GSK-J4 (BioDeep_00000788966)
代谢物信息卡片
化学式: C24H27N5O2 (417.2164642)
中文名称: N-[2-(2-吡啶基)-6-(1,2,4,5-四氢-3H-3-苯并氮杂卓-3-基)-4-嘧啶基]-BETA-丙氨酸乙酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)CCNC1=CC(=NC(=N1)C2=CC=CC=N2)N3CCC4=CC=CC=C4CC3
InChI: InChI=1S/C24H27N5O2/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29/h3-9,13,17H,2,10-12,14-16H2,1H3,(H,26,27,28)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Peir-Haur Hung, Yung-Chien Hsu, Tsung-Hsien Chen, Cheng Ho, Chun-Liang Lin. The Histone Demethylase Inhibitor GSK-J4 Is a Therapeutic Target for the Kidney Fibrosis of Diabetic Kidney Disease via DKK1 Modulation.
International journal of molecular sciences.
2022 Aug; 23(16):. doi:
10.3390/ijms23169407. [PMID: 36012674] - Anna K Kania, Muyao Guo, Christopher D Scharer, Jeremy M Boss. Inhibition of H3K27me3 Demethylases Promotes Plasmablast Formation.
ImmunoHorizons.
2021 12; 5(12):918-930. doi:
10.4049/immunohorizons.2000087. [PMID: 34880105] - Jayasri Nanduri, Ning Wang, Benjamin L Wang, Nanduri R Prabhakar. Lysine demethylase KDM6B regulates HIF-1α-mediated systemic and cellular responses to intermittent hypoxia.
Physiological genomics.
2021 09; 53(9):385-394. doi:
10.1152/physiolgenomics.00045.2021. [PMID: 34297635] - Yuhang Jiang, Fengfeng Li, Bowen Gao, Mengjun Ma, Meng Chen, Yanfeng Wu, Weidong Zhang, Yangbai Sun, Sanhong Liu, Huiyong Shen. KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma.
Theranostics.
2021; 11(8):3868-3881. doi:
10.7150/thno.53347. [PMID: 33664867] - Yanyan Guo, Zuying Xiong, Xiaoqiang Guo. Histone demethylase KDM6B regulates human podocyte differentiation in vitro.
The Biochemical journal.
2019 06; 476(12):1741-1751. doi:
10.1042/bcj20180968. [PMID: 31138771] - Hong Chen, Yixue Huang, Xiuqin Zhu, Chong Liu, Yangmian Yuan, Hua Su, Chun Zhang, Chengyu Liu, Mingrui Xiong, Yannan Qu, Peng Yun, Ling Zheng, Kun Huang. Histone demethylase UTX is a therapeutic target for diabetic kidney disease.
The Journal of physiology.
2019 03; 597(6):1643-1660. doi:
10.1113/jp277367. [PMID: 30516825] - Wanwan Jia, Weijun Wu, Di Yang, Chenxi Xiao, Zhenghua Su, Zheng Huang, Zhongzheng Li, Ming Qin, Mengwei Huang, Siyu Liu, Fen Long, Jianchun Mao, Xinhua Liu, Yi Zhun Zhu. Histone demethylase JMJD3 regulates fibroblast-like synoviocyte-mediated proliferation and joint destruction in rheumatoid arthritis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2018 07; 32(7):4031-4042. doi:
10.1096/fj.201701483r. [PMID: 29481307]