Pyridazine (BioDeep_00000784146)

   


代谢物信息卡片


Pyridazine

化学式: C4H4N2 (80.0374)
中文名称: 哒嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=NN=C1
InChI: InChI=1S/C4H4N2/c1-2-4-6-5-3-1/h1-4H

描述信息

同义名列表

2 个代谢物同义名

Pyridazine; Pyridazine



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Abida Khan, Anupama Diwan, Hamdy Kh Thabet, Mohd Imran, Md Afroz Bakht. Discovery of Novel Pyridazine-Based Cyclooxygenase-2 Inhibitors with a Promising Gastric Safety Profile. Molecules (Basel, Switzerland). 2020 Apr; 25(9):. doi: 10.3390/molecules25092002. [PMID: 32344801]
  • Chungang Gu, Michelle L Lamb, Jeffrey W Johannes, Mark A Sylvester, Mark S Eisman, Rane A Harrison, Haiqing Hu, Steven Kazmirski, Keith Mikule, Bo Peng, Nancy Su, Wenxian Wang, Qing Ye, Xiaolan Zheng, Paul D Lyne, David A Scott. Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering. Bioorganic & medicinal chemistry letters. 2016 10; 26(19):4775-4780. doi: 10.1016/j.bmcl.2016.08.030. [PMID: 27578247]
  • Martin P Green, Gordon McMurray, R Ian Storer. Selective 5-HT2C receptor agonists: Design and synthesis of pyridazine-fused azepines. Bioorganic & medicinal chemistry letters. 2016 08; 26(16):4117-21. doi: 10.1016/j.bmcl.2016.06.060. [PMID: 27381086]
  • Guangyi Wang, Jinqiao Wan, Yujian Hu, Xiangyang Wu, Marija Prhavc, Natalia Dyatkina, Vivek K Rajwanshi, David B Smith, Andreas Jekle, April Kinkade, Julian A Symons, Zhinan Jin, Jerome Deval, Qingling Zhang, Yuen Tam, Sushmita Chanda, Lawrence Blatt, Leonid Beigelman. Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues. Journal of medicinal chemistry. 2016 05; 59(10):4611-24. doi: 10.1021/acs.jmedchem.5b01933. [PMID: 27120583]
  • Laszlo G Harsing, Julia Timar, Geza Szabo, Szabolcs Udvari, Katalin M Nagy, Bernadett Marko, Gabriella Zsilla, Andrea Czompa, Pal Tapolcsanyi, Akos Kocsis, Peter Matyus. Sarcosine-Based Glycine Transporter Type-1 (GlyT-1) Inhibitors Containing Pyridazine Moiety: A Further Search for Drugs with Potential to Influence Schizophrenia Negative Symptoms. Current pharmaceutical design. 2015; 21(17):2291-303. doi: 10.2174/1381612821666150109125623. [PMID: 25578890]
  • Nadia Abdalla Khalil, Eman Mohamed Ahmed, Khaled Omar Mohamed, Yassin Mohammed Nissan, Sawsan Abo-Bakr Zaitone. Synthesis and biological evaluation of new pyrazolone-pyridazine conjugates as anti-inflammatory and analgesic agents. Bioorganic & medicinal chemistry. 2014 Apr; 22(7):2080-9. doi: 10.1016/j.bmc.2014.02.042. [PMID: 24631365]
  • Shyh-Ming Yang, Yuting Tang, Thomas Rano, Huajun Lu, Gee-Hong Kuo, Michael D Gaul, Yaxin Li, George Ho, Wensheng Lang, James G Conway, Yin Liang, James M Lenhard, Keith T Demarest, William V Murray. 4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs. Bioorganic & medicinal chemistry letters. 2014 Mar; 24(5):1437-41. doi: 10.1016/j.bmcl.2013.12.075. [PMID: 24405703]
  • Clemens Lamberth, Stephan Trah, Sebastian Wendeborn, Raphael Dumeunier, Mikael Courbot, Jeremy Godwin, Peter Schneiter. Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 2: pyridazines. Bioorganic & medicinal chemistry. 2012 May; 20(9):2803-10. doi: 10.1016/j.bmc.2012.03.035. [PMID: 22494843]
  • Jian Wu, Shenghong Kang, Baoan Song, Deyu Hu, Ming He, Linhong Jin, Song Yang. Synthesis and antibacterial activity against ralstonia solanacearum for novel hydrazone derivatives containing a pyridine moiety. Chemistry Central journal. 2012 Apr; 6(?):28. doi: 10.1186/1752-153x-6-28. [PMID: 22483270]
  • Robert H Bradbury, Neil J Hales, Alfred A Rabow, Graeme E Walker, David G Acton, David M Andrews, Peter Ballard, Nigel A N Brooks, Nicola Colclough, Alan Girdwood, Urs J Hancox, Owen Jones, David Jude, Sarah A Loddick, Andrew A Mortlock. Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer. Bioorganic & medicinal chemistry letters. 2011 Sep; 21(18):5442-5. doi: 10.1016/j.bmcl.2011.06.122. [PMID: 21782422]
  • Hirohisa Nagahori, Haruyuki Matsunaga, Yoshitaka Tomigahara, Naohiko Isobe, Hideo Kaneko. Metabolism of flufenpyr-ethyl in rats and mice. Journal of agricultural and food chemistry. 2009 Jun; 57(11):4872-7. doi: 10.1021/jf9011592. [PMID: 19397263]
  • Dmytro Berezhnoy, Maria C Gravielle, Scott Downing, Emmanuel Kostakis, Anthony S Basile, Phil Skolnick, Terrell T Gibbs, David H Farb. Pharmacological Properties of DOV 315,090, an ocinaplon metabolite. BMC pharmacology. 2008 Jun; 8(?):11. doi: 10.1186/1471-2210-8-11. [PMID: 18554397]
  • Burcu Caliskan-Ergün, Murat Süküroğlu, Tulay Coban, Erden Banoğlu, Sibel Suzen. Screening and evaluation of antioxidant activity of some pyridazine derivatives. Journal of enzyme inhibition and medicinal chemistry. 2008 Apr; 23(2):225-9. doi: 10.1080/14756360701475167. [PMID: 18343908]
  • E Elçin Oruç, Oya Unsal, Ayla Balkan, Fügen Ozkanli, M Zafer Gören, Berna Terzioğlu, Sevim Rollas. The in vivo metabolism of 3-oxo-5-benzylidene-6-methyl-(4H)-2-(benzoylmethyl)pyridazine in rats. European journal of drug metabolism and pharmacokinetics. 2006 Jan; 31(1):21-5. doi: 10.1007/bf03190638. [PMID: 16715779]
  • Francis X Tavares, Joyce A Boucheron, Scott H Dickerson, Robert J Griffin, Frank Preugschat, Stephen A Thomson, Tony Y Wang, Hui-Qiang Zhou. N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular efficacy. Journal of medicinal chemistry. 2004 Sep; 47(19):4716-30. doi: 10.1021/jm040063i. [PMID: 15341487]
  • W N Wu, G W Caldwell, J A Masucci, A D Gauthier. Evaluation of the excretion, and metabolism of the cardiotonic agent bemoradan in male rats and female beagle dogs. European journal of drug metabolism and pharmacokinetics. 2001 Oct; 26(4):263-71. doi: 10.1007/bf03226381. [PMID: 11808869]
  • O B Østby, L L Gundersen, F Rise, O Antonsen, K Fosnes, V Larsen, A Bast, I Custers, G R Haenen. Synthesis of 5-substituted pyrrolo[1,2-b]pyridazines with antioxidant properties. Archiv der Pharmazie. 2001 Jan; 334(1):21-4. doi: 10.1002/1521-4184(200101)334:1<21::aid-ardp21>3.0.co;2-w. [PMID: 11218573]
  • H H Borchert, S Pfeifer, B Helbig, P Franke, G Heinisch. [Biotransformation of pyridazines. 1. Pyridazine and 3-methylpyridazine]. Die Pharmazie. 1989 Sep; 44(9):625-30. doi: NULL. [PMID: 2608708]
  • Z PLACKOVA, J WAGNER, I M HAIS. [COMPARISON OF THE FATE OF VARIOUS PYRIDAZINE SULFONAMIDES IN THE ANIMAL BODY]. Ceskoslovenska farmacie. 1963 Jun; 12(?):239-42. doi: NULL. [PMID: 14076174]