Cetirizine hydrochloride (BioDeep_00000788038)
代谢物信息卡片
Cetirizine Dihydrochloride
化学式: C21H27Cl3N2O3 (460.1087)
中文名称: 盐酸西替利嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl
InChI: 2*1H
描述信息
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018926 - Anti-Allergic Agents
Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:3562
- KEGGdrug: D00664
- PubChem: 55182
- ChEMBL: CHEMBL1607273
- MeSH: Cetirizine
- CAS: 83881-52-1
- medchemexpress: HY-17042A
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Warangkana Arpornchayanon, Soraya Klinprung, Sunee Chansakaow, Nutthiya Hanprasertpong, Saisawat Chaiyasate, Masaaki Tokuda, Hirotoshi Tamura. Antiallergic activities of shallot (Allium ascalonicum L.) and its therapeutic effects in allergic rhinitis.
Asian Pacific journal of allergy and immunology.
2022 Dec; 40(4):393-400. doi:
10.12932/ap-300319-0529. [PMID: 31421664] - Hongjun Chen, Yujie Cheng, Hongmei Du, Cui Zhang, Yuan Zhou, Zhentao Zhao, Yong Li, Thomas Friedemann, Jinyu Mei, Sven Schröder, Ming Chen. Shufeng Jiedu capsule ameliorates olfactory dysfunction via the AMPK/mTOR autophagy pathway in a mouse model of allergic rhinitis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Dec; 107(?):154426. doi:
10.1016/j.phymed.2022.154426. [PMID: 36116201] - Christine Wegler, Aljona Saleh, Annika Lindqvist, Hedvig Nordeng, John Smeraglia, Pawel Baranczewski. Simple and rapid quantification of cetirizine, venlafaxine, and O-desmethylvenlafaxine in human breast milk, and metformin in human milk and plasma with UHPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 Aug; 1205(?):123340. doi:
10.1016/j.jchromb.2022.123340. [PMID: 35732105] - Tingnian Qu, Bo Huang, Li Lei, Shirong Luo. [Cetirizine inhibits activation of JAK2-STAT3 pathway and mast cell activation in lung tissue of asthmatic mice].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2022 Mar; 38(3):193-198. doi:
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Journal of fluorescence.
2022 Mar; 32(2):549-558. doi:
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
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Journal of veterinary pharmacology and therapeutics.
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Burns : journal of the International Society for Burn Injuries.
2013 Feb; 39(1):24-9. doi:
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Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2013 Feb; 33(1):60-4. doi:
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Journal of separation science.
2012 Aug; 35(15):1959-66. doi:
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International journal of pediatric otorhinolaryngology.
2012 Jul; 76(7):994-1001. doi:
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Pulmonary pharmacology & therapeutics.
2012 Feb; 25(1):87-93. doi:
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Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2012; 15(4):519-27. doi:
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Skinmed.
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Journal of drugs in dermatology : JDD.
2011 Dec; 10(12):1444-50. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Sep; 879(25):2624-31. doi:
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Talanta.
2011 Aug; 85(2):906-12. doi:
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Journal of alternative and complementary medicine (New York, N.Y.).
2011 May; 17(5):459-64. doi:
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Electrophoresis.
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Journal of the Formosan Medical Association = Taiwan yi zhi.
2011 Mar; 110(3):175-82. doi:
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Veterinary journal (London, England : 1997).
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Colloids and surfaces. B, Biointerfaces.
2011 Mar; 83(1):133-8. doi:
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Arzneimittel-Forschung.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Dec; 878(32):3351-7. doi:
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Chinese journal of integrative medicine.
2010 Aug; 16(4):353-6. doi:
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Journal of chromatographic science.
2010 May; 48(5):382-5. doi:
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Therapeutic drug monitoring.
2010 Feb; 32(1):112-5. doi:
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International archives of allergy and immunology.
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2009 Dec; 74(5):1189-96. doi:
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Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2009 Oct; 29(10):925-8. doi:
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Fundamental & clinical pharmacology.
2009 Oct; 23(5):537; author reply 538. doi:
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Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.
2009 Sep; 20(6):551-5. doi:
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Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.
2009 Aug; 20(5):493-9. doi:
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Journal of forensic sciences.
2009 Mar; 54(2):495-6. doi:
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Journal of investigational allergology & clinical immunology.
2009; 19(6):465-73. doi:
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Arzneimittel-Forschung.
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Biomedical chromatography : BMC.
2008 Dec; 22(12):1393-402. doi:
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Veterinary dermatology.
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Veterinary journal (London, England : 1997).
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Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2008 Jul; 6(7):700-3. doi:
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International journal of clinical pharmacology and therapeutics.
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American journal of veterinary research.
2008 May; 69(5):670-4. doi:
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Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2008 Apr; 28(4):358-60. doi:
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