Chlormequat chloride (BioDeep_00000788441)

   


代谢物信息卡片


2-Chloro-N,N,N-trimethylethanaminium chloride

化学式: C5H13Cl2N (157.0424998)
中文名称: 矮壮素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C[N+](C)(C)CCCl.[Cl-]
InChI: /p-1

描述信息

D006133 - Growth Substances > D010937 - Plant Growth Regulators

同义名列表

2 个代谢物同义名

2-Chloro-N,N,N-trimethylethanaminium chloride; Chlormequat chloride



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Zongzhen Wu, Long Ma, Deqi Su, Bayindala Xiagedeer. The disrupting effect of chlormequat chloride on growth hormone is associated with pregnancy. Toxicology letters. 2024 May; 395(?):17-25. doi: 10.1016/j.toxlet.2024.03.004. [PMID: 38552810]
  • Wanqian Guo, Chenping Kang, Xiaoxia Wang, Haoran Zhang, Lilan Yuan, Xuetao Wei, Qianqian Xiao, Weidong Hao. Chlorocholine chloride exposure induced spermatogenic dysfunction via iron overload caused by AhR/PERK axis-dependent ferritinophagy activation. Ecotoxicology and environmental safety. 2024 Apr; 274(?):116193. doi: 10.1016/j.ecoenv.2024.116193. [PMID: 38460407]
  • Alexis M Temkin, Sydney Evans, Demetri D Spyropoulos, Olga V Naidenko. A pilot study of chlormequat in food and urine from adults in the United States from 2017 to 2023. Journal of exposure science & environmental epidemiology. 2024 Mar; 34(2):317-321. doi: 10.1038/s41370-024-00643-4. [PMID: 38355783]
  • Xiaoxia Wang, Chenping Kang, Wanqian Guo, Lilan Yuan, Haoran Zhang, Qiong Zhang, Qianqian Xiao, Weidong Hao. Chlormequat chloride induced activation of calmodulin mediated PI3K/AKT signaling pathway led to impaired sperm quality in pubertal mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024 Jan; 185(?):114475. doi: 10.1016/j.fct.2024.114475. [PMID: 38286265]
  • Honghan Qin, Lei Xie, Yimei Zang, Jia Han, Jing Yu, Zuliang Luo, Xiaojun Ma. Residue of Chlormequat and Regulatory Effects on the Specialized Metabolites of Astragali Radix. Molecules (Basel, Switzerland). 2023 Sep; 28(19):. doi: 10.3390/molecules28196754. [PMID: 37836597]
  • Junjun Feng, Haiyun Jiang, Jing Wang, Zhengyi Jing, Fan Zhang, Tianyu Tan, Feng He, Lihua Jiang, Haiqin Li, Shimin Chang, Tengfei Li. [Simultaneous determination of 40 plant growth regulators, fungicides, insecticides, and antibiotics in bean sprouts by QuEChERS-high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2022 Sep; 40(9):843-853. doi: 10.3724/sp.j.1123.2021.12028. [PMID: 36156631]
  • Qianqian Xiao, Xiaohong Hou, Chenping Kang, Linglu Xu, Lilan Yuan, Zhe Zhao, Qinghe Meng, Jianjun Jiang, Weidong Hao. Chlorocholine chloride induced testosterone secretion inhibition mediated by endoplasmic reticulum stress in primary rat Leydig cells. Toxicology letters. 2022 Mar; 356(?):161-171. doi: 10.1016/j.toxlet.2021.12.018. [PMID: 34958886]
  • Qianqian Xiao, Xiaohong Hou, Chenping Kang, Bayindala Xiagedeer, Hong Hu, Qinghe Meng, Jianjun Jiang, Weidong Hao. Effects of prenatal chlorocholine chloride exposure on pubertal development and reproduction of male offspring in rats. Toxicology letters. 2021 Oct; 351(?):28-36. doi: 10.1016/j.toxlet.2021.08.005. [PMID: 34411681]
  • Siel Desmet, Emmy Dhooghe, Ellen De Keyser, Johan Van Huylenbroeck, Danny Geelen. Compact shoot architecture of Osteospermum fruticosum transformed with Rhizobium rhizogenes. Plant cell reports. 2021 Sep; 40(9):1665-1678. doi: 10.1007/s00299-021-02719-z. [PMID: 34052885]
  • Zheng-Bo Ma, Xue-Rui Dong, Meng-Ying Fang, Qi Wang, Peng Yan, Qing-Yan Wang, Lin Lu, Zhi-Qiang Dong. Effects of basic application of chlorocholine chloride combined with nitrogen fertilizer on nitrogen use of summer maize in North China Plain. Ying yong sheng tai xue bao = The journal of applied ecology. 2021 Mar; 32(3):931-941. doi: 10.13287/j.1001-9332.202103.021. [PMID: 33754559]
  • Ingo Hartter, Daniela Remane, Christian Rabe, Dirk K Wissenbach, Frank T Peters, Florian Eyer. Surviving chlormequat poisoning - pharmacokinetics and the role of atropine. Clinical toxicology (Philadelphia, Pa.). 2021 01; 59(1):74-76. doi: 10.1080/15563650.2020.1758326. [PMID: 32336166]
  • Shreosi Biswas, Tirthankar Banerjee, Talaviya Harshang, Neeraj Patanjali, Viswanathan Chinnusamy, Arkadeb Mukhopadhyay, Anupama Singh. Development of a QuEChERS-LCMS/MS method for simultaneous estimation of tebuconazole and chlormequat chloride in wheat crop. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2021; 56(3):212-221. doi: 10.1080/03601234.2021.1882822. [PMID: 33560902]
  • Bayindala Xiagedeer, Xiaohong Hou, Qi Zhang, Hong Hu, Chenping Kang, Qianqian Xiao, Weidong Hao. Maternal chlormequat chloride exposure disrupts embryonic growth and produces postnatal adverse effects. Toxicology. 2020 09; 442(?):152534. doi: 10.1016/j.tox.2020.152534. [PMID: 32622971]
  • Bjørn Eriksen, Aurélien Desmarchelier, Nancy Frank, Richard H Stadler, Thierry Delatour. Occurrence of the Plant Growth Regulator Chlormequat in Food May Be Due to Natural Formation: A Preliminary Mechanistic Study. Journal of agricultural and food chemistry. 2020 Jul; 68(29):7727-7733. doi: 10.1021/acs.jafc.0c02650. [PMID: 32578985]
  • Tricia McMillan, Breanne D Tidemann, John T OʼDonovan, Marta S Izydorczyk. Effects of plant growth regulator application on the malting quality of barley. Journal of the science of food and agriculture. 2020 Mar; 100(5):2082-2089. doi: 10.1002/jsfa.10231. [PMID: 31875963]
  • Yong Xiao, Haizhi Wu, Liejiang Yuan, Jiwang Tang, Shuxia Wang, Xiu Wang, Hang Deng, Lin Wu. [Determination of chlormequat chloride residues in animal derived foods by high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2020 Feb; 38(2):218-223. doi: 10.3724/sp.j.1123.2019.04036. [PMID: 34213171]
  • Xiaohong Hou, Hong Hu, Bayindala Xiagedeer, Pengmin Wang, Chenping Kang, Qi Zhang, Qinghe Meng, Weidong Hao. Effects of chlorocholine chloride on pubertal development and reproductive functions in male rats. Toxicology letters. 2020 Feb; 319(?):1-10. doi: 10.1016/j.toxlet.2019.10.024. [PMID: 31689472]
  • Bayindala Xiagedeer, Chenping Kang, Xiaohong Hou, Hong Hu, Qianqian Xiao, Weidong Hao. Chlormequat chloride promotes rat embryonic growth and GH-IGF-1 axis. Toxicology. 2020 01; 429(?):152326. doi: 10.1016/j.tox.2019.152326. [PMID: 31704167]
  • Ladislav Holik, Valerie Vranová. Proteolytic Activity in Meadow Soil after the Application of Phytohormones. Biomolecules. 2019 09; 9(9):. doi: 10.3390/biom9090507. [PMID: 31546949]
  • Yanhai Ji, Guanxing Chen, Xuyang Zheng, Qiwen Zhong, Mingyun Zhang, Zhanhui Wu, Changlong Wen, Mingchi Liu. Comprehensive Transcriptome Reveals an Opposite Regulatory Effect of Plant Growth Retardants in Controlling Seedling Overgrowth between Roots and Shoots. International journal of molecular sciences. 2019 Jul; 20(13):. doi: 10.3390/ijms20133307. [PMID: 31284415]
  • Sophie Allard, Pierre-Marie Allard, Isabelle Morel, Thomas Gicquel. Application of a molecular networking approach for clinical and forensic toxicology exemplified in three cases involving 3-MeO-PCP, doxylamine, and chlormequat. Drug testing and analysis. 2019 May; 11(5):669-677. doi: 10.1002/dta.2550. [PMID: 30468699]
  • Michael Urban, Stephan Hann, Helmut Rost. Simultaneous determination of pesticides, mycotoxins, tropane alkaloids, growth regulators, and pyrrolizidine alkaloids in oats and whole wheat grains after online clean-up via two-dimensional liquid chromatography tandem mass spectrometry. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2019; 54(2):98-111. doi: 10.1080/03601234.2018.1531662. [PMID: 30600768]
  • Rongrong Guo, Bo Wang, Ling Lin, Guo Cheng, Sihong Zhou, Shuyu Xie, Xiaofang Shi, Muming Cao, Ying Zhang, Xianjin Bai. Evolutionary, interaction and expression analysis of floral meristem identity genes in inflorescence induction of the second crop in two-crop-a-year grape culture system. Journal of genetics. 2018 Jun; 97(2):439-451. doi: . [PMID: 29932064]
  • Xiaohong Hou, Dan Huang, Qinghe Meng, Qi Zhang, Lixia Jia, Siqi Wang, Zhiyuan Cheng, Shuang Wu, Lanqin Shang, Jianjun Jiang, Weidong Hao. Pubertal chlorocholine chloride exposure inhibits testicular testosterone synthesis by down-regulating steroidogenic enzymes in adult rats. Toxicology letters. 2018 May; 288(?):17-24. doi: 10.1016/j.toxlet.2018.02.015. [PMID: 29447956]
  • Shenglan Qi, Huida Guan, Gang Deng, Tao Yang, Xuemei Cheng, Wei Liu, Ping Liu, Changhong Wang. Rapid, reliable, and sensitive detection of adenosine deaminase activity by UHPLC-Q-Orbitrap HRMS and its application to inhibitory activity evaluation of traditional Chinese medicines. Journal of pharmaceutical and biomedical analysis. 2018 May; 153(?):175-181. doi: 10.1016/j.jpba.2018.02.045. [PMID: 29499460]
  • Nathalie Bonvallot, Cécile Canlet, Florence Blas-Y-Estrada, Roselyne Gautier, Marie Tremblay-Franco, Sylvie Chevolleau, Sylvaine Cordier, Jean-Pierre Cravedi. Metabolome disruption of pregnant rats and their offspring resulting from repeated exposure to a pesticide mixture representative of environmental contamination in Brittany. PloS one. 2018; 13(6):e0198448. doi: 10.1371/journal.pone.0198448. [PMID: 29924815]
  • Razieh Jafari Hajati, Vahide Payamnoor, Najmeh Ahmadian Chashmi, Kamal Ghasemi Bezdi. Improved accumulation of betulin and betulinic acid in cell suspension culture of Betula pendula roth by abiotic and biotic elicitors. Preparative biochemistry & biotechnology. 2018; 48(9):867-876. doi: 10.1080/10826068.2018.1514514. [PMID: 30296385]
  • Hongxia Zhang, Zheng Feei Ma, Haiyan Yang, Lingming Kong. Determination of chlormequat and mepiquat residues and their dissipation rates in tomato cultivation matrices by ultra-performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Oct; 1064(?):75-84. doi: 10.1016/j.jchromb.2017.09.012. [PMID: 28915421]
  • Dan Huang, Shuang Wu, Xiaohong Hou, Lixia Jia, Qinghe Meng, Hongqian Chu, Jianjun Jiang, Lanqin Shang, Weidong Hao. The skeletal developmental toxicity of chlormequat chloride and its underlying mechanisms. Toxicology. 2017 04; 381(?):1-9. doi: 10.1016/j.tox.2017.02.003. [PMID: 28214531]
  • Dan Huang, Shuang Wu, Yao Pan, Qinghe Meng, Hongqian Chu, Jianjun Jiang, Lanqin Shang, Weidong Hao. The effects of chlormequat chloride on the development of pubertal male rats. Environmental toxicology and pharmacology. 2016 Oct; 47(?):92-99. doi: 10.1016/j.etap.2016.09.002. [PMID: 27653211]
  • Sandra Halwachs, Ingo Schäfer, Carsten Kneuer, Peter Seibel, Walther Honscha. Assessment of ABCG2-mediated transport of pesticides across the rabbit placenta barrier using a novel MDCKII in vitro model. Toxicology and applied pharmacology. 2016 08; 305(?):66-74. doi: 10.1016/j.taap.2016.06.007. [PMID: 27288731]
  • Bayindala Xiagedeer, Shuang Wu, Yingjuan Liu, Weidong Hao. Chlormequat chloride retards rat embryo growth in vitro. Toxicology in vitro : an international journal published in association with BIBRA. 2016 Aug; 34(?):274-282. doi: 10.1016/j.tiv.2016.05.001. [PMID: 27165806]
  • V Vijitharan, J Warnasekare, N C Lokunarangoda, M F Farah, S H Siribaddana. Fatal poisoning with plant growth regulator - chlormequat. The Ceylon medical journal. 2016 Jun; 61(2):89-90. doi: 10.4038/cmj.v61i2.8297. [PMID: 27423755]
  • Yacine Boumrah, Thomas Gicquel, Chloé Hugbart, Alain Baert, Isabelle Morel, Renaud Bouvet. Suicide by self-injection of chlormequat trademark C5SUN(®). Forensic science international. 2016 Jun; 263(?):e9-e13. doi: 10.1016/j.forsciint.2016.03.007. [PMID: 27020619]
  • Pibiao Shi, Kateta Malangisha Guy, Weifang Wu, Bingsheng Fang, Jinghua Yang, Mingfang Zhang, Zhongyuan Hu. Genome-wide identification and expression analysis of the ClTCP transcription factors in Citrullus lanatus. BMC plant biology. 2016 Apr; 16(?):85. doi: 10.1186/s12870-016-0765-9. [PMID: 27072931]
  • Yongchao Wang, Wanrong Gu, Tenglong Xie, Lijie Li, Yang Sun, He Zhang, Jing Li, Shi Wei. Mixed Compound of DCPTA and CCC Increases Maize Yield by Improving Plant Morphology and Up-Regulating Photosynthetic Capacity and Antioxidants. PloS one. 2016; 11(2):e0149404. doi: 10.1371/journal.pone.0149404. [PMID: 26872260]
  • P Nisse, R Majchrzak, J Ph Kahn, P A Mielcarek, M Mathieu-Nolf. Chlormequat poisoning is not without risk: Examination of seven fatal cases. Journal of forensic and legal medicine. 2015 Nov; 36(?):1-3. doi: 10.1016/j.jflm.2015.08.001. [PMID: 26318380]
  • Karen S Galea, Laura MacCalman, Kate Jones, John Cocker, Paul Teedon, John W Cherrie, Martie van Tongeren. Urinary biomarker concentrations of captan, chlormequat, chlorpyrifos and cypermethrin in UK adults and children living near agricultural land. Journal of exposure science & environmental epidemiology. 2015 Nov; 25(6):623-31. doi: 10.1038/jes.2015.54. [PMID: 26374656]
  • Abdollah Gholampour, Davood Hashemabadi, Shahram Sedaghathoor, Behzad Kaviani. Effect of chlormequat (cycocel) on the growth of ornamental cabbage and kale (Brassica oleracea) cultivars 'Kamome White' and 'Nagoya Red'. Journal of environmental biology. 2015 Jan; 36(1):273-7. doi: ". [PMID: 26536804]
  • Oksana Sytar, Asel Borankulova, Irene Hemmerich, Cornelia Rauh, Iryna Smetanska. Effect of chlorocholine chlorid on phenolic acids accumulation and polyphenols formation of buckwheat plants. Biological research. 2014 May; 47(?):19. doi: 10.1186/0717-6287-47-19. [PMID: 25027783]
  • Oliver A H Jones, Steven Murfitt, Claus Svendsen, Anthony Turk, Hazel Turk, David J Spurgeon, Lee A Walker, Richard F Shore, Sara M Long, Julian L Griffin. Comparisons of metabolic and physiological changes in rats following short term oral dosing with pesticides commonly found in food. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Sep; 59(?):438-45. doi: 10.1016/j.fct.2013.06.041. [PMID: 23822974]
  • Mehdi Farshad Ashraf, Maheran Abd Aziz, Mihdzar Abdul Kadir, Johnson Stanslas, Elmira Farokhian. In vitro tuberization of Chlorophytum Borivilianum Sant & Fern (Safed musli) as influenced by sucrose, CCC and culture systems. Plant & cell physiology. 2013 Aug; 54(8):1356-64. doi: 10.1093/pcp/pct083. [PMID: 23749812]
  • Kai Hou, Jun-Wen Chen, Juan-Yuan Zhai, Hao Shen, Li Chen, Wei Wu. [Effect of different plant growth regulators on yield and quality of Angelica dahurica var. formosana development]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Jul; 38(13):2082-5. doi: . [PMID: 24079230]
  • Yan-Hong Zhang, Su-Fang Gao, Hong-Gang Chen, Xiao-Xia Li, Ling Jin. [Study on rapid propagation of Scutellaria baicalensis variation]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Apr; 36(4):511-4. doi: ". [PMID: 24133989]
  • Avishek Dey, Sayanti Kundu, Abhijit Bandyopadhyay, Aloke Bhattacharjee. Efficient micropropagation and chlorocholine chloride induced stevioside production of Stevia rebaudiana Bertoni. Comptes rendus biologies. 2013 Jan; 336(1):17-28. doi: 10.1016/j.crvi.2012.11.007. [PMID: 23537766]
  • Chunmei Li, Fen Jin, Zhiyong Yu, Yamei Qi, Xiaomei Shi, Miao Wang, Hua Shao, Maojun Jin, Jing Wang, Mingqi Yang. Rapid determination of chlormequat in meat by dispersive solid-phase extraction and hydrophilic interaction liquid chromatography (HILIC)-electrospray tandem mass spectrometry. Journal of agricultural and food chemistry. 2012 Jul; 60(27):6816-22. doi: 10.1021/jf3010756. [PMID: 22686367]
  • Ri-ru Zheng, Yun Wu, Yi-ping Xia. Chlorocholine chloride and paclobutrazol treatments promote carbohydrate accumulation in bulbs of Lilium Oriental hybrids 'Sorbonne'. Journal of Zhejiang University. Science. B. 2012 Feb; 13(2):136-44. doi: 10.1631/jzus.b1000425. [PMID: 22302427]
  • Karen S Galea, Laura MacCalman, Kate Jones, John Cocker, Paul Teedon, Anne J Sleeuwenhoek, John W Cherrie, Martie van Tongeren. Biological monitoring of pesticide exposures in residents living near agricultural land. BMC public health. 2011 Nov; 11(?):856. doi: 10.1186/1471-2458-11-856. [PMID: 22074397]
  • Christian H Lindh, Margareta Littorin, Gunvor Johannesson, Bo A G Jönsson. Analysis of chlormequat in human urine as a biomarker of exposure using liquid chromatography triple quadrupole mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Jun; 879(19):1551-6. doi: 10.1016/j.jchromb.2011.03.046. [PMID: 21497564]
  • Mónica Meijón, María Jesús Cañal, Luis Valledor, Roberto Rodríguez, Isabel Feito. Epigenetic and physiological effects of gibberellin inhibitors and chemical pruners on the floral transition of azalea. Physiologia plantarum. 2011 Mar; 141(3):276-88. doi: 10.1111/j.1399-3054.2010.01430.x. [PMID: 21077902]
  • Xu Zhou, Jingang Xu, Zhidong Chen, Yan Zhu. [Simultaneous determination of chlormequat chloride and mepiquat chloride in plants by mobile phase ion chromatography]. Se pu = Chinese journal of chromatography. 2011 Mar; 29(3):244-8. doi: 10.3724/sp.j.1123.2011.00244. [PMID: 21657055]
  • Hua Cheng, Linling Li, Shuiyuan Cheng, Fuliang Cao, Yan Wang, Honghui Yuan. Molecular cloning and function assay of a chalcone isomerase gene (GbCHI) from Ginkgo biloba. Plant cell reports. 2011 Jan; 30(1):49-62. doi: 10.1007/s00299-010-0943-4. [PMID: 21046109]
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  • S L Reynolds, A R C Hill, M R Thomas, P Y Hamey. Occurrence and risks associated with chlormequat residues in a range of foodstuffs in the UK. Food additives and contaminants. 2004 May; 21(5):457-71. doi: 10.1080/02652030410001677781. [PMID: 15204547]
  • Sonja Riediker, Heinrich Obrist, Natalia Varga, Richard H Stadler. Determination of chlormequat and mepiquat in pear, tomato, and wheat flour using on-line solid-phase extraction (Prospekt) coupled with liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of chromatography. A. 2002 Aug; 966(1-2):15-23. doi: 10.1016/s0021-9673(02)00737-9. [PMID: 12214689]
  • A Songsang, S Chakeredza, G Thinggaard, T Vearasilp, U ter Meulen. Distribution of 15N-chlorocholine chloride in eggs of laying hens. Journal of animal physiology and animal nutrition. 2002 Jun; 86(5-6):129-36. doi: 10.1046/j.1439-0396.2002.00344.x. [PMID: 15379914]
  • C S Evans, B J Keely. Comment on 'Determination of chlormequat in pears by liquid chromatography/mass spectrometry' by H.G.J. Mol, R.C.J. Van Dam, R.J. Vreeken, and O.M. Steijger (J. AOAC Int. 83, 742-747). Journal of AOAC International. 2001 Nov; 84(6):123A. doi: ". [PMID: 11767130]
  • K Granby, M Vahl. Investigation of the herbicide glyphosate and the plant growth regulators chlormequat and mepiquat in cereals produced in Denmark. Food additives and contaminants. 2001 Oct; 18(10):898-905. doi: 10.1080/02652030119594. [PMID: 11569770]
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