Ciclopirox Olamine (BioDeep_00000782740)
代谢物信息卡片
Ciclopirox Olamine
化学式: C14H24N2O3 (268.1787)
中文名称: 环吡酮胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC(=O)N(C(=C1)C2CCCCC2)O.C(CO)N
InChI: 4H,1-3H2
描述信息
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yiying Zhu, Zhangxun Zhao, Minggao Xue, Dan Wang, Guifeng Su, Xiaoman Ju, Qihong Yang, Shaohua Zhang, Dongmei Fan, Huifang Zhu, Min Yu, Yan Li, Lingmei Kong, Hongyu Zhou. Ciclopirox olamine sensitizes leukemia cells to natural killer cell-mediated cytolysis by upregulating NKG2DLs via the Akt signaling pathway.
Biochemical and biophysical research communications.
2023 06; 659(?):10-19. doi:
10.1016/j.bbrc.2023.03.062. [PMID: 37030020] - Dan Huang, Xin Dong, Jianzhe Li, Yudan Chen, Ying Zhou, Qingjie Chen, Yuewen Sun. Steroidal saponin SSPH I induces ferroptosis in HepG2 cells via regulating iron metabolism.
Medical oncology (Northwood, London, England).
2023 Mar; 40(5):132. doi:
10.1007/s12032-023-02000-1. [PMID: 36977862] - Tom Bellmann, Ruth Luber, Lisa Kischio, Berit Karl, Yvette Pötzinger, Uwe Beekmann, Dana Kralisch, Cornelia Wiegand, Dagmar Fischer. Bacterial nanocellulose patches as a carrier for hydrating formulations to improve the topical treatment of nail diseases.
International journal of pharmaceutics.
2022 Nov; 628(?):122267. doi:
10.1016/j.ijpharm.2022.122267. [PMID: 36209980] - Paulo H F Carmo, Gustavo J C Freitas, João C M Dornelas, Bruna C T Almeida, Ludmila M Baltazar, Gabriella F Ferreira, Nalu T A Peres, Daniel A Santos. Reactive oxygen and nitrogen species are crucial for the antifungal activity of amorolfine and ciclopirox olamine against the dermatophyte Trichophyton interdigitale.
Medical mycology.
2022 Aug; 60(8):. doi:
10.1093/mmy/myac058. [PMID: 35896502] - Priyanka S Radadiya, Mackenzie M Thornton, Rajni V Puri, Sireesha Yerrathota, Johnny Dinh-Phan, Brenda Magenheimer, Dharmalingam Subramaniam, Pamela V Tran, Hao Zhu, Subhashini Bolisetty, James P Calvet, Darren P Wallace, Madhulika Sharma. Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic kidney disease.
JCI insight.
2021 03; 6(8):. doi:
10.1172/jci.insight.141299. [PMID: 33784251] - Markéta Gajdošová, David Vetchý, Jan Muselík, Jan Gajdziok, Jan Juřica, Martina Vetchá, Karel Hauptman, Vladimír Jekl. Bilayer mucoadhesive buccal films with prolonged release of ciclopirox olamine for the treatment of oral candidiasis: In vitro development, ex vivo permeation testing, pharmacokinetic and efficacy study in rabbits.
International journal of pharmaceutics.
2021 Jan; 592(?):120086. doi:
10.1016/j.ijpharm.2020.120086. [PMID: 33188896] - Mariusz Dyląg, Ewa Leniak, Sebastian Gnat, Jacek C Szepietowski, Lukasz Kozubowski. A case of anti- pityriasis versicolor therapy that preserves healthy mycobiome.
BMC dermatology.
2020 09; 20(1):9. doi:
10.1186/s12895-020-00106-x. [PMID: 32993612] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Scott J Weir, Robyn Wood, Karl Schorno, Amanda E Brinker, Prabhu Ramamoorthy, Kathy Heppert, Lian Rajewski, Mehmet Tanol, Tammy Ham, Michael J McKenna, William McCulloch, Michael Dalton, Gregory A Reed, Roy A Jensen, Michael J Baltezor, Shrikant Anant, John A Taylor. Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs.
The Journal of pharmacology and experimental therapeutics.
2019 08; 370(2):148-159. doi:
10.1124/jpet.119.257972. [PMID: 31113837] - Shari R Lipner, Richard K Scher. Onychomycosis: Treatment and prevention of recurrence.
Journal of the American Academy of Dermatology.
2019 Apr; 80(4):853-867. doi:
10.1016/j.jaad.2018.05.1260. [PMID: 29959962] - Aditya K Gupta, Sarah G Versteeg. Topical Treatment of Facial Seborrheic Dermatitis: A Systematic Review.
American journal of clinical dermatology.
2017 Apr; 18(2):193-213. doi:
10.1007/s40257-016-0232-2. [PMID: 27804089] - Ivana Lukášová, Jan Muselík, David Vetchý, Jan Gajdziok, Markéta Gajdošová, Jan Juřica, Zdeněk Knotek, Karel Hauptman, Vladimír Jekl. Pharmacokinetics of Ciclopirox Olamine after Buccal Administration in Rabbits.
Current drug delivery.
2017; 14(1):99-108. doi:
10.2174/1567201813666160502142856. [PMID: 27138296] - Hongyu Zhou, Chaowei Shang, Min Wang, Tao Shen, Lingmei Kong, Chunlei Yu, Zhennan Ye, Yan Luo, Lei Liu, Yan Li, Shile Huang. Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK.
Biochemical pharmacology.
2016 09; 116(?):39-50. doi:
10.1016/j.bcp.2016.07.005. [PMID: 27396756] - L Long, C Hager, M Ghannoum. Evaluation of the Efficacy of ME1111 in the Topical Treatment of Dermatophytosis in a Guinea Pig Model.
Antimicrobial agents and chemotherapy.
2016 Apr; 60(4):2343-5. doi:
10.1128/aac.03073-15. [PMID: 26833160] - Hongyu Zhou, Tao Shen, Chaowei Shang, Yan Luo, Lei Liu, Juming Yan, Yan Li, Shile Huang. Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway.
Oncotarget.
2014 Oct; 5(20):10140-50. doi:
10.18632/oncotarget.2471. [PMID: 25294812] - Sarah Annette Von Schulz-Hausmann, Leonard Christopher Schmeel, Frederic Carsten Schmeel, Ingo G H Schmidt-Wolf. Targeting the Wnt/beta-catenin pathway in renal cell carcinoma.
Anticancer research.
2014 08; 34(8):4101-8. doi:
NULL. [PMID: 25075035] - Farhaan Hafeez, Xiaoying Hui, Marc Selner, Bert Rosenthal, Howard Maibach. Ciclopirox delivery into the human nail plate using novel lipid diffusion enhancers.
Drug development and industrial pharmacy.
2014 Jun; 40(6):838-44. doi:
10.3109/03639045.2013.788016. [PMID: 23600655] - Mark D Minden, Donna E Hogge, Scott J Weir, Jim Kasper, Debra A Webster, Lavonne Patton, Yulia Jitkova, Rose Hurren, Marcela Gronda, Carolyn A Goard, Lian G Rajewski, John L Haslam, Kathleen E Heppert, Kevin Schorno, Hong Chang, Joseph M Brandwein, Vikas Gupta, Andre C Schuh, Suzanne Trudel, Karen W L Yee, Gregory A Reed, Aaron D Schimmer. Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies.
American journal of hematology.
2014 Apr; 89(4):363-8. doi:
10.1002/ajh.23640. [PMID: 24273151] - Anroop B Nair, Kishan Singh, Bandar E Al-Dhubiab, Mahesh Attimarad, Sree Harsha, Ibrahim A Alhaider. Skin uptake and clearance of ciclopirox following topical application.
Biopharmaceutics & drug disposition.
2013 Dec; 34(9):540-9. doi:
10.1002/bdd.1866. [PMID: 24123146] - Christiane M Koller, Young Kim, Ingo G H Schmidt-Wolf. Targeting renal cancer with a combination of WNT inhibitors and a bi-functional peptide.
Anticancer research.
2013 Jun; 33(6):2435-40. doi:
NULL. [PMID: 23749892] - Christian Diehl, Alicia Ferrari. Efficacy of topical 4\% Quassia amara gel in facial seborrheic dermatitis:a randomized, double-blind, comparative study.
Journal of drugs in dermatology : JDD.
2013 Mar; 12(3):312-5. doi:
". [PMID: 23545914] - Debby Budihardja, Viviane Freund, Peter Mayser. Widespread erosive tinea corporis by Arthroderma benhamiae in a renal transplant recipient: case report.
Mycoses.
2010 Nov; 53(6):530-2. doi:
10.1111/j.1439-0507.2009.01736.x. [PMID: 19558430] - Albrecht Serfling, Johannes Wohlrab, Holger B Deising. Treatment of a clinically relevant plant-pathogenic fungus with an agricultural azole causes cross-resistance to medical azoles and potentiates caspofungin efficacy.
Antimicrobial agents and chemotherapy.
2007 Oct; 51(10):3672-6. doi:
10.1128/aac.00654-07. [PMID: 17620378] - Michael Burg, Dagmar Jaekel, Eva Kiss, Volker Kliem. Majocchi's granuloma after kidney transplantation.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2006 Dec; 4(2):518-20. doi:
NULL. [PMID: 17238850] - Michael Saeftel, Ramadan Salem Sarite, Tujo Njuguna, Ulrike Holzgrabe, Daniela Ulmer, Achim Hoerauf, Annette Kaiser. Piperidones with activity against Plasmodium falciparum.
Parasitology research.
2006 Aug; 99(3):281-6. doi:
10.1007/s00436-006-0173-4. [PMID: 16550432] - Falk Martin, Tobias Linden, Dörthe M Katschinski, Felix Oehme, Ingo Flamme, Chinmay K Mukhopadhyay, Katrin Eckhardt, Juliane Tröger, Sandra Barth, Gieri Camenisch, Roland H Wenger. Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.
Blood.
2005 Jun; 105(12):4613-9. doi:
10.1182/blood-2004-10-3980. [PMID: 15741220] - Markus Niewerth, Donika Kunze, Michael Seibold, Martin Schaller, Hans Christian Korting, Bernhard Hube. Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors.
Antimicrobial agents and chemotherapy.
2003 Jun; 47(6):1805-17. doi:
10.1128/aac.47.6.1805-1817.2003. [PMID: 12760852] - Tobias Linden, Dörthe M Katschinski, Katrin Eckhardt, Annette Scheid, Horst Pagel, Roland H Wenger. The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2003 Apr; 17(6):761-3. doi:
10.1096/fj.02-0586fje. [PMID: 12594177] - J-J Choi, M Y Kong, S J Lee, H-C Kim, K H Ko, W-K Kim. Ciclopirox prevents peroxynitrite toxicity in astrocytes by maintaining their mitochondrial function: a novel mechanism for cytoprotection by ciclopirox.
Neuropharmacology.
2002 Sep; 43(3):408-17. doi:
10.1016/s0028-3908(02)00081-3. [PMID: 12243770] - I Harada, K Mitsui, K Uchida, H Yamaguchi. [The in vitro properties of a new hydroxypyridone antimycotic rilopirox, with special reference to its anti-Candida activity].
The Japanese journal of antibiotics.
1999 Feb; 52(2):146-52. doi:
NULL. [PMID: 10221179] - G Coppi, S Silingardi, R Girardello, D De Aloysio, S Manzardo. Pharmacokinetics of ciclopirox olamine after vaginal application to rabbits and patients.
Journal of chemotherapy (Florence, Italy).
1993 Oct; 5(5):302-6. doi:
10.1080/1120009x.1993.11755468. [PMID: 8106903] - G Coppi, S Silingardi. HPLC method for pharmacokinetic studies on ciclopirox olamine in rabbits after intravenous and intravaginal administrations.
Farmaco (Societa chimica italiana : 1989).
1992 May; 47(5 Suppl):779-86. doi:
NULL. [PMID: 1524626] - B D Hoffman, H M Hanauske-Abel, A Flint, M Lalande. A new class of reversible cell cycle inhibitors.
Cytometry.
1991; 12(1):26-32. doi:
10.1002/cyto.990120105. [PMID: 1900227] - H M Kellner, C Arnold, O E Christ, H G Eckert, J Herok, I Hornke, W Rupp. [Pharmacokinetics and biotransformation of the antimycotic drug ciclopiroxolamine in animals and man after topical and systemic administration].
Arzneimittel-Forschung.
1981; 31(8A):1337-53. doi:
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