Trestolone (BioDeep_00000788059)
代谢物信息卡片
Trestolone
化学式: C19H28O2 (288.2089)
中文名称: 曲托龙
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC2=CC(=O)CCC2C3C1C4CCC(C4(CC3)C)O
InChI: InChI=1S/C19H28O2/c1-11-9-12-10-13(20)3-4-14(12)15-7-8-19(2)16(18(11)15)5-6-17(19)21/h10-11,14-18,21H,3-9H2,1-2H3/t11-,14+,15-,16+,17+,18-,19+/m1/s1
描述信息
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Barbara J Attardi, Sheri A Hild, Sailaja Koduri, Trung Pham, Laurent Pessaint, Jean Engbring, Bruce Till, David Gropp, Anne Semon, Jerry R Reel. The potent synthetic androgens, dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone, do not require 5α-reduction to exert their maximal androgenic effects.
The Journal of steroid biochemistry and molecular biology.
2010 Oct; 122(4):212-8. doi:
10.1016/j.jsbmb.2010.06.009. [PMID: 20599615] - Sheri Ann Hild, Barbara J Attardi, Sailaja Koduri, Bruce A Till, Jerry R Reel. Effects of synthetic androgens on liver function using the rabbit as a model.
Journal of andrology.
2010 Sep; 31(5):472-81. doi:
10.2164/jandrol.109.009365. [PMID: 20378929] - Pramod Vishwanath Prasad, Ramamani Arumugam, Mark Willman, Ren-Shan Ge, Regine Sitruk-Ware, Narender Kumar. Distribution, metabolism and excretion of a synthetic androgen 7alpha-methyl-19-nortestosterone, a potential male-contraceptive.
Steroids.
2009 Jan; 74(1):121-31. doi:
10.1016/j.steroids.2008.09.012. [PMID: 18992267] - Louis J G Gooren, Mathijs C M Bunck. Androgen replacement therapy: present and future.
Drugs.
2004; 64(17):1861-91. doi:
10.2165/00003495-200464170-00002. [PMID: 15329035] - S G Ramachandra, V Ramesh, H N Krishnamurthy, N Kumar, K Sundaram, M P Hardy, A Jagannadha Rao. Effect of chronic administration of 7alpha-methyl-19-nortestosterone on serum testosterone, number of spermatozoa and fertility in adult male bonnet monkeys (Macaca radiata).
Reproduction (Cambridge, England).
2002 Aug; 124(2):301-9. doi:
10.1530/rep.0.1240301. [PMID: 12141943] - A H Bandivdekar, R Karp, K Sundaram, N Kumar. The antigonadotropic action of testosterone but not 7alpha-methyl-19-nortestosterone is attenuated through the 5alpha-reductase pathway in the castrated male rat pituitary gland.
Journal of andrology.
2000 Mar; 21(2):268-75. doi:
NULL. [PMID: 10714822] - N Kumar, A Crozat, F Li, J F Catterall, C W Bardin, K Sundaram. 7alpha-methyl-19-nortestosterone, a synthetic androgen with high potency: structure-activity comparisons with other androgens.
The Journal of steroid biochemistry and molecular biology.
1999 Dec; 71(5-6):213-22. doi:
10.1016/s0960-0760(99)00143-0. [PMID: 10704910] - R A Anderson, C W Martin, A W Kung, D Everington, T C Pun, K C Tan, J Bancroft, K Sundaram, A J Moo-Young, D T Baird. 7Alpha-methyl-19-nortestosterone maintains sexual behavior and mood in hypogonadal men.
The Journal of clinical endocrinology and metabolism.
1999 Oct; 84(10):3556-62. doi:
10.1210/jcem.84.10.6028. [PMID: 10522995] - D E Cummings, N Kumar, C W Bardin, K Sundaram, W J Bremner. Prostate-sparing effects in primates of the potent androgen 7alpha-methyl-19-nortestosterone: a potential alternative to testosterone for androgen replacement and male contraception.
The Journal of clinical endocrinology and metabolism.
1998 Dec; 83(12):4212-9. doi:
10.1210/jcem.83.12.5324. [PMID: 9851754] - N Kumar, J Suvisaari, Y Y Tsong, C Aguillaume, C W Bardin, P Lähteenmaki, K Sundaram. Pharmacokinetics of 7 alpha-methyl-19-nortestosterone in men and cynomolgus monkeys.
Journal of andrology.
1997 Jul; 18(4):352-8. doi:
NULL. [PMID: 9283946] - J Suvisaari, K Sundaram, G Noé, N Kumar, C Aguillaume, Y Y Tsong, P Lähteenmäki, C W Bardin. Pharmacokinetics and pharmacodynamics of 7alpha-methyl-19-nortestosterone after intramuscular administration in healthy men.
Human reproduction (Oxford, England).
1997 May; 12(5):967-73. doi:
10.1093/humrep/12.5.967. [PMID: 9194649] - K Sundaram, N Kumar, C Monder, C W Bardin. Different patterns of metabolism determine the relative anabolic activity of 19-norandrogens.
The Journal of steroid biochemistry and molecular biology.
1995 Jun; 53(1-6):253-7. doi:
10.1016/0960-0760(95)00056-6. [PMID: 7626464] - G Moralí, A E Lemus, R Munguía, M Arteaga, G Pérez-Palacios, K Sundaram, N Kumar, C W Bardin. Induction of male sexual behavior in the rat by 7 alpha-methyl-19-nortestosterone, an androgen that does not undergo 5 alpha-reduction.
Biology of reproduction.
1993 Sep; 49(3):577-81. doi:
10.1095/biolreprod49.3.577. [PMID: 8399852] - K Sundaram, N Kumar, C W Bardin. 7 alpha-methyl-nortestosterone (MENT): the optimal androgen for male contraception.
Annals of medicine.
1993 Apr; 25(2):199-205. doi:
10.3109/07853899309164168. [PMID: 8489761] - N Kumar, A K Didolkar, C Monder, C W Bardin, K Sundaram. The biological activity of 7 alpha-methyl-19-nortestosterone is not amplified in male reproductive tract as is that of testosterone.
Endocrinology.
1992 Jun; 130(6):3677-83. doi:
10.1210/endo.130.6.1597164. [PMID: 1597164] - A Liu, K E Carlson, J A Katzenellenbogen. Synthesis of high affinity fluorine-substituted ligands for the androgen receptor. Potential agents for imaging prostatic cancer by positron emission tomography.
Journal of medicinal chemistry.
1992 May; 35(11):2113-29. doi:
10.1021/jm00089a024. [PMID: 1597861] - N Kumar, A K Didolkar, A Ladd, R Thau, C Monder, C W Bardin, K Sundaram. Radioimmunoassay of 7 alpha-methyl-19-nortestosterone and investigation of its pharmacokinetics in animals.
The Journal of steroid biochemistry and molecular biology.
1990 Nov; 37(4):587-91. doi:
10.1016/0960-0760(90)90405-a. [PMID: 2278844]
