Bucladesine sodium (BioDeep_00000780395)
代谢物信息卡片
化学式: C18H23N5NaO8P (491.11818880000004)
中文名称: N6,2′-O-二丁酰基腺苷3′,5′-环磷酸 钠盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCC(=O)NC1=C2C(=NC=N1)N(C=N2)C3C(C4C(O3)COP(=O)(O4)[O-])OC(=O)CCC.[Na+]
InChI: /q
描述信息
C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides > C01CE - Phosphodiesterase inhibitors
Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing[1][2][3][4].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:31313
- KEGGdrug: D01238
- PubChem: 23663967
- ChEMBL: CHEMBL1522836
- MeSH: Bucladesine
- CAS: 19436-29-4
- CAS: 16980-89-5
- medchemexpress: HY-B0764
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
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2008 Sep; 39(9):1062-70. doi:
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Molecular and cellular biochemistry.
2008 Aug; 315(1-2):31-9. doi:
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Cellular and molecular neurobiology.
2008 Jun; 28(4):519-28. doi:
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Microvascular research.
2008 May; 76(1):46-51. doi:
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Theriogenology.
2008 Mar; 69(5):639-50. doi:
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The Journal of endocrinology.
2008 Feb; 196(2):413-24. doi:
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Progress in brain research.
2008; 170(?):581-8. doi:
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Biochimica et biophysica acta.
2008 Jan; 1778(1):283-90. doi:
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Cell transplantation.
2008; 17(1-2):99-109. doi:
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Journal of cellular physiology.
2008 Jan; 214(1):221-9. doi:
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Journal of neurochemistry.
2007 Dec; 103(6):2610-9. doi:
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The Journal of physiology.
2007 Dec; 585(Pt 2):339-49. doi:
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Experimental parasitology.
2007 Oct; 117(2):171-7. doi:
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American journal of physiology. Renal physiology.
2007 Jul; 293(1):F299-305. doi:
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American journal of human genetics.
2007 Jun; 80(6):1115-24. doi:
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European journal of cell biology.
2007 Jun; 86(6):315-30. doi:
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Stem cells and development.
2007 Jun; 16(3):371-80. doi:
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Journal of neurochemistry.
2007 Jan; 100(1):87-104. doi:
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Molecular human reproduction.
2006 Dec; 12(12):781-9. doi:
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Anesthesiology.
2006 Nov; 105(5):976-83. doi:
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Reproductive toxicology (Elmsford, N.Y.).
2006 Nov; 22(4):631-5. doi:
10.1016/j.reprotox.2006.04.011
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Experimental hematology.
2006 Oct; 34(10):1420-8. doi:
10.1016/j.exphem.2006.05.017
. [PMID: 16982335] - Natsumi Sawada, Masayoshi Yamaguchi. Overexpression of RGPR-p117 enhances regucalcin gene promoter activity in cloned normal rat kidney proximal tubular epithelial cells: involvement of TTGGC motif.
Journal of cellular biochemistry.
2006 Oct; 99(2):589-97. doi:
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Diabetologia.
2006 Oct; 49(10):2427-36. doi:
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Molecular biology of the cell.
2006 Aug; 17(8):3638-50. doi:
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. [PMID: 16723498] - Julie Baumber, Stuart A Meyers. Changes in membrane lipid order with capacitation in rhesus macaque (Macaca mulatta) spermatozoa.
Journal of andrology.
2006 Jul; 27(4):578-87. doi:
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. [PMID: 16582419] - Raogo Ouedraogo, Xiangdong Wu, Shi-Qiong Xu, Lauren Fuchsel, Hiroyuki Motoshima, Kalyankar Mahadev, Kelly Hough, Rosario Scalia, Barry J Goldstein. Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway.
Diabetes.
2006 Jun; 55(6):1840-6. doi:
10.2337/db05-1174
. [PMID: 16731851] - Yih-Jer Wu, Mark Bond, Graciela B Sala-Newby, Andrew C Newby. Altered S-phase kinase-associated protein-2 levels are a major mediator of cyclic nucleotide-induced inhibition of vascular smooth muscle cell proliferation.
Circulation research.
2006 May; 98(9):1141-50. doi:
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Journal of andrology.
2006 May; 27(3):459-68. doi:
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The Journal of antibiotics.
2006 May; 59(5):281-7. doi:
10.1038/ja.2006.39
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The Journal of biological chemistry.
2006 Mar; 281(13):8656-66. doi:
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. [PMID: 16407249] - I Julie Hagen, Makoto Kusakabe, Graham Young. Effects of ACTH and cAMP on steroidogenic acute regulatory protein and P450 11beta-hydroxylase messenger RNAs in rainbow trout interrenal cells: relationship with in vitro cortisol production.
General and comparative endocrinology.
2006 Feb; 145(3):254-62. doi:
10.1016/j.ygcen.2005.09.014
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Arteriosclerosis, thrombosis, and vascular biology.
2006 Jan; 26(1):49-55. doi:
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. [PMID: 16239597] - Wen-Chi C Lee, J Peter Rubin, Kacey G Marra. Regulation of alpha-smooth muscle actin protein expression in adipose-derived stem cells.
Cells, tissues, organs.
2006; 183(2):80-6. doi:
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In vitro cellular & developmental biology. Animal.
2005 Nov; 41(10):356-63. doi:
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. [PMID: 16448226] - Katherine Karas, Philip Brauer, David Petzel. Actin redistribution in mosquito malpighian tubules after a blood meal and cyclic AMP stimulation.
Journal of insect physiology.
2005 Sep; 51(9):1041-54. doi:
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. [PMID: 15993891] - Tetsuo Nishikawa, Sachiko Suematsu, Jun Saito, Akiko Soyama, Hiroko Ito, Tomoshige Kino, George Chrousos. Human renal mesangial cells produce aldosterone in response to low-density lipoprotein (LDL).
The Journal of steroid biochemistry and molecular biology.
2005 Aug; 96(3-4):309-16. doi:
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