Pelubiprofen (BioDeep_00000785920)
代谢物信息卡片
化学式: C16H18O3 (258.1256)
中文名称: 培鲁比洛芬
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1=CC=C(C=C1)C=C2CCCCC2=O)C(=O)O
InChI: InChI=1S/C16H18O3/c1-11(16(18)19)13-8-6-12(7-9-13)10-14-4-2-3-5-15(14)17/h6-11H,2-5H2,1H3,(H,18,19)/b14-10+
描述信息
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D01865
- PubChem: 5282203
- DrugBank: DB12150
- ChEMBL: CHEMBL69308
- CAS: 69956-77-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yeo-Song Lee, Jae Guen Song, Sang Hoon Lee, Hyo-Kyung Han. Sustained-release solid dispersion of pelubiprofen using the blended mixture of aminoclay and pH independent polymers: preparation and in vitro/in vivo characterization.
Drug delivery.
2017 Nov; 24(1):1731-1739. doi:
10.1080/10717544.2017.1399304
. [PMID: 29124978] - Ju-Hee Ryu, Joo-Il Kim, Hyung Son Kim, Gyu-Jeong Noh, Kyung-Tae Lee, Eun Kyoung Chung. Pharmacokinetic Interactions Between Pelubiprofen and Eperisone Hydrochloride: A Randomized, Open-label, Crossover Study of Healthy Korean Men.
Clinical therapeutics.
2017 Jan; 39(1):138-149. doi:
10.1016/j.clinthera.2016.11.020
. [PMID: 27989618] - Seh Hyon Song, Bo Ram Chae, Se Il Sohn, Dong Woo Yeom, Ho Yong Son, Jin Han Kim, Sung Rae Kim, Sang Gon Lee, Young Wook Choi. Formulation of controlled-release pelubiprofen tablet using Kollidon(®) SR.
International journal of pharmaceutics.
2016 Sep; 511(2):864-75. doi:
10.1016/j.ijpharm.2016.07.074
. [PMID: 27492018] - Ju-Hee Ryu, Ji-Sun Park, Min-Ho Jo, Joo-Il Kim, Wang-Seob Shim, Bo-Hyung Kim, Sung-Vin Yim, Jongki Hong, Kyung-Tae Lee. Development and validation of an LC-MS/MS method for the determination of pelubiprofen and its active metabolite, trans-alcohol, in human plasma and its application to pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Mar; 983-984(?):62-7. doi:
10.1016/j.jchromb.2014.12.037
. [PMID: 25618252] - M Asami, A Shigeta, Y Tanaka. Disposition of CS-670, a novel nonsteroidal anit-inflammatory drug, and its metabolites in healthy human volunteers.
Chirality.
1996; 8(2):207-13. doi:
10.1002/(sici)1520-636x(1996)8:2<207::aid-chir6>3.0.co;2-f
. [PMID: 8857182] - M Asami, W Takasaki, H Iwabuchi, H Haruyama, K Wachi, A Terada, Y Tanaka. Stereospecific taurine conjugation of the trans-OH metabolite (active metabolite) of CS-670, a new 2-arylpropionic acid nonsteroidal anti-inflammatory drug, in dogs.
Biological & pharmaceutical bulletin.
1995 Nov; 18(11):1584-9. doi:
10.1248/bpb.18.1584
. [PMID: 8593485] - M Asami, M Yamamura, W Takasaki, Y Tanaka. Quantitative determination of diol metabolites of CS-670, a new antiinflammatory agent, by capillary column gas chromatography-mass spectrometry.
Journal of chromatography. B, Biomedical applications.
1995 Mar; 665(1):107-16. doi:
10.1016/0378-4347(94)00513-5
. [PMID: 7795780] - W Takasaki, M Asami, S Muramatsu, R Hayashi, Y Tanaka, K Kawabata, K Hoshiyama. Stereoselective determination of the active metabolites of a new anti-inflammatory agent (CS-670) in human and rat plasma using antibody-mediated extraction and high-performance liquid chromatography.
Journal of chromatography.
1993 Mar; 613(1):67-77. doi:
10.1016/0378-4347(93)80198-d
. [PMID: 8458904]