ergoline (BioDeep_00000788880)
代谢物信息卡片
化学式: C14H16N2 (212.1313)
中文名称: 麦角灵
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2C(CC3=CNC4=CC=CC2=C34)NC1
InChI: InChI=1S/C14H16N2/c1-3-11-10-4-2-6-15-13(10)7-9-8-16-12(5-1)14(9)11/h1,3,5,8,10,13,15-16H,2,4,6-7H2/t10-,13-/m1/s1
描述信息
An indole alkaloid whose structural skeleton is found in many naturally occurring and synthetic ergolines which are known to bind to neurotransmitter receptors, such as dopamine, noradrenaline and serotonin receptors and function as unselective agonists or antagonists at these receptors.
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:38484
- PubChem: 6857537
- MeSH: Ergolines
- CAS: 478-88-6
- MetaboLights: MTBLC38484
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Isabelle Boucoiran, Melissa Roy, Vanessa Poliquin, Chelsea Elwood, Nancy L Sheehan, Rosie Thibaudeau, Ema Ferreira, Julie Autmizguine, Fatima Kakkar, Marc Boucher, Deborah Money, Karen Tulloch. Evaluation of cabergoline for lactation inhibition in women living with HIV.
International journal of STD & AIDS.
2021 06; 32(7):654-661. doi:
10.1177/0956462420984694
. [PMID: 33612017] - Lukas Andereggen, Janine Frey, Emanuel Christ. Long-term IGF-1 monitoring in prolactinoma patients treated with cabergoline might not be indicated.
Endocrine.
2021 04; 72(1):216-222. doi:
10.1007/s12020-020-02557-1
. [PMID: 33275185] - R Bharadwaj, H Jagadeesan, S R Kumar, S Ramalingam. Molecular mechanisms in grass-Epichloë interactions: towards endophyte driven farming to improve plant fitness and immunity.
World journal of microbiology & biotechnology.
2020 Jun; 36(7):92. doi:
10.1007/s11274-020-02868-5
. [PMID: 32562008] - Wiebke Rudolph, Daniela Remane, Dirk K Wissenbach, Frank T Peters. Comparative study on the metabolism of the ergot alkaloids ergocristine, ergocryptine, ergotamine, and ergovaline in equine and human S9 fractions and equine liver preparations.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 Oct; 49(10):1149-1157. doi:
10.1080/00498254.2018.1542187
. [PMID: 30623698] - Chitra Choudhary, Amir H Hamrahian, James F Bena, Pablo Recinos, Laurence Kennedy, Georgiana Dobri. THE EFFECT OF RALOXIFENE ON SERUM PROLACTIN LEVEL IN PATIENTS WITH PROLACTINOMA.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2019 Jul; 25(7):684-688. doi:
10.4158/ep-2018-0321
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Toxins.
2019 05; 11(5):. doi:
10.3390/toxins11050249
. [PMID: 31052510] - Samantha J Fabian, Matthew D Maust, Daniel G Panaccione. Ergot Alkaloid Synthesis Capacity of Penicillium camemberti.
Applied and environmental microbiology.
2018 10; 84(19):. doi:
10.1128/aem.01583-18
. [PMID: 30076193] - Matevž Likar, Marjana Grandič, Breda Jakovac Strajn, Katarina Kos, Franci Aco Celar. Links Between Genetic Groups, Host Specificity, and Ergot-Alkaloid Profiles within Claviceps purpurea (Fr.) Tul. on Slovenian Grasses.
Plant disease.
2018 Jul; 102(7):1334-1340. doi:
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. [PMID: 30673578] - Mehrnaz Imani, Mohammad Ebrahim Khamseh, Poopak Asadi, Mohammad Ghorbani, Hamideh Akbari, Fariba Alaei-Shahmiri, Maryam Honardoost, Mahmoud Reza Kaynama, Mojtaba Malek. COMPARISON OF CABERGOLINE VERSUS RALOXIFENE ADD-ON THERAPY TO LONG-ACTING SOMATOSTATIN ANALOGUE IN PATIENTS WITH INADEQUATELY CONTROLLED ACROMEGALY: A RANDOMIZED OPEN LABEL CLINICAL TRIAL.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2018 Jun; 24(6):542-547. doi:
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Veterinary pathology.
2017 11; 54(6):972-976. doi:
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The Journal of clinical endocrinology and metabolism.
2017 11; 102(11):4218-4225. doi:
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. [PMID: 28945897] - Ricardo Costa, C A Santa-Maria, D M Scholtens, S Jain, L Flaum, W J Gradishar, C V Clevenger, V G Kaklamani. A pilot study of cabergoline for the treatment of metastatic breast cancer.
Breast cancer research and treatment.
2017 Oct; 165(3):585-592. doi:
10.1007/s10549-017-4370-x
. [PMID: 28674764] - Shalini Kunasegaran, Michael S Croxson, Ian Holdaway, Rinki Murphy. An unusual case of Cushing's syndrome due to bihormonal ACTH-prolactin secreting pituitary macroadenoma with rapid response to cabergoline.
BMJ case reports.
2017 Aug; 2017(?):. doi:
10.1136/bcr-2017-219921
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Pituitary.
2017 Aug; 20(4):464-470. doi:
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. [PMID: 28523537] - F Hasanpour, M Taei, S H Banitaba, M Heidari. Template synthesis of maghemite nanoparticle in carboxymethyl cellulose and its application for electrochemical cabergoline sensing.
Materials science & engineering. C, Materials for biological applications.
2017 Jul; 76(?):88-93. doi:
10.1016/j.msec.2017.02.128
. [PMID: 28482603] - Robert Krysiak, Witold Szkróbka, Bogusław Okopień. Alternative Treatment Strategies in Women Poorly Tolerating Moderate Doses of Bromocriptine.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
2017 Jun; 125(6):360-364. doi:
10.1055/s-0042-123041
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European journal of endocrinology.
2017 Mar; 176(3):305-314. doi:
10.1530/eje-16-0662
. [PMID: 28007845] - Asghar Mogheiseh, Mohammad Javad Mosavi Ghiri, Esmaeil Bandarian. The Clinical Follow-Up of Estradiol Benzoate Priming During Induction of Estrus With Cabergoline in Dogs.
Topics in companion animal medicine.
2017 Mar; 32(1):16-19. doi:
10.1053/j.tcam.2017.07.001
. [PMID: 28750784] - Verena Schwetz, Rosaria Librizzi, Christian Trummer, Georg Theiler, Claudia Stiegler, Thomas R Pieber, Barbara Obermayer-Pietsch, Stefan Pilz. Treatment of hyperprolactinaemia reduces total cholesterol and LDL in patients with prolactinomas.
Metabolic brain disease.
2017 02; 32(1):155-161. doi:
10.1007/s11011-016-9882-2
. [PMID: 27525431] - Shinya Watanabe, Hiroyoshi Akutsu, Shingo Takano, Tetsuya Yamamoto, Eiichi Ishikawa, Hiroaki Suzuki, Akira Matsumura. Long-term results of cabergoline therapy for macroprolactinomas and analyses of factors associated with remission after withdrawal.
Clinical endocrinology.
2017 Feb; 86(2):207-213. doi:
10.1111/cen.13240
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The Cochrane database of systematic reviews.
2017 01; 1(?):CD012103. doi:
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. [PMID: 28111738] - Pedro Iglesias, Carles Villabona, Juan José Díez. [Serum concentrations of glucose, cholesterol and triglycerides in men with prolactinoma treated with cabergoline].
Medicina clinica.
2016 Nov; 147(10):466-467. doi:
10.1016/j.medcli.2016.05.025
. [PMID: 27452305] - Ilyas M Eli, Amol Raheja, Heather J Corn, Debra L Simmons, Cheryl Ann Palmer, William T Couldwell. Sellar Wegener Granulomatosis Masquerading as Cabergoline-Resistant Prolactinoma.
World neurosurgery.
2016 Nov; 95(?):622.e1-622.e5. doi:
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PLoS genetics.
2016 Nov; 12(11):e1006374. doi:
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Current genetics.
2016 Nov; 62(4):853-860. doi:
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. [PMID: 26972831] - Adele Bahar, Zahra Kashi, Ezzatossadat Daneshpour, Ozra Akha, Shahram Ala. Effects of cabergoline on blood glucose levels in type 2 diabetic patients: A double-blind controlled clinical trial.
Medicine.
2016 Oct; 95(40):e4818. doi:
10.1097/md.0000000000004818
. [PMID: 27749534] - Laura D Ratner, Guillermina Stevens, Maria Marta Bonaventura, Victoria A Lux-Lantos, Matti Poutanen, Ricardo S Calandra, Ilpo T Huhtaniemi, Susana B Rulli. Hyperprolactinemia induced by hCG leads to metabolic disturbances in female mice.
The Journal of endocrinology.
2016 07; 230(1):157-69. doi:
10.1530/joe-15-0528
. [PMID: 27154336] - M Boutinaud, N Isaka, V Lollivier, F Dessauge, E Gandemer, P Lamberton, A I De Prado Taranilla, A Deflandre, L M Sordillo. Cabergoline inhibits prolactin secretion and accelerates involution in dairy cows after dry-off.
Journal of dairy science.
2016 Jul; 99(7):5707-5718. doi:
10.3168/jds.2015-10782
. [PMID: 27179868] - Nur Şahin, Nesin Apaydın, Emrah Töz, Oya Nermin Sivrikoz, Mine Genç, Gülüzar Arzu Turan, Hakan Cengiz, Fatma Eskicioğlu. Comparison of the effects of letrozole and cabergoline on vascular permeability, ovarian diameter, ovarian tissue VEGF levels, and blood PEDF levels, in a rat model of ovarian hyperstimulation syndrome.
Archives of gynecology and obstetrics.
2016 May; 293(5):1101-6. doi:
10.1007/s00404-015-3987-4
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The journal of headache and pain.
2016; 17(?):23. doi:
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Boletin de la Asociacion Medica de Puerto Rico.
2016; 108(1):31-36. doi:
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European journal of endocrinology.
2016 Jan; 174(1):17-24. doi:
10.1530/eje-15-0807
. [PMID: 26582653] - Eider Pascual-Corrales, Alejandra Tomás Velázquez, José Luis Zubieta, Javier Salvador, Juan Carlos Galofré. Cabergoline for Cushing's disease: A case report.
Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion.
2015 Dec; 62(10):516-8. doi:
10.1016/j.endonu.2015.07.002
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BMJ case reports.
2015 Nov; 2015(?):. doi:
10.1136/bcr-2015-212221
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European journal of endocrinology.
2015 Nov; 173(5):693-702. doi:
10.1530/eje-15-0500
. [PMID: 26429918] - A Bach, A De-Prado, A Aris. Short communication: The effects of cabergoline administration at dry-off of lactating cows on udder engorgement, milk leakages, and lying behavior.
Journal of dairy science.
2015 Oct; 98(10):7097-101. doi:
10.3168/jds.2015-9751
. [PMID: 26277312] - Muzaffer Ilhan, Ozlem Timirci Kahraman, Saime Turan, Seda Turgut, Ozcan Karaman, Umit Zeybek, Samir Shukurov, Ilhan Yaylim, Ertugrul Tasan. Does DRD2 polymorphism influence the clinical characteristics of prolactinoma?.
Annales d'endocrinologie.
2015 Oct; 76(5):614-9. doi:
10.1016/j.ando.2015.08.005
. [PMID: 26514951] - R Krysiak, J Okrzesik, B Okopien. Different Effects of Metformin on the Hypothalamic-Pituitary-Thyroid Axis in Bromocriptine- and Cabergoline-treated Patients with Hashimoto's Thyroiditis and Glucose Metabolism Abnormalities.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
2015 Oct; 123(9):561-6. doi:
10.1055/s-0035-1564073
. [PMID: 26372847] - F S Cunha, S Domenice, V L Câmara, M H P Sircili, L J G Gooren, B B Mendonça, E M F Costa. Diagnosis of prolactinoma in two male-to-female transsexual subjects following high-dose cross-sex hormone therapy.
Andrologia.
2015 Aug; 47(6):680-4. doi:
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Pituitary.
2015 Jun; 18(3):405-9. doi:
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Journal of endocrinological investigation.
2015 Apr; 38(4):447-53. doi:
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. [PMID: 25421155] - Robert Krysiak, Bogusław Okopien. Different effects of cabergoline and bromocriptine on metabolic and cardiovascular risk factors in patients with elevated prolactin levels.
Basic & clinical pharmacology & toxicology.
2015 Mar; 116(3):251-6. doi:
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. [PMID: 25123447] - Renata S Auriemma, Mariano Galdiero, Pasquale Vitale, Luciana Granieri, Fabio Lo Calzo, Ciro Salzano, Lucia Ferreri, Claudia Pivonello, Federica Cariati, Giorgio Coppola, Cristina de Angelis, Annamaria Colao, Rosario Pivonello. Effect of chronic cabergoline treatment and testosterone replacement on metabolism in male patients with prolactinomas.
Neuroendocrinology.
2015; 101(1):66-81. doi:
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. [PMID: 25592453] - Hadar Amir, Dan Yaniv, Joseph Hasson, Ami Amit, David Gordon, Foad Azem. Cabergoline for reducing ovarian hyperstimulation syndrome in assisted reproductive technology treatment cycles. A prospective randomized controlled trial.
The Journal of reproductive medicine.
2015 Jan; 60(1-2):48-54. doi:
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Pomeranian journal of life sciences.
2015; 61(3):263-9. doi:
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2014 Dec; 46(13):939-42. doi:
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Pituitary.
2014 Oct; 17(5):451-6. doi:
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Applied and environmental microbiology.
2014 Oct; 80(20):6465-72. doi:
10.1128/aem.02137-14
. [PMID: 25107976] - Kari A Morfeld, Ray L Ball, Janine L Brown. Recurrence of hyperprolactinemia and continuation of ovarian acyclicity in captive African elephants (Loxodonta africana) treated with cabergoline.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2014 Sep; 45(3):569-76. doi:
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Fitoterapia.
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ChemMedChem.
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Journal of Ayub Medical College, Abbottabad : JAMC.
2014 Jul; 26(3):269-74. doi:
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European journal of endocrinology.
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BMC research notes.
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Pituitary.
2013 Dec; 16(4):536-44. doi:
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Clinical endocrinology.
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European journal of obstetrics, gynecology, and reproductive biology.
2013 Oct; 170(2):439-43. doi:
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Clinical endocrinology.
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Clinical neurology and neurosurgery.
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Current opinion in endocrinology, diabetes, and obesity.
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Medicina clinica.
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Neuroendocrinology.
2013; 98(4):299-310. doi:
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