Vactosertib (BioDeep_00000789154)
代谢物信息卡片
化学式: C22H18FN7 (399.1608)
中文名称: EW-7197
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NC(=CC=C1)C2=C(N=C(N2)CNC3=CC=CC=C3F)C4=CN5C(=NC=N5)C=C4
InChI: InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28-19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29)
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Kyung Bong Ha, Eun Soo Lee, Na Won Park, Su Ho Jo, Soyeon Shim, Dae-Kee Kim, Chan Mug Ahn, Choon Hee Chung. Beneficial Effects of a Curcumin Derivative and Transforming Growth Factor-β Receptor I Inhibitor Combination on Nonalcoholic Steatohepatitis.
Diabetes & metabolism journal.
2023 07; 47(4):500-513. doi:
10.4093/dmj.2022.0110. [PMID: 37096379] - Kyung Bong Ha, Weerapon Sangartit, Ah Reum Jeong, Eun Soo Lee, Hong Min Kim, Soyeon Shim, Upa Kukongviriyapan, Dae-Kee Kim, Eun Young Lee, Choon Hee Chung. EW-7197 Attenuates the Progression of Diabetic Nephropathy in db/db Mice through Suppression of Fibrogenesis and Inflammation.
Endocrinology and metabolism (Seoul, Korea).
2022 02; 37(1):96-111. doi:
10.3803/enm.2021.1305. [PMID: 35255604] - Su Young Jung, Sunjin Hwang, Jeffery M Clarke, Todd M Bauer, Vicki L Keedy, Hukeun Lee, Neunggyu Park, Seong-Jin Kim, Jangik I Lee. Pharmacokinetic characteristics of vactosertib, a new activin receptor-like kinase 5 inhibitor, in patients with advanced solid tumors in a first-in-human phase 1 study.
Investigational new drugs.
2020 06; 38(3):812-820. doi:
10.1007/s10637-019-00835-y. [PMID: 31300967] - Su Young Jung, Ju-Hwan Park, Min-Jun Baek, Gyu-Ho Kim, Jaehwan Kim, Hong-Mei Zheng, Jae-Min Kim, Il-Mo Kang, Dae-Duk Kim, Jangik I Lee. Development of an oral bentonite-based modified-release freeze-dried powder of vactosertib: Pharmacokinetics and anti-colitis activity in rodent models of ulcerative colitis.
International journal of pharmaceutics.
2020 Mar; 578(?):119103. doi:
10.1016/j.ijpharm.2020.119103. [PMID: 32036008] - Su Young Jung, Ji Seob Yug, Jeffery M Clarke, Todd M Bauer, Vicki L Keedy, Sunjin Hwang, Seong-Jin Kim, Eun Kyoung Chung, Jangik I Lee. Population pharmacokinetics of vactosertib, a new TGF-β receptor type Ι inhibitor, in patients with advanced solid tumors.
Cancer chemotherapy and pharmacology.
2020 01; 85(1):173-183. doi:
10.1007/s00280-019-03979-z. [PMID: 31673825] - Sang-A Park, Min-Jin Kim, So-Yeon Park, Jung-Shin Kim, Seon-Joo Lee, Hyun Ae Woo, Dae-Kee Kim, Jeong-Seok Nam, Yhun Yhong Sheen. EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling.
Cellular and molecular life sciences : CMLS.
2015 May; 72(10):2023-39. doi:
10.1007/s00018-014-1798-6. [PMID: 25487606] - Cheng Hua Jin, Maddeboina Krishnaiah, Domalapally Sreenu, Vura B Subrahmanyam, Kota S Rao, Hwa Jeong Lee, So-Jung Park, Hyun-Ju Park, Kiho Lee, Yhun Yhong Sheen, Dae-Kee Kim. Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-β type I receptor kinase as cancer immunotherapeutic/antifibrotic agent.
Journal of medicinal chemistry.
2014 May; 57(10):4213-38. doi:
10.1021/jm500115w. [PMID: 24786585]
