U0126-EtOH (BioDeep_00000786552)
代谢物信息卡片
U0126-EtOH
化学式: C20H22N6OS2 (426.1296)
中文名称: U0126-EtOH
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCO.C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
InChI: InChI=1S/C18H16N6S2.C2H6O/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22
描述信息
U0126 (U0126-EtOH) is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor[1][2][3][4].
同义名列表
1 个代谢物同义名
数据库引用编号
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相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ken Shirato, Jun Takanari, Takako Kizaki. Standardized Extract of Asparagus officinalis Stem Attenuates SARS-CoV-2 Spike Protein-Induced IL-6 and IL-1β Production by Suppressing p44/42 MAPK and Akt Phosphorylation in Murine Primary Macrophages.
Molecules (Basel, Switzerland).
2021 Oct; 26(20):. doi:
10.3390/molecules26206189. [PMID: 34684771] - Riho Tange, Ryuji Tachibana, Takeshi Sato. Phosphorylation of Specificity Protein 3 Is Critical for Activation of β4-Galactosyltransferase 3 Gene Promoter in SH-SY5Y Human Neuroblastoma Cell Line.
Biological & pharmaceutical bulletin.
2021 Apr; 44(4):557-563. doi:
10.1248/bpb.b20-00906. [PMID: 33504757] - Ling Liu, Jie Zheng, YaZhen Yang, Lingjuan Ni, Hongyu Chen, Dongrong Yu. Hesperetin alleviated glucocorticoid-induced inhibition of osteogenic differentiation of BMSCs through regulating the ERK signaling pathway.
Medical molecular morphology.
2021 Mar; 54(1):1-7. doi:
10.1007/s00795-020-00251-9. [PMID: 32253606] - Takato Takenouchi, Takeya Morozumi, Emi Wada, Shunichi Suzuki, Yasutaka Nishiyama, Shin Sukegawa, Hirohide Uenishi. Dexamethasone enhances CD163 expression in porcine IPKM immortalized macrophages.
In vitro cellular & developmental biology. Animal.
2021 Jan; 57(1):10-16. doi:
10.1007/s11626-020-00535-5. [PMID: 33447967] - Yutaka Gomita, Satoru Esumi, Soichiro Ushio, Yoshihisa Kitamura, Toshiaki Sendo, Hirotoshi Motoda, Shigeki Inoue, Hiroaki Araki, Yoshio Kano. Intracranial self-stimulation-reward or immobilization-aversion had different effects on neurite extension and the ERK pathway in neurotransmitter-sensitive mutant PC12 cells.
Behavioural brain research.
2021 01; 396(?):112920. doi:
10.1016/j.bbr.2020.112920. [PMID: 32961216] - Consuelo Mori, Ángel G Valdivieso, Mariángeles Clauzure, María M Massip-Copiz, María Á Aguilar, Eduardo G A Cafferata, Tomás A Santa Coloma. Identification and characterization of human PEIG-1/GPRC5A as a 12-O-tetradecanoyl phorbol-13-acetate (TPA) and PKC-induced gene.
Archives of biochemistry and biophysics.
2020 07; 687(?):108375. doi:
10.1016/j.abb.2020.108375. [PMID: 32339486] - Shan Chen, Xiuyan Feng, Xinxin Chen, Zhizhi Zhuang, Jia Xiao, Haian Fu, Janet D Klein, Xiaonan H Wang, Robert S Hoover, Douglas C Eaton, Hui Cai. 14-3-3γ, a novel regulator of the large-conductance Ca2+-activated K+ channel.
American journal of physiology. Renal physiology.
2020 07; 319(1):F52-F62. doi:
10.1152/ajprenal.00584.2019. [PMID: 32463725] - Carolyn N Brown, Daniel J Atwood, Deepak Pokhrel, Kameswaran Ravichandran, Sara J Holditch, Sanskriti Saxena, Makoto Miyazaki, Raphael Nemenoff, Mary C M Weiser-Evans, Danica Galesic Ljubanovic, Melanie S Joy, Charles L Edelstein. The effect of MEK1/2 inhibitors on cisplatin-induced acute kidney injury (AKI) and cancer growth in mice.
Cellular signalling.
2020 07; 71(?):109605. doi:
10.1016/j.cellsig.2020.109605. [PMID: 32194168] - Manuel Rieber, Luis A Gomez-Sarosi, Mary Strasberg Rieber. Nitroprusside induces melanoma ferroptosis with serum supplementation and prolongs survival under serum depletion or hypoxia.
Biochemical and biophysical research communications.
2020 05; 525(3):626-632. doi:
10.1016/j.bbrc.2020.02.107. [PMID: 32122653] - Cheng-Hao Weng, Yi-Jung Li, Hsin-Hsu Wu, Shou-Hsuan Liu, Hsiang-Hao Hsu, Yung-Chang Chen, Chih-Wei Yang, Pao-Hsien Chu, Ya-Chung Tian. Interleukin-17A induces renal fibrosis through the ERK and Smad signaling pathways.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Mar; 123(?):109741. doi:
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Cell death & disease.
2019 04; 10(5):341. doi:
10.1038/s41419-019-1572-7. [PMID: 31000696] - Min Tao, Yingfeng Shi, Lunxian Tang, Yi Wang, Lu Fang, Wei Jiang, Tao Lin, Andong Qiu, Shougang Zhuang, Na Liu. Blockade of ERK1/2 by U0126 alleviates uric acid-induced EMT and tubular cell injury in rats with hyperuricemic nephropathy.
American journal of physiology. Renal physiology.
2019 04; 316(4):F660-F673. doi:
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Cell cycle (Georgetown, Tex.).
2019 03; 18(5):596-604. doi:
10.1080/15384101.2019.1578149. [PMID: 30724698] - Xiaozhao Li, Chunyu Bao, Zhinan Ma, Boqun Xu, Xiaoyan Ying, Xiaoqiu Liu, Xuesen Zhang. Perfluorooctanoic acid stimulates ovarian cancer cell migration, invasion via ERK/NF-κB/MMP-2/-9 pathway.
Toxicology letters.
2018 Sep; 294(?):44-50. doi:
10.1016/j.toxlet.2018.05.009. [PMID: 29753068] - Zhonghua Wang, Aijun Jiang, Jingwei Mei, Xinyan Zhang. 1α,25(OH)2-Vitamin D3 Inhibits C2C12 Cell Differentiation by Activating c-Src and ERK1/2.
Clinical laboratory.
2018 May; 64(5):687-698. doi:
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Oncogene.
2018 04; 37(16):2104-2121. doi:
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Microscopy (Oxford, England).
2018 Apr; 67(2):99-111. doi:
10.1093/jmicro/dfy005. [PMID: 29474583] - Wenxia Chen, Yongbin Yan, Chundong Song, Ying Ding, Tao Du. Microvesicles derived from human Wharton's Jelly mesenchymal stem cells ameliorate ischemia-reperfusion-induced renal fibrosis by releasing from G2/M cell cycle arrest.
The Biochemical journal.
2017 Dec; 474(24):4207-4218. doi:
10.1042/bcj20170682. [PMID: 29150436] - Yang Liu, Xiao-Lan Chen, Cang-Bao Xu, Lei Cao, Jie Lin, Gen Chen, Jie Li. Tail vein injection of mmLDL upregulates mouse mesenteric artery ETB receptors via activation of the ERK1/2 pathway.
Vascular pharmacology.
2017 09; 96-98(?):33-39. doi:
10.1016/j.vph.2017.08.002. [PMID: 28797761] - M L Totty, B C Morrell, L J Spicer. Fibroblast growth factor 9 (FGF9) regulation of cyclin D1 and cyclin-dependent kinase-4 in ovarian granulosa and theca cells of cattle.
Molecular and cellular endocrinology.
2017 01; 440(?):25-33. doi:
10.1016/j.mce.2016.11.002. [PMID: 27816766] - Chien-Min Chen, Shu-Ching Hsieh, Chia-Liang Lin, Yu-Syun Lin, Jen-Pi Tsai, Yi-Hsien Hsieh. Alpha-Mangostin Suppresses the Metastasis of Human Renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription Activity.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 44(4):1460-1470. doi:
10.1159/000485582. [PMID: 29190630] - Lei Cao, Na-Na Ping, Yong-Xiao Cao, Wei Li, Yan Cai, Karin Warfvinge, Lars Edvinsson. The effects of MEK1/2 inhibition on cigarette smoke exposure-induced ET receptor upregulation in rat cerebral arteries.
Toxicology and applied pharmacology.
2016 08; 304(?):70-8. doi:
10.1016/j.taap.2016.05.013. [PMID: 27212444] - Jacob Notbohm, Shiladitya Banerjee, Kazage J C Utuje, Bomi Gweon, Hwanseok Jang, Yongdoo Park, Jennifer Shin, James P Butler, Jeffrey J Fredberg, M Cristina Marchetti. Cellular Contraction and Polarization Drive Collective Cellular Motion.
Biophysical journal.
2016 Jun; 110(12):2729-2738. doi:
10.1016/j.bpj.2016.05.019. [PMID: 27332131] - Xiaoju Li, Xingyue Cao, Xiaomeng Zhang, Yanhua Kang, Wenwen Zhang, Miao Yu, Chuanrui Ma, Jihong Han, Yajun Duan, Yuanli Chen. MEK1/2 inhibitors induce interleukin-5 expression in mouse macrophages and lymphocytes.
Biochemical and biophysical research communications.
2016 05; 473(4):939-946. doi:
10.1016/j.bbrc.2016.03.156. [PMID: 27045084] - Mehul Sharma, Yulia Merkulova, Sheetal Raithatha, Leigh G Parkinson, Yue Shen, Dawn Cooper, David J Granville. Extracellular granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1.
The FEBS journal.
2016 05; 283(9):1734-47. doi:
10.1111/febs.13699. [PMID: 26936634] - Zhiwen Zeng, Haitao Wang, Fu Shang, Lihua Zhou, Peter J Little, Remi Quirion, Wenhua Zheng. Lithium ions attenuate serum-deprivation-induced apoptosis in PC12 cells through regulation of the Akt/FoxO1 signaling pathways.
Psychopharmacology.
2016 Mar; 233(5):785-94. doi:
10.1007/s00213-015-4168-7. [PMID: 26626328] - Wei Zhang, Changmai Chen, Hengfei Shi, Manyi Yang, Yu Liu, Ping Ji, Huijun Chen, Ren Xiang Tan, Erguang Li. Curcumin is a biologically active copper chelator with antitumor activity.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2016 Jan; 23(1):1-8. doi:
10.1016/j.phymed.2015.11.005. [PMID: 26902401] - Liyan Sun, Yanhui Gao, Wei Zhang, Xiaona Liu, Bingyun Li, Xiaohui Cui, Dianjun Sun. Mechanisms Underlying Endothelin-1 Level Elevations Caused by Excessive Fluoride Exposure.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 40(5):861-873. doi:
10.1159/000453145. [PMID: 27941335] - Guanxiong Ding, Jie Fang, Shijun Tong, Lianxi Qu, Haowen Jiang, Qiang Ding, Jun Liu. Over-expression of lipocalin 2 promotes cell migration and invasion through activating ERK signaling to increase SLUG expression in prostate cancer.
The Prostate.
2015 Jun; 75(9):957-68. doi:
10.1002/pros.22978. [PMID: 25728945] - Ling Qin, Bo Tang, Bingqing Deng, Chandra Mohan, Tianfu Wu, Ai Peng. Extracellular regulated protein kinases play a key role via bone morphogenetic protein 4 in high phosphate-induced endothelial cell apoptosis.
Life sciences.
2015 Jun; 131(?):37-43. doi:
10.1016/j.lfs.2015.03.017. [PMID: 25896660] - Peiqun Wu, Fang Xie, Minmin Xue, Xiaoping Xu, Shuying He, Minyi Lin, Lan Bai. Advanced oxidation protein products decrease the expression of calcium transport channels in small intestinal epithelium via the p44/42 MAPK signaling pathway.
European journal of cell biology.
2015 May; 94(5):190-203. doi:
10.1016/j.ejcb.2015.02.002. [PMID: 25801217] - Katarzyna Winiarska, Robert Jarzyna, Jolanta M Dzik, Adam K Jagielski, Michal Grabowski, Agata Nowosielska, Dorota Focht, Bartosz Sierakowski. ERK1/2 pathway is involved in renal gluconeogenesis inhibition under conditions of lowered NADPH oxidase activity.
Free radical biology & medicine.
2015 Apr; 81(?):13-21. doi:
10.1016/j.freeradbiomed.2014.12.024. [PMID: 25601753] - S Sen, K Diercke, S Zingler, C J Lux, R Erber. Compression induces Ephrin-A2 in PDL fibroblasts via c-fos.
Journal of dental research.
2015 Mar; 94(3):464-72. doi:
10.1177/0022034514567197. [PMID: 25604255] - Atsuko Ohoka, Mihoko Kajita, Junichi Ikenouchi, Yuta Yako, Sho Kitamoto, Shunsuke Kon, Masaya Ikegawa, Takashi Shimada, Susumu Ishikawa, Yasuyuki Fujita. EPLIN is a crucial regulator for extrusion of RasV12-transformed cells.
Journal of cell science.
2015 Feb; 128(4):781-9. doi:
10.1242/jcs.163113. [PMID: 25609711] - Alexandra Wolf, René Eulenfeld, Hannes Bongartz, Wiebke Hessenkemper, Philip C Simister, Sam Lievens, Jan Tavernier, Stephan M Feller, Fred Schaper. MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch.
Cellular signalling.
2015 Feb; 27(2):340-52. doi:
10.1016/j.cellsig.2014.11.017. [PMID: 25460044] - M V Zlobina, Yu Yu Steblyanko, M A Shklyaeva, V V Kharchenko, A V Salova, E S Kornilova. [INHIBITORS OF MAP-KINASE PATHWAY U0126 AND PD98059 DIFFERENTLY AFFECT ORGANIZATION OF TUBULIN CYTOSKELETON AFTER STIMULATION OF EGF RECEPTOR ENDOCYTOSIS].
Tsitologiia.
2015; 57(4):269-77. doi:
NULL. [PMID: 26349244] - Vicky García-Hernández, Catalina Flores-Maldonado, Ruth Rincon-Heredia, Odette Verdejo-Torres, José Bonilla-Delgado, Ivan Meneses-Morales, Patricio Gariglio, Rubén G Contreras. EGF regulates claudin-2 and -4 expression through Src and STAT3 in MDCK cells.
Journal of cellular physiology.
2015 Jan; 230(1):105-15. doi:
10.1002/jcp.24687. [PMID: 24909426] - Yarong Guo, Yun Zhang, Qianqian Zhang, Xiaohong Guo, Haiyan Zhang, Guoping Zheng, Lixin Liu. Insulin-like growth factor binding protein-related protein 1 (IGFBPrP1) contributes to liver inflammation and fibrosis via activation of the ERK1/2 pathway.
Hepatology international.
2015 Jan; 9(1):130-41. doi:
10.1007/s12072-014-9578-9. [PMID: 25788387] - Camilla Ingeson-Carlsson, Mikael Nilsson. Dual contribution of MAPK and PI3K in epidermal growth factor-induced destabilization of thyroid follicular integrity and invasion of cells into extracellular matrix.
Experimental cell research.
2014 Aug; 326(2):210-8. doi:
10.1016/j.yexcr.2014.04.006. [PMID: 24726885] - Yibo Zhuang, Quancheng Feng, Guixia Ding, Min Zhao, Ruochen Che, Mi Bai, Huaying Bao, Aihua Zhang, Songming Huang. Activation of ERK1/2 by NADPH oxidase-originated reactive oxygen species mediates uric acid-induced mesangial cell proliferation.
American journal of physiology. Renal physiology.
2014 Aug; 307(4):F396-406. doi:
10.1152/ajprenal.00565.2013. [PMID: 24573389] - Roya Waldsee, Sajedeh Eftekhari, Hilda Ahnstedt, Leif E Johnson, Lars Edvinsson. CaMKII and MEK1/2 inhibition time-dependently modify inflammatory signaling in rat cerebral arteries during organ culture.
Journal of neuroinflammation.
2014 May; 11(?):90. doi:
10.1186/1742-2094-11-90. [PMID: 24886705] - Heyang Wang, Hongxia Li, Xin Jiang, Wencai Shi, Zhilei Shen, Min Li. Hepcidin is directly regulated by insulin and plays an important role in iron overload in streptozotocin-induced diabetic rats.
Diabetes.
2014 May; 63(5):1506-18. doi:
10.2337/db13-1195. [PMID: 24379355] - Xin-yuan Wang, Yao Cheng, Ji-pei Du, De-gao Chen, Xue-shan Yang, Zhi-mei Yang, Ning Huang. [Synergistic effect of targeted inhibition of MEK/ERK and PI3K/AKT survival signaling pathways on induction of apoptosis in melanoma].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2014 May; 45(3):355-61. doi:
NULL. [PMID: 24941796] - Flaviana Mouawad, Lamine Aoudjit, Ruihua Jiang, Katalin Szaszi, Tomoko Takano. Role of guanine nucleotide exchange factor-H1 in complement-mediated RhoA activation in glomerular epithelial cells.
The Journal of biological chemistry.
2014 Feb; 289(7):4206-18. doi:
10.1074/jbc.m113.506816. [PMID: 24356971] - Chuan Ma, Gaoyi Wu, Zhaoling Wang, Peihuan Wang, Longmei Wu, Guoxiong Zhu, Huaqiang Zhao. Effects of chronic sleep deprivation on the extracellular signal-regulated kinase pathway in the temporomandibular joint of rats.
PloS one.
2014; 9(9):e107544. doi:
10.1371/journal.pone.0107544. [PMID: 25226519] - Yingxing Yue, Ying Wang, Yang He, Shuting Yang, Zixing Chen, Yuanyuan Wang, Shanshan Xing, Congcong Shen, Hesham M Amin, Depei Wu, Yao-Hua Song. Reversal of bortezomib resistance in myelodysplastic syndrome cells by MAPK inhibitors.
PloS one.
2014; 9(3):e90992. doi:
10.1371/journal.pone.0090992. [PMID: 24608798] - Sara Clark, Jennifer Rainville, Xing Zhao, Benita S Katzenellenbogen, Donald Pfaff, Nandini Vasudevan. Estrogen receptor-mediated transcription involves the activation of multiple kinase pathways in neuroblastoma cells.
The Journal of steroid biochemistry and molecular biology.
2014 Jan; 139(?):45-53. doi:
10.1016/j.jsbmb.2013.09.010. [PMID: 24121066] - Camilla Ingeson-Carlsson, Mikael Nilsson. Switching from MAPK-dependent to MAPK-independent repression of the sodium-iodide symporter in 2D and 3D cultured normal thyroid cells.
Molecular and cellular endocrinology.
2013 Dec; 381(1-2):241-54. doi:
10.1016/j.mce.2013.08.006. [PMID: 23969277] - Hee-Seong Jang, Sang Jun Han, Jee In Kim, Sanggyu Lee, Joshua H Lipschutz, Kwon Moo Park. Activation of ERK accelerates repair of renal tubular epithelial cells, whereas it inhibits progression of fibrosis following ischemia/reperfusion injury.
Biochimica et biophysica acta.
2013 Dec; 1832(12):1998-2008. doi:
10.1016/j.bbadis.2013.07.001. [PMID: 23851027] - Akira Ikari, Kosuke Atomi, Yasuhiro Yamazaki, Hideki Sakai, Hisayoshi Hayashi, Masahiko Yamaguchi, Junko Sugatani. Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation.
Biochimica et biophysica acta.
2013 Dec; 1833(12):2617-2627. doi:
10.1016/j.bbamcr.2013.06.016. [PMID: 23816505] - Yue-Hua Yang, Ke Chen, Bo Li, Jiang-Wei Chen, Xin-Feng Zheng, Yu-Ren Wang, Sheng-Dan Jiang, Lei-Sheng Jiang. Estradiol inhibits osteoblast apoptosis via promotion of autophagy through the ER-ERK-mTOR pathway.
Apoptosis : an international journal on programmed cell death.
2013 Nov; 18(11):1363-1375. doi:
10.1007/s10495-013-0867-x. [PMID: 23743762] - K Harada, H Miyake, M Kumano, M Fujisawa. Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2.
British journal of cancer.
2013 Oct; 109(9):2389-95. doi:
10.1038/bjc.2013.602. [PMID: 24091619] - Shixuan Wang, Qingqing Wei, Guie Dong, Zheng Dong. ERK-mediated suppression of cilia in cisplatin-induced tubular cell apoptosis and acute kidney injury.
Biochimica et biophysica acta.
2013 Oct; 1832(10):1582-90. doi:
10.1016/j.bbadis.2013.05.023. [PMID: 23727409] - L Fan, P Li, Z Yin, G Fu, D J Liao, Y Liu, J Zhu, Y Zhang, L Wang, Q Yan, Y Guo, C Shao, G Huang, Z Wang. Ribosomal s6 protein kinase 4: a prognostic factor for renal cell carcinoma.
British journal of cancer.
2013 Sep; 109(5):1137-46. doi:
10.1038/bjc.2013.463. [PMID: 23942078] - Marie-Christine Paquin, Sébastien Cagnol, Julie C Carrier, Caroline Leblanc, Nathalie Rivard. ERK-associated changes in E2F4 phosphorylation, localization and transcriptional activity during mitogenic stimulation in human intestinal epithelial crypt cells.
BMC cell biology.
2013 Aug; 14(?):33. doi:
10.1186/1471-2121-14-33. [PMID: 23919615] - Ayodeji Odunewu, Larry Fliegel. Acidosis-mediated regulation of the NHE1 isoform of the Na⁺/H⁺ exchanger in renal cells.
American journal of physiology. Renal physiology.
2013 Aug; 305(3):F370-81. doi:
10.1152/ajprenal.00598.2012. [PMID: 23678047] - Chitoku Toda, Tetsuya Shiuchi, Haruaki Kageyama, Shiki Okamoto, Eulalia A Coutinho, Tatsuya Sato, Yuko Okamatsu-Ogura, Shigefumi Yokota, Kazuyo Takagi, Lijun Tang, Kumiko Saito, Seiji Shioda, Yasuhiko Minokoshi. Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptin-induced glucose uptake in red-type skeletal muscle.
Diabetes.
2013 Jul; 62(7):2295-307. doi:
10.2337/db12-1629. [PMID: 23530005] - Leo G Flores, Hsin-Hsien Yeh, Suren Soghomonyan, Daniel Young, James Bankson, Qianghua Hu, Mian Alauddin, Vicki Huff, Juri G Gelovani. Monitoring therapy with MEK inhibitor U0126 in a novel Wilms tumor model in Wt1 knockout Igf2 transgenic mice using 18F-FDG PET with dual-contrast enhanced CT and MRI: early metabolic response without inhibition of tumor growth.
Molecular imaging and biology.
2013 Apr; 15(2):175-85. doi:
10.1007/s11307-012-0588-5. [PMID: 22875335] - Otgonzaya Ayush, Chang-Hoon Lee, Hae-Kyoung Kim, Suhn-Young Im, Baik-Hwan Cho, Hern-Ku Lee. Glutamine suppresses DNFB-induced contact dermatitis by deactivating p38 mitogen-activated protein kinase via induction of MAPK phosphatase-1.
The Journal of investigative dermatology.
2013 Mar; 133(3):723-731. doi:
10.1038/jid.2012.373. [PMID: 23076500] - Li-Mei Zhao, Xing-Li Su, Yan Wang, Gui-Rong Li, Xiu-Ling Deng. KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells.
Laboratory investigation; a journal of technical methods and pathology.
2013 Feb; 93(2):159-67. doi:
10.1038/labinvest.2012.163. [PMID: 23212096] - Wei-Hui Liu, Hong-Bao Liu, Da-Kuan Gao, Guan-Qun Ge, Peng Zhang, Shi-Ren Sun, Han-Min Wang, Shui-Bing Liu. ABCG2 protects kidney side population cells from hypoxia/reoxygenation injury through activation of the MEK/ERK pathway.
Cell transplantation.
2013; 22(10):1859-68. doi:
10.3727/096368912x657206. [PMID: 23032069] - Kechen Ban, Zhanglong Peng, Rosemary A Kozar. Inhibition of ERK1/2 worsens intestinal ischemia/reperfusion injury.
PloS one.
2013; 8(9):e76790. doi:
10.1371/journal.pone.0076790. [PMID: 24073294] - Soo Hyeon Bae, Jee Won Hwang, Sang Joon Shin, Gyu Hwan Park, Kee Dong Yoon, Soo Kyung Bae. Quantitation and pharmacokinetics of 1,4-diamino-2,3-dicyano-1,4-bis (2-aminophenylthio) butadiene (U0126) in rat plasma by liquid chromatography-tandem mass spectrometry.
Journal of separation science.
2013 Jan; 36(2):239-45. doi:
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PloS one.
2013; 8(3):e58848. doi:
10.1371/journal.pone.0058848. [PMID: 23544048] - María Eugenia Matzkin, Eliana Herminia Pellizzari, Soledad Paola Rossi, Ricardo Saúl Calandra, Selva Beatriz Cigorraga, Mónica Beatriz Frungieri. Exploring the cyclooxygenase 2 (COX2)/15d-Δ(12,14)PGJ(2) system in hamster Sertoli cells: regulation by FSH/testosterone and relevance to glucose uptake.
General and comparative endocrinology.
2012 Nov; 179(2):254-64. doi:
10.1016/j.ygcen.2012.08.020. [PMID: 22974512] - Kimberly D Fisher, Juan Codina, Snezana Petrovic, Thomas D DuBose. Pyk2 regulates H+-ATPase-mediated proton secretion in the outer medullary collecting duct via an ERK1/2 signaling pathway.
American journal of physiology. Renal physiology.
2012 Nov; 303(9):F1353-62. doi:
10.1152/ajprenal.00008.2012. [PMID: 22811489] - Won Seok Yang, Jai Won Chang, Nam Jeong Han, Sang Koo Lee, Su-Kil Park. Spleen tyrosine kinase mediates high glucose-induced transforming growth factor-β1 up-regulation in proximal tubular epithelial cells.
Experimental cell research.
2012 Sep; 318(15):1867-76. doi:
10.1016/j.yexcr.2012.05.016. [PMID: 22659134] - Sadie C Slater, Raina D Ramnath, Kate Uttridge, Moin A Saleem, Paul A Cahill, Peter W Mathieson, Gavin I Welsh, Simon C Satchell. Chronic exposure to laminar shear stress induces Kruppel-like factor 2 in glomerular endothelial cells and modulates interactions with co-cultured podocytes.
The international journal of biochemistry & cell biology.
2012 Sep; 44(9):1482-90. doi:
10.1016/j.biocel.2012.05.020. [PMID: 22683691] - Guoyuan Wang, Chengyan Jin, Yuanyuan Hou, Lijing Zhang, Shanshan Li, Luquan Zhang, Bo Wu, Quanfeng Li, Changqing Xu, Ye Tian, Li Zhang. Overexpression of Shp-2 attenuates apoptosis in neonatal rat cardiac myocytes through the ERK pathway.
Experimental and molecular pathology.
2012 Aug; 93(1):50-5. doi:
10.1016/j.yexmp.2012.04.005. [PMID: 22537548] - Yajun Duan, Yuanli Chen, Wenquan Hu, Xiaoju Li, Xiaoxiao Yang, Xin Zhou, Zhinan Yin, Deling Kong, Zhi Yao, David P Hajjar, Lin Liu, Qiang Liu, Jihong Han. Peroxisome Proliferator-activated receptor γ activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression.
The Journal of biological chemistry.
2012 Jul; 287(28):23667-77. doi:
10.1074/jbc.m112.350181. [PMID: 22593575] - Jinqi Ren, Wei Guo. ERK1/2 regulate exocytosis through direct phosphorylation of the exocyst component Exo70.
Developmental cell.
2012 May; 22(5):967-78. doi:
10.1016/j.devcel.2012.03.005. [PMID: 22595671] - Chien-An Chen, Yu-Chi Cheng, Jyh-Chang Hwang, Jer-Ming Chang, Jinn-Yuh Guh, Hung-Chun Chen. Cyclin D1 expression in podocytes: regulated by mitogens in collaboration with integrin-extracellular matrix interaction through extracellular signal-regulated kinase.
Experimental biology and medicine (Maywood, N.J.).
2012 May; 237(5):516-23. doi:
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American journal of physiology. Renal physiology.
2012 Apr; 302(8):F959-66. doi:
10.1152/ajprenal.00130.2011. [PMID: 22237798] - Jia Wei Zhu, Ji Fang Yuan, Hui Min Yang, Shu Ting Wang, Chen Guang Zhang, Li Li Sun, Hui Yang, Hong Zhang. Extracellular cysteine (Cys)/cystine (CySS) redox regulates metabotropic glutamate receptor 5 activity.
Biochimie.
2012 Mar; 94(3):617-27. doi:
10.1016/j.biochi.2011.09.013. [PMID: 21964032] - Moran Dvela, Haim Rosen, Hagit Cohen Ben-Ami, David Lichtstein. Endogenous ouabain regulates cell viability.
American journal of physiology. Cell physiology.
2012 Jan; 302(2):C442-52. doi:
10.1152/ajpcell.00336.2011. [PMID: 22031604] - Youjia Zeng, Xiao Yang, Juan Wang, Jinjin Fan, Qingyu Kong, Xueqing Yu. Aristolochic acid I induced autophagy extenuates cell apoptosis via ERK 1/2 pathway in renal tubular epithelial cells.
PloS one.
2012; 7(1):e30312. doi:
10.1371/journal.pone.0030312. [PMID: 22276178] - Haiwei Yang, Xue Kong, Jifu Wei, Chengcheng Liu, Weijuan Song, Wei Zhang, Wei Wei, Shaoheng He. Cockroach allergen Per a 7 down-regulates expression of Toll-like receptor 9 and IL-12 release from P815 cells through PI3K and MAPK signaling pathways.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2012; 29(3-4):561-70. doi:
10.1159/000338510. [PMID: 22508063] - Yasushi Hirasawa, Takayuki Sakai, Masanori Ito, Hiromitsu Yoshimura, Yibin Feng, Tadashi Nagamatsu. Advanced-glycation-end-product-cholesterol-aggregated-protein accelerates the proliferation of mesangial cells mediated by transforming-growth-factor-beta 1 receptors and the ERK-MAPK pathway.
European journal of pharmacology.
2011 Dec; 672(1-3):159-68. doi:
10.1016/j.ejphar.2011.09.185. [PMID: 21989075] - Natalia Martin-Martin, Craig Slattery, Tara McMorrow, Michael P Ryan. TGF-β1 mediates sirolimus and cyclosporine A-induced alteration of barrier function in renal epithelial cells via a noncanonical ERK1/2 signaling pathway.
American journal of physiology. Renal physiology.
2011 Dec; 301(6):F1281-92. doi:
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Journal of cellular physiology.
2011 Nov; 226(11):3022-31. doi:
10.1002/jcp.22650. [PMID: 21935933] - Hongyu Yang, Yuan Dou, Xuehua Zheng, Yun Tan, Jiajun Cheng, Lu Li, Yue Du, Danyan Zhu, Yijia Lou. Cysteinyl leukotrienes synthesis is involved in aristolochic acid I-induced apoptosis in renal proximal tubular epithelial cells.
Toxicology.
2011 Sep; 287(1-3):38-45. doi:
10.1016/j.tox.2011.05.014. [PMID: 21658425] - Minghui Gao, Junjian Wang, Na Lu, Fang Fang, Jinsong Liu, Chi-Wai Wong. Mitogen-activated protein kinase kinases promote mitochondrial biogenesis in part through inducing peroxisome proliferator-activated receptor γ coactivator-1β expression.
Biochimica et biophysica acta.
2011 Jun; 1813(6):1239-44. doi:
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Zhonghua zhong liu za zhi [Chinese journal of oncology].
2011 Jun; 33(6):421-5. doi:
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Biochimica et biophysica acta.
2011 Jun; 1808(6):1502-8. doi:
10.1016/j.bbamem.2010.11.006. [PMID: 21073857] - Erin E Mulvihill, Julia M Assini, Justin K Lee, Emma M Allister, Brian G Sutherland, Julie B Koppes, Cynthia G Sawyez, Jane Y Edwards, Dawn E Telford, Alexandre Charbonneau, Philippe St-Pierre, André Marette, Murray W Huff. Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance.
Diabetes.
2011 May; 60(5):1446-57. doi:
10.2337/db10-0589. [PMID: 21471511] - Chen Chen Jiang, Fritz Lai, Rick F Thorne, Fan Yang, Hao Liu, Peter Hersey, Xu Dong Zhang. MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2011 Feb; 17(4):721-30. doi:
10.1158/1078-0432.ccr-10-2225. [PMID: 21088259] - Liang Xi, Changting Xiao, Robert H J Bandsma, Mark Naples, Khosrow Adeli, Gary F Lewis. C-reactive protein impairs hepatic insulin sensitivity and insulin signaling in rats: role of mitogen-activated protein kinases.
Hepatology (Baltimore, Md.).
2011 Jan; 53(1):127-35. doi:
10.1002/hep.24011. [PMID: 20967757] - Susan Yeyeodu, Nailya Gilyazova, Eun Young Huh, Srinivasa R Dandepally, Carla Oldham, Alfred Williams, Gordon Ibeanu. A trifluoromethyl analog of verbenachalcone promotes neurite outgrowth and cell proliferation of NeuroScreen-1 cells.
Cellular and molecular neurobiology.
2011 Jan; 31(1):145-53. doi:
10.1007/s10571-010-9563-3. [PMID: 20848307] - Daniel Flores, Lorenzo Battini, G Luca Gusella, Rajeev Rohatgi. Fluid shear stress induces renal epithelial gene expression through polycystin-2-dependent trafficking of extracellular regulated kinase.
Nephron. Physiology.
2011; 117(4):p27-36. doi:
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Thrombosis and haemostasis.
2010 Dec; 104(6):1219-27. doi:
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BMC cancer.
2010 Nov; 10(?):657. doi:
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European journal of cell biology.
2010 Sep; 89(9):712-22. doi:
10.1016/j.ejcb.2010.05.002. [PMID: 20605057] - Takafumi Ono, Eri Hashimoto, Wataru Ukai, Takao Ishii, Toshikazu Saito. The role of neural stem cells for in vitro models of schizophrenia: neuroprotection via Akt/ERK signal regulation.
Schizophrenia research.
2010 Sep; 122(1-3):239-47. doi:
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American journal of physiology. Cell physiology.
2010 Jul; 299(1):C51-7. doi:
10.1152/ajpcell.00081.2010. [PMID: 20375273] - Faiza Waheed, Pam Speight, Glenn Kawai, Qinghong Dan, András Kapus, Katalin Szászi. Extracellular signal-regulated kinase and GEF-H1 mediate depolarization-induced Rho activation and paracellular permeability increase.
American journal of physiology. Cell physiology.
2010 Jun; 298(6):C1376-87. doi:
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Virus research.
2010 Jun; 150(1-2):22-7. doi:
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Cellular signalling.
2010 May; 22(5):821-7. doi:
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Journal of periodontal research.
2010 Apr; 45(2):200-6. doi:
10.1111/j.1600-0765.2009.01218.x. [PMID: 19909407] - Vladislav Levchenko, Nadezhda N Zheleznova, Tengis S Pavlov, Alain Vandewalle, Patricia D Wilson, Alexander Staruschenko. EGF and its related growth factors mediate sodium transport in mpkCCDc14 cells via ErbB2 (neu/HER-2) receptor.
Journal of cellular physiology.
2010 Apr; 223(1):252-9. doi:
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