Rifalazil (BioDeep_00000787216)

   


代谢物信息卡片


Rifalazil

化学式: C51H64N4O13 (940.447)
中文名称: 利福拉齐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C=CC=C(C(=O)NC2=C3C(=C4C(=C(C(=C5C4=C(C(O5)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)O)C)O)C2=O)N=C6C(=CC(=CC6=O)N7CCN(CC7)CC(C)C)O3)C
InChI: InChI=1S/C51H64N4O13/c1-24(2)23-54-16-18-55(19-17-54)32-21-33(57)39-35(22-32)67-48-40(52-39)36-37-44(60)30(8)47-38(36)49(62)51(10,68-47)65-20-15-34(64-11)27(5)46(66-31(9)56)29(7)43(59)28(6)42(58)25(3)13-12-14-26(4)50(63)53-41(48)45(37)61/h12-15,20-22,24-25,27-29,34,42-43,46,58-60,62H,16-19,23H2,1-11H3,(H,53,63)/b13-12+,20-15+,26-14-/t25-,27+,28+,29+,34-,42-,43+,46+,51-/m0/s1

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007917 - Leprostatic Agents
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D012294 - Rifamycins
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

1 个代谢物同义名

Rifalazil



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • William M Geisler, Maria Luz G Pascual, Judy Mathew, William D Koltun, Franklin Morgan, Byron E Batteiger, Annette Mayes, Sijia Tao, Selwyn J Hurwitz, Chalom Sayada, Raymond F Schinazi. Randomized, double-blind, multicenter safety and efficacy study of rifalazil compared with azithromycin for treatment of uncomplicated genital Chlamydia trachomatis infection in women. Antimicrobial agents and chemotherapy. 2014 Jul; 58(7):4014-9. doi: 10.1128/aac.02521-14. [PMID: 24798277]
  • Sumandeep K Gill, Hao Xu, Paul D Kirchhoff, Tomasz Cierpicki, Anjanette J Turbiak, Baojie Wan, Nan Zhang, Kuan-Wei Peng, Scott G Franzblau, George A Garcia, H D Hollis Showalter. Structure-based design of novel benzoxazinorifamycins with potent binding affinity to wild-type and rifampin-resistant mutant Mycobacterium tuberculosis RNA polymerases. Journal of medicinal chemistry. 2012 Apr; 55(8):3814-26. doi: 10.1021/jm201716n. [PMID: 22452568]
  • Marita Larsson, Feng Han. Determination of rifalazil in dog plasma by liquid-liquid extraction and LC-MS/MS: quality assessment by incurred sample analysis. Journal of pharmaceutical and biomedical analysis. 2007 Nov; 45(4):616-24. doi: 10.1016/j.jpba.2007.09.006. [PMID: 17942263]
  • Marita Larsson, Arthur F Michaelis, Yongdong Zhu, Kumar Ramu. Determination of rifalazil, a potent antibacterial agent, in human plasma by liquid-liquid extraction and LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Nov; 859(1):103-10. doi: 10.1016/j.jchromb.2007.09.013. [PMID: 17936092]
  • Y-X Chen, B Cabana, N Kivel, H Pieniaszek, S Gilman, A Michaelis. Lack of effect of rifalazil on ethinyl estradiol pharmacokinetics in healthy postmenopausal women. International journal of clinical pharmacology and therapeutics. 2007 Jul; 45(7):418-22. doi: 10.5414/cpp45418. [PMID: 17725249]
  • Pauline M Anton, Michael O'Brien, Efi Kokkotou, Barry Eisenstein, Arthur Michaelis, David Rothstein, Sophia Paraschos, Ciáran P Kelly, Charalabos Pothoulakis. Rifalazil treats and prevents relapse of clostridium difficile-associated diarrhea in hamsters. Antimicrobial agents and chemotherapy. 2004 Oct; 48(10):3975-9. doi: 10.1128/aac.48.10.3975-3979.2004. [PMID: 15388461]
  • R Dietze, L Teixeira, L M Rocha, M Palaci, J L Johnson, C Wells, L Rose, K Eisenach, J J Ellner. Safety and bactericidal activity of rifalazil in patients with pulmonary tuberculosis. Antimicrobial agents and chemotherapy. 2001 Jul; 45(7):1972-6. doi: 10.1128/aac.45.7.1972-1976.2001. [PMID: 11408210]
  • T Wichelhaus, V Schäfer, V Brade, B Böddinghaus. Differential effect of rpoB mutations on antibacterial activities of rifampicin and KRM-1648 against Staphylococcus aureus. The Journal of antimicrobial chemotherapy. 2001 Feb; 47(2):153-6. doi: 10.1093/jac/47.2.153. [PMID: 11157898]
  • T Mae, E Konishi, K Hosoe, T Hidaka. Isolation and identification of major metabolites of rifalazil in mouse and human. Xenobiotica; the fate of foreign compounds in biological systems. 1999 Nov; 29(11):1073-87. doi: 10.1080/004982599237967. [PMID: 10598743]
  • T Shimizu, H Tomioka, K Sato, C Sano, T Akaki, S Dekio, Y Yamada, T Kamei, H Shibata, N Higashi. Effects of the Chinese traditional medicine mao-bushi-saishin-to on therapeutic efficacy of a new benzoxazinorifamycin, KRM-1648, against Mycobacterium avium infection in mice. Antimicrobial agents and chemotherapy. 1999 Mar; 43(3):514-9. doi: 10.1128/aac.43.3.514. [PMID: 10049260]
  • T Shimizu, H Tomioka, K Sato, C Sano, Y Yamada, H Shibata, N Higashi. Effects of Yokuinin on the therapeutic efficacy of a new benzoxazinorifamycin KRM-1648 against Mycobacterium avium infection. International journal of antimicrobial agents. 1999 Jan; 11(1):69-74. doi: 10.1016/s0924-8579(98)00078-8. [PMID: 10075281]
  • K Sato, T Shimizu, H Tomioka, S Kawahara. [Effects of half-sized secretory leukocyte protease inhibitor and Chinese traditional medicines, yokuinin and mao-bushi-saishin-to, on therapeutic efficacies of benzoxazinorifamycin KRM-1648 against Mycobacterium avium complex infection induced in mice]. Kekkaku : [Tuberculosis]. 1998 Aug; 73(8):501-6. doi: ". [PMID: 9780605]
  • K Suzuki, K Tsuyuguchi, H Matsumoto, T Yamamoto, T Hashimoto, E Tanaka, R Amitani, F Kuze. Activity of KRM 1648 or rifabutin alone or in combination with clarithromycin against Mycobacterium avium complex in human alveolar macrophages. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 1997 Oct; 1(5):460-7. doi: . [PMID: 9441102]
  • K Hosoe, T Mae, E Konishi, K Fujii, K Yamashita, T Yamane, T Hidaka, T Ohashi. Pharmacokinetics of KRM-1648, a new benzoxazinorifamycin, in rats and dogs. Antimicrobial agents and chemotherapy. 1996 Dec; 40(12):2749-55. doi: 10.1128/aac.40.12.2749. [PMID: 9124834]
  • K Hosoe, T Mae, K Yamashita, K Fujii, T Yamane, T Hidaka, T Ohashi. Identification and antimicrobial activity of urinary metabolites of a rifamycin derivative in dog. Xenobiotica; the fate of foreign compounds in biological systems. 1996 Mar; 26(3):321-32. doi: 10.3109/00498259609046711. [PMID: 8730923]
  • K Hosoe, E Konishi, T Hidaka, T Yamane, K Yamashita, T Ohashi. High-performance liquid chromatographic determination of 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin (KRM-1648) and its deacetyl metabolite in plasma, whole blood, urine and tissue samples in rats. Journal of chromatography. B, Biomedical applications. 1994 Mar; 653(2):177-86. doi: 10.1016/0378-4347(93)e0431-o. [PMID: 8205245]
  • T Yamane, T Hashizume, K Yamashita, E Konishi, K Hosoe, T Hidaka, K Watanabe, H Kawaharada, T Yamamoto, F Kuze. Synthesis and biological activity of 3'-hydroxy-5'-aminobenzoxazinorifamycin derivatives. Chemical & pharmaceutical bulletin. 1993 Jan; 41(1):148-55. doi: 10.1248/cpb.41.148. [PMID: 8448815]
  • T Yamamoto, R Amitani, F Kuze, K Suzuki. [In vitro activities of new rifamycin derivatives against Mycobacterium tuberculosis and M. avium complex]. Kekkaku : [Tuberculosis]. 1990 Dec; 65(12):805-10. doi: NULL. [PMID: 2127615]