Deflazacort (BioDeep_00000788389)
代谢物信息卡片
Deflazacort
化学式: C25H31NO6 (441.2151266)
中文名称: 地夫可特
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NC2(C(O1)CC3C2(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)C(=O)COC(=O)C
InChI: InChI=1S/C25H31NO6/c1-13-26-25(20(30)12-31-14(2)27)21(32-13)10-18-17-6-5-15-9-16(28)7-8-23(15,3)22(17)19(29)11-24(18,25)4/h7-9,17-19,21-22,29H,5-6,10-12H2,1-4H3/t17-,18-,19-,21+,22+,23-,24-,25+/m0/s1
描述信息
H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02A - Corticosteroids for systemic use, plain > H02AB - Glucocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D000893 - Anti-Inflammatory Agents
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:135720
- KEGGdrug: D03671
- PubChem: 189821
- DrugBank: DB11921
- ChEMBL: CHEMBL1201891
- CAS: 14484-47-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- W Douglas Biggar, Andrew Skalsky, Craig M McDonald. Comparing Deflazacort and Prednisone in Duchenne Muscular Dystrophy.
Journal of neuromuscular diseases.
2022; 9(4):463-476. doi:
10.3233/jnd-210776. [PMID: 35723111] - Jiyuan Ma, Brian Beers, Ravi Manohar, Stephen Roe, Joseph M Colacino, Ronald Kong. In vitro cytochrome P450- and transporter-mediated drug interaction potential of 6β-hydroxy-21-desacetyl deflazacort-A major human metabolite of deflazacort.
Pharmacology research & perspectives.
2021 04; 9(2):e00748. doi:
10.1002/prp2.748. [PMID: 33749127] - Ronald Kong, Jiyuan Ma, Brian Beers, Diksha Kaushik, E Lin, Elizabeth Goodwin, Joseph Colacino, Francesco Bibbiani. Metabolite V, an epoxide species is a minor circulating metabolite in humans following a single oral dose of deflazacort.
Pharmacology research & perspectives.
2020 12; 8(6):e00677. doi:
10.1002/prp2.677. [PMID: 33090712] - Gustavo Adolfo Guerrero, Luis Francisco Guerrero, Tatiana González. Non-lupus full house nephropathy in pediatrics: Case reports.
Biomedica : revista del Instituto Nacional de Salud.
2020 06; 40(2):220-227. doi:
10.7705/biomedica.4863. [PMID: 32673451] - Mahmoud A Tantawy, Soheir Alweshahy, Dalia A Elshabasy, Nadia F Youssef. Simultaneous Determination of Co-administrated Deflazacort, Aprepitant and Granisetron in Dosage Forms and Spiked Human Plasma by RP-HPLC/PAD.
Journal of chromatographic science.
2019 Oct; 57(9):790-798. doi:
10.1093/chromsci/bmz062. [PMID: 31504281] - Bo Hyon Yun, Dong Jin Joo, Seok Kyo Seo, Si Hyun Cho, Young Sik Choi, Byung Seok Lee. Effect of deflazacort on pregnancy outcome in kidney transplant patients: should we change the immunosuppressant before conception?.
BMC nephrology.
2019 05; 20(1):161. doi:
10.1186/s12882-019-1346-6. [PMID: 31088388] - Samara Camaçari de Carvalho, Cintia Yuri Matsumura, Humberto Santo Neto, Maria Julia Marques. Identification of plasma interleukins as biomarkers for deflazacort and omega-3 based Duchenne muscular dystrophy therapy.
Cytokine.
2018 02; 102(?):55-61. doi:
10.1016/j.cyto.2017.12.006. [PMID: 29276972] - A I Escudero, P Marín, C M Cárceles, E Escudero. Pharmacokinetics of deflazacort in rabbits after intravenous and oral administration and its interaction with erythromycin.
Journal of veterinary pharmacology and therapeutics.
2018 Feb; 41(1):e10-e15. doi:
10.1111/jvp.12442. [PMID: 28741668] - Filippo Carta, Milena Lussu, Fabrizio Bandino, Antonio Noto, Marcello Peppi, Natalia Chuchueva, Luigi Atzori, Vassilios Fanos, Roberto Puxeddu. Metabolomic analysis of urine with Nuclear Magnetic Resonance spectroscopy in patients with idiopathic sudden sensorineural hearing loss: A preliminary study.
Auris, nasus, larynx.
2017 Aug; 44(4):381-389. doi:
10.1016/j.anl.2016.10.003. [PMID: 27817938] - L Jensen, S J Petersson, N O Illum, H C Laugaard-Jacobsen, T Thelle, L H Jørgensen, H D Schrøder. Muscular response to the first three months of deflazacort treatment in boys with Duchenne muscular dystrophy.
Journal of musculoskeletal & neuronal interactions.
2017 06; 17(2):8-18. doi:
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2015 Jul; 5(3):1223-39. doi:
10.1002/cphy.c140048. [PMID: 26140716] - Wen Ding, Li Ding, Wen-Bo Li, Hong Pan, Hong-Da Lin. [Pharmacokinetics of deflazacort tablets in healthy Chinese volunteers].
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Respiratory care.
2013 Jul; 58(7):e72-6. doi:
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Retina (Philadelphia, Pa.).
2011 Oct; 31(9):1896-903. doi:
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Clinical and experimental nephrology.
2010 Aug; 14(4):385-8. doi:
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2010 Apr; 25(4):753-62. doi:
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2010 Mar; 73(3):247-9. doi:
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Pediatric nephrology (Berlin, Germany).
2010 Mar; 25(3):567-8. doi:
10.1007/s00467-009-1358-8. [PMID: 19902265] - N Joshi, K Rajeshwari. Deflazacort.
Journal of postgraduate medicine.
2009 Oct; 55(4):296-300. doi:
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Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.
2009 Apr; 15(3):133-7. doi:
10.1097/rhu.0b013e31819e6798. [PMID: 19300283] - Jorge Vega, Helmuth Goecke, Héctor Tapia, Eduardo Labarca, Mario Santamarina, Gonzalo Martínez. Treatment of idiopathic retroperitoneal fibrosis with colchicine and steroids: a case series.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2009 Apr; 53(4):628-37. doi:
10.1053/j.ajkd.2008.09.025. [PMID: 19117656] - J A Moro, L Almenar Bonet, L Martínez-Dolz, R Raso, I Sánchez-Lázaro, J Agüero, Antonio Salvador. Randomized prospective study of the evolution of renal function depending on the anticalcineurin used.
Transplantation proceedings.
2008 Nov; 40(9):2906-8. doi:
10.1016/j.transproceed.2008.08.117. [PMID: 19010143] - G Saviola, L Abdi Ali, S Shams Eddin, A Coppini, F Cavalieri, L Campostrini, S Sacco, M Bucci, G Cirino, M Rossini. Compared clinical efficacy and bone metabolic effects of low-dose deflazacort and methyl prednisolone in male inflammatory arthropathies: a 12-month open randomized pilot study.
Rheumatology (Oxford, England).
2007 Jun; 46(6):994-8. doi:
10.1093/rheumatology/kem030. [PMID: 17384176] - Jorge R Ferraris, Titania Pasqualini, Guillermo Alonso, Susana Legal, Patricia Sorroche, Ana M Galich, Héctor Jasper. Effects of deflazacort vs. methylprednisone: a randomized study in kidney transplant patients.
Pediatric nephrology (Berlin, Germany).
2007 May; 22(5):734-41. doi:
10.1007/s00467-006-0403-0. [PMID: 17294225] - R T Moxley, S Ashwal, S Pandya, A Connolly, J Florence, K Mathews, L Baumbach, C McDonald, M Sussman, C Wade. Practice parameter: corticosteroid treatment of Duchenne dystrophy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.
Neurology.
2005 Jan; 64(1):13-20. doi:
10.1212/01.wnl.0000148485.00049.b7. [PMID: 15642897] - Claudia Grossmann, Tim Scholz, Marina Rochel, Christiane Bumke-Vogt, Wolfgang Oelkers, Andreas F H Pfeiffer, Sven Diederich, Volker Bahr. Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in CV-1 cells: a comparison of their glucocorticoid and mineralocorticoid properties.
European journal of endocrinology.
2004 Sep; 151(3):397-406. doi:
10.1530/eje.0.1510397. [PMID: 15362971] - W D Biggar, L Politano, V A Harris, L Passamano, J Vajsar, B Alman, A Palladino, L I Comi, G Nigro. Deflazacort in Duchenne muscular dystrophy: a comparison of two different protocols.
Neuromuscular disorders : NMD.
2004 Sep; 14(8-9):476-82. doi:
10.1016/j.nmd.2004.05.001. [PMID: 15336688] - M A Tarnopolsky, D J Mahoney, J Vajsar, C Rodriguez, T J Doherty, B D Roy, D Biggar. Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy.
Neurology.
2004 May; 62(10):1771-7. doi:
10.1212/01.wnl.0000125178.18862.9d. [PMID: 15159476] - G Klaus, N Jeck, M Konrad, B Förster, M Soergel. Risk of steroid withdrawal in pediatric renal transplant patients with suspected steroid toxicity.
Clinical nephrology.
2001 Dec; 56(6):S37-42. doi:
NULL. [PMID: 11770812] - O González-La Riviere, F de la Torre-Rendón, R Hernández-Vásquez, C A Arce-Salinas. Polyarteritis nodosa mimicking prostatic cancer.
The Journal of rheumatology.
2000 Oct; 27(10):2504-6. doi:
NULL. [PMID: 11036851] - J R Ferraris, T Pasqualini, S Legal, P Sorroche, A M Galich, P Pennisi, H Domene, H Jasper. Effect of deflazacort versus methylprednisone on growth, body composition, lipid profile, and bone mass after renal transplantation. The Deflazacort Study Group.
Pediatric nephrology (Berlin, Germany).
2000 Jul; 14(7):682-8. doi:
10.1007/s004670000337. [PMID: 10912543] - K Schärer, R Feneberg, G Klaus, C Paschen, C Wüster, O Mehls, F Schaefer. Experience with deflazacort in children and adolescents after renal transplantation.
Pediatric nephrology (Berlin, Germany).
2000 Jun; 14(6):457-63. doi:
10.1007/s004670050792. [PMID: 10872183] - M Rooney, U M Davies, J Reeve, M Preece, B M Ansell, P M Woo. Bone mineral content and bone mineral metabolism: changes after growth hormone treatment in juvenile chronic arthritis.
The Journal of rheumatology.
2000 Apr; 27(4):1073-81. doi:
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The Cochrane database of systematic reviews.
2000; ?(4):CD001533. doi:
NULL. [PMID: 11034723] - J Rebollo Bernárdez, C Cifuentes Mimoso, A Piñar Moreno, A Caunedo Alvarez, E Salas Herrero, M Jiménez-Sáenz, J Herrerías Gutiérrez. Deflazacort for long-term maintenance of remission in type I autoimmune hepatitis.
Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva.
1999 Sep; 91(9):630-8. doi:
NULL. [PMID: 10502711] - F Baş, F Darendeliler, I Petorak, B Sadikoğlu, A Bilir, R Bundak, N Saka, H Günöz. Deflazacort treatment in progressive diaphyseal dysplasia (Camurati-Engelmann disease).
Journal of paediatrics and child health.
1999 Aug; 35(4):401-5. doi:
10.1046/j.1440-1754.1999.00381.x. [PMID: 10457303] - I Börcsök, H U Schairer, U Sommer, G K Wakley, U Schneider, F Geiger, F U Niethard, R Ziegler, C H Kasperk. Glucocorticoids regulate the expression of the human osteoblastic endothelin A receptor gene.
The Journal of experimental medicine.
1998 Nov; 188(9):1563-73. doi:
10.1084/jem.188.9.1563. [PMID: 9802968] - M S Kim, Y S Kim, S K Lim, S I Kim, J I Moon, K Park. Effect of deflazacort on bone mineral density in renal transplant recipients.
Transplantation proceedings.
1998 Nov; 30(7):3041-2. doi:
10.1016/s0041-1345(98)00921-x. [PMID: 9838340] - K Lippuner, J P Casez, F F Horber, P Jaeger. Effects of deflazacort versus prednisone on bone mass, body composition, and lipid profile: a randomized, double blind study in kidney transplant patients.
The Journal of clinical endocrinology and metabolism.
1998 Nov; 83(11):3795-802. doi:
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The Journal of pediatrics.
1998 Oct; 133(4):533-6. doi:
10.1016/s0022-3476(98)70063-0. [PMID: 9787693] - J Ferraris, R Krmar, D Flores, S Giogieri, L Díaz, J Tessler. Pharmacokinetics of deflazacort in renal transplanted and hemodialyzed children.
Clinical nephrology.
1998 Sep; 50(3):172-7. doi:
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Pediatric transplantation.
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Respiratory medicine.
1997 Sep; 91(8):449-60. doi:
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Pediatric nephrology (Berlin, Germany).
1997 Jun; 11(3):394. doi:
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Pediatric nephrology (Berlin, Germany).
1997 Jun; 11(3):322-4. doi:
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
1997 Feb; 12(2):200-9. doi:
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British journal of rheumatology.
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European journal of clinical pharmacology.
1993; 45 Suppl 1(?):S29-34. doi:
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Transplantation.
1993 Jan; 55(1):209-12. doi:
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European journal of clinical pharmacology.
1993; 45 Suppl 1(?):S35-41. doi:
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The Journal of rheumatology.
1992 Dec; 19(12):1895-900. doi:
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The Journal of pediatrics.
1992 Nov; 121(5 Pt 1):809-13. doi:
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
1992 Jul; 24(7):333-5. doi:
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Calcified tissue international.
1992 Jun; 50(6):490-7. doi:
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International journal of dermatology.
1992 Jan; 31(1):33-6. doi:
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European journal of clinical pharmacology.
1992; 43(1):47-50. doi:
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Clinical endocrinology.
1991 Dec; 35(6):485-90. doi:
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Transplantation proceedings.
1991 Feb; 23(1 Pt 2):1122-4. doi:
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Chest.
1991 Feb; 99(2):301-9. doi:
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Transplantation proceedings.
1990 Aug; 22(4):1689-90. doi:
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Archives of internal medicine.
1989 May; 149(5):1098-101. doi:
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Clinical rheumatology.
1988 Sep; 7(3):366-71. doi:
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Calcified tissue international.
1987 Dec; 41(6):316-20. doi:
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Calcified tissue international.
1987 Jun; 40(6):303-9. doi:
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Archives of internal medicine.
1987 Apr; 147(4):679-80. doi:
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Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
1986; 19(1):39-47. doi:
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Advances in experimental medicine and biology.
1984; 171(?):399-405. doi:
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Advances in experimental medicine and biology.
1984; 171(?):9-23. doi:
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Advances in experimental medicine and biology.
1984; 171(?):407-15. doi:
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Advances in experimental medicine and biology.
1984; 171(?):301-11. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
1983 Mar; 13(3):185-96. doi:
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European journal of clinical pharmacology.
1982; 22(5):469-71. doi:
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European journal of pharmacology.
1981 Dec; 76(4):427-30. doi:
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International journal of clinical pharmacology, therapy, and toxicology.
1980 Jan; 18(1):37-41. doi:
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European journal of drug metabolism and pharmacokinetics.
1980; 5(4):207-15. doi:
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Arzneimittel-Forschung.
1980; 30(9):1543-9. doi:
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The Biochemical journal.
1975 Sep; 150(3):305-14. doi:
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Wiener medizinische Wochenschrift. Supplement.
1975; 27(?):20-3. doi:
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