tranylcypromine (BioDeep_00000789027)

   


代谢物信息卡片


(1R,2S)-Tranylcypromine

  化学式: C9H11N (133.0891)
中文名称: (1R,2S)-2-苯基环丙胺, 反苯环丙胺盐酸盐
  谱图信息: 最多检出来源 () %

分子结构信息

SMILES: C1C(C1N)C2=CC=CC=C2
InChI: InChI=1S/C9H11N/c10-9-6-8(9)7-4-2-1-3-5-7/h1-5,8-9H,6,10H2/t8-,9+/m0/s1


描述信息

N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AF - Monoamine oxidase inhibitors, non-selective
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor

同义名列表

4 个代谢物同义名

(1R,2S)-Tranylcypromine; tranylcypromine; Tranylcypromine; Parnate



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Sara Silva, Joana Marto, Lídia M Gonçalves, Diana Duarte, O Salomé G P Soares, Francisco Vasques-Nóvoa, António J Almeida, Nuno Vale. New Peptide Functionalized Nanostructured Lipid Carriers with CNS Drugs and Evaluation Anti-proliferative Activity. International journal of molecular sciences. 2022 Jun; 23(13):. doi: 10.3390/ijms23137109. [PMID: 35806112]
  • Sven Ulrich, Daniela Hock, Volker Guth, Aydin Erenmemisoglu, Bernhard Scheidel. Insufficient recovery of monoamine oxidase in a bioequivalence study of the monoamine oxidase inhibitor tranylcypromine: Recommendation of the tranylcypromine enantiomer test. International journal of clinical pharmacology and therapeutics. 2022 May; 60(5):242-252. doi: 10.5414/cp204169. [PMID: 35279222]
  • Maxi Wass, Stefanie Göllner, Birgit Besenbeck, Richard F Schlenk, Petra Mundmann, Joachim R Göthert, Richard Noppeney, Christoph Schliemann, Jan-Henrik Mikesch, Georg Lenz, Martin Dugas, Martin Wermke, Christoph Röllig, Martin Bornhäuser, Hubert Serve, Uwe Platzbecker, Kathrin I Foerster, Jürgen Burhenne, Walter E Haefeli, Lutz P Müller, Mascha Binder, Caroline Pabst, Carsten Müller-Tidow. A proof of concept phase I/II pilot trial of LSD1 inhibition by tranylcypromine combined with ATRA in refractory/relapsed AML patients not eligible for intensive therapy. Leukemia. 2021 03; 35(3):701-711. doi: 10.1038/s41375-020-0892-z. [PMID: 32561840]
  • Alexander Dmitriev, Dmitry Filimonov, Alexey Lagunin, Dmitry Karasev, Pavel Pogodin, Anastasiya Rudik, Vladimir Poroikov. Prediction of Severity of Drug-Drug Interactions Caused by Enzyme Inhibition and Activation. Molecules (Basel, Switzerland). 2019 Oct; 24(21):. doi: 10.3390/molecules24213955. [PMID: 31683720]
  • Ali Reza Fakhari, Hasan Mohammadi Kosalar, Sajad Asadi, Kobra Sadat Hasheminasab. Surfactant-assisted electromembrane extraction combined with cyclodextrin-modified capillary electrophoresis for the separation and quantification of Tranylcypromine enantiomers in biological samples. Journal of separation science. 2018 Jan; 41(2):475-482. doi: 10.1002/jssc.201700488. [PMID: 28988449]
  • Sven Ulrich, Roland Ricken, Mazda Adli. Tranylcypromine in mind (Part I): Review of pharmacology. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2017 08; 27(8):697-713. doi: 10.1016/j.euroneuro.2017.05.007. [PMID: 28655495]
  • Maryam Akhgari, Farzaneh Jokar, Afshar Etemadi-Aleagha, Ali Ghasemi. Discrimination Between Drug Abuse and Medical Therapy: Case report of a tranylcypromine overdose-related fatality. Sultan Qaboos University medical journal. 2017 May; 17(2):e213-e217. doi: 10.18295/squmj.2016.17.02.013. [PMID: 28690895]
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