Ceftarolin Fosamil (BioDeep_00000788946)
代谢物信息卡片
Ceftaroline fosamil acetate
化学式: C24H27N8O11PS4 (762.042)
中文名称: 头孢洛林酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCON=C(C1=NSC(=N1)NP(=O)(O)O)C(=O)NC2C3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C=C5)C)C(=O)[O-].CC(=O)O.O
InChI: 1-2(3)4
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use
同义名列表
2 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:70714
- KEGGdrug: D08884
- PubChem: 16007393
- ChEMBL: CHEMBL3544973
- CAS: 866021-48-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Victória Etges Helfer, Bruna Bernar Dias, Graziela de Araújo Lock, Caroline Andrade Tomaszewski, Lucas Suchecki Barnet, Fabiano Barreto, Alexandre P Zavascki, Bibiana Verlindo de Araújo, Teresa Dalla Costa. Population Pharmacokinetic Modeling of Free Plasma and Free Brain Concentrations of Ceftaroline in Healthy and Methicillin-Resistant Staphylococcus aureus-Infected Wistar Rats.
Antimicrobial agents and chemotherapy.
2023 07; 67(7):e0038223. doi:
10.1128/aac.00382-23. [PMID: 37367389] - Jie Zhou, Xiang You, Guimu Guo, Meng Ke, Jianwen Xu, Lingling Ye, Wanhong Wu, Pinfang Huang, Cuihong Lin. Ceftaroline Dosage Optimized for Pediatric Patients With Renal Impairment Using Physiologically Based Pharmacokinetic Modeling.
Journal of clinical pharmacology.
2021 12; 61(12):1646-1656. doi:
10.1002/jcph.1944. [PMID: 34329494] - M Edlinger-Stanger, V Al Jalali, M Andreas, W Jäger, M Böhmdorfer, M Zeitlinger, D Hutschala. Plasma and Lung Tissue Pharmacokinetics of Ceftaroline Fosamil in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass: an In Vivo Microdialysis Study.
Antimicrobial agents and chemotherapy.
2021 09; 65(10):e0067921. doi:
10.1128/aac.00679-21. [PMID: 34280013] - Phylinda L S Chan, Lynn McFadyen, Andrea Quaye, Heidi Leister-Tebbe, Victoria M Hendrick, Jennifer Hammond, Susan Raber. The use of extrapolation based on modeling and simulation to support high-dose regimens of ceftaroline fosamil in pediatric patients with complicated skin and soft-tissue infections.
CPT: pharmacometrics & systems pharmacology.
2021 06; 10(6):551-563. doi:
10.1002/psp4.12608. [PMID: 33687148] - Todd A Riccobene, Timothy J Carrothers, William Knebel, Susan Raber, Phylinda L S Chan. Pharmacokinetic and Pharmacodynamic Target Attainment in Adult and Pediatric Patients Following Administration of Ceftaroline Fosamil as a 5-Minute Infusion.
Clinical pharmacology in drug development.
2021 04; 10(4):420-427. doi:
10.1002/cpdd.907. [PMID: 33465279] - Raj Kumar, Vikas Kumar, Keun Woo Lee. A computational drug repurposing approach in identifying the cephalosporin antibiotic and anti-hepatitis C drug derivatives for COVID-19 treatment.
Computers in biology and medicine.
2021 03; 130(?):104186. doi:
10.1016/j.compbiomed.2020.104186. [PMID: 33360831] - Jianguo Li, Shampa Das, Diansong Zhou, Nidal Al-Huniti. Population Pharmacokinetic Modeling and Probability of Target Attainment Analyses in Asian Patients With Community-Acquired Pneumonia Treated With Ceftaroline Fosamil.
Clinical pharmacology in drug development.
2019 07; 8(5):682-694. doi:
10.1002/cpdd.673. [PMID: 31044546] - Federica Andreoni, Masanori Toyofuku, Carmen Menzi, Ratchara Kalawong, Srikanth Mairpady Shambat, Patrice François, Annelies S Zinkernagel, Leo Eberl. Antibiotics Stimulate Formation of Vesicles in Staphylococcus aureus in both Phage-Dependent and -Independent Fashions and via Different Routes.
Antimicrobial agents and chemotherapy.
2019 02; 63(2):. doi:
10.1128/aac.01439-18. [PMID: 30509943] - Jennifer Le, John S Bradley, Sara Hingtgen, Shannon Skochko, Nanette Black, Ronald N Jones, Meerana Lim, Edmund V Capparelli. Pharmacokinetics of single-dose ceftaroline fosamil in children with cystic fibrosis.
Pediatric pulmonology.
2017 Nov; 52(11):1424-1434. doi:
10.1002/ppul.23827. [PMID: 28910514] - Vasilios Athans, Rachel M Kenney, Jacob Wong, Susan L Davis. Outpatient use of ceftaroline fosamil versus vancomycin for osteoarticular infection: a matched cohort study.
The Journal of antimicrobial chemotherapy.
2016 12; 71(12):3568-3574. doi:
10.1093/jac/dkw326. [PMID: 27530754] - Peter Matzneller, Edith Lackner, Heimo Lagler, Beatrix Wulkersdorfer, Zoe Österreicher, Markus Zeitlinger. Single- and Repeated-Dose Pharmacokinetics of Ceftaroline in Plasma and Soft Tissues of Healthy Volunteers for Two Different Dosing Regimens of Ceftaroline Fosamil.
Antimicrobial agents and chemotherapy.
2016 06; 60(6):3617-25. doi:
10.1128/aac.00097-16. [PMID: 27044549] - Maria Sunzel, Maria Learoyd, Jianguo Li, Yan Li, Ngoc Ngo, Timi Edeki. An open-label, non-randomised, phase 1, single-dose study to assess the pharmacokinetics of ceftaroline in patients with end-stage renal disease requiring intermittent haemodialysis.
International journal of antimicrobial agents.
2015 Dec; 46(6):682-8. doi:
10.1016/j.ijantimicag.2015.09.009. [PMID: 26545441] - Li Yang, Maria Sunzel, Peng Xu, Timi Edeki, David Wilson, Jianguo Li, Haiyan Li. Evaluation of the pharmacokinetics and safety of single and multiple ceftaroline fosamil infusions in healthy Chinese and Western subjects.
International journal of clinical pharmacology and therapeutics.
2015 Aug; 53(8):681-91. doi:
10.5414/cp202343. [PMID: 26152131] - A Canut, A Isla, A Rodríguez-Gascón. Pharmacokinetic/pharmacodynamic analysis to evaluate ceftaroline fosamil dosing regimens for the treatment of community-acquired bacterial pneumonia and complicated skin and skin-structure infections in patients with normal and impaired renal function.
International journal of antimicrobial agents.
2015 Apr; 45(4):399-405. doi:
10.1016/j.ijantimicag.2014.12.023. [PMID: 25700566] - Timi Edeki, Mirjana Kujacic, Helen Broadhurst, Jianguo Li, Maria Sunzel. Safety, local tolerability and pharmacokinetics of ceftaroline fosamil administered in a reduced infusion volume.
British journal of clinical pharmacology.
2014 Dec; 78(6):1291-7. doi:
10.1111/bcp.12465. [PMID: 25041494] - Todd Riccobene, Abhijeet Jakate, Doug Rank. A series of pharmacokinetic studies of ceftaroline fosamil in select populations: normal subjects, healthy elderly subjects, and subjects with renal impairment or end-stage renal disease requiring hemodialysis.
Journal of clinical pharmacology.
2014 Jul; 54(7):742-52. doi:
10.1002/jcph.265. [PMID: 24431097] - Shampa Das, Jon Armstrong, David Mathews, Jianguo Li, Timi Edeki. Randomized, placebo-controlled study to assess the impact on QT/QTc interval of supratherapeutic doses of ceftazidime-avibactam or ceftaroline fosamil-avibactam.
Journal of clinical pharmacology.
2014 Mar; 54(3):331-40. doi:
10.1002/jcph.199. [PMID: 24150927] - Scott A Van Wart, Paul G Ambrose, Christopher M Rubino, Tatiana Khariton, Todd A Riccobene, H David Friedland, Ian A Critchley, Sujata M Bhavnani. Pharmacokinetic-pharmacodynamic target attainment analyses to evaluate in vitro susceptibility test interpretive criteria for ceftaroline against Staphylococcus aureus and Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy.
2014; 58(2):885-91. doi:
10.1128/aac.01680-13. [PMID: 24277021] - Alasdair P MacGowan, Alan R Noel, Sharon Tomaselli, Karen E Bowker. Pharmacodynamics of ceftaroline against Staphylococcus aureus studied in an in vitro pharmacokinetic model of infection.
Antimicrobial agents and chemotherapy.
2013 Jun; 57(6):2451-6. doi:
10.1128/aac.01386-12. [PMID: 23459495] - Todd A Riccobene, Ludmyla Rekeda, Douglas Rank, Lily Llorens. Evaluation of the effect of a supratherapeutic dose of intravenous ceftaroline fosamil on the corrected QT interval.
Antimicrobial agents and chemotherapy.
2013 Apr; 57(4):1777-83. doi:
10.1128/aac.02352-12. [PMID: 23357764] - Todd A Riccobene, Sheng Fang Su, Douglas Rank. Single- and multiple-dose study to determine the safety, tolerability, and pharmacokinetics of ceftaroline fosamil in combination with avibactam in healthy subjects.
Antimicrobial agents and chemotherapy.
2013 Mar; 57(3):1496-504. doi:
10.1128/aac.02134-12. [PMID: 23295928] - Amira A Bhalodi, Jared L Crandon, Donald Biek, David P Nicolau. Efficacy of ceftaroline fosamil in a staphylococcal murine pneumonia model.
Antimicrobial agents and chemotherapy.
2012 Dec; 56(12):6160-5. doi:
10.1128/aac.01078-12. [PMID: 22985880] - Donald Biek, Ian A Critchley, Todd A Riccobene, Dirk A Thye. Ceftaroline fosamil: a novel broad-spectrum cephalosporin with expanded anti-Gram-positive activity.
The Journal of antimicrobial chemotherapy.
2010 Nov; 65 Suppl 4(?):iv9-16. doi:
10.1093/jac/dkq251. [PMID: 21115457]
