Belinostat (BioDeep_00000784580)
代谢物信息卡片
Belinostat (PXD101)
化学式: C15H14N2O4S (318.0674)
中文名称: 贝利司他
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C=CC(=O)NO
InChI: InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01X - Other antineoplastic agents > L01XH - Histone deacetylase (hdac) inhibitors
D004791 - Enzyme Inhibitors > D056572 - Histone Deacetylase Inhibitors
C471 - Enzyme Inhibitor > C1946 - Histone Deacetylase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent
D000970 - Antineoplastic Agents
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:61076
- ChEBI: CHEBI:94531
- KEGGdrug: D08870
- PubChem: 6918638
- DrugBank: DB05015
- ChEMBL: CHEMBL408513
- CAS: 866323-14-0
- CAS: 414864-00-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Kommera Sai Pradyuth, Shubham A Salunkhe, Arihant Kumar Singh, Deepak Chitkara, Anupama Mittal. Belinostat loaded lipid-polymer hybrid nanoparticulate delivery system for breast cancer: improved pharmacokinetics and biodistribution in a tumor model.
Journal of materials chemistry. B.
2023 11; 11(45):10859-10872. doi:
10.1039/d3tb01317k. [PMID: 37938124] - Frédéric Anglès, Darren M Hutt, William E Balch. HDAC inhibitors rescue multiple disease-causing CFTR variants.
Human molecular genetics.
2019 06; 28(12):1982-2000. doi:
10.1093/hmg/ddz026. [PMID: 30753450] - Cody J Peer, Oliver M Hall, Tristan M Sissung, Richard Piekarz, Sanjeeve Balasubramaniam, Susan E Bates, William D Figg. A population pharmacokinetic/toxicity model for the reduction of platelets during a 48-h continuous intravenous infusion of the histone deacetylase inhibitor belinostat.
Cancer chemotherapy and pharmacology.
2018 09; 82(3):565-570. doi:
10.1007/s00280-018-3631-7. [PMID: 29951694] - S M Attia, M A Al-Hamamah, M R Alotaibi, G I Harisa, M M Attia, S F Ahmad, M A Ansari, A Nadeem, S A Bakheet. Investigation of belinostat-induced genomic instability by molecular cytogenetic analysis and pathway-focused gene expression profiling.
Toxicology and applied pharmacology.
2018 07; 350(?):43-51. doi:
10.1016/j.taap.2018.05.002. [PMID: 29733868] - Sanjeeve Balasubramaniam, Christophe E Redon, Cody J Peer, Christine Bryla, Min-Jung Lee, Jane B Trepel, Yusuke Tomita, Arun Rajan, Giuseppe Giaccone, William M Bonner, William D Figg, Tito Fojo, Richard L Piekarz, Susan E Bates. Phase I trial of belinostat with cisplatin and etoposide in advanced solid tumors, with a focus on neuroendocrine and small cell cancers of the lung.
Anti-cancer drugs.
2018 06; 29(5):457-465. doi:
10.1097/cad.0000000000000596. [PMID: 29420340] - Ming Jang Chua, Megan S J Arnold, Weijun Xu, Julien Lancelot, Suzanne Lamotte, Gerald F Späth, Eric Prina, Raymond J Pierce, David P Fairlie, Tina S Skinner-Adams, Katherine T Andrews. Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth.
International journal for parasitology. Drugs and drug resistance.
2017 04; 7(1):42-50. doi:
10.1016/j.ijpddr.2016.12.005. [PMID: 28107750] - P S Suresh, V C Devaraj, Nuggehally R Srinivas, Ramesh Mullangi. Review of bioanalytical assays for the quantitation of various HDAC inhibitors such as vorinostat, belinostat, panobinostat, romidepsin and chidamine.
Biomedical chromatography : BMC.
2017 Jan; 31(1):. doi:
10.1002/bmc.3807. [PMID: 27511598] - Kenneth Kin-Wah To, Wing-Sum Tong, Li-Wu Fu. Reversal of platinum drug resistance by the histone deacetylase inhibitor belinostat.
Lung cancer (Amsterdam, Netherlands).
2017 01; 103(?):58-65. doi:
10.1016/j.lungcan.2016.11.019. [PMID: 28024697] - Hanna Bailey, Jordan P McPherson, Erin B Bailey, Theresa L Werner, Sumati Gupta, Julia Batten, Guru Reddy, Gajanan Bhat, Sunil Sharma, Neeraj Agarwal. A phase I study to determine the pharmacokinetics and urinary excretion of belinostat and metabolites in patients with advanced solid tumors.
Cancer chemotherapy and pharmacology.
2016 Nov; 78(5):1059-1071. doi:
10.1007/s00280-016-3167-7. [PMID: 27744565] - Emiliano Calvo, Guru Reddy, Valentina Boni, Lina García-Cañamaque, Tao Song, Jette Tjornelund, Mi Rim Choi, Lee F Allen. Pharmacokinetics, metabolism, and excretion of (14)C-labeled belinostat in patients with recurrent or progressive malignancies.
Investigational new drugs.
2016 Apr; 34(2):193-201. doi:
10.1007/s10637-015-0321-8. [PMID: 26769244] - Andrew K L Goey, William D Figg. UGT genotyping in belinostat dosing.
Pharmacological research.
2016 Mar; 105(?):22-7. doi:
10.1016/j.phrs.2016.01.002. [PMID: 26773202] - Makoto Isono, Akinori Sato, Kazuki Okubo, Takako Asano, Tomohiko Asano. Ritonavir Interacts With Belinostat to Cause Endoplasmic Reticulum Stress and Histone Acetylation in Renal Cancer Cells.
Oncology research.
2016; 24(5):327-335. doi:
10.3727/096504016x14666990347635. [PMID: 27712589] - Mi Joung Kim, Jee Suk Lee, Sang Eun Park, Hye-Jin Yi, In Gab Jeong, Jong Soon Kang, Jieun Yun, Joo-Yong Lee, Seonggu Ro, Jung Shin Lee, Eun Kyung Choi, Jung Jin Hwang, Choung-Soo Kim. Combination treatment of renal cell carcinoma with belinostat and 5-fluorouracil: a role for oxidative stress induced DNA damage and HSP90 regulated thymidine synthase.
The Journal of urology.
2015 May; 193(5):1660-8. doi:
10.1016/j.juro.2014.11.091. [PMID: 25433307] - Brian F Kiesel, Robert A Parise, Jette Tjørnelund, Mette K Christensen, Einars Loza, Hussein Tawbi, Edward Chu, Shivaani Kummar, Jan H Beumer. LC-MS/MS assay for the quantitation of the HDAC inhibitor belinostat and five major metabolites in human plasma.
Journal of pharmaceutical and biomedical analysis.
2013 Jul; 81-82(?):89-98. doi:
10.1016/j.jpba.2013.03.025. [PMID: 23644904] - Ling-Zhi Wang, Jacqueline Ramírez, Winnie Yeo, Mei-Yi Michelle Chan, Win-Lwin Thuya, Jie-Ying Amelia Lau, Seow-Ching Wan, Andrea Li-Ann Wong, Ying-Kiat Zee, Robert Lim, Soo-Chin Lee, Paul C Ho, How-Sung Lee, Anthony Chan, Sherry Ansher, Mark J Ratain, Boon-Cher Goh. Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients.
PloS one.
2013; 8(1):e54522. doi:
10.1371/journal.pone.0054522. [PMID: 23382909] - Mi Joung Kim, Dong Eun Kim, In Gab Jeong, Jene Choi, Sejin Jang, Je-Hwan Lee, Seonggu Ro, Jung Jin Hwang, Choung-Soo Kim. HDAC inhibitors synergize antiproliferative effect of sorafenib in renal cell carcinoma cells.
Anticancer research.
2012 Aug; 32(8):3161-8. doi:
NULL. [PMID: 22843888] - Ling-Zhi Wang, Daniel Chan, Winnie Yeo, Seow-Ching Wan, Stephen Chan, Anthony Chan, Soo-Chin Lee, How-Sung Lee, Boon-Cher Goh. A sensitive and specific liquid chromatography-tandem mass spectrometric method for determination of belinostat in plasma from liver cancer patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Sep; 878(26):2409-14. doi:
10.1016/j.jchromb.2010.07.015. [PMID: 20724229] - Katherine E Warren, Cindy McCully, Henrik Dvinge, Jette Tjørnelund, Maxwell Sehested, Henri S Lichenstein, Frank M Balis. Plasma and cerebrospinal fluid pharmacokinetics of the histone deacetylase inhibitor, belinostat (PXD101), in non-human primates.
Cancer chemotherapy and pharmacology.
2008 Aug; 62(3):433-7. doi:
10.1007/s00280-007-0622-5. [PMID: 17960383] - Lena Marquard, Kamille Dumong Petersen, Morten Persson, Kirsten Damgaard Hoff, Peter Buhl Jensen, Maxwell Sehested. Monitoring the effect of belinostat in solid tumors by H4 acetylation.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.
2008 May; 116(5):382-92. doi:
10.1111/j.1600-0463.2008.00957.x. [PMID: 18452428] - Philip Jones, Sergio Altamura, Raffaele De Francesco, Paola Gallinari, Armin Lahm, Petra Neddermann, Michael Rowley, Sergio Serafini, Christian Steinkühler. Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
Bioorganic & medicinal chemistry letters.
2008 Mar; 18(6):1814-9. doi:
10.1016/j.bmcl.2008.02.025. [PMID: 18308563] - Ningning Zhang, Boon Cher Goh, Yok Moi Khoo, Winnie Yeo, How Sung Lee. A simple and sensitive high-performance liquid chromatographic method for quantification of PXD101, a histone deacetylase inhibitor in human plasma.
Therapeutic drug monitoring.
2007 Apr; 29(2):231-5. doi:
10.1097/ftd.0b013e31802c573e. [PMID: 17417079]
