Potassium Perchlorate (BioDeep_00000783919)
代谢物信息卡片
Potassium Perchlorate
化学式: ClKO4 (137.912221)
中文名称: 高氯酸钾
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: [O-]Cl(=O)(=O)=O.[K+]
InChI: /q
描述信息
H - Systemic hormonal preparations, excl. sex hormones and insulins > H03 - Thyroid therapy > H03B - Antithyroid preparations > H03BC - Perchlorates
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C885 - Antithyroid Agent
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D07232
- PubChem: 516900
- DrugBank: DB09418
- ChEMBL: CHEMBL1200696
- CAS: 7778-74-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- S Salina M Stilborn, Lori A Manzon, Jennifer D Schauenberg, Richard G Manzon. Thyroid hormone deiodinase type 2 mRNA levels in sea lamprey (Petromyzon marinus) are regulated during metamorphosis and in response to a thyroid challenge.
General and comparative endocrinology.
2013 Mar; 183(?):63-8. doi:
10.1016/j.ygcen.2012.12.007. [PMID: 23295540] - Caterina Constantinou, Panagiotis K Chrysanthopoulos, Marigoula Margarity, Maria I Klapa. GC-MS metabolomic analysis reveals significant alterations in cerebellar metabolic physiology in a mouse model of adult onset hypothyroidism.
Journal of proteome research.
2011 Feb; 10(2):869-79. doi:
10.1021/pr100699m. [PMID: 21028881] - Toshio Imai, Shigeaki Takami, Young-Man Cho, Masao Hirose, Akiyoshi Nishikawa. Modifying effects of prepubertal exposure to potassium perchlorate and tetrabromobisphenol A on susceptibility to N-bis(2-hydroxypropyl)nitrosamine- and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in rats.
Toxicology letters.
2009 Mar; 185(3):160-7. doi:
10.1016/j.toxlet.2008.12.013. [PMID: 19152830] - F Lairion, E A Disalvo. Effect of dipole potential variations on the surface charge potential of lipid membranes.
The journal of physical chemistry. B.
2009 Feb; 113(6):1607-14. doi:
10.1021/jp808007g. [PMID: 19193165] - M F Izaguirre, M N García-Sancho, L A Miranda, J Tomas, V H Casco. Expression of cell adhesion molecules in the normal and T3 blocked development of the tadpole's kidney of Bufo arenarum (Amphibian, Anuran, Bufonidae).
Brazilian journal of biology = Revista brasleira de biologia.
2008 Aug; 68(3):561-9. doi:
10.1590/s1519-69842008000300014. [PMID: 18833478] - F Bogazzi, L Bartalena, L Tomisti, E Dell'Unto, C Cosci, C Sardella, M L Tanda, A Lai, M Gasperi, F Aghini-Lombardi, E Martino. Potassium perchlorate only temporarily restores euthyroidism in patients with amiodarone-induced hypothyroidism who continue amiodarone therapy.
Journal of endocrinological investigation.
2008 Jun; 31(6):515-9. doi:
10.1007/bf03346400. [PMID: 18591883] - G Coelho-Palermo Cunha, B van Ravenzwaay. Standardization of the perchlorate discharge assay for thyroid toxicity testing in rats.
Regulatory toxicology and pharmacology : RTP.
2007 Aug; 48(3):270-8. doi:
10.1016/j.yrtph.2007.04.007. [PMID: 17573170] - F Bogazzi, D Russo, F Raggi, F Ultimieri, S Berrettini, F Forli, L Grasso, C Ceccarelli, S Mariotti, A Pinchera, L Bartalena, E Martino. Mutations in the SLC26A4 (pendrin) gene in patients with sensorineural deafness and enlarged vestibular aqueduct.
Journal of endocrinological investigation.
2004 May; 27(5):430-5. doi:
10.1007/bf03345286. [PMID: 15279074] - Grazyna Bednarek-Tupikowska, Alicja Filus, Justyna Kuliczkowska, Jarosław Bugajski. [Amiodarone and the thyroid gland].
Postepy higieny i medycyny doswiadczalnej (Online).
2004 Apr; 58(?):216-25. doi:
NULL. [PMID: 15114257] - Murat Faik Erdogan, Sadi Güleç, Eralp Tutar, Nilgün Başkal, Gürbüz Erdogan. A stepwise approach to the treatment of amiodarone-induced thyrotoxicosis.
Thyroid : official journal of the American Thyroid Association.
2003 Feb; 13(2):205-9. doi:
10.1089/105072503321319521. [PMID: 12699596] - Richard G Manzon, John H Youson. KClO(4) inhibits thyroidal activity in the larval lamprey endostyle in vitro.
General and comparative endocrinology.
2002 Oct; 128(3):214-23. doi:
10.1016/s0016-6480(02)00505-1. [PMID: 12392695] - Kyung O Yu, Latha Narayanan, David R Mattie, Richard J Godfrey, Paula N Todd, Teresa R Sterner, Deirdre A Mahle, Michael H Lumpkin, Jeffrey W Fisher. The pharmacokinetics of perchlorate and its effect on the hypothalamus-pituitary-thyroid axis in the male rat.
Toxicology and applied pharmacology.
2002 Jul; 182(2):148-59. doi:
10.1006/taap.2002.9432. [PMID: 12140178] - R G Manzon, J A Holmes, J H Youson. Variable effects of goitrogens in inducing precocious metamorphosis in sea lampreys (Petromyzon marinus).
The Journal of experimental zoology.
2001 Apr; 289(5):290-303. doi:
10.1002/1097-010x(20010415/30)289:5<290::aid-jez3>3.0.co;2-m. [PMID: 11241400] - R G Manzon, J H Youson. Temperature and KClO(4)-induced metamorphosis in the sea lamprey (Petromyzon marinus).
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.
1999 Nov; 124(3):253-7. doi:
10.1016/s0742-8413(99)00072-9. [PMID: 10661717] - Y Kao, R G Manzon, M A Sheridan, J H Youson. Study of the relationship between thyroid hormones and lipid metabolism during KClO4-induced metamorphosis of landlocked lamprey, Petromyzon marinus.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.
1999 Mar; 122(3):363-73. doi:
10.1016/s0742-8413(99)00004-3. [PMID: 10336097] - R G Manzon, J G Eales, J H Youson. Blocking of KC1O4-induced metamorphosis in premetamorphic sea lampreys by exogenous thyroid hormones (TH); effects of KC1O4 and TH on serum TH concentrations and intestinal thyroxine outer-ring deiodination.
General and comparative endocrinology.
1998 Oct; 112(1):54-62. doi:
10.1006/gcen.1998.7129. [PMID: 9748403] - R Martin-Du Pan, O Konfino, M Zimmermann. [Treatment of amiodarone-induced hyperthyroidism: corticosteroids or potassium perchlorate? What value do interleukin-6 levels have?].
Revue medicale de la Suisse romande.
1997 Oct; 117(10):805-10. doi:
. [PMID: 9441365] - F Bogazzi, L Bartalena, S Brogioni, S Mazzeo, P Vitti, A Burelli, C Bartolozzi, E Martino. Color flow Doppler sonography rapidly differentiates type I and type II amiodarone-induced thyrotoxicosis.
Thyroid : official journal of the American Thyroid Association.
1997 Aug; 7(4):541-5. doi:
10.1089/thy.1997.7.541. [PMID: 9292940] - R G Manzon, J H Youson. The effects of exogenous thyroxine (T4) or triiodothyronine (T3), in the presence and absence of potassium perchlorate, on the incidence of metamorphosis and on serum T4 and T3 concentrations in larval sea lampreys (Petromyzon marinus L.).
General and comparative endocrinology.
1997 May; 106(2):211-20. doi:
10.1006/gcen.1996.6867. [PMID: 9169117] - T M Behr, M E Juweid, R M Sharkey, R M Dunn, Z Ying, W S Becker, J A Siegel, D M Goldenberg. Thyroid radiation doses during radioimmunotherapy of CEA-expressing tumours with 131I-labelled monoclonal antibodies.
Nuclear medicine communications.
1996 Sep; 17(9):767-80. doi:
10.1097/00006231-199609000-00007. [PMID: 8895904] - L Bartalena, S Brogioni, L Grasso, F Bogazzi, A Burelli, E Martino. Treatment of amiodarone-induced thyrotoxicosis, a difficult challenge: results of a prospective study.
The Journal of clinical endocrinology and metabolism.
1996 Aug; 81(8):2930-3. doi:
10.1210/jcem.81.8.8768854. [PMID: 8768854] - E Solé, R Calvo, M J Obregón, A Meseguer. Effects of thyroid hormone on the androgenic expression of KAP gene in mouse kidney.
Molecular and cellular endocrinology.
1996 May; 119(2):147-59. doi:
10.1016/0303-7207(96)03603-9. [PMID: 8807634] - E Roti, R Minelli, E Gardini, L Bianconi, G Gavaruzzi, G Ugolotti, T M Neri, L E Braverman. Iodine-induced subclinical hypothyroidism in euthyroid subjects with a previous episode of amiodarone-induced thyrotoxicosis.
The Journal of clinical endocrinology and metabolism.
1992 Nov; 75(5):1273-7. doi:
10.1210/jcem.75.5.1331165. [PMID: 1331165] - E Roti, R Minelli, E Gardini, L Bianconi, T Neri, G Gavaruzzi, G Ugolotti, D Salvo, L E Braverman. Impaired intrathyroidal iodine organification and iodine-induced hypothyroidism in euthyroid women with a previous episode of postpartum thyroiditis.
The Journal of clinical endocrinology and metabolism.
1991 Nov; 73(5):958-63. doi:
10.1210/jcem-73-5-958. [PMID: 1658032] - V Foresti, A Villa, E Parisio, C Terenzio, N Scolari, F Confalonieri. [Transitory efficacy of potassium perchlorate in hypothyroidism caused by amiodarone].
Recenti progressi in medicina.
1989 Apr; 80(4):201-3. doi:
NULL. [PMID: 2548263] - K Okamura, K Sato, H Ikenoue, M Yoshinari, M Nakagawa, T Kuroda, M Fujishima. Reevaluation of the thyroidal radioactive iodine uptake test, with special reference to reversible primary hypothyroidism with elevated thyroid radioiodine uptake.
The Journal of clinical endocrinology and metabolism.
1988 Oct; 67(4):720-6. doi:
10.1210/jcem-67-4-720. [PMID: 2843560] - H H Newnham, D J Topliss, B A Le Grand, N Chosich, R W Harper, J R Stockigt. Amiodarone-induced hyperthyroidism: assessment of the predictive value of biochemical testing and response to combined therapy using propylthiouracil and potassium perchlorate.
Australian and New Zealand journal of medicine.
1988 Feb; 18(1):37-44. doi:
10.1111/j.1445-5994.1988.tb02237.x. [PMID: 2840057] - Y Hiasa, Y Kitahori, Y Kato, M Ohshima, N Konishi, T Shimoyama, Y Sakaguchi, H Hashimoto, S Minami, Y Murata. Potassium perchlorate, potassium iodide, and propylthiouracil: promoting effect on the development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)-nitrosamine.
Japanese journal of cancer research : Gann.
1987 Dec; 78(12):1335-40. doi:
. [PMID: 2828294] - R C Smallridge, F M De Keyser, A J Van Herle, N E Butkus, L Wartofsky. Thyroid iodine content and serum thyroglobulin: cues to the natural history of destruction-induced thyroiditis.
The Journal of clinical endocrinology and metabolism.
1986 Jun; 62(6):1213-9. doi:
10.1210/jcem-62-6-1213. [PMID: 3009523] - K Saito, K Yamamoto, T Takai, T Kuzuya. Efflux of preloaded iodide from the thyroid induced by externally added iodide. A study using a biological model of the thyroid iodide transport system.
Journal of biochemistry.
1985 Feb; 97(2):599-604. doi:
10.1093/oxfordjournals.jbchem.a135095. [PMID: 2989257] - J Ortiz-Caro, R M Pastor, T Jolin. Effects of KClO4 in propylthiouracil-hypothyroid rats.
Acta endocrinologica.
1983 May; 103(1):81-7. doi:
10.1530/acta.0.1030081. [PMID: 6305078] - J V Rivera, R Ramírez-González, J Morales. Altered anion handling by choroid plexus in renal insufficiency.
Kidney international.
1983 Feb; 23(2):387-92. doi:
10.1038/ki.1983.31. [PMID: 6302362] - D S Cooper, V C Saxe, M Meskell, F Maloof, E C Ridgway. Acute effects of propylthiouracil (PTU) on thyroidal iodide organification and peripheral iodothyronine deiodination: correlation with serum PTU levels measured by radioimmunoassay.
The Journal of clinical endocrinology and metabolism.
1982 Jan; 54(1):101-7. doi:
10.1210/jcem-54-1-101. [PMID: 6274892] - J R Prince, S Bancroft, W G Dukstein. Pharmacokinetics of pertechnetate administered after pretreatment with 400 mg of potassium perchlorate: concise communication.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1980 Aug; 21(8):763-6. doi:
NULL. [PMID: 6249897]