Saxagliptin Hydrochloride (BioDeep_00000789038)

   


代谢物信息卡片


Saxagliptin Hydrochloride

化学式: C18H26ClN3O2 (351.1713)
中文名称: 盐酸沙格列汀
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C2CC2N(C1C#N)C(=O)C(C34CC5CC(C3)CC(C5)(C4)O)N.Cl
InChI: /m1./s1

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C98086 - Dipeptidyl Peptidase-4 Inhibitor
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D054795 - Incretins
D007004 - Hypoglycemic Agents > D054873 - Dipeptidyl-Peptidase IV Inhibitors
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor

同义名列表

1 个代谢物同义名

Saxagliptin Hydrochloride



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Yangchen Tang, Mengli Yan, Zemin Fang, Song Jin, Tingjuan Xu. Effects of metformin, saxagliptin and repaglinide on gut microbiota in high-fat diet/streptozocin-induced type 2 diabetic mice. BMJ open diabetes research & care. 2024 May; 12(3):. doi: 10.1136/bmjdrc-2023-003837. [PMID: 38719505]
  • Chao Yu, Mingyu Cui, Yifeng Yin, Fengmei Zhu, Yue Sui, Xueying Yan, Yingli Gai. Influence of Gegenqinlian decoction on pharmacokinetics and pharmacodynamics of saxagliptin in type 2 diabetes mellitus rats. Biopharmaceutics & drug disposition. 2023 Dec; 44(6):396-405. doi: 10.1002/bdd.2374. [PMID: 37596705]
  • Sabry M Attia, Sheikh F Ahmad, Ahmed Nadeem, Mohamed S M Attia, Mushtaq A Ansari, Abdelkader E Ashour, Norah A Albekairi, Mohammed A Al-Hamamah, Ali A Alshamrani, Saleh A Bakheet. Saxagliptin, a selective dipeptidyl peptidase-4 inhibitor, alleviates somatic cell aneugenicity and clastogenicity in diabetic mice. Mutation research. Genetic toxicology and environmental mutagenesis. 2023 Nov; 892(?):503707. doi: 10.1016/j.mrgentox.2023.503707. [PMID: 37973297]
  • Yahya Alhamhoom, Gundawar Ravi, Riyaz Ali M Osmani, Umme Hani, Gowrav M Prakash. Formulation, Characterization, and Evaluation of Eudragit-Coated Saxagliptin Nanoparticles Using 3 Factorial Design Modules. Molecules (Basel, Switzerland). 2022 Nov; 27(21):. doi: 10.3390/molecules27217510. [PMID: 36364338]
  • Hany H Arab, Ahmed M Ashour, Amany M Gad, Ayman M Mahmoud, Ahmed M Kabel. Activation of AMPK/mTOR-driven autophagy and inhibition of NLRP3 inflammasome by saxagliptin ameliorate ethanol-induced gastric mucosal damage. Life sciences. 2021 Sep; 280(?):119743. doi: 10.1016/j.lfs.2021.119743. [PMID: 34166711]
  • Yuzhan Zhang, Ke Li, Yan Li, Weihao Zhao, Li Wang, Zhao Chen, Xiaotao Ma, Tian Yao, Jinhua Wang, Wei Dong, Xiancheng Li, Xuefei Tian, Rongguo Fu. Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells. Pharmacological research. 2021 07; 169(?):105630. doi: 10.1016/j.phrs.2021.105630. [PMID: 33932609]
  • Raafat A Abdel-Aal, Mahran S Abdel-Rahman, Soad Al Bayoumi, Laila A Ali. Effect of stevia aqueous extract on the antidiabetic activity of saxagliptin in diabetic rats. Journal of ethnopharmacology. 2021 Jan; 265(?):113188. doi: 10.1016/j.jep.2020.113188. [PMID: 32783985]
  • Yuejuan Qin, John Adams, Carolina Solis-Herrera, Curtis Triplitt, Ralph DeFronzo, Eugenio Cersosimo. Clinical Parameters, Fuel Oxidation, and Glucose Kinetics in Patients With Type 2 Diabetes Treated With Dapagliflozin Plus Saxagliptin. Diabetes care. 2020 10; 43(10):2519-2527. doi: 10.2337/dc19-1993. [PMID: 32694214]
  • Zhihui Chen, Jing Yu, Menglu Fu, Ruolan Dong, Yan Yang, Jinlan Luo, Shuiqing Hu, Wenhua Li, Xizhen Xu, Ling Tu. Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway. Biochemical pharmacology. 2020 07; 177(?):113951. doi: 10.1016/j.bcp.2020.113951. [PMID: 32251672]
  • Per Lundkvist, Maria J Pereira, Prasad G Kamble, Petros Katsogiannos, Anna Maria Langkilde, Russell Esterline, Eva Johnsson, Jan W Eriksson. Glucagon Levels During Short-Term SGLT2 Inhibition Are Largely Regulated by Glucose Changes in Patients With Type 2 Diabetes. The Journal of clinical endocrinology and metabolism. 2019 01; 104(1):193-201. doi: 10.1210/jc.2018-00969. [PMID: 30137410]
  • Yang Yang, Yunhong Lu, Fei Han, Yunpeng Chang, Xiaoyu Li, Zhe Han, Mei Xue, Ying Cheng, Bei Sun, Liming Chen. Saxagliptin regulates M1/M2 macrophage polarization via CaMKKβ/AMPK pathway to attenuate NAFLD. Biochemical and biophysical research communications. 2018 09; 503(3):1618-1624. doi: 10.1016/j.bbrc.2018.07.090. [PMID: 30060948]
  • Lujin Wu, Ke Wang, Wei Wang, Zheng Wen, Peihua Wang, Lei Liu, Dao Wen Wang. Glucagon-like peptide-1 ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via the PPARα pathway. Aging cell. 2018 08; 17(4):e12763. doi: 10.1111/acel.12763. [PMID: 29659121]
  • Gulay Nephan, Zeynep Mine Coskun, Sema Bolkent. Dipeptidyl peptidase-4 inhibition prevents cell death via extrinsic and intrinsic apoptotic pathways in rat pancreas with insulin resistance. Cell biochemistry and function. 2018 Jun; 36(4):212-220. doi: 10.1002/cbf.3333. [PMID: 29748970]
  • Tao Tao, Peihong Wu, Yuying Wang, Wei Liu. Comparison of glycemic control and β-cell function in new onset T2DM patients with PCOS of metformin and saxagliptin monotherapy or combination treatment. BMC endocrine disorders. 2018 Feb; 18(1):14. doi: 10.1186/s12902-018-0243-5. [PMID: 29482528]
  • Karen E Elkind-Hirsch, Martha S Paterson, Ericka L Seidemann, Hanh C Gutowski. Short-term therapy with combination dipeptidyl peptidase-4 inhibitor saxagliptin/metformin extended release (XR) is superior to saxagliptin or metformin XR monotherapy in prediabetic women with polycystic ovary syndrome: a single-blind, randomized, pilot study. Fertility and sterility. 2017 01; 107(1):253-260.e1. doi: 10.1016/j.fertnstert.2016.09.023. [PMID: 28228317]
  • Nicolangelo Iazzetta, Carlo Garofalo, Manuela Savino, Adelia Sagliocca, Sara Santangelo, Mario Pacilio, Maria Elena Liberti, Andrea Camocardi, Camilla Ambrosca, Roberto Minutolo, Luca De Nicola, Giuseppe Conte. Nephroprotection with saxagliptin. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. 2015 Nov; 32(6):. doi: NULL. [PMID: 26845214]
  • G Schernthaner, S Durán-Garcia, M Hanefeld, G Langslet, L Niskanen, C J Östgren, E Malvolti, E Hardy. Efficacy and tolerability of saxagliptin compared with glimepiride in elderly patients with type 2 diabetes: a randomized, controlled study (GENERATION). Diabetes, obesity & metabolism. 2015 Jul; 17(7):630-8. doi: 10.1111/dom.12461. [PMID: 25761977]
  • Noha N Nassar, Muhammad Y Al-Shorbagy, Hany H Arab, Dalaal M Abdallah. Saxagliptin: a novel antiparkinsonian approach. Neuropharmacology. 2015 Feb; 89(?):308-17. doi: 10.1016/j.neuropharm.2014.10.007. [PMID: 25446674]
  • Yan Liu, Zhen Zhang, Rongping Chen, Jia Sun, Hong Chen. [Therapeutic effect of saxagliptin in rat models of nonalcoholic fatty liver and type 2 diabetes]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2014 Jun; 34(6):862-8. doi: ". [PMID: 24968846]
  • Jingwen Gao, Zhan Shi, Shuzhen Zhu, George Q Li, Ru Yan, Meicun Yao. Influences of processed rhubarbs on the activities of four CYP isozymes and the metabolism of saxagliptin in rats based on probe cocktail and pharmacokinetics approaches. Journal of ethnopharmacology. 2013 Jan; 145(2):566-72. doi: 10.1016/j.jep.2012.11.030. [PMID: 23207062]
  • Michael E Cobble, Robert Frederich. Saxagliptin for the treatment of type 2 diabetes mellitus: assessing cardiovascular data. Cardiovascular diabetology. 2012 Jan; 11(?):6. doi: 10.1186/1475-2840-11-6. [PMID: 22248301]
  • Paul S Jellinger. Focus on incretin-based therapies: targeting the core defects of type 2 diabetes. Postgraduate medicine. 2011 Jan; 123(1):53-65. doi: 10.3810/pgm.2011.01.2245. [PMID: 21293084]