Trelagliptin (BioDeep_00000784453)
代谢物信息卡片
化学式: C18H20FN5O2 (357.1600952)
中文名称: 曲格列汀
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C(=O)C=C(N(C1=O)CC2=C(C=CC(=C2)F)C#N)N3CCCC(C3)N
InChI: InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C98086 - Dipeptidyl Peptidase-4 Inhibitor
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:134715
- KEGGdrug: D10178
- PubChem: 15983988
- DrugBank: DB15323
- ChEMBL: CHEMBL1650443
- CAS: 865759-25-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Deep Dutta, Ritin Mohindra, Vineet Surana, Meha Sharma. Safety and efficacy of once weekly dipeptidyl-peptidase-4 inhibitor trelagliptin in type-2 diabetes: A meta-analysis.
Diabetes & metabolic syndrome.
2022 Apr; 16(4):102469. doi:
10.1016/j.dsx.2022.102469. [PMID: 35344848] - Guang Wang, Bing Wu, Lening Zhang, Xuefei Jin, Kun Wang, Wenzhou Xu, Bo Zhang, Heyuan Wang. The protective effects of trelagliptin on high-fat diet-induced nonalcoholic fatty liver disease in mice.
Journal of biochemical and molecular toxicology.
2021 Apr; 35(4):e22696. doi:
10.1002/jbt.22696. [PMID: 33421258] - Kohei Kaku, Kazuyuki Ishida, Kohei Shimizu, Meguru Achira, Yuusuke Umeda. Efficacy and safety of trelagliptin in Japanese patients with type 2 diabetes with severe renal impairment or end-stage renal disease: Results from a randomized, phase 3 study.
Journal of diabetes investigation.
2020 Mar; 11(2):373-381. doi:
10.1111/jdi.13126. [PMID: 31389201] - Li Zhou, Wang Xi, Hui Zhang, Lili Sun, Jinlong Yu, Qiaogen Zou. The Chiral Bioconversion and Pharmacokinetic Analysis of Trelagliptin in Beagle Dog Plasma by LC-MS/MS.
Journal of chromatographic science.
2019 Dec; 58(1):31-36. doi:
10.1093/chromsci/bmz105. [PMID: 31844877] - Ying Han, Liqing Chen, Wei Liu, Xin Xin, Lingwei Meng, Xiaoyang Chu, Wei Huang, Mingji Jin, Zhonggao Gao. An HPLC-MS/MS method for quantitation of trelagliptin and application in a comparative pharmacokinetic study.
Bioanalysis.
2019 Oct; 11(19):1755-1765. doi:
10.4155/bio-2018-0238. [PMID: 31648536] - Hiroyuki Ito, Shigenori Ando, Emiko Tsugami, Rie Araki, Eiji Kusano, Suzuko Matsumoto, Kosuke Uemura, Shinya Nishio, Shinichi Antoku, Tomoko Yamasaki, Toshiko Mori, Michiko Togane. Changes in medication adherence and unused drugs after switching from daily dipeptidyl peptidase-4 inhibitors to once-weekly trelagliptin in patients with type 2 diabetes.
Diabetes research and clinical practice.
2019 Jul; 153(?):41-48. doi:
10.1016/j.diabres.2019.05.025. [PMID: 31150724] - Ruixue Gan, Ludan Zhao, Qiaomei Sun, Peixiao Tang, Shuangshuang Zhang, Hongqin Yang, Jiawei He, Hui Li. Binding behavior of trelagliptin and human serum albumin: Molecular docking, dynamical simulation, and multi-spectroscopy.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2018 Sep; 202(?):187-195. doi:
10.1016/j.saa.2018.05.049. [PMID: 29787915] - Bassam M Ayoub, Shereen Mowaka, Marwa M Safar, Nermeen Ashoush, Mona G Arafa, Haidy E Michel, Mariam M Tadros, Mohamed M Elmazar, Shaker A Mousa. Repositioning of Omarigliptin as a once-weekly intranasal Anti-parkinsonian Agent.
Scientific reports.
2018 06; 8(1):8959. doi:
10.1038/s41598-018-27395-0. [PMID: 29895906] - Satoshi Ida, Kazuya Murata, Katunori Betou, Chiaki Kobayashi, Yuki Ishihara, Kanako Imataka, Akihiro Uchida, Kou Monguchi, Ryutaro Kaneko, Ryoko Fujiwara, Hiroka Takahashi. Effect of trelagliptin on vascular endothelial functions and serum adiponectin level in patients with type 2 diabetes: a preliminary single-arm prospective pilot study.
Cardiovascular diabetology.
2016 11; 15(1):153. doi:
10.1186/s12933-016-0468-4. [PMID: 27809903] - Xiao-Xia Hu, Tian Lan, Zhe Chen, Cheng-Cheng Yang, Peng-Fei Tang, Ling-Jing Yuan, Guo-Xin Hu, Jian-Ping Cai. A rapid and sensitive UHPLC-MS/MS assay for the determination of trelagliptin in rat plasma and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Oct; 1033-1034(?):166-171. doi:
10.1016/j.jchromb.2016.08.024. [PMID: 27561183] - Nobuya Inagaki, Hiroki Sano, Yoshifumi Seki, Shingo Kuroda, Kohei Kaku. Long-term safety and efficacy of a novel once-weekly oral trelagliptin as monotherapy or in combination with an existing oral antidiabetic drug in patients with type 2 diabetes mellitus: A 52-week open-label, phase 3 study.
Journal of diabetes investigation.
2016 Sep; 7(5):718-26. doi:
10.1111/jdi.12499. [PMID: 27181699] - Zhiyuan Zhang, Michael B Wallace, Jun Feng, Jeffrey A Stafford, Robert J Skene, Lihong Shi, Bumsup Lee, Kathleen Aertgeerts, Andy Jennings, Rongda Xu, Daniel B Kassel, Stephen W Kaldor, Marc Navre, David R Webb, Stephen L Gwaltney. Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV.
Journal of medicinal chemistry.
2011 Jan; 54(2):510-24. doi:
10.1021/jm101016w. [PMID: 21186796]