Pirmagrel (BioDeep_00000785966)
代谢物信息卡片
Pirmagrel
化学式: C13H16N2O2 (232.1211716)
中文名称: 吡吗格雷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC2=CN=CN2C(=C1)CCCCCC(=O)O
InChI: InChI=1S/C13H16N2O2/c16-13(17)8-3-1-2-5-11-6-4-7-12-9-14-10-15(11)12/h4,6-7,9-10H,1-3,5,8H2,(H,16,17)
描述信息
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- K Lutnicki, E Szpringer, K Czerny, A Ledwozyw. Effects of ethanol and arachidonic acid pathway inhibitors on the effectiveness of gastric mucosa cytoprotection.
Folia morphologica.
2001; 60(1):47-56. doi:
". [PMID: 11234698] - K Brännström, W J Arendshorst. Thromboxane A2 contributes to the enhanced tubuloglomerular feedback activity in young SHR.
The American journal of physiology.
1999 05; 276(5):F758-66. doi:
10.1152/ajprenal.1999.276.5.f758. [PMID: 10330058] - M Schilling, A Saunder, J H Southard, F O Belzer. Long-term renal preservation and prevention of acute tubular necrosis by inhibition of arachidonate metabolism.
Swiss surgery = Schweizer Chirurgie = Chirurgie suisse = Chirurgia svizzera.
1995; ?(4):205-9. doi:
NULL. [PMID: 9127638] - Q Li, J S Lopez, R R Caspi, F G Roberge, R B Nussenblatt, P F Kador, C C Chan. Suppression of S-antigen-induced experimental autoimmune uveoretinitis in Lewis rats by oral administration with CGS-13080, a thromboxane synthetase inhibitor.
Experimental eye research.
1993 Nov; 57(5):601-8. doi:
10.1006/exer.1993.1165. [PMID: 8282047] - M Schilling, A Saunder, J H Southard, F O Belzer. Long-term renal preservation and prevention of acute tubular necrosis by inhibition of arachidonate metabolism.
Transplantation proceedings.
1993 Aug; 25(4):2534-5. doi:
NULL. [PMID: 8356657] - B C Abels, R A Branch, R Sabra. Interaction between thromboxane A2 and angiotensin II in postischemic renal vasoconstriction in dogs.
The Journal of pharmacology and experimental therapeutics.
1993 Mar; 264(3):1285-92. doi:
NULL. [PMID: 8450463] - M L Chouinard, L L Martin, T Coffman, B H Hamilton, L F Linberg, A Pamidi, J P Simke, A Rakhit. Pharmacokinetics and biochemical efficacy of pirmagrel, a thromboxane synthase inhibitor, in renal allograft recipients.
Clinical pharmacology and therapeutics.
1992 Dec; 52(6):597-604. doi:
10.1038/clpt.1992.197. [PMID: 1458769] - J Keith, T Rowles, K Warwick, E Yau. Effects of a 48 hour continuous intravenous infusion of CGS 13080-primagrel, a selective thromboxane synthetase inhibitor, on the perinatal and early postnatal period in the guinea pig.
Teratology.
1992 Aug; 46(2):159-67. doi:
10.1002/tera.1420460209. [PMID: 1440419] - J S Fomsgaard, Y D Kim, T A Burke, T Viswanathan, A V Schaffer, J Peppard, F L Douglas, M Danchak, A K Myers. Comparison of thromboxane synthetase inhibitor and methylprednisolone effects on protamine responses in dogs.
Anesthesia and analgesia.
1992 Jan; 74(1):38-43. doi:
10.1213/00000539-199201000-00007. [PMID: 1734796] - S R Smith, E A Creech, A V Schaffer, L L Martin, A Rakhit, F L Douglas, P E Klotman, T M Coffman. Effects of thromboxane synthase inhibition with CGS 13080 in human cyclosporine nephrotoxicity.
Kidney international.
1992 Jan; 41(1):199-205. doi:
10.1038/ki.1992.27. [PMID: 1593856] - P J Manning, W H Stevens, D W Cockcroft, P M O'Byrne. The role of thromboxane in allergen-induced asthmatic responses.
The European respiratory journal.
1991 Jun; 4(6):667-72. doi:
NULL. [PMID: 1889493] - J P Cardin, M G Ross, M G Ervin, A V Schaffer, F L Douglas, J P Simke. Fetal and maternal response to intravenous infusion of a thromboxane synthetase inhibitor.
American journal of obstetrics and gynecology.
1990 Oct; 163(4 Pt 1):1345-9. doi:
10.1016/0002-9378(90)90717-l. [PMID: 2220946] - P Henriksson, G Rasmanis, O Edhag, O Vesterqvist, K Gréen. Thromboxane synthase inhibition: 'endoperoxide shunt phenomenon' does not occur in healthy humans in vivo.
Prostaglandins.
1990 Jan; 39(1):99-107. doi:
10.1016/0090-6980(90)90098-g. [PMID: 2106716] - M R Weir, D K Klassen, N Hoover, F L Douglas. Preliminary observations of the acute effects of selective serum thromboxane inhibition and angiotensin converting enzyme inhibition on blood pressure and renal hemodynamics in hypertensive humans.
Journal of clinical pharmacology.
1989 Dec; 29(12):1108-16. doi:
10.1002/j.1552-4604.1989.tb03287.x. [PMID: 2693500] - J Nowak, G A FitzGerald. Redirection of prostaglandin endoperoxide metabolism at the platelet-vascular interface in man.
The Journal of clinical investigation.
1989 Feb; 83(2):380-5. doi:
10.1172/jci113895. [PMID: 2643628] - Y D Kim, M L Foegh, R B Wallace, L Ng, S W Ahmed, N M Katz, R Siegelman, K Franco, F Douglas, E Ku. Effects of CGS-13080, a thromboxane inhibitor, on pulmonary vascular resistance in patients after mitral valve replacement surgery.
Circulation.
1988 Sep; 78(3 Pt 2):I44-50. doi:
NULL. [PMID: 3409518] - M L Foegh, K Lim, F Douglas, J Turk, G B Helfrich, S A Taher, M R Alijani. Differential effect of CGS 13080, a thromboxane synthase inhibitor, in suppressing serum and urine immunoreactive thromboxane B2 in kidney transplant patients.
Transplantation proceedings.
1988 Feb; 20(1 Suppl 1):424-7. doi:
NULL. [PMID: 3279631] - R P Kaufman, H Anner, L Kobzik, C R Valeri, D Shepro, H B Hechtman. A high plasma prostaglandin to thromboxane ratio protects against renal ischemia.
Surgery, gynecology & obstetrics.
1987 Nov; 165(5):404-9. doi:
. [PMID: 3672299] - H Bitterman, G R Phillips, G Dragon, A M Lefer. Potentiation of the protective effects of a converting enzyme inhibitor and a thromboxane synthetase inhibitor in hemorrhagic shock.
The Journal of pharmacology and experimental therapeutics.
1987 Jul; 242(1):8-14. doi:
NULL. [PMID: 3039116] - K D Butler, R A Shand, R B Wallis. The effects of modulation of prostanoid metabolism on the thoracic platelet accumulation induced by intravenous administration of collagen in the guinea-pig.
Thrombosis and haemostasis.
1986 Dec; 56(3):263-7. doi:
NULL. [PMID: 3105104] - W M DeCampli, D Goodwin, J C Kosek, C E Handen, R S Mitchell, D C Miller. Pharmacological, hematological, and physiological effects of a new thromboxane synthetase inhibitor (CGS-13080) during cardiopulmonary bypass in dogs.
The Annals of thoracic surgery.
1986 Dec; 42(6):690-6. doi:
10.1016/s0003-4975(10)64611-5. [PMID: 3789860] - P J Simpson, C B Smith, G Rosenthal, B R Lucchesi. Reduction in the incidence of thrombosis by the thromboxane synthetase inhibitor CGS 13080 in a canine model of coronary artery injury.
The Journal of pharmacology and experimental therapeutics.
1986 Aug; 238(2):497-501. doi:
NULL. [PMID: 3735129] - I A Reilly, J B Doran, B Smith, G A FitzGerald. Increased thromboxane biosynthesis in a human preparation of platelet activation: biochemical and functional consequences of selective inhibition of thromboxane synthase.
Circulation.
1986 Jun; 73(6):1300-9. doi:
10.1161/01.cir.73.6.1300. [PMID: 2938849] - J Mehta, P Mehta, D L Lawson, N Ostrowski, L Brigmon. Influence of selective thromboxane synthetase blocker CGS-13080 on thromboxane and prostacyclin biosynthesis in whole blood: evidence for synthesis of prostacyclin by leukocytes from platelet-derived endoperoxides.
The Journal of laboratory and clinical medicine.
1985 Sep; 106(3):246-52. doi:
NULL. [PMID: 3928780] - I Leprán, A M Lefer. Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia.
Basic research in cardiology.
1985 Mar; 80(2):135-41. doi:
10.1007/bf01910460. [PMID: 4039929] - G A FitzGerald, J A Oates. Selective and nonselective inhibition of thromboxane formation.
Clinical pharmacology and therapeutics.
1984 May; 35(5):633-40. doi:
10.1038/clpt.1984.87. [PMID: 6370554] - M W MacNab, E L Foltz, B S Graves, R K Rinehart, S L Tripp, N R Feliciano, S Sen. The effects of a new thromboxane synthetase inhibitor, CGS-13080, in man.
Journal of clinical pharmacology.
1984 Feb; 24(2-3):76-83. doi:
10.1002/j.1552-4604.1984.tb02768.x. [PMID: 6371062] - J A Oates, A Brash, G Fitzgerald. Comparison of the effects of selective inhibition of thromboxane synthase with those of inhibition of the cyclooxygenase enzyme in man.
Transactions of the American Clinical and Climatological Association.
1984; 95(?):157-62. doi:
NULL. [PMID: 6433527] - E D Maguire, R B Wallis. In vivo redirection of prostaglandin endoperoxides into 6-keto PGF1 alpha formation by thromboxane synthetase inhibitors in the rat.
Thrombosis research.
1983 Oct; 32(1):15-27. doi:
10.1016/0049-3848(83)90150-0. [PMID: 6689221] - S E Burke, G DiCola, A M Lefer. Protection of ischemic cat myocardium by CGS-13080, a selective potent thromboxane A2 synthesis inhibitor.
Journal of cardiovascular pharmacology.
1983 Sep; 5(5):842-7. doi:
10.1097/00005344-198309000-00021. [PMID: 6195474] - E C Ku, S E McPherson, C Signor, H Chertock, W D Cash. Characterization of imidazo[1,5-a]pyridine-5-hexanoic acid (CGS 13080) as a selective thromboxane synthetase inhibitor using in vitro and in vivo biochemical models.
Biochemical and biophysical research communications.
1983 May; 112(3):899-906. doi:
10.1016/0006-291x(83)91702-3. [PMID: 6687803]
