Otilonium Bromide (BioDeep_00000788306)

   


代谢物信息卡片


Otilonium Bromide

化学式: C29H43BrN2O4 (562.2406018)
中文名称: 奥替溴铵
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCOC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)OCC[N+](C)(CC)CC.[Br-]
InChI: 1H

描述信息

A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders > A03AB - Synthetic anticholinergics, quaternary ammonium compounds
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
D005765 - Gastrointestinal Agents
Otilonium bromide (OB) is an orally active mAChR inhibitor and smooth muscle relaxant which can interfere with the mobilization of calcium in intestinal smooth muscle, OB can be used for research of irritable bowel syndrome[1][2][3].

同义名列表

4 个代谢物同义名

Otilonium Bromide; Octylonium bromide; SP63; Otilonium (bromide)



数据库引用编号

5 个数据库交叉引用编号

分类词条

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Joong Il Kim, Pumsoo Kim, Jin-Hyun Lee, Yoo-Jin Kim, Na-Rae Yang, Myong Ki Baeg, Ja Sung Choi, Hye-Jung Kim, Jayoung Kim, Yun-Young Sunwoo, Jung-Han Lee, Hyekyung Ha, Tae-Yong Park. Effect of herbal extract granules combined with otilonium bromide on irritable bowel syndrome with diarrhoea: a study protocol for a randomised controlled trial. BMJ open. 2017 Dec; 7(11):e018362. doi: 10.1136/bmjopen-2017-018362. [PMID: 29196484]
  • Michael Camilleri, Guy Boeckxstaens. Dietary and pharmacological treatment of abdominal pain in IBS. Gut. 2017 05; 66(5):966-974. doi: 10.1136/gutjnl-2016-313425. [PMID: 28232472]
  • Yan-Rong Zhao, Li Ding, Hong-Wei Fan, Yong Yu, Xie-Min Qi, Ye Leng, Ya-Kun Rao. Determination of the unstable drug otilonium bromide in human plasma by LC-ESI-MS and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Oct; 878(28):2896-900. doi: 10.1016/j.jchromb.2010.08.003. [PMID: 20810330]
  • Beom Soo Shin, Jung Jun Kim, John Kim, Sul Ki Hu, Hyoung Jun Kim, Seok Hyun Hong, Han Kyung Kim, Hye Suk Lee, Sun Dong Yoo. Oral bioavailability and enterohepatic recirculation of otilonium bromide in rats. Archives of pharmacal research. 2008 Jan; 31(1):117-24. doi: 10.1007/s12272-008-1129-2. [PMID: 18277617]
  • S Evangelista. Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome. Current pharmaceutical design. 2004; 10(28):3561-8. doi: 10.2174/1381612043382972. [PMID: 15579053]
  • S Evangelista, P Cochet, N Bromet, M Criscuoli, C A Maggi. A distribution study with (14)C-otilonium bromide in the rat: evidence for selective tropism for large intestine after oral administration. Drug metabolism and disposition: the biological fate of chemicals. 2000 Jun; 28(6):643-7. doi: NULL. [PMID: 10820135]
  • P Rivera, S Pamos, J Cuquerella, L Ferrer, A Tomé, E Ortí, I Salvador, E Medina. [Collagenous colitis: presentation of 12 cases]. Gastroenterologia y hepatologia. 1997 Dec; 20(10):484-9. doi: NULL. [PMID: 9508483]
  • A Pinelli, S Trivulzio, S Vignati. Effects exerted by otilonium bromide administration on precipitated opioid withdrawal syndrome in rats. Toxicology. 1997 Sep; 122(1-2):23-37. doi: 10.1016/s0300-483x(97)00073-5. [PMID: 9274799]
  • A Subissi, M Del Monte, S Evangelista, P Santicioli, M Criscuoli. Octylonium bromide, an antagonist of platelet-activating factor. Archives internationales de pharmacodynamie et de therapie. 1989 Nov; 302(?):255-67. doi: NULL. [PMID: 2636821]