Aliskiren hemifumarate (BioDeep_00000789096)
代谢物信息卡片
化学式: C64H110N6O16 (1218.79779)
中文名称: 阿利克仑半富马酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.C(=CC(=O)O)C(=O)O
InChI: /m00./s1
描述信息
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:53777
- KEGGdrug: D06412
- PubChem: 6918427
- ChEMBL: CHEMBL3545059
- CAS: 173334-58-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Alokkumar S Pathak, Mauricio Rojas, George A Stouffer. Expression of Cyr61 in ApoE-/- mice with chronic unilateral renal artery ligation.
Scientific reports.
2021 02; 11(1):3606. doi:
10.1038/s41598-021-81646-1
. [PMID: 33574403] - Wenfei Ding, Xue Li, Weihua Wu, Hongyan He, Ying Li, Lichao Gao, Linwang Gan, Mengping Wang, Santao Ou, Jian Liu. [Aliskiren inhibits angiotensin II/angiotensin 1-7(Ang II/Ang1-7) signal pathway in rats with diabetic nephropathy].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2018 Oct; 34(10):891-895. doi:
. [PMID: 30554582]
- Miaojuan Qiu, Suchun Li, Lizi Jin, Pinning Feng, Yonglun Kong, Xiaoduo Zhao, Yu Lin, Yunyun Xu, Chunling Li, Weidong Wang. Combination of Chymostatin and Aliskiren attenuates ER stress induced by lipid overload in kidney tubular cells.
Lipids in health and disease.
2018 Jul; 17(1):183. doi:
10.1186/s12944-018-0818-1
. [PMID: 30064425] - Sean L Zheng, Alistair J Roddick, Salma Ayis. Effects of aliskiren on mortality, cardiovascular outcomes and adverse events in patients with diabetes and cardiovascular disease or risk: A systematic review and meta-analysis of 13,395 patients.
Diabetes & vascular disease research.
2017 09; 14(5):400-406. doi:
10.1177/1479164117715854
. [PMID: 28844155] - Saad Abdulrahman Hussain, Rabab Mohammed Utba, Ajwad Muhammad Assumaidaee. Effects of Azilsartan, Aliskiren or their Combination on High Fat Diet-induced Non-alcoholic Liver Disease Model in Rats.
Medical archives (Sarajevo, Bosnia and Herzegovina).
2017 Aug; 71(4):251-255. doi:
10.5455/medarh.2017.71.251-255
. [PMID: 28974844] - Stefan Engeli, Marcus May, Juerg Nussberger, A H Jan Danser, William P Dole, Margaret F Prescott, Marion Dahlke, Sylvie Stitah, Parasar Pal, Michael Boschmann, Jens Jordan. Systemic and tissue-specific effects of aliskiren on the RAAS and carbohydrate/lipid metabolism in obese patients with hypertension.
Journal of the American Society of Hypertension : JASH.
2017 Aug; 11(8):488-497. doi:
10.1016/j.jash.2017.06.002
. [PMID: 28666704] - Sally A Abuelezz, Nevien Hendawy, Wesam M Osman. Aliskiren attenuates bleomycin-induced pulmonary fibrosis in rats: focus on oxidative stress, advanced glycation end products, and matrix metalloproteinase-9.
Naunyn-Schmiedeberg's archives of pharmacology.
2016 Aug; 389(8):897-909. doi:
10.1007/s00210-016-1253-3
. [PMID: 27154762] - Abdelaziz M Hussein, Hala Abdel Malek, Mohamed-Ahdy Saad. Renoprotective effects of aliskiren on adenine-induced tubulointerstitial nephropathy: possible underlying mechanisms.
Canadian journal of physiology and pharmacology.
2016 Aug; 94(8):829-37. doi:
10.1139/cjpp-2015-0364
. [PMID: 27322834] - Sandeep Kaur, Arunachalam Muthuraman. Therapeutic evaluation of rutin in two-kidney one-clip model of renovascular hypertension in rat.
Life sciences.
2016 Apr; 150(?):89-94. doi:
10.1016/j.lfs.2016.02.080
. [PMID: 26920631] - Saliha Sena Karcioglu, Saziye Sezin Palabiyik, Yasin Bayir, Emre Karakus, Tolga Mercantepe, Zekai Halici, Abdulmecit Albayrak. The Role of RAAS Inhibition by Aliskiren on Paracetamol-Induced Hepatotoxicity Model in Rats.
Journal of cellular biochemistry.
2016 Mar; 117(3):638-46. doi:
10.1002/jcb.25313
. [PMID: 26280784] - Kuei-Chuan Lee, Yun-Cheng Hsieh, Ying-Ying Yang, Che-Chang Chan, Yi-Hsiang Huang, Han-Chieh Lin. Aliskiren Reduces Hepatic steatosis and Epididymal Fat Mass and Increases Skeletal Muscle Insulin Sensitivity in High-Fat Diet-Fed Mice.
Scientific reports.
2016 Jan; 6(?):18899. doi:
10.1038/srep18899
. [PMID: 26732252] - Naif O Al-Harbi, Faisal Imam, Mohammed M Al-Harbi, Muzaffar Iqbal, Ahmed Nadeem, Othman A Al-Shahrah, Hesham M Korashy, Khalid A Al-Hosaini, Mukhtar Ahmed, Saleh Bahashwar. Treatment with aliskiren ameliorates tacrolimus-induced nephrotoxicity in rats.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2015 Dec; 16(4):1329-36. doi:
10.1177/1470320314530178
. [PMID: 24737642] - A Sadeghpour, M Rappolt, D Ntountaniotis, P Chatzigeorgiou, K Viras, G Megariotis, M G Papadopoulos, E Siapi, G Mali, T Mavromoustakos. Comparative study of interactions of aliskiren and AT1 receptor antagonists with lipid bilayers.
Biochimica et biophysica acta.
2015 Apr; 1848(4):984-94. doi:
10.1016/j.bbamem.2014.12.004
. [PMID: 25534713] - Weidong Wang, Liru Qiu, Allison Howard, Nathaniel Solis, Chunling Li, Xiaoxin Wang, Jeffrey B Kopp, Moshe Levi. Protective effects of aliskiren and valsartan in mice with diabetic nephropathy.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2014 Dec; 15(4):384-95. doi:
10.1177/1470320313507123
. [PMID: 25031296] - Azhar Rashikh, Krishna Kolappa Pillai, Abul Kalam Najmi. Protective effect of a direct renin inhibitor in acute murine model of cardiotoxicity and nephrotoxicity.
Fundamental & clinical pharmacology.
2014 Oct; 28(5):489-500. doi:
10.1111/fcp.12054
. [PMID: 24117488] - Erol Akpinar, Zekai Halici, Elif Cadirci, Yasin Bayir, Emre Karakus, Muhammet Calik, Atilla Topcu, Beyzagul Polat. What is the role of renin inhibition during rat septic conditions: preventive effect of aliskiren on sepsis-induced lung injury.
Naunyn-Schmiedeberg's archives of pharmacology.
2014 Oct; 387(10):969-78. doi:
10.1007/s00210-014-1014-0
. [PMID: 25005757] - Eliete Dalla Corte Frantz, Aline Penna-de-Carvalho, Thais de Medeiros Batista, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda. Comparative effects of the renin-angiotensin system blockers on nonalcoholic fatty liver disease and insulin resistance in C57BL/6 mice.
Metabolic syndrome and related disorders.
2014 May; 12(4):191-201. doi:
10.1089/met.2013.0129
. [PMID: 24517411] - Zehra Eren, Mehmet Yalçin Günal, Elif Arı Bakir, Jale Coban, Berrak Çağlayan, Nur Ekimci, Sinem Ethemoglu, Ozgur Albayrak, Tuba Akdeniz, Gülderen Yanikkaya Demirel, Ertuğrul Kiliç, Gülçin Kantarci. Effects of paricalcitol and aliskiren combination therapy on experimental diabetic nephropathy model in rats.
Kidney & blood pressure research.
2014; 39(6):581-90. doi:
10.1159/000368471
. [PMID: 25532067] - Salvatore Mascia, Patrick L Heider, Haitao Zhang, Richard Lakerveld, Brahim Benyahia, Paul I Barton, Richard D Braatz, Charles L Cooney, James M B Evans, Timothy F Jamison, Klavs F Jensen, Allan S Myerson, Bernhardt L Trout. End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation.
Angewandte Chemie (International ed. in English).
2013 Nov; 52(47):12359-63. doi:
10.1002/anie.201305429
. [PMID: 24115355] - Azhar Rashikh, Krishna K Pillai, Shibli J Ahmad, Mohammad Akhtar, Abul K Najmi. Aliskiren alleviates doxorubicin-induced nephrotoxicity by inhibiting oxidative stress and podocyte injury.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2013 Mar; 14(1):14-22. doi:
10.1177/1470320312459980
. [PMID: 23060472] - Chu-Lin Chou, Cheng-Yong Pang, Tony J F Lee, Te-Chao Fang. Direct renin inhibitor prevents and ameliorates insulin resistance, aortic endothelial dysfunction and vascular remodeling in fructose-fed hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2013 Feb; 36(2):123-8. doi:
10.1038/hr.2012.124
. [PMID: 22895064] - Kuei-Chuan Lee, Che-Chang Chan, Ying-Ying Yang, Yun-Cheng Hsieh, Yi-Hsiang Huang, Han-Chieh Lin. Aliskiren attenuates chronic carbon tetrachloride-induced liver injury in mice.
European journal of clinical investigation.
2012 Dec; 42(12):1261-71. doi:
10.1111/j.1365-2362.2012.02725.x
. [PMID: 22998019] - Yuji Nakamura, Teppei Fujimoto, Yasuyuki Ogawa, Chie Sugita, Shojiro Miyazaki, Kazuhiko Tamaki, Mizuki Takahashi, Yumi Matsui, Takahiro Nagayama, Kenichi Manabe, Makoto Mizuno, Noriko Masubuchi, Katsuyoshi Chiba, Takahide Nishi. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor.
ACS medicinal chemistry letters.
2012 Sep; 3(9):754-8. doi:
10.1021/ml300168e
. [PMID: 24900544] - Rania A Elrashidy, Mervat E Asker, Hoda E Mohamed. Beneficial effects of pioglitazone against cardiovascular injury are enhanced by combination with aliskiren in a rat model of diabetic nephropathy.
The Journal of pharmacy and pharmacology.
2012 Jun; 64(6):862-71. doi:
10.1111/j.2042-7158.2012.01508.x
. [PMID: 22571265] - Yasutomi Higashikuni, Minoru Takaoka, Hiroshi Iwata, Kimie Tanaka, Yasunobu Hirata, Ryozo Nagai, Masataka Sata. Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice.
Hypertension research : official journal of the Japanese Society of Hypertension.
2012 Jan; 35(1):62-9. doi:
10.1038/hr.2011.136
. [PMID: 21833001] - Diego Rodríguez-Penas, Sandra Feijóo-Bandín, Pamela V Lear, Ana Mosquera-Leal, Vanessa García-Rúa, Manuel F Otero, Miguel Rivera, Oreste Gualillo, José Ramón González-Juanatey, Francisca Lago. Aliskiren affects fatty-acid uptake and lipid-related genes in rodent and human cardiomyocytes.
Biochemical pharmacology.
2011 Sep; 82(5):491-504. doi:
10.1016/j.bcp.2011.05.021
. [PMID: 21640714] - Young Sun Kang, Mi Hwa Lee, Hye Kyoung Song, Young Youl Hyun, Jin Joo Cha, Gang Jee Ko, Sung Hwan Kim, Ji Eun Lee, Jee Young Han, Dae Ryong Cha. Aliskiren improves insulin resistance and ameliorates diabetic vascular complications in db/db mice.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Apr; 26(4):1194-204. doi:
10.1093/ndt/gfq579
. [PMID: 20921292] - W Krone, M Hanefeld, H-F Meyer, T Jung, M Bartlett, C-M Yeh, I Rajman, M F Prescott, W P Dole. Comparative efficacy and safety of aliskiren and irbesartan in patients with hypertension and metabolic syndrome.
Journal of human hypertension.
2011 Mar; 25(3):186-95. doi:
10.1038/jhh.2010.38
. [PMID: 20376075] - Azhar Rashikh, Abul Kalam Najmi, Mohammad Akhtar, Danish Mahmood, Krishna K Pillai, Shibli J Ahmad. Protective effects of aliskiren in doxorubicin-induced acute cardiomyopathy in rats.
Human & experimental toxicology.
2011 Feb; 30(2):102-9. doi:
10.1177/0960327110369819
. [PMID: 20418268] - Janet B McGill. Improving microvascular outcomes in patients with diabetes through management of hypertension.
Postgraduate medicine.
2009 Mar; 121(2):89-101. doi:
10.3810/pgm.2009.03.1980
. [PMID: 19332966] - Petra Gratze, Michael Boschmann, Ralf Dechend, Fatimunnisa Qadri, Jeanette Malchow, Sabine Graeske, Stefan Engeli, Jürgen Janke, Jochen Springer, Aurelie Contrepas, Ralph Plehm, Susanne Klaus, Genevieve Nguyen, Friedrich C Luft, Dominik N Muller. Energy metabolism in human renin-gene transgenic rats: does renin contribute to obesity?.
Hypertension (Dallas, Tex. : 1979).
2009 Mar; 53(3):516-23. doi:
10.1161/hypertensionaha.108.124966
. [PMID: 19171793] - Sujata Vaidyanathan, Mojdeh Maboudian, Vance Warren, Ching-Ming Yeh, Hans Armin Dieterich, Dan Howard, William P Dole. A study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with metformin, pioglitazone and fenofibrate in healthy subjects.
Current medical research and opinion.
2008 Aug; 24(8):2313-26. doi:
10.1185/03007990802259354
. [PMID: 18786303] - Jürg Nussberger, Jean-François Aubert, Karima Bouzourene, Maxime Pellegrin, Daniel Hayoz, Lucia Mazzolai. Renin inhibition by aliskiren prevents atherosclerosis progression: comparison with irbesartan, atenolol, and amlodipine.
Hypertension (Dallas, Tex. : 1979).
2008 May; 51(5):1306-11. doi:
10.1161/hypertensionaha.108.110932
. [PMID: 18391092] - G Lefévre, M Duval, A Poncin. Direct micro-radioimmunoassay of the new renin inhibitor CGP 60536.
Journal of immunoassay.
2000 Feb; 21(1):65-84. doi:
10.1080/01971520009349500
. [PMID: 10805319] - G Lefèvre, S Gauron. Automated quantitative determination of the new renin inhibitor CGP 60536 by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
2000 Jan; 738(1):129-36. doi:
10.1016/s0378-4347(99)00509-5
. [PMID: 10778934]