学式: C41H43N3O7S (721.2822)
中文名称: HDAC6 抑制剂
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(OC(OC1C2=CC=C(C=C2)CO)C3=CC=C(C=C3)NC(=O)CCCCCCC(=O)NO)CSC4=NC(=C(O4)C5=CC=CC=C5)C6=CC=CC=C6
InChI: InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:94166
- PubChem: 6675804
- ChEMBL: CHEMBL356769
- CAS: 1350555-93-9
- CAS: 537049-40-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Qiangni Liu, Inna Sabirzhanova, Emily Anne Smith Bergbower, Murali Yanda, William G Guggino, Liudmila Cebotaru. The CFTR Corrector, VX-809 (Lumacaftor), Rescues ABCA4 Trafficking Mutants: a Potential Treatment for Stargardt Disease.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2019; 53(2):400-412. doi:
10.33594/000000146. [PMID: 31403270] - Olivia S Chao, Tim C Chang, Maria A Di Bella, Riccardo Alessandro, Fabio Anzanello, Germana Rappa, Oscar B Goodman, Aurelio Lorico. The HDAC6 Inhibitor Tubacin Induces Release of CD133+ Extracellular Vesicles From Cancer Cells.
Journal of cellular biochemistry.
2017 12; 118(12):4414-4424. doi:
10.1002/jcb.26095. [PMID: 28452069] - Murali K Yanda, Qiangni Liu, Valeriu Cebotaru, William B Guggino, Liudmila Cebotaru. Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease.
The Journal of biological chemistry.
2017 10; 292(43):17897-17908. doi:
10.1074/jbc.m117.803775. [PMID: 28887310] - Liudmila Cebotaru, Qiangni Liu, Murali K Yanda, Clement Boinot, Patricia Outeda, David L Huso, Terry Watnick, William B Guggino, Valeriu Cebotaru. Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease.
Kidney international.
2016 07; 90(1):90-9. doi:
10.1016/j.kint.2016.01.026. [PMID: 27165822] - Matloob Husain, Chen-Yi Cheung. Histone deacetylase 6 inhibits influenza A virus release by downregulating the trafficking of viral components to the plasma membrane via its substrate, acetylated microtubules.
Journal of virology.
2014 Oct; 88(19):11229-39. doi:
10.1128/jvi.00727-14. [PMID: 25031336] - Kun-Peng Liu, Dan Zhou, Dong-Yun Ouyang, Li-Hui Xu, Yao Wang, Li-Xian Wang, Hao Pan, Xian-Hui He. LC3B-II deacetylation by histone deacetylase 6 is involved in serum-starvation-induced autophagic degradation.
Biochemical and biophysical research communications.
2013 Nov; 441(4):970-5. doi:
10.1016/j.bbrc.2013.11.007. [PMID: 24220335] - Wei Liu, Lucy X Fan, Xia Zhou, William E Sweeney, Ellis D Avner, Xiaogang Li. HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells.
PloS one.
2012; 7(11):e49418. doi:
10.1371/journal.pone.0049418. [PMID: 23152903] - Teru Hideshima, James E Bradner, Jason Wong, Dharminder Chauhan, Paul Richardson, Stuart L Schreiber, Kenneth C Anderson. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.
Proceedings of the National Academy of Sciences of the United States of America.
2005 Jun; 102(24):8567-72. doi:
10.1073/pnas.0503221102. [PMID: 15937109]
