Methyl palmoxirate (BioDeep_00000782764)
代谢物信息卡片
2-Tetradecyl-2-oxiranecarboxylic acid methyl ester
化学式: C18H34O3 (298.2507814)
中文名称: 2-十四烷基-2-环氧乙烷羧酸甲酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCC1(CO1)C(=O)OC
InChI: InChI=1S/C18H34O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-18(16-21-18)17(19)20-2/h3-16H2,1-2H3
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent
D007004 - Hypoglycemic Agents
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Simona M Ceccarelli, Odile Chomienne, Marcel Gubler, Arduino Arduini. Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
Journal of medicinal chemistry.
2011 May; 54(9):3109-52. doi:
10.1021/jm100809g. [PMID: 21504156] - Michael Christopher, Christian Rantzau, Zhi-Ping Chen, Rodney Snow, Bruce Kemp, Frank P Alford. Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion.
American journal of physiology. Endocrinology and metabolism.
2006 Nov; 291(5):E1131-40. doi:
10.1152/ajpendo.00518.2005. [PMID: 16772328] - I J Martins, R Vermeulen, T G Redgrave. Relative roles of mitochondrial and peroxisomal fatty acid oxidation in the metabolism of chylomicron remnants in rats and mice as assessed by a stable-isotope breath test.
Atherosclerosis.
2000 May; 150(1):13-20. doi:
10.1016/s0021-9150(99)00359-7. [PMID: 10781631] - M I Friedman, R B Harris, H Ji, I Ramirez, M G Tordoff. Fatty acid oxidation affects food intake by altering hepatic energy status.
The American journal of physiology.
1999 04; 276(4):R1046-53. doi:
10.1152/ajpregu.1999.276.4.r1046. [PMID: 10198384] - M C Chang, C Connolly, D Hill, A D Purdon, T Hayakawa, G Grimes, H U Shetty. Pharmacokinetics of methyl palmoxirate, an inhibitor of beta-oxidation, in rats and humans.
Life sciences.
1998; 63(20):PL297-302. doi:
10.1016/s0024-3205(98)00458-5. [PMID: 9820128] - M C Chang, E Grange, O Rabin, J M Bell. Incorporation of [U-14C]palmitate into rat brain: effect of an inhibitor of beta-oxidation.
Journal of lipid research.
1997 Feb; 38(2):295-300. doi:
10.1016/s0022-2275(20)37442-3. [PMID: 9162749] - N E Rawson, P M Ulrich, M I Friedman. Fatty acid oxidation modulates the eating response to the fructose analogue 2,5-anhydro-D-mannitol.
The American journal of physiology.
1996 Jul; 271(1 Pt 2):R144-8. doi:
10.1152/ajpregu.1996.271.1.r144. [PMID: 8760215] - T Arai, S Wakabayashi, M A Channing, B B Dunn, M G Der, J M Bell, P Herscovitch, W C Eckelman, S I Rapoport, M C Chang. Incorporation of [1-carbon-11]palmitate in monkey brain using PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1995 Dec; 36(12):2261-7. doi:
NULL. [PMID: 8523117] - M C Chang, S Wakabayashi, J M Bell. The effect of methyl palmoxirate on incorporation of [U-14C]palmitate into rat brain.
Neurochemical research.
1994 Sep; 19(9):1217-23. doi:
10.1007/bf00965159. [PMID: 7824078] - L M Freed, S Wakabayashi, J M Bell, S I Rapoport. Effect of inhibition of beta-oxidation on incorporation of [U-14C]palmitate and [1-14C]arachidonate into brain lipids.
Brain research.
1994 May; 645(1-2):41-8. doi:
10.1016/0006-8993(94)91636-5. [PMID: 8062099] - A B Jenkins, L H Storlien, G J Cooney, G S Denyer, I D Caterson, E W Kraegen. Effects of blockade of fatty acid oxidation on whole body and tissue-specific glucose metabolism in rats.
The American journal of physiology.
1993 Oct; 265(4 Pt 1):E592-600. doi:
10.1152/ajpendo.1993.265.4.e592. [PMID: 8238335] - Z Q Shi, A Giacca, K Yamatani, S J Fisher, H L Lickley, M Vranic. Effects of subbasal insulin infusion on resting and exercise-induced glucose turnover in depancreatized dogs.
The American journal of physiology.
1993 Mar; 264(3 Pt 1):E334-41. doi:
10.1152/ajpendo.1993.264.3.e334. [PMID: 8460681] - E Bachmann, E Weber. Recirculating, retrograde heart perfusion according to the Langendorff method for evaluation of MTG--methyl-2-tetradecylglycidate, McNeil 3716--cardiomyopathy.
Pharmacology & toxicology.
1993 Feb; 72(2):98-106. doi:
10.1111/j.1600-0773.1993.tb00298.x. [PMID: 8474971] - N E Rowland. Effects of glucose and fat antimetabolites on norepinephrine turnover in rat hypothalamus and brainstem.
Brain research.
1992 Nov; 595(2):291-4. doi:
10.1016/0006-8993(92)91062-j. [PMID: 1361415] - C H Lang, C Dobrescu. Regulation of glucose metabolism by free fatty acid availability in septic and nonseptic rats.
Circulatory shock.
1992 Oct; 38(2):91-102. doi:
NULL. [PMID: 1423926] - J W Bailey, M D Jensen, J M Miles. Effects of intravenous methyl palmoxirate on the turnover and oxidation of fatty acids in conscious dogs.
Metabolism: clinical and experimental.
1991 Apr; 40(4):428-31. doi:
10.1016/0026-0495(91)90155-p. [PMID: 1901373] - M Leshem, F W Flynn, A N Epstein. Brain glucoprivation and ketoprivation do not promote ingestion in the suckling rat pup.
The American journal of physiology.
1990 Feb; 258(2 Pt 2):R365-75. doi:
10.1152/ajpregu.1990.258.2.r365. [PMID: 2309930] - M I Friedman, I Ramirez, C R Bowden, M G Tordoff. Fuel partitioning and food intake: role for mitochondrial fatty acid transport.
The American journal of physiology.
1990 Jan; 258(1 Pt 2):R216-21. doi:
10.1152/ajpregu.1990.258.1.r216. [PMID: 2301636] - A R Gagliardi, S Goldstein, L S Phillips. Nutrition and somatomedin. XXI. Insulin-like growth factor-I and somatomedin inhibitor in streptozotocin-diabetic rats: relation to ketogenesis and gluconeogenesis.
Metabolism: clinical and experimental.
1990 Jan; 39(1):75-80. doi:
10.1016/0026-0495(90)90151-2. [PMID: 2403622] - R W Tuman, C R Bowden, M Inman, N Altszuler, G F Tutwiler. Effect of the fatty acid oxidation inhibitor methyl palmoxirate (methyl 2-tetradecylglycidate) on recovery from insulin-induced hypoglycemia in diabetic dogs.
The Journal of pharmacology and experimental therapeutics.
1989 Sep; 250(3):836-41. doi:
NULL. [PMID: 2674419] - R W Tuman, G F Tutwiler, J M Joseph, N H Wallace. Hypoglycaemic and hypoketonaemic effects of single and repeated oral doses of methyl palmoxirate (methyl 2-tetradecylglycidate) in streptozotocin/alloxan-induced diabetic dogs.
British journal of pharmacology.
1988 May; 94(1):130-6. doi:
10.1111/j.1476-5381.1988.tb11507.x. [PMID: 3401631] - M F Kenel, J H Krayer, K T Ng, C H Kircher. Hydronephrosis in rats associated with postnatal exposure to a fatty acid oxidation inhibitor.
Toxicology and applied pharmacology.
1988 Mar; 93(1):127-36. doi:
10.1016/0041-008x(88)90032-4. [PMID: 3353998] - J E Schneider, S J Lazzarini, M I Friedman, G N Wade. Role of fatty acid oxidation in food intake and hunger motivation in Syrian hamsters.
Physiology & behavior.
1988; 43(5):617-23. doi:
10.1016/0031-9384(88)90216-8. [PMID: 3200917] - S Wilson, P L Thurlby, J R Arch. Substrate supply for thermogenesis induced by the beta-adrenoceptor agonist BRL 26830A.
Canadian journal of physiology and pharmacology.
1987 Feb; 65(2):113-9. doi:
10.1139/y87-023. [PMID: 2882828] - J C Young, J L Treadway, E I Fader, R F Caslin. Effects of oral hypoglycemic agent methylpalmoxirate on exercise capacity of streptozocin diabetic rats.
Diabetes.
1986 Jul; 35(7):744-8. doi:
10.2337/diab.35.7.744. [PMID: 3721061] - A G Tahiliani, J H McNeill. Prevention of diabetes-induced myocardial dysfunction in rats by methyl palmoxirate and triiodothyronine treatment.
Canadian journal of physiology and pharmacology.
1985 Aug; 63(8):925-31. doi:
10.1139/y85-153. [PMID: 2934121] - G F Tutwiler, H J Brentzel, T C Kiorpes. Inhibition of mitochondrial carnitine palmitoyl transferase A in vivo with methyl 2-tetradecylglycidate (methyl palmoxirate) and its relationship to ketonemia and glycemia.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1985 Feb; 178(2):288-96. doi:
10.3181/00379727-178-42012. [PMID: 3969383] - L Mandarino, E Tsalikian, S Bartold, H Marsh, A Carney, E Buerklin, G Tutwiler, M Haymond, B Handwerger, R Rizza. Mechanism of hyperglycemia and response to treatment with an inhibitor of fatty acid oxidation in a patient with insulin resistance due to antiinsulin receptor antibodies.
The Journal of clinical endocrinology and metabolism.
1984 Oct; 59(4):658-64. doi:
10.1210/jcem-59-4-658. [PMID: 6480801] - J W Oldham, R F Preston, J D Paulson, J F Pritchard. Alterations of drug-induced toxicity in the mouse lymphoma assay by a rat hepatic microsomal metabolizing system (S-9).
Journal of applied toxicology : JAT.
1984 Jun; 4(3):124-30. doi:
10.1002/jat.2550040303. [PMID: 6235269] - G F Tutwiler, R Mohrbacher, W Ho. Methyl 2-tetradecylglycidate, an orally effective hypoglycemic agent that inhibits long chain fatty acid oxidation selectively.
Diabetes.
1979 Mar; 28(3):242-8. doi:
10.2337/diab.28.3.242. [PMID: 446909] - G F Tutwiler, T Kirsch, R J Mohrbacher, W Ho. Pharmacologic profile of methyl 2-tetradecylglycidate (McN-3716)--an orally effective hypoglycemic agent.
Metabolism: clinical and experimental.
1978 Oct; 27(10):1539-56. doi:
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