VX-765 (BioDeep_00000784573)
代谢物信息卡片
化学式: C24H33ClN4O6 (508.20885080000005)
中文名称: 贝尔纳卡桑(VX-765)
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC1C(CC(=O)O1)NC(=O)C2CCCN2C(=O)C(C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl
InChI: InChI=1S/C24H33ClN4O6/c1-5-34-23-16(12-18(30)35-23)27-21(32)17-7-6-10-29(17)22(33)19(24(2,3)4)28-20(31)13-8-9-15(26)14(25)11-13/h8-9,11,16-17,19,23H,5-7,10,12,26H2,1-4H3,(H,27,32)(H,28,31)/t16-,17-,19+,23+/m0/s1
描述信息
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C38461 - Caspase Inhibitor
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:188567
- KEGGdrug: D10416
- PubChem: 11398092
- ChEMBL: CHEMBL2107819
- CAS: 273404-37-8
- CAS: 851091-96-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaokang Wang, Tiesong Wu, Hongyan Ma, Xiaoling Huang, Kaiyuan Huang, Chunxiao Ye, Shiping Zhu. VX-765 ameliorates inflammation and extracellular matrix accumulation by inhibiting the NOX1/ROS/NF-κB pathway in diabetic nephropathy.
The Journal of pharmacy and pharmacology.
2022 Mar; 74(3):377-386. doi:
10.1093/jpp/rgab112. [PMID: 34383065] - Si Wen, Fei Deng, Lulu Li, Li Xu, Xin Li, Qiuling Fan. VX-765 ameliorates renal injury and fibrosis in diabetes by regulating caspase-1-mediated pyroptosis and inflammation.
Journal of diabetes investigation.
2022 Jan; 13(1):22-33. doi:
10.1111/jdi.13660. [PMID: 34494385] - Jia Li, Jia-Huan Hao, Di Yao, Rong Li, Xue-Fei Li, Zhi-Yuan Yu, Xiang Luo, Xing-Hua Liu, Ming-Huan Wang, Wei Wang. Caspase-1 inhibition prevents neuronal death by targeting the canonical inflammasome pathway of pyroptosis in a murine model of cerebral ischemia.
CNS neuroscience & therapeutics.
2020 09; 26(9):925-939. doi:
10.1111/cns.13384. [PMID: 32343048] - Yi-Hao Wang, Yan Li, Jun-Nan Wang, Qing-Xiang Zhao, Shuang Wen, Si-Cong Wang, Tao Sun. A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome.
Neurochemical research.
2020 Aug; 45(8):1860-1869. doi:
10.1007/s11064-020-03050-x. [PMID: 32410045] - Yiyi Li, Xuan Niu, Haitao Xu, Qingwen Li, Lanxia Meng, Mingyang He, Jie Zhang, Zhentao Zhang, Zhaohui Zhang. VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis.
Experimental cell research.
2020 04; 389(1):111847. doi:
10.1016/j.yexcr.2020.111847. [PMID: 31972218] - Daohang Liu, Zhi Dong, Fei Xiang, Hailin Liu, Yuchun Wang, Qian Wang, Jiangyan Rao. Dendrobium Alkaloids Promote Neural Function After Cerebral Ischemia-Reperfusion Injury Through Inhibiting Pyroptosis Induced Neuronal Death in both In Vivo and In Vitro Models.
Neurochemical research.
2020 Feb; 45(2):437-454. doi:
10.1007/s11064-019-02935-w. [PMID: 31865520] - Yongfeng Zhang, Yi Zheng. Effects and mechanisms of potent caspase-1 inhibitor VX765 treatment on collagen-induced arthritis in mice.
Clinical and experimental rheumatology.
2016 Jan; 34(1):111-8. doi:
NULL. [PMID: 26742834] - Yi Zhang, Lei Liu, Yun-Zi Liu, Xiao-Liang Shen, Teng-Yun Wu, Ting Zhang, Wei Wang, Yun-Xia Wang, Chun-Lei Jiang. NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation.
The international journal of neuropsychopharmacology.
2015 Jan; 18(8):. doi:
10.1093/ijnp/pyv006. [PMID: 25603858]