FGIN-1-27 (BioDeep_00000780389)
代谢物信息卡片
化学式: C28H37FN2O (436.289)
中文名称: N,N-二己基-2-(4-氟苯)吲哚-3-乙酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCN(CCCCCC)C(=O)CC1=C(NC2=CC=CC=C21)C3=CC=C(C=C3)F
InChI: InChI=1S/C28H37FN2O/c1-3-5-7-11-19-31(20-12-8-6-4-2)27(32)21-25-24-13-9-10-14-26(24)30-28(25)22-15-17-23(29)18-16-22/h9-10,13-18,30H,3-8,11-12,19-21H2,1-2H3
描述信息
D006133 - Growth Substances > D010937 - Plant Growth Regulators > D007210 - Indoleacetic Acids
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jin-Yong Chung, Sean Brown, Haolin Chen, June Liu, Vassilios Papadopoulos, Barry Zirkin. Effects of pharmacologically induced Leydig cell testosterone production on intratesticular testosterone and spermatogenesis†.
Biology of reproduction.
2020 02; 102(2):489-498. doi:
10.1093/biolre/ioz174. [PMID: 31504200] - Fenfen Chen, Hemin Lu, Panpan Chen, Xingxing Zhao, Xiaojui Guan, Qingquan Liang, Barry R Zirkin, Leping Ye, Haolin Chen. Acute effects of the translocator protein drug ligand FGIN-1-27 on serum testosterone and luteinizing hormone levels in male Sprague-Dawley rats†.
Biology of reproduction.
2019 03; 100(3):824-832. doi:
10.1093/biolre/ioy220. [PMID: 30299464] - Lincoln Biswas, Xinzhi Zhou, Baljean Dhillon, Annette Graham, Xinhua Shu. Retinal pigment epithelium cholesterol efflux mediated by the 18 kDa translocator protein, TSPO, a potential target for treating age-related macular degeneration.
Human molecular genetics.
2017 11; 26(22):4327-4339. doi:
10.1093/hmg/ddx319. [PMID: 28973423] - Beatriz Caballero, Leo Veenman, Julia Bode, Svetlana Leschiner, Moshe Gavish. Concentration-dependent bimodal effect of specific 18 kDa translocator protein (TSPO) ligands on cell death processes induced by ammonium chloride: potential implications for neuropathological effects due to hyperammonemia.
CNS & neurological disorders drug targets.
2014; 13(4):574-92. doi:
10.2174/18715273113126660194. [PMID: 24168369] - J Y Chung, H Chen, A Midzak, A L Burnett, V Papadopoulos, B R Zirkin. Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged brown Norway rat Leydig cells.
Endocrinology.
2013 Jun; 154(6):2156-65. doi:
10.1210/en.2012-2226. [PMID: 23525219] - Weiping Yu, Eric Wang, Ronald J Voll, Andrew H Miller, Mark M Goodman. Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor.
Bioorganic & medicinal chemistry.
2008 Jun; 16(11):6145-55. doi:
10.1016/j.bmc.2008.04.046. [PMID: 18472268] - Ming Liu, Tian-Yi Zhang, Wei-Hua Xu. A cDNA encoding diazepam-binding inhibitor/acyl-CoA-binding protein in Helicoverpa armigera: molecular characterization and expression analysis associated with pupal diapause.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2005 Jun; 141(2):168-76. doi:
10.1016/j.cca.2005.05.011. [PMID: 15993651] - Taketoshi Okubo, Ryoko Yoshikawa, Shigeyuki Chaki, Shigeru Okuyama, Atsuro Nakazato. Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands.
Bioorganic & medicinal chemistry.
2004 Jan; 12(2):423-38. doi:
10.1016/j.bmc.2003.10.050. [PMID: 14723961] - D Bitran, M Foley, D Audette, N Leslie, C A Frye. Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat.
Psychopharmacology.
2000 Jul; 151(1):64-71. doi:
10.1007/s002130000471. [PMID: 10958118] - E Romeo, S Cavallaro, A Korneyev, A P Kozikowski, D Ma, A Polo, E Costa, A Guidotti. Stimulation of brain steroidogenesis by 2-aryl-indole-3-acetamide derivatives acting at the mitochondrial diazepam-binding inhibitor receptor complex.
The Journal of pharmacology and experimental therapeutics.
1993 Oct; 267(1):462-71. doi:
. [PMID: 8229777]
