Desmethyl Erlotinib (BioDeep_00000784572)
代谢物信息卡片
2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
化学式: C21H21N3O4 (379.1532)
中文名称: 去甲基厄洛替尼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COCCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCO
InChI: InChI=1S/C21H21N3O4/c1-3-15-5-4-6-16(11-15)24-21-17-12-19(27-8-7-25)20(28-10-9-26-2)13-18(17)22-14-23-21/h1,4-6,11-14,25H,7-10H2,2H3,(H,22,23,24)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Samuel J Reddick, Olivia Campagne, Jie Huang, Arzu Onar-Thomas, Alberto Broniscer, Amar Gajjar, Clinton F Stewart. Pharmacokinetics and safety of erlotinib and its metabolite OSI-420 in infants and children with primary brain tumors.
Cancer chemotherapy and pharmacology.
2019 10; 84(4):829-838. doi:
10.1007/s00280-019-03921-3. [PMID: 31392390] - Tae Hwan Kim, Soyoung Shin, Sarah Kim, Jürgen B Bulitta, Kwon-Yeon Weon, Sang Hoon Joo, Eunsook Ma, Sun Dong Yoo, Gi-Young Park, Dong Rak Kwon, Seok Won Jeong, Da Young Lee, Beom Soo Shin. Alterations in Pharmacokinetics of Gemcitabine and Erlotinib by Concurrent Administration of Hyangsayukgunja-Tang, a Gastroprotective Herbal Medicine.
Molecules (Basel, Switzerland).
2017 Sep; 22(9):. doi:
10.3390/molecules22091515. [PMID: 28891960] - Anna Svedberg, Henrik Gréen, Anders Vikström, Joakim Lundeberg, Svante Vikingsson. A validated liquid chromatography tandem mass spectrometry method for quantification of erlotinib, OSI-420 and didesmethyl erlotinib and semi-quantification of erlotinib metabolites in human plasma.
Journal of pharmaceutical and biomedical analysis.
2015 Mar; 107(?):186-95. doi:
10.1016/j.jpba.2014.12.022. [PMID: 25594896] - Masahide Fukudo, Yasuaki Ikemi, Yosuke Togashi, Katsuhiro Masago, Young Hak Kim, Tadashi Mio, Tomohiro Terada, Satoshi Teramukai, Michiaki Mishima, Ken-Ichi Inui, Toshiya Katsura. Population pharmacokinetics/pharmacodynamics of erlotinib and pharmacogenomic analysis of plasma and cerebrospinal fluid drug concentrations in Japanese patients with non-small cell lung cancer.
Clinical pharmacokinetics.
2013 Jul; 52(7):593-609. doi:
10.1007/s40262-013-0058-5. [PMID: 23532985] - Katsuhiro Masago, Yosuke Togashi, Masahide Fukudo, Tomohiro Terada, Kaoru Irisa, Yuichi Sakamori, Young Hak Kim, Tadashi Mio, Ken-Ichi Inui, Michiaki Mishima. Plasma and pleural fluid pharmacokinetics of erlotinib and its active metabolite OSI-420 in patients with non-small-cell lung cancer with pleural effusion.
Clinical lung cancer.
2011 Sep; 12(5):307-12. doi:
10.1016/j.cllc.2011.06.004. [PMID: 21775215] - Melanie White-Koning, Elodie Civade, Birgit Geoerger, Fabienne Thomas, Marie-Cécile Le Deley, Isabelle Hennebelle, Jean-Pierre Delord, Etienne Chatelut, Gilles Vassal. Population analysis of erlotinib in adults and children reveals pharmacokinetic characteristics as the main factor explaining tolerance particularities in children.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2011 Jul; 17(14):4862-71. doi:
10.1158/1078-0432.ccr-10-3278. [PMID: 21653689] - Mohamed A Elmeliegy, Angel M Carcaboso, Michael Tagen, Feng Bai, Clinton F Stewart. Role of ATP-binding cassette and solute carrier transporters in erlotinib CNS penetration and intracellular accumulation.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2011 Jan; 17(1):89-99. doi:
10.1158/1078-0432.ccr-10-1934. [PMID: 21088257] - Yosuke Togashi, Katsuhiro Masago, Masahide Fukudo, Tomohiro Terada, Shiro Fujita, Kaoru Irisa, Yuichi Sakamori, Young Hak Kim, Tadashi Mio, Ken-ichi Inui, Michiaki Mishima. Cerebrospinal fluid concentration of erlotinib and its active metabolite OSI-420 in patients with central nervous system metastases of non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2010 Jul; 5(7):950-5. doi:
10.1097/jto.0b013e3181e2138b. [PMID: 20479691] - Yosuke Togashi, Katsuhiro Masago, Masahide Fukudo, Tomohiro Terada, Yasuaki Ikemi, Young Hak Kim, Shiro Fujita, Kaoru Irisa, Yuichi Sakamori, Tadashi Mio, Ken-Ichi Inui, Michiaki Mishima. Pharmacokinetics of erlotinib and its active metabolite OSI-420 in patients with non-small cell lung cancer and chronic renal failure who are undergoing hemodialysis.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2010 May; 5(5):601-5. doi:
10.1097/jto.0b013e3181d32287. [PMID: 20234322] - Fabienne Thomas, Philippe Rochaix, Melanie White-Koning, Isabelle Hennebelle, Jérôme Sarini, Adil Benlyazid, Laurence Malard, Jean-Louis Lefebvre, Etienne Chatelut, Jean Pierre Delord. Population pharmacokinetics of erlotinib and its pharmacokinetic/pharmacodynamic relationships in head and neck squamous cell carcinoma.
European journal of cancer (Oxford, England : 1990).
2009 Sep; 45(13):2316-23. doi:
10.1016/j.ejca.2009.05.007. [PMID: 19523815] - Laura K Zerbe, Lori D Dwyer-Nield, Jason M Fritz, Elizabeth F Redente, Robert J Shroyer, Elizabeth Conklin, Shawn Kane, Chris Tucker, S Gail Eckhardt, Daniel L Gustafson, Kenneth K Iwata, Alvin M Malkinson. Inhibition by erlotinib of primary lung adenocarcinoma at an early stage in male mice.
Cancer chemotherapy and pharmacology.
2008 Sep; 62(4):605-20. doi:
10.1007/s00280-007-0644-z. [PMID: 18030469] - Holly J Meany, Elizabeth Fox, Cynthia McCully, Chris Tucker, Frank M Balis. The plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite (OSI-420) after intravenous administration of erlotinib in non-human primates.
Cancer chemotherapy and pharmacology.
2008 Aug; 62(3):387-92. doi:
10.1007/s00280-007-0616-3. [PMID: 17932674] - Jie Ling, Scott Fettner, Bert L Lum, Myriam Riek, Ashok Rakhit. Effect of food on the pharmacokinetics of erlotinib, an orally active epidermal growth factor receptor tyrosine-kinase inhibitor, in healthy individuals.
Anti-cancer drugs.
2008 Feb; 19(2):209-16. doi:
10.1097/cad.0b013e3282f2d8e4. [PMID: 18176118] - Andrea R Masters, Christopher J Sweeney, David R Jones. The quantification of erlotinib (OSI-774) and OSI-420 in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Apr; 848(2):379-83. doi:
10.1016/j.jchromb.2006.10.046. [PMID: 17101305] - Alberto Broniscer, John C Panetta, Melinda O'Shaughnessy, Charles Fraga, Feng Bai, Matthew J Krasin, Amar Gajjar, Clinton F Stewart. Plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite OSI-420.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2007 Mar; 13(5):1511-5. doi:
10.1158/1078-0432.ccr-06-2372. [PMID: 17332296] - Paul Frohna, Jianfeng Lu, Steve Eppler, Marta Hamilton, Julie Wolf, Ashok Rakhit, Jie Ling, Saraswati R Kenkare-Mitra, Bert L Lum. Evaluation of the absolute oral bioavailability and bioequivalence of erlotinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in a randomized, crossover study in healthy subjects.
Journal of clinical pharmacology.
2006 Mar; 46(3):282-90. doi:
10.1177/0091270005284193. [PMID: 16490804] - Wenjiang Zhang, Lillian L Siu, Malcolm J Moore, Eric X Chen. Simultaneous determination of OSI-774 and its major metabolite OSI-420 in human plasma by using HPLC with UV detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Jan; 814(1):143-7. doi:
10.1016/j.jchromb.2004.10.016. [PMID: 15607718] - Ming Zhao, Ping He, Michelle A Rudek, Manuel Hidalgo, Sharyn D Baker. Specific method for determination of OSI-774 and its metabolite OSI-420 in human plasma by using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Aug; 793(2):413-20. doi:
10.1016/s1570-0232(03)00356-8. [PMID: 12906916]
