N-Hydroxyacetamidine (BioDeep_00000786338)
代谢物信息卡片
N-Hydroxyacetimidamide
化学式: C2H6N2O (74.0480106)
中文名称: 乙酰胺肟
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=NO)N
InChI: InChI=1S/C2H6N2O/c1-2(3)4-5/h5H,1H3,(H2,3,4)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Silvia M Titan, Gabriela Venturini, Kallyandra Padilha, Alessandra C Goulart, Paulo A Lotufo, Isabela J Bensenor, Jose E Krieger, Ravi I Thadhani, Eugene P Rhee, Alexandre C Pereira. Metabolomics biomarkers and the risk of overall mortality and ESRD in CKD: Results from the Progredir Cohort.
PloS one.
2019; 14(3):e0213764. doi:
10.1371/journal.pone.0213764. [PMID: 30883578] - Gülay Akyüz, Emre Menteşe, Mustafa Emirik, Nimet Baltaş. Synthesis and molecular docking study of some novel 2,3-disubstituted quinazolin-4(3H)-one derivatives as potent inhibitors of urease.
Bioorganic chemistry.
2018 10; 80(?):121-128. doi:
10.1016/j.bioorg.2018.06.011. [PMID: 29894891] - Lihua Tan, Cailan Li, Hanbin Chen, Zhizhun Mo, Jiangtao Zhou, Yuhong Liu, Zhilin Ma, Yuyao Xu, Xiaobo Yang, Jianhui Xie, Ziren Su. Epiberberine, a natural protoberberine alkaloid, inhibits urease of Helicobacter pylori and jack bean: Susceptibility and mechanism.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Dec; 110(?):77-86. doi:
10.1016/j.ejps.2017.02.004. [PMID: 28167234] - Yuh-Hwa Liu, Yeh-Lin Lu, Der-Zen Liu, Wen-Chi Hou. Antiglycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in vitro.
Drug design, development and therapy.
2017; 11(?):2139-2147. doi:
10.2147/dddt.s141740. [PMID: 28761331] - Muhammad Waqas Iqbal, Ramy F Youssef, Andreas Neisius, Nicholas Kuntz, Jonathan Hanna, Michael N Ferrandino, Glenn M Preminger, Michael E Lipkin. Contemporary Management of Struvite Stones Using Combined Endourologic and Medical Treatment: Predictors of Unfavorable Clinical Outcome.
Journal of endourology.
2016 07; 30(7):771-7. doi:
10.1089/end.2013.0257. [PMID: 24251429] - Ana C Ochogavía, Gabriela Breccia, Tatiana Vega, Silvina A Felitti, Liliana A Picardi, Graciela Nestares. Acetohydroxyacid synthase activity and transcripts profiling reveal tissue-specific regulation of ahas genes in sunflower.
Plant science : an international journal of experimental plant biology.
2014 Jul; 224(?):144-50. doi:
10.1016/j.plantsci.2014.04.018. [PMID: 24908515] - Grzegorz Czerwonka, Michał Arabski, Sławomir Wąsik, Agnieszka Jabłońska-Wawrzycka, Patrycja Rogala, Wiesław Kaca. Morphological changes in Proteus mirabilis O18 biofilm under the influence of a urease inhibitor and a homoserine lactone derivative.
Archives of microbiology.
2014 Mar; 196(3):169-77. doi:
10.1007/s00203-014-0952-8. [PMID: 24481535] - A N Loes, L Ruyle, M Arvizu, K E Gresko, A L Wilson, C E Deutch. Inhibition of urease activity in the urinary tract pathogen Staphylococcus saprophyticus.
Letters in applied microbiology.
2014 Jan; 58(1):31-41. doi:
10.1111/lam.12153. [PMID: 24001038] - Howard A Fink, Timothy J Wilt, Keith E Eidman, Pranav S Garimella, Roderick MacDonald, Indulis R Rutks, Michelle Brasure, Robert L Kane, Jeannine Ouellette, Manoj Monga. Medical management to prevent recurrent nephrolithiasis in adults: a systematic review for an American College of Physicians Clinical Guideline.
Annals of internal medicine.
2013 Apr; 158(7):535-43. doi:
10.7326/0003-4819-158-7-201304020-00005. [PMID: 23546565] - Idoia Ariz, Saioa Cruchaga, Berta Lasa, Jose F Moran, Ivan Jauregui, Pedro M Aparicio-Tejo. The physiological implications of urease inhibitors on N metabolism during germination of Pisum sativum and Spinacea oleracea seeds.
Journal of plant physiology.
2012 May; 169(7):673-81. doi:
10.1016/j.jplph.2012.01.012. [PMID: 22405591] - Rashmi Sharma, Wesley R Harris. Allosteric effects of sulfonate anions on the rates of iron release from serum transferrin.
Journal of inorganic biochemistry.
2011 Sep; 105(9):1148-55. doi:
10.1016/j.jinorgbio.2011.05.021. [PMID: 21708099] - Y Li, W R Harris. Iron removal from monoferric human serum transferrins by 1, 2-dimethyl-3-hydroxypyridin-4-one, 1-hydroxypyridin-2-one and acetohydroxamic acid.
Biochimica et biophysica acta.
1998 Sep; 1387(1-2):89-102. doi:
10.1016/s0167-4838(98)00109-5. [PMID: 9748517] - N S Morris, D J Stickler. The effect of urease inhibitors on the encrustation of urethral catheters.
Urological research.
1998; 26(4):275-9. doi:
10.1007/s002400050057. [PMID: 9760002] - T Yoshioka, H Ohno, T Uematsu. Pyruvate dehydrogenase complex-catalyzed formation of N-arylacetohydroxamic acids from nitroso aromatic compounds in rat isolated cells and perfused organs.
The Journal of pharmacology and experimental therapeutics.
1996 Dec; 279(3):1282-9. doi:
NULL. [PMID: 8968352] - R B Nadler, T A Hoffman, B L McClennan, R V Clayman. Corynebacterium urealyticum (CDC Group D2) associated with staghorn calculus: treatment by percutaneous debulking and chemolysis.
Journal of endourology.
1996 Feb; 10(1):31-4. doi:
10.1089/end.1996.10.31. [PMID: 9156691] - R A Star, A D Gillin, V J Parikh, J M Sands. The urease inhibitor acetohydroxamic acid is transported by the urea pathway in rat terminal IMCD.
The American journal of physiology.
1993 Sep; 265(3 Pt 2):F385-90. doi:
10.1152/ajprenal.1993.265.3.f385. [PMID: 8214097] - J A Downey, J C Nickel, L Clapham, R J McLean. In vitro inhibition of struvite crystal growth by acetohydroxamic acid.
British journal of urology.
1992 Oct; 70(4):355-9. doi:
10.1111/j.1464-410x.1992.tb15787.x. [PMID: 1450840] - M Arrizabalaga, J Extramiana, M Mora, J Navarro, A Mañas, M J Pérez, P González, P Paniagua. [Alkaline encrusted cystitis: factors affecting prognosis].
Actas urologicas espanolas.
1991 Sep; 15(5):474-6. doi:
NULL. [PMID: 1807130] - A M el Nujumi, C A Dorrian, R S Chittajallu, W D Neithercut, K E McColl. Effect of inhibition of Helicobacter pylori urease activity by acetohydroxamic acid on serum gastrin in duodenal ulcer subjects.
Gut.
1991 Aug; 32(8):866-70. doi:
10.1136/gut.32.8.866. [PMID: 1885067] - Y Shirokane, M Nakajima, K Mizusawa. Easier enzymatic determination of guanidinoacetic acid in urine.
Clinical chemistry.
1991 Mar; 37(3):478-9. doi:
10.1093/clinchem/37.3.478. [PMID: 2004466] - J Lorenz, K Lorenz, B Dabrowska, R Kowal. [Acetylhydroxamic acid in the treatment of nephrolithiasis, caused by infection with urease forming microorganisms].
Zeitschrift fur Urologie und Nephrologie.
1989 Dec; 82(12):685-9. doi:
NULL. [PMID: 2698024] - D P Griffith, F Khonsari, J H Skurnick, K E James. A randomized trial of acetohydroxamic acid for the treatment and prevention of infection-induced urinary stones in spinal cord injury patients.
The Journal of urology.
1988 Aug; 140(2):318-24. doi:
10.1016/s0022-5347(17)41592-8. [PMID: 3294442] - J E Tateson, R W Randall, C H Reynolds, W P Jackson, P Bhattacherjee, J A Salmon, L G Garland. Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: biochemical assessment in vitro and ex vivo.
British journal of pharmacology.
1988 Jun; 94(2):528-39. doi:
10.1111/j.1476-5381.1988.tb11557.x. [PMID: 2840160] - A N Payne, L G Garland, I W Lees, J A Salmon. Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on bronchial anaphylaxis in anaesthetized guinea-pigs.
British journal of pharmacology.
1988 Jun; 94(2):540-6. doi:
10.1111/j.1476-5381.1988.tb11558.x. [PMID: 3395791] - F Soriano, C Ponte, M Santamaría, A Torres, R Fernández-Roblas. Susceptibility of urinary isolates of Corynebacterium group D2 to fifteen antimicrobials and acetohydroxamic acid.
The Journal of antimicrobial chemotherapy.
1987 Sep; 20(3):349-55. doi:
10.1093/jac/20.3.349. [PMID: 3479417] - J S Rodman, J J Williams, R L Jones. Hypercoagulability produced by treatment with acetohydroxamic acid.
Clinical pharmacology and therapeutics.
1987 Sep; 42(3):346-50. doi:
10.1038/clpt.1987.159. [PMID: 3621791] - J Lorenz, K Lorenz, B Dabrowska, R Kowal. [Acetohydroxamic acid in the treatment of kidney calculi caused by an infection with urease-producing microorganisms].
Polski tygodnik lekarski (Warsaw, Poland : 1960).
1987 May; 42(18):541-3. doi:
NULL. [PMID: 3306625] - F Soriano, C Ponte, M Santamaría, R Fernández-Roblas. Struvite crystal formation by Corynebacterium group D2 in human urine and its prevention by acetohydroxamic acid.
European urology.
1987; 13(4):271-3. doi:
10.1159/000472793. [PMID: 3653169] - P Puppo, F Germinale, P Bottino, G Ricciotti, L Giuliani. Propionhydroxamic acid in the management of struvite urinary stones.
Contributions to nephrology.
1987; 58(?):201-6. doi:
10.1159/000414518. [PMID: 3691127] - E Dybing, E J Søderlund, W P Gordon, J A Holme, T Christensen, G Becher, E Rivedal, S S Thorgeirsson. Studies on the mechanism of acetamide hepatocarcinogenicity.
Pharmacology & toxicology.
1987 Jan; 60(1):9-16. doi:
10.1111/j.1600-0773.1987.tb01712.x. [PMID: 3550769] - B J Corden. Hemosiderosis in rodents and the effect of acetohydroxamic acid on urinary iron excretion.
Experimental hematology.
1986 Nov; 14(10):971-4. doi:
NULL. [PMID: 3770104] - K Tatsumi, S Kitamura. N-hydroxy-2-acetylaminofluorene as effective inhibitor of aldehyde oxidase.
Biochemical and biophysical research communications.
1986 Jul; 138(1):312-7. doi:
10.1016/0006-291x(86)90281-0. [PMID: 3741414] - J Morote Robles, F J Ruiz Marcellán, J Bernstham Ballester, B Pinto Mateos, A Soler Roselló. [Clinical study of the treatment of infectious renal lithiasis with acetohydroxamic acid].
Medicina clinica.
1986 Jun; 87(4):144-6. doi:
NULL. [PMID: 3736234] - S Isorna Martínez de la Riva, F J Regadera Sejas, F J Martínez Gómez. [Our experience in the treatment of infectious lithiasis with acetohydroxamic acid. Partial dissolution of a complex coralliform calculus].
Actas urologicas espanolas.
1986 May; 10(3):185-90. doi:
NULL. [PMID: 3739787] - M Ben Amar, G L'Espérance, R Tawashi. S.E.M. study of urease-induced crystalluria in the presence of hydroxamic derivatives.
International urology and nephrology.
1986; 18(3):227-33. doi:
10.1007/bf02082708. [PMID: 3771124] - K D Lake, D C Brown. New drug therapy for kidney stones: a review of cellulose sodium phosphate, acetohydroxamic acid, and potassium citrate.
Drug intelligence & clinical pharmacy.
1985 Jul; 19(7-8):530-9. doi:
10.1177/106002808501900705. [PMID: 3896714] - F Soriano, C Ponte, M Santamaria, J M Aguado, I Wilhelmi, R Vela, L C Delatte. Corynebacterium group D2 as a cause of alkaline-encrusted cystitis: report of four cases and characterization of the organisms.
Journal of clinical microbiology.
1985 May; 21(5):788-92. doi:
10.1128/jcm.21.5.788-792.1985. [PMID: 3998111] - E V De Buysscher, J A Appleton, S Kadis. Appearance of immunoglobulin classes and complement (C3) during Corynebacterium renale-induced experimental pyelonephritis in the rat.
American journal of veterinary research.
1985 Feb; 46(2):401-3. doi:
NULL. [PMID: 3888008] - L Putcha, D P Griffith, S Feldman. Pharmacokinetics of acetohydroxamic acid in patients with staghorn renal calculi.
European journal of clinical pharmacology.
1985; 28(4):439-45. doi:
10.1007/bf00544364. [PMID: 3928387] - L Grenabo, J E Brorson, H Hedelin, S Pettersson. Ureaplasma urealyticum-induced crystallization of magnesium ammonium phosphate and calcium phosphates in synthetic urine.
The Journal of urology.
1984 Oct; 132(4):795-9. doi:
10.1016/s0022-5347(17)49876-4. [PMID: 6381769] - L H Smith. New treatment for struvite urinary stones.
The New England journal of medicine.
1984 Sep; 311(12):792-4. doi:
10.1056/nejm198409203111210. [PMID: 6472369] - J J Williams, J S Rodman, C M Peterson. A randomized double-blind study of acetohydroxamic acid in struvite nephrolithiasis.
The New England journal of medicine.
1984 Sep; 311(12):760-4. doi:
10.1056/nejm198409203111203. [PMID: 6472365] - D R Krawiec, C A Osborne, J R Leininger, D P Griffith. Effect of acetohydroxamic acid on dissolution of canine struvite uroliths.
American journal of veterinary research.
1984 Jul; 45(7):1266-75. doi:
. [PMID: 24049882] - L Putcha, D P Griffith, S Feldman. Disposition of 14C-acetohydroxamic acid and 14C-acetamide in the rat.
Drug metabolism and disposition: the biological fate of chemicals.
1984 Jul; 12(4):438-43. doi:
NULL. [PMID: 6148210] - D R Krawiec, C A Osborne, J R Leininger, D P Griffith. Effect of acetohydroxamic acid on prevention of canine struvite uroliths.
American journal of veterinary research.
1984 Jul; 45(7):1276-82. doi:
. [PMID: 24049883] - J Texier, M T Clerc, C Bébéar, M Aparicio, M Clerc, L Potaux. [Experimental magnesium ammonium phosphate lithiasis induced by Ureaplasma in the rat].
Nephrologie.
1984; 5(5):222-4. doi:
NULL. [PMID: 6531060] - M Clerc, J Texier, C Bebear. Experimental production of bladder calculi in rats by ureaplasma injection.
Annales de microbiologie.
1984 Jan; 135A(1):135-40. doi:
10.1016/s0769-2609(84)80070-8. [PMID: 6712056] - . Oral acetohydroxamic acid (LithoStat) for staghorn calculi.
The Medical letter on drugs and therapeutics.
1983 Dec; 25(650):110-1. doi:
. [PMID: 6656689] - J S Rodman, J J Williams, C M Peterson. Partial dissolution of struvite calculus with oral acetohydroxamic acid.
Urology.
1983 Oct; 22(4):410-2. doi:
10.1016/0090-4295(83)90424-7. [PMID: 6356559] - J C Ricardo Cid, A G Rusconi de Mendia, G Ruis Espina, J Chavarria Mendoza, N Serrallach Mila. [Clinical study of patients with renal lithiasis treated with acetohydroxamic acid].
Actas urologicas espanolas.
1983 Sep; 7(5):339-42. doi:
NULL. [PMID: 6660071] - F J Ruiz Marcellán, J Bernshtam Ballester, B Pinto Mateos. [Treatment of infectious renal lithiasis with acetohydroxamic acid].
Archivos espanoles de urologia.
1983 Sep; 36(5):354-62. doi:
NULL. [PMID: 6660940] - C Marwick. New drugs selectively inhibit kidney stone formation.
JAMA.
1983 Jul; 250(3):321-2. doi:
NULL. [PMID: 6854890] - R G Burr, I Nuseibeh. The effect of oral acetohydroxamic acid on urinary saturation in stone-forming spinal cord patients.
British journal of urology.
1983 Apr; 55(2):162-5. doi:
10.1111/j.1464-410x.1983.tb06545.x. [PMID: 6839086] - A Aroldi, G Graziani, C Castelnovo, G Colussi, M Surian, A Mandressi, E Mascheroni, I Pazardjiklian, A Pagano, C Ponticelli. Acetohydroxamate in struvite stones: in vivo study.
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association.
1983; 20(?):469-72. doi:
NULL. [PMID: 6657671] - A Martelli, P Buli, E Brunocilla. Propionohydroxamic acid in infected renal stones. A preliminary clinical report.
The Journal of urology.
1982 Nov; 128(5):1130-2. doi:
10.1016/s0022-5347(17)53359-5. [PMID: 7176043] - J P Witter, E Balish, S J Gatley. Origin of excess urinary nitrate in the rat.
Cancer research.
1982 Sep; 42(9):3654-8. doi:
NULL. [PMID: 7105036] - R E Cowart, N Kojima, G W Bates. The exchange of Fe3+ between acetohydroxamic acid and transferrin. Spectrophotometric evidence for a mixed ligand complex.
The Journal of biological chemistry.
1982 Jul; 257(13):7560-5. doi:
. [PMID: 7085638] - M A Brown, S Kadis, W L Chapman. Evaluation of penicillin in conjunction with acetohydroxamic acid in treatment of experimental Corynebacterium renale pyelonephritis.
Canadian journal of microbiology.
1981 Dec; 27(12):1306-11. doi:
10.1139/m81-200. [PMID: 7332881] - A Martelli, P Buli, V Cortecchia. Acetohydroxamic acid therapy in infected renal stones.
Urology.
1981 Apr; 17(4):320-2. doi:
10.1016/0090-4295(81)90254-5. [PMID: 7222319] - A Martelli, P Buli, V Cortecchia. Urease inhibitor therapy in infected renal stones.
European urology.
1981; 7(5):291-3. doi:
10.1159/000473243. [PMID: 7250161] - P Buli, V Cortecchia, E Brunocilla, A Martelli, G Biagini, R Caudarella, M Gatti. [The use of acetohydroxamic acid in infected renal lithiasis].
Minerva nefrologica.
1980 Oct; 27(4):621-4. doi:
NULL. [PMID: 7254689] - I Rosenstein, J M Hamilton-Miller, W Brumfitt. The effect of acetohydroxamic acid on the induction of bacterial ureases.
Investigative urology.
1980 Sep; 18(2):112-4. doi:
NULL. [PMID: 6997229] - D M Musher, D P Griffith, G B Templeton. Further observations on the potentiation of the antibacterial effect of methenamine by acetohydroxamic acid.
The Journal of infectious diseases.
1976 May; 133(5):564-7. doi:
10.1093/infdis/133.5.564. [PMID: 4573] - W N FISHBEIN, P P CARBONE. HYDROXYUREA: MECHANISM OF ACTION.
Science (New York, N.Y.).
1963 Nov; 142(3595):1069-70. doi:
10.1126/science.142.3595.1069. [PMID: 14068223]