AMG131 (BioDeep_00000788248)

   


代谢物信息卡片


Benzenesulfonamide, 2,4-dichloro-N-(3,5-dichloro-4-(3-quinolinyloxy)phenyl)-

化学式: C21H12Cl4N2O3S (511.93227220000006)
中文名称: 2,4-二氯-N-[3,5-二氯-4-(喹啉-3-基氧基)苯基]苯磺酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C2C(=C1)C=C(C=N2)OC3=C(C=C(C=C3Cl)NS(=O)(=O)C4=C(C=C(C=C4)Cl)Cl)Cl
InChI: InChI=1S/C21H12Cl4N2O3S/c22-13-5-6-20(16(23)8-13)31(28,29)27-14-9-17(24)21(18(25)10-14)30-15-7-12-3-1-2-4-19(12)26-11-15/h1-11,27H

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C154291 - Peroxisome Proliferator-Activated Receptor Agonist
AMG131 (INT131), a potent and highly selective PPARγ partial agonist, binds to PPARγ and displaces Rosiglitazone with a Ki of ~10 nM. AMG131 can be used for research of type-2 diabetes mellitus (T2DM)[1][2].

同义名列表

3 个代谢物同义名

Benzenesulfonamide, 2,4-dichloro-N-(3,5-dichloro-4-(3-quinolinyloxy)phenyl)-; AMG131; INT131



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yu Yang, Yu Zhao, Wenzhen Li, Yuyao Wu, Xin Wang, Yijie Wang, Tingmei Liu, Tinghong Ye, Yongmei Xie, Zhiqiang Cheng, Jun He, Peng Bai, Yiwen Zhang, Liang Ouyang. Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment. European journal of medicinal chemistry. 2020 Jul; 197(?):112311. doi: 10.1016/j.ejmech.2020.112311. [PMID: 32339855]
  • Stergios A Polyzos, Elisabetta Bugianesi, Jannis Kountouras, Christos S Mantzoros. Nonalcoholic fatty liver disease: Updates on associations with the metabolic syndrome and lipid profile and effects of treatment with PPAR-γ agonists. Metabolism: clinical and experimental. 2017 01; 66(?):64-68. doi: 10.1016/j.metabol.2016.08.001. [PMID: 27594084]
  • Shogo Okazaki, Ryuta Shioi, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi. Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists. Bioorganic & medicinal chemistry. 2016 11; 24(21):5455-5461. doi: 10.1016/j.bmc.2016.08.067. [PMID: 27622746]
  • Amirhossein Sahebkar, Gerard T Chew, Gerald F Watts. New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease. Expert opinion on pharmacotherapy. 2014 Mar; 15(4):493-503. doi: 10.1517/14656566.2014.876992. [PMID: 24428677]
  • Tongwei Yew, Sue-Anne Toh, John S Millar. Selective peroxisome proliferator-activated receptor-γ modulation to reduce cardiovascular risk in patients with insulin resistance. Recent patents on cardiovascular drug discovery. 2012 Apr; 7(1):33-41. doi: 10.2174/157489012799362359. [PMID: 22044303]
  • Fredrick L Dunn, Linda S Higgins, Jill Fredrickson, Alex M DePaoli. Selective modulation of PPARγ activity can lower plasma glucose without typical thiazolidinedione side-effects in patients with Type 2 diabetes. Journal of diabetes and its complications. 2011 May; 25(3):151-8. doi: 10.1016/j.jdiacomp.2010.06.006. [PMID: 20739195]
  • Ulrich Kintscher, Matthias Goebel. INT-131, a PPARgamma agonist for the treatment of type 2 diabetes. Current opinion in investigational drugs (London, England : 2000). 2009 Apr; 10(4):381-7. doi: NULL. [PMID: 19337960]
  • Alykhan Motani, Zhulun Wang, Jennifer Weiszmann, Lawrence R McGee, Gary Lee, Qingxiang Liu, Jocelyn Staunton, Zexu Fang, Helen Fuentes, Michelle Lindstrom, Jinsong Liu, Donna H T Biermann, Juan Jaen, Nigel P C Walker, R Marc Learned, Jin-Long Chen, Yang Li. INT131: a selective modulator of PPAR gamma. Journal of molecular biology. 2009 Mar; 386(5):1301-11. doi: 10.1016/j.jmb.2009.01.025. [PMID: 19452630]