Sonidegib (BioDeep_00000789074)
代谢物信息卡片
化学式: C26H26F3N3O3 (485.1926162000001)
中文名称: 雷特格韦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
InChI: InChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01X - Other antineoplastic agents > L01XJ - Hedgehog pathway inhibitors
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C188731 - Hedgehog Pathway Inhibitor
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:90863
- KEGGdrug: D10119
- PubChem: 24775005
- DrugBank: DB09143
- ChEMBL: CHEMBL2105737
- CAS: 956697-53-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Sabiha Trabelsi, Fawaz Khidher. Rapid onset of response to sonidegib for multiple facial basal cell carcinomas during COVID-19 pandemic.
Dermatologic therapy.
2022 04; 35(4):e15317. doi:
10.1111/dth.15317
. [PMID: 35023271] - Bharath S Padya, Aswathi R Hegde, Sadhana P Mutalik, Swati Biswas, Srinivas Mutalik. Analytical and bioanalytical HPLC method for simultaneous estimation of 5-fluorouracil and sonidegib.
Bioanalysis.
2022 Jan; 14(1):29-45. doi:
10.4155/bio-2021-0212
. [PMID: 34786955] - Darcy B Pooler, Dylan B Ness, John Sarantopoulos, Nicholas Squittieri, Shoba Ravichandran, Carolyn D Britten, Ravi K Amaravadi, Ulka Vaishampayan, Patricia LoRusso, Geoffrey I Shapiro, Anthony J Olszanski, Raymond Perez, Martin Gutierrez, Mark Allen O'Rourke, Vincent Chung, James J Lee, Lionel D Lewis. The effect of sonidegib (LDE225) on the pharmacokinetics of bupropion and warfarin in patients with advanced solid tumours.
British journal of clinical pharmacology.
2021 03; 87(3):1291-1302. doi:
10.1111/bcp.14508
. [PMID: 32736411] - Michael Migden, Aaron S Farberg, Reinhard Dummer, Nicholas Squittieri, C William Hanke. A Review of Hedgehog Inhibitors Sonidegib and Vismodegib for Treatment of Advanced Basal Cell Carcinoma.
Journal of drugs in dermatology : JDD.
2021 02; 20(2):156-165. doi:
10.36849/jdd.5657
. [PMID: 33538567] - Alessia Villani, Gabriella Fabbrocini, Claudia Costa, Massimiliano Scalvenzi. Complete remission of an advanced basal cell carcinoma after only 3-month treatment with sonidegib: Report of a case and drug management during COVID-19 pandemic.
Dermatologic therapy.
2020 11; 33(6):e14200. doi:
10.1111/dth.14200
. [PMID: 32870541] - Alessia Villani, Gabriella Fabbrocini, Claudia Costa, Massimiliano Scalvenzi. Patients with advanced basal cell carcinomas in treatment with sonic hedgehog inhibitors during the coronavirus disease 2019 (COVID-19) period: Management and adherence to treatment.
Journal of the American Academy of Dermatology.
2020 06; 82(6):e205. doi:
10.1016/j.jaad.2020.03.057
. [PMID: 32244017] - Yves Horsmans, Jocelyn Zhou, Mateva Liudmila, George Golor, Oren Shibolet, Michelle Quinlan, Corinne Emotte, Hildegard Boss, Henry Castro, Dalila Sellami, Richard A Preston. Effects of Mild to Severe Hepatic Impairment on the Pharmacokinetics of Sonidegib: A Multicenter, Open-Label, Parallel-Group Study.
Clinical pharmacokinetics.
2018 03; 57(3):345-354. doi:
10.1007/s40262-017-0560-2
. [PMID: 28577129] - Jocelyn Zhou, Michelle Quinlan, Eunju Hurh, Dalila Sellami. Exposure-Response Analysis of Sonidegib (LDE225), an Oral Inhibitor of the Hedgehog Signaling Pathway, for Effectiveness and Safety in Patients With Advanced Solid Tumors.
Journal of clinical pharmacology.
2016 11; 56(11):1406-1415. doi:
10.1002/jcph.749
. [PMID: 27095306] - Jocelyn Zhou, Michelle Quinlan, Kelli Glenn, Hildegard Boss, Franck Picard, Henry Castro, Dalila Sellami. Effect of esomeprazole, a proton pump inhibitor on the pharmacokinetics of sonidegib in healthy volunteers.
British journal of clinical pharmacology.
2016 10; 82(4):1022-9. doi:
10.1111/bcp.13038
. [PMID: 27277189] - C D'Amato, R Rosa, R Marciano, V D'Amato, L Formisano, L Nappi, L Raimondo, C Di Mauro, A Servetto, F Fulciniti, A Cipolletta, C Bianco, F Ciardiello, B M Veneziani, S De Placido, R Bianco. Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells.
British journal of cancer.
2014 Sep; 111(6):1168-79. doi:
10.1038/bjc.2014.421
. [PMID: 25093491] - Markus Zollinger, Frédéric Lozac'h, Eunju Hurh, Corinne Emotte, Hounayda Bauly, Piet Swart. Absorption, distribution, metabolism, and excretion (ADME) of ¹⁴C-sonidegib (LDE225) in healthy volunteers.
Cancer chemotherapy and pharmacology.
2014 Jul; 74(1):63-75. doi:
10.1007/s00280-014-2468-y
. [PMID: 24817600] - Jordi Rodon, Hussein A Tawbi, Anne L Thomas, Ronald G Stoller, Christian P Turtschi, Jose Baselga, John Sarantopoulos, Devalingam Mahalingam, Yaping Shou, Melissa A Moles, Lin Yang, Camille Granvil, Eunju Hurh, Kristine L Rose, Dereck D Amakye, Reinhard Dummer, Alain C Mita. A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor Sonidegib (LDE225) in patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2014 Apr; 20(7):1900-9. doi:
10.1158/1078-0432.ccr-13-1710
. [PMID: 24523439] - Simona Blotta, Jana Jakubikova, Teresa Calimeri, Aldo M Roccaro, Nicola Amodio, Abdel Kareem Azab, Umberto Foresta, Constantine S Mitsiades, Marco Rossi, Katia Todoerti, Stefano Molica, Fortunato Morabito, Antonino Neri, Piersandro Tagliaferri, Pierfrancesco Tassone, Kenneth C Anderson, Nikhil C Munshi. Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma.
Blood.
2012 Dec; 120(25):5002-13. doi:
10.1182/blood-2011-07-368142
. [PMID: 22821765]