Isoprenaline hydrochloride (BioDeep_00000780387)
代谢物信息卡片
1,2-Benzenediol,4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, hydrochloride (1:1)
化学式: C11H18ClNO3 (247.0975148)
中文名称: 盐酸异丙肾上腺素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)NCC(C1=CC(=C(C=C1)O)O)O.Cl
InChI: 1H
描述信息
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D020011 - Protective Agents > D002316 - Cardiotonic Agents
D002317 - Cardiovascular Agents
Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma[1][2][3][4][5][6].
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:31453
- KEGGdrug: D01390
- PubChem: 5807
- ChEMBL: CHEMBL1711
- MeSH: Isoproterenol
- CAS: 1336-89-6
- CAS: 949-36-0
- CAS: 51-30-9
- medchemexpress: HY-B0468
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Linlin Liu, Mozhu Jin, Xueying Han, Deqiang Dou. Identifying biomarkers of ginseng medicines with different natures on heart failure.
Journal of ethnopharmacology.
2024 Jul; 329(?):118134. doi:
10.1016/j.jep.2024.118134. [PMID: 38574777] - Julia G Odnoshivkina, Alexey M Petrov. 25-hydroxycholesterol triggers antioxidant signaling in mouse atria.
Prostaglandins & other lipid mediators.
2024 Jun; 172(?):106834. doi:
10.1016/j.prostaglandins.2024.106834. [PMID: 38521490] - Jianfa Wu, Ying Cui, Weixing Ding, Jing Zhang, Lulu Wang. The protective effect of Macrostemonoside T from Allium macrostemon Bunge against Isoproterenol-Induced myocardial injury via the PI3K/Akt/mTOR signaling pathway.
International immunopharmacology.
2024 May; 133(?):112086. doi:
10.1016/j.intimp.2024.112086. [PMID: 38642441] - Fu Peng, Minru Liao, Wenke Jin, Wei Liu, Zixiang Li, Zhichao Fan, Ling Zou, Siwei Chen, Lingjuan Zhu, Qian Zhao, Gu Zhan, Liang Ouyang, Cheng Peng, Bo Han, Jin Zhang, Leilei Fu. 2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis.
Signal transduction and targeted therapy.
2024 May; 9(1):133. doi:
10.1038/s41392-024-01816-1. [PMID: 38744811] - Khushboo Bisht, Vipin Kumar Verma, Zia Abdullah, Vaishali Prajapati, Narang Rajiv, Jagriti Bhatia, Ruma Ray, Tapas Chandra Nag, Dharamvir Singh Arya. Arglabin: A mediator of inflammasome modulated and independent myocardial injury (PARA-AMI study).
European journal of pharmacology.
2024 May; 970(?):176465. doi:
10.1016/j.ejphar.2024.176465. [PMID: 38479722] - Jincheng Jing, Shumei Fang, Yueting Li, Wenting Liu, Cong Wang, Yanyu Lan, Yonglin Wang, Chang Yang. An enhanced cardio-protective effect of nanoparticles loaded with active components from Polygonum orientale L. against isoproterenol-induced myocardial ischemia in rats.
International journal of pharmaceutics.
2024 Apr; 655(?):124047. doi:
10.1016/j.ijpharm.2024.124047. [PMID: 38531434] - X Y Liao, P Liu, T F Luo, Y Li, Y Gao, F Y Pan, K C Wang. Punicalagin attenuates isoproterenol-induced myocardial infarction through nuclear factor erythroid 2-related factor 2/silent information regulator transcript-1-mediated inhibition of inflammation and cardiac stress markers in experimental animal models.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2024 Apr; 75(2):123-136. doi:
10.26402/jpp.2024.2.02. [PMID: 38736260] - Shweta Jaiswal, Md Meraj Anjum, Dilip Kumar Arya, Sunita Thakur, Prashant Pandey, Payal Deepak, Shubham Kanaujiya, Sneha Anand, Arjun Singh Kaushik, Vikas Mishra, Paruvathanahalli Siddalingam Rajinikanth. Surface entrenched β-sitosterol niosomes for enhanced cardioprotective activity against isoproterenol induced cardiotoxicity in rats.
International journal of pharmaceutics.
2024 Mar; 653(?):123872. doi:
10.1016/j.ijpharm.2024.123872. [PMID: 38336178] - Shaoling Lin, Shengxi Zhang, Angyu Zhan, Jiaojiao Feng, Qianqian Yang, Tongjun Li, Zijian Liu, Quqian Mo, Hui Fan, Keke Wang, Lexun Wang. Palmatine alleviates cardiac fibrosis by inhibiting fibroblast activation through the STAT3 pathway.
European journal of pharmacology.
2024 Mar; 967(?):176395. doi:
10.1016/j.ejphar.2024.176395. [PMID: 38350592] - Eve-Julie Tremblay, André Tchernof, Mélissa Pelletier, Denis R Joanisse, Pascale Mauriège. Plasma adiponectin/leptin ratio associates with subcutaneous abdominal and omental adipose tissue characteristics in women.
BMC endocrine disorders.
2024 Mar; 24(1):39. doi:
10.1186/s12902-024-01567-8. [PMID: 38481206] - Xiao-Ting Zhang, Xu Zhang, Meng-Wei Wang, Chen Zhang, Rui Weng, Xu Xu, Zu-Xi Gu, Jian-Ping Gao. Multiple organs injury and myocardial energy metabolism disorders induced by isoproterenol.
Toxicology.
2024 Mar; 503(?):153752. doi:
10.1016/j.tox.2024.153752. [PMID: 38369011] - Stanely Mainzen Prince Ponnian, Shervin Prince Stanely, Abhro Jyoti Roy. Cardioprotective effects of p-coumaric acid on tachycardia, inflammation, ion pump dysfunction, and electrolyte imbalance in isoproterenol-induced experimental myocardial infarction.
Journal of biochemical and molecular toxicology.
2024 Mar; 38(3):e23668. doi:
10.1002/jbt.23668. [PMID: 38439645] - Bingmin Wu, Ruiyan Zheng, Minhua Ouyang, Yong Zhu, Huanjun Lu, Kaihao Liao, Yuhe Dong, Bolun Su, Junying Huang, Tian Zhong, Zhongqiu Liu, Jingyan Li. The water extract of Amydrium sinense (Engl.) H. Li ameliorates Isoproterenol-induced cardiac hypertrophy through inhibiting the NF-κB signaling pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Mar; 172(?):116241. doi:
10.1016/j.biopha.2024.116241. [PMID: 38330711] - Kai He, Xiaoying Wang, Tingting Li, Yanfei Li, Linlin Ma. Chlorogenic Acid Attenuates Isoproterenol Hydrochloride-Induced Cardiac Hypertrophy in AC16 Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway.
Molecules (Basel, Switzerland).
2024 Feb; 29(4):. doi:
10.3390/molecules29040760. [PMID: 38398512] - Tanja Sobot, Zorislava Bajic, Ranko Skrbic, Snezana Uletilovic, Nebojsa Mandic-Kovacevic, Tanja Cvjetkovic, Ugljesa Malicevic, Djordje Djukanovic, Milica Gajic Bojic, Sanja Jovicic, Maja Barudzija, Milos P Stojiljkovic, Dragan M Djuric. Effect of folic acid on isoprenaline-induced myocardial injury in rats.
Physiology international.
2024 Jan; ?(?):. doi:
10.1556/2060.2023.00291. [PMID: 38261080] - Huiling Luan, Zhenhui Wang, Zhenzhen Zhang, Baohua Hou, Zhenzhen Liu, Lanping Yang, Mengmeng Yang, Yile Ma, Baobao Zhang. Brassica oleracea L. extract ameliorates isoproterenol-induced myocardial injury by regulating HIF-1α-mediated glycolysis.
Fitoterapia.
2024 Jan; 172(?):105715. doi:
10.1016/j.fitote.2023.105715. [PMID: 37907131] - Shuai-Nan Zhang, Qi Liu, Xu-Zhao Li, Wu-De Yang, Ying Zhou. Sophora tonkinensis and active compounds inhibit mitochondrial impairments, inflammation, and LDLR deficiency in myocardial ischemia mice through regulating the vesicle-mediated transport pathway.
Fitoterapia.
2024 Jan; 172(?):105756. doi:
10.1016/j.fitote.2023.105756. [PMID: 38007052] - Ziwei Xing, Chao Yang, Yaqian Feng, Junyao He, Cheng Peng, Dan Li. Understanding aconite's anti-fibrotic effects in cardiac fibrosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jan; 122(?):155112. doi:
10.1016/j.phymed.2023.155112. [PMID: 37924690] - Natalia V Belosludtseva, Lubov L Pavlik, Irina B Mikheeva, Eugeny Yu Talanov, Dmitriy A Serov, Dmitriy A Khurtin, Konstantin N Belosludtsev, Galina D Mironova. Protective Effect of Uridine on Structural and Functional Rearrangements in Heart Mitochondria after a High-Dose Isoprenaline Exposure Modelling Stress-Induced Cardiomyopathy in Rats.
International journal of molecular sciences.
2023 Dec; 24(24):. doi:
10.3390/ijms242417300. [PMID: 38139129] - Xing-Yu Fan, Xiao-Qian Liao, Shu-Min Huang, Zi-Yi Wang, Lin Li, Zhi-Xi Hu. [Shenfu Injection improves chronic heart failure by regulating pyroptosis based on NLRP3/caspase-1 pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Dec; 48(23):6475-6482. doi:
10.19540/j.cnki.cjcmm.20230914.701. [PMID: 38212004] - Anita Yovas, Shervin Prince Stanely, Reya Issac, Stanely Mainzen Prince Ponnian. β-caryophyllene blocks reactive oxygen species-mediated hyperlipidemia in isoproterenol-induced myocardial infarcted rats.
European journal of pharmacology.
2023 Oct; ?(?):176102. doi:
10.1016/j.ejphar.2023.176102. [PMID: 37827479] - Abhinav Rana, Thakur Uttam Singh, Meemansha Sharma, Manju Gari, Tarun Kumar, Subhashree Parida, Madhu Cholenahalli Lingaraju, Asok Kumar Mariappan, Akhilesh Kumar, Dinesh Kumar. Pravastatin attenuates isoprenaline induced cardiac fibrosis in a mouse model.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2023 Oct; ?(?):1-11. doi:
10.1080/10520295.2023.2260303. [PMID: 37814775] - Muthana M Jghef, Khadija Boukholda, Yassine Chtourou, Bernd L Fiebich, Mohammed Kebieche, Rachid Soulimani, Fatiha Chigr, Hamadi Fetoui. Punicalagin attenuates myocardial oxidative damage, inflammation, and apoptosis in isoproterenol-induced myocardial infarction in rats: Biochemical, immunohistochemical, and in silico molecular docking studies.
Chemico-biological interactions.
2023 Oct; 385(?):110745. doi:
10.1016/j.cbi.2023.110745. [PMID: 37806379] - Lei Jiang, Tingchao Gao, Miao Liu, Fangxu Li. Chitosan-sodium alginate-polyethylene glycol-Ally isothiocyante nanocomposites ameliorates isoproterenol-induced myocardial infarction in rats.
Journal of biochemical and molecular toxicology.
2023 Sep; ?(?):e23531. doi:
10.1002/jbt.23531. [PMID: 37724821] - Shereen S El-Mancy, Sylvia A Boshra, Osama S Elnahas, Sahar M Fayez, Nermin M Sheta. Enhancement of Bottle Gourd Oil Activity via Optimized Self-Dispersing Lipid Formulations (SDLFs) to Mitigate Isoproterenol-Evoked Cardiac Toxicity in Rats via Modulating BMP, MMP2, and miRNA-21 and miRNA-23a Genes' Expression.
Molecules (Basel, Switzerland).
2023 Aug; 28(16):. doi:
10.3390/molecules28166168. [PMID: 37630419] - Xuemei Zhang, Ying Zhao, Xin Zhao, Ji Zhang, Jiayu Diao, Shuo Jia, Panpan Feng, Penghua Yu, Gong Cheng. Anti-inflammatory, cardioprotective effect of gypenoside against isoproterenol-induced cardiac remodeling in rats via alteration of inflammation and gut microbiota.
Inflammopharmacology.
2023 Aug; ?(?):. doi:
10.1007/s10787-023-01307-9. [PMID: 37603159] - Jingyu Liao, Yuhao Zhang, Chi Ma, Gaosong Wu, Weidong Zhang. Microbiome-metabolome reveals that the Suxiao Jiuxin pill attenuates acute myocardial infarction associated with fatty acid metabolism.
Journal of ethnopharmacology.
2023 Aug; 312(?):116529. doi:
10.1016/j.jep.2023.116529. [PMID: 37086873] - Huihui Wang, Baoping Xie, Shuotao Shi, Rong Zhang, Qi Liang, Zhongqiu Liu, Yuanyuan Cheng. Curdione inhibits ferroptosis in isoprenaline-induced myocardial infarction via regulating Keap1/Trx1/GPX4 signaling pathway.
Phytotherapy research : PTR.
2023 Jul; ?(?):. doi:
10.1002/ptr.7964. [PMID: 37500597] - Yi Chen, Xiaoyun Guo, Yachang Zeng, Xiaoliang Mo, Siqi Hong, Hui He, Jing Li, Rachel Steinmetz, Qinghang Liu. Ferroptosis contributes to catecholamine-induced cardiotoxicity and pathological remodeling.
Free radical biology & medicine.
2023 Jul; 207(?):227-238. doi:
10.1016/j.freeradbiomed.2023.07.025. [PMID: 37499888] - Yi-Hsin Chan, Feng-Chun Tsai, Gwo-Jyh Chang, Ying-Ju Lai, Shang-Hung Chang, Wei-Jan Chen, Yung-Hsin Yeh. CD44 regulates Epac1-mediated β-adrenergic-receptor-induced Ca2+-handling abnormalities: implication in cardiac arrhythmias.
Journal of biomedical science.
2023 Jul; 30(1):55. doi:
10.1186/s12929-023-00944-0. [PMID: 37452346] - Anam Ali, Fatima Saqib. Ethnopharmacological basis and pharmacodynamics prospectives for folkloric claims of Rosa webbiana wall. Ex. Royle in diarrhea and asthma via In vitro, In vivo and In silico techniques.
Journal of ethnopharmacology.
2023 Jun; 317(?):116696. doi:
10.1016/j.jep.2023.116696. [PMID: 37315649] - Miao Ye, Lingjie Ruan, Lina Huang, Haiyin Zheng, Wen Xu, Wei Xu, Lixia Chen, Hua Li. Triterpenoids with diverse skeletons from the roots of Rhus chinensis and their protective effects on isoproterenol-induced heart failure in zebrafish.
Phytochemistry.
2023 Jun; 213(?):113749. doi:
10.1016/j.phytochem.2023.113749. [PMID: 37307886] - Anita Yovas, Shervin Prince Stanely, Stanely Mainzen Prince Ponnian. Protective effects of β-caryophyllene on mitochondrial damage and cardiac hypertrophy pathways in isoproterenol-induced myocardial infarcted rats.
European journal of pharmacology.
2023 May; ?(?):175785. doi:
10.1016/j.ejphar.2023.175785. [PMID: 37207967] - Zijing Guo, Nan Zhang, Kexin Ma, Qinghua Lei, Guoping Ma, Baozhu Ding, Yi Zhong, Wenjie Liang, Nan Li. Establishment of a new arrhythmia model in SD rats induced by isoproterenol.
Acta cardiologica.
2023 Apr; ?(?):1-10. doi:
10.1080/00015385.2023.2201726. [PMID: 37103119] - Meemansha Sharma, Thakur Uttam Singh, Abhinav Rana, Tarun Kumar, Manju Gari, Pashupathi Mani, Madhu Cholenahalli Lingaraju, Subhashree Parida, Vidya Singh, Monalisa Sahoo, Dinesh Kumar. Biochanin-A alleviates fibrosis and inflammation in cardiac injury in mice.
Journal of biochemical and molecular toxicology.
2023 Apr; ?(?):e23360. doi:
10.1002/jbt.23360. [PMID: 37016276] - Doa'a G F Al-U'datt, Carole C Tranchant, Muhammad Alu'datt, Sara Abusara, Ahmed Al-Dwairi, Mohammad AlQudah, Othman Al-Shboul, Roddy Hiram, Yasemin Altuntas, Saied Jaradat, Karem H Alzoubi. Inhibition of transglutaminase 2 (TG2) ameliorates ventricular fibrosis in isoproterenol-induced heart failure in rats.
Life sciences.
2023 Mar; 321(?):121564. doi:
10.1016/j.lfs.2023.121564. [PMID: 36931499] - Wei Wu, Qun Lu, Shan Ma, Jin-Chan Du, Kevin Huynh, Thy Duong, Zheng-Da Pang, Daniel Donner, Peter J Meikle, Xiu-Ling Deng, Xiao-Jun Du. Mitochondrial damage in a Takotsubo syndrome-like mouse model mediated by activation of b-adrenoceptor-Hippo signaling pathway.
American journal of physiology. Heart and circulatory physiology.
2023 Mar; ?(?):. doi:
10.1152/ajpheart.00459.2022. [PMID: 36867446] - Xi Tao, Yaxin Xu, Joseph Adu-Amankwaah, Zheng Gong, Yuxuan Wang, Fei Huang, Hong Sun. β2AR against myocarditis-lipid deposition depends on estrogenic environment in stress.
The Journal of endocrinology.
2023 Mar; 256(3):. doi:
10.1530/joe-22-0335. [PMID: 36633355] - Zorislava Bajic, Tanja Sobot, Snezana Uletilovic, Nebojsa Mandic-Kovacevic, Tanja Cvjetkovic, Ugljesa Malicevic, Đorđe Đukanović, Mladen Duran, Nikolina Vesic, Sanja Avram, Sanja Jovicic, Maja Katana, Amela Matavulj, Nenad Ponorac, Dragan Djuric, Milos P Stojiljkovic, Ranko Škrbic. CARDIOPROTECTIVE EFFECTS OF LIRAGLUTIDE PRETREATMENT ON ISOPRENALINE-INDUCED MYOCARDIAL INJURY IN RATS.
Canadian journal of physiology and pharmacology.
2023 Feb; ?(?):. doi:
10.1139/cjpp-2022-0534. [PMID: 36848640] - Jian Xiong, Xiang Li, Hongjuan Fu, Xinye Luo, Xiao Li, Yanrong Ren, Xueying Liu, Qianhua Zheng, Wenchuan Qi, Fanrong Liang. Study on the specific expression of infrared radiation temperature on the body surface of acupoint in rats with chronic myocardial ischemic injury.
Current medical imaging.
2023 Feb; ?(?):. doi:
10.2174/1573405619666230217120343. [PMID: 36799419] - Tao Song, Yuanyuan Hao, Mingye Wang, Tongtong Li, Chi Zhao, Jiajia Li, Yunlong Hou. Sophoridine manifests as a leading compound for anti-arrhythmia with multiple ion-channel blocking effects.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jan; 112(?):154688. doi:
10.1016/j.phymed.2023.154688. [PMID: 36738478] - Faisal K Alkholifi, Sushma Devi, Hasan S Yusufoglu, Aftab Alam. The Cardioprotective Effect of Corosolic Acid in the Diabetic Rats: A Possible Mechanism of the PPAR-γ Pathway.
Molecules (Basel, Switzerland).
2023 Jan; 28(3):. doi:
10.3390/molecules28030929. [PMID: 36770602] - Shrook Y Abdellatif, Nagui H Fares, Samar H Elsharkawy, Yomna I Mahmoud. Calanus oil attenuates isoproterenol-induced cardiac hypertrophy by regulating myocardial remodeling and oxidative stress.
Ultrastructural pathology.
2023 Jan; 47(1):12-21. doi:
10.1080/01913123.2022.2163016. [PMID: 36588172] - Karyne Garcia Tafarelo Moreno, Thiago Lima de Almeida, Aline Aparecida Macedo Marques, Guilherme Donadel, Emerson Luiz Botelho Lourenço, Danielle Ayr Tavares de Almeida, Arquimedes Gasparotto. Evidence of the Cardioprotective Effects of Aloysia polystachya in Isoproterenol-Induced Myocardial Infarction in Rats.
Journal of medicinal food.
2023 Jan; 26(1):36-39. doi:
10.1089/jmf.2022.0027. [PMID: 36637440] - Thais M Holanda, Danilo G Rocha, João Alison M Silveira, Paula Priscila C Costa, Pedro Henrique F Maia, Catherine Ingram, Maria Elisabete A DE Moraes, Francisco V Fechine, Manoel O DE Moraes Filho. Effect of essential oil of Alpinia zerumbet on cardiovascular and autonomic function in rats with isoproterenol induced acute myocardial infarction.
Anais da Academia Brasileira de Ciencias.
2023; 95(suppl 1):e20201878. doi:
10.1590/0001-3765202320201878. [PMID: 37585966] - Rubin Tan, Qiang You, Jie Cui, Mingming Wang, Nina Song, Ke An, Lili Lin, Joseph Adu-Amankwaah, Jinxiang Yuan, Hong Sun. Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jan; 109(?):154590. doi:
10.1016/j.phymed.2022.154590. [PMID: 36610170] - Wei Zhang, Manli Yu, Cenxi Zhang, Qing Yu, Sheng Xu, Qiongzhi Yan, Zhifu Guo, Yawei Xu. Active Ingredient Paeonol of Jijiu Huiyang Decoction Alleviates Isoproterenol-Induced Chronic Heart Failure via the GSK3A/PPARα Pathway.
Oxidative medicine and cellular longevity.
2023; 2023(?):3271057. doi:
10.1155/2023/3271057. [PMID: 36785789] - Dany Silva, Katarzyna Kacprzak, Clara Quintas, Jorge Gonçalves, Paula Fresco. Activation of β-Adrenoceptors Promotes Lipid Droplet Accumulation in MCF-7 Breast Cancer Cells via cAMP/PKA/EPAC Pathways.
International journal of molecular sciences.
2023 Jan; 24(1):. doi:
10.3390/ijms24010767. [PMID: 36614209] - Yu Yin, Lihui Wang, Guifang Chen, Hongwen You. Effect of Fraxetin on Oxidative Damage Caused by Isoproterenol-Induced Myocardial Infarction in Rats.
Applied biochemistry and biotechnology.
2022 Dec; 194(12):5666-5679. doi:
10.1007/s12010-022-04019-y. [PMID: 35802243] - Zhu Lingyan, Wei Yihong, Wang Youhua, Yang Jianmei, L I Jiawei, Cao Min, Zhou Duan. Protective efficacy of Shenge San on mitochondria in H9c2 cardiomyocytes.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2022 12; 42(6):892-899. doi:
10.19852/j.cnki.jtcm.2022.06.005. [PMID: 36378046] - H Li, J Shen, Y Zhang, L Hu, W Luo. 6-Shogaol protects against isoproterenol-induced cardiac injury in rats through attenutating oxidative stress, inflammation, apoptosis and activating nuclear respiratory factor-2/heme oxygenase-1 signaling pathway.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2022 Dec; 73(6):. doi:
10.26402/jpp.2022.6.06. [PMID: 37087565] - Zhi-Rong Lin, Zhen-Zhen Li, Yan-Jun Cao, Wen-Jing Yu, Jian-Tao Ye, Pei-Qing Liu. GDH promotes isoprenaline-induced cardiac hypertrophy by activating mTOR signaling via elevation of α-ketoglutarate level.
Naunyn-Schmiedeberg's archives of pharmacology.
2022 11; 395(11):1373-1385. doi:
10.1007/s00210-022-02252-0. [PMID: 35904584] - YaJuan Ni, Jing Zhang, Wenjing Zhu, Yixuan Duan, HongYuan Bai, Chunhong Luan. Echinacoside inhibited cardiomyocyte pyroptosis and improved heart function of HF rats induced by isoproterenol via suppressing NADPH/ROS/ER stress.
Journal of cellular and molecular medicine.
2022 11; 26(21):5414-5425. doi:
10.1111/jcmm.17564. [PMID: 36201630] - Anita Yovas, W A Manjusha, Stanely Mainzen Prince Ponnian. β-caryophyllene modulates B-cell lymphoma gene-2 family genes and inhibits the intrinsic pathway of apoptosis in isoproterenol-induced myocardial infarcted rats; A molecular mechanism.
European journal of pharmacology.
2022 Oct; 932(?):175181. doi:
10.1016/j.ejphar.2022.175181. [PMID: 35988788] - Anastasiia Vasileva, Tyler Marx, Jacqueline L Beaudry, Jennifer H Stern. Glucagon receptor signaling at white adipose tissue does not regulate lipolysis.
American journal of physiology. Endocrinology and metabolism.
2022 Oct; 323(4):E389-E401. doi:
10.1152/ajpendo.00078.2022. [PMID: 36002172] - Xiaoying Wang, Kai He, Linlin Ma, Lan Wu, Yan Yang, Yanfei Li. Puerarin attenuates isoproterenol‑induced myocardial hypertrophy via inhibition of the Wnt/β‑catenin signaling pathway.
Molecular medicine reports.
2022 10; 26(4):. doi:
10.3892/mmr.2022.12822. [PMID: 35946454] - Mahmood Salim Yaseen, Nidhal Mohammed Ali. The effect of bempedoic acid an ATP-citrate lyase inhibitor on cardiovascular risk factors in rats with experimentally induced myocardial infarction and hyperlipidemia.
Cellular and molecular biology (Noisy-le-Grand, France).
2022 Sep; 68(10):94-99. doi:
10.14715/cmb/2022.68.10.15. [PMID: 37114265] - Toshio Kaneda, Farida Ifadotunnikmah, Alfarius Eko Nugroho, Sae Koshikawa, Sasaki Tadahiro, Yusuke Hirasawa, Hiroshi Morita. Calofolic Acid-A from Calophyllum scriblitifolium Bark Has Vasorelaxant Activity via Indirect PKA Activation Caused by PI-3 Kinase Inhibition in Rat Vascular Smooth Muscle Cells.
Journal of natural products.
2022 09; 85(9):2192-2198. doi:
10.1021/acs.jnatprod.2c00502. [PMID: 35983865] - Md Sayeed Akhtar, Md Quamrul Hassan, Obaid Afzal, Abdulmalik S A Altamimi, Mohd Zaheen Hassan, Arun Kumar, Asif Ansari Shaik Mohammad, Fauzia Tabassum. Comparative efficacy of levosimendan, ramipril, and sacubitril/valsartan in isoproterenol induced experimental heart failure: a hemodynamic and molecular approach.
Current molecular pharmacology.
2022 Sep; ?(?):. doi:
10.2174/1874467215666220919104526. [PMID: 36121084] - Neelum Gul Qazi, Arif-Ullah Khan, Sumra Wajid Abbasi, Fawad Ali Shah, Faisal Rasheed, Fawad Ali, Syed Shams Ul Hassan, Simona Bungau. Pharmacological Basis of Rumex hastatus D. Don in Gastrointestinal Diseases with Focusing Effects on H+/K+-ATPase, Calcium Channels Inhibition and PDE Mediated Signaling: Toxicological Evaluation on Vital Organs.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27185919. [PMID: 36144661] - Miao Zhao, Meng Han, Lina Liang, Qixue Song, Xia Li, Yimei Du, Dongping Hu, Yu Cheng, Qing K Wang, Tie Ke. Mog1 deficiency promotes cardiac contractile dysfunction and isoproterenol-induced arrhythmias associated with cardiac fibrosis and Cx43 remodeling.
Biochimica et biophysica acta. Molecular basis of disease.
2022 09; 1868(9):166429. doi:
10.1016/j.bbadis.2022.166429. [PMID: 35533905] - Yanni Yang, Juanping Han, Renju G Lilly, Qin Yang, Yanjie Guo. Bergapten mediated inflammatory and apoptosis through AMPK/eNOS/AKT signaling pathway of isoproterenol-induced myocardial infarction in Wistar rats.
Journal of biochemical and molecular toxicology.
2022 Sep; 36(9):e23143. doi:
10.1002/jbt.23143. [PMID: 35815753] - Govindasami Sangeethadevi, Sathibabu Uddandrao V V, Rani Antony Rathinasamy Jansy Isabella, Ganapathy Saravanan, Ponnusamy Ponmurugan, Ponnusamy Chandrasekaran, Singaravel Sengottuvelu, Sasikumar Vadivukkarasi. Attenuation of lipid metabolic abnormalities, proinflammatory cytokines, and matrix metalloproteinase expression by biochanin-A in isoproterenol-induced myocardial infarction in rats.
Drug and chemical toxicology.
2022 Sep; 45(5):1951-1962. doi:
10.1080/01480545.2021.1894707. [PMID: 33719799] - Guilherme Henrique Souza Bomfim, Diego Castro Musial, Katiucha Rocha, Aron Jurkiewicz, Neide Hyppolito Jurkiewicz. Red wine but not alcohol consumption improves cardiovascular function and oxidative stress of the hypertensive-SHR and diabetic-STZ rats.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2022 Aug; 44(6):573-584. doi:
10.1080/10641963.2022.2085737. [PMID: 35699125] - Gangqiang Zou, Jia Wan, Agilan Balupillai, Ernest David, Babujanarthanam Ranganathan, Kalaimani Saravanan. Geraniol enhances peroxiredoxin-1, and prevents isoproterenol-induced oxidative stress and inflammation associated with myocardial infarction in experimental animal models.
Journal of biochemical and molecular toxicology.
2022 Aug; 36(8):e23098. doi:
10.1002/jbt.23098. [PMID: 35608392] - Fengyun Zhang, Bailu Duan, Zhenxiang Zhou, Lintao Han, Ping Huang, Yan Ye, Qiong Wang, Fang Huang, Jingjing Li. Integration of metabolomics and transcriptomics to reveal anti-chronic myocardial ischemia mechanism of Gualou Xiebai decoction.
Journal of ethnopharmacology.
2022 Jul; 297(?):115530. doi:
10.1016/j.jep.2022.115530. [PMID: 35830899] - Mehreen Fatima, Jie Gao, Tuo Han, Yiming Ding, Yali Zhang, Ergang Wen, Linying Jia, Rong Wang, Weirong Wang, Sihai Zhao, Liang Bai, Enqi Liu. MED1 Deficiency in Macrophages Aggravates Isoproterenol-Induced Cardiac Fibrosis in Mice.
The American journal of pathology.
2022 07; 192(7):1016-1027. doi:
10.1016/j.ajpath.2022.03.013. [PMID: 35461855] - Sumit Rathod, Yogeeta Agrawal, Abdulla Sherikar, Kartik T Nakhate, Chandragouda R Patil, M F Nagoor Meeran, Shreesh Ojha, Sameer N Goyal. Thymoquinone Produces Cardioprotective Effect in β-Receptor Stimulated Myocardial Infarcted Rats via Subsiding Oxidative Stress and Inflammation.
Nutrients.
2022 Jun; 14(13):. doi:
10.3390/nu14132742. [PMID: 35807920] - Zhan-Wang Gao, Xin Zhang, Qing-Yuan Zhuo, Mei-Xian Chen, Chong Yang, Zhao-Jie Chen, Ying Chen, Yi-Qiu Liao, Ling-Li Wang. Metabolomics and integrated network pharmacology analysis reveal attenuates cardiac hypertrophic mechanisms of HuoXin pill.
Journal of ethnopharmacology.
2022 Jun; 292(?):115150. doi:
10.1016/j.jep.2022.115150. [PMID: 35304274] - Danting Fu, Jiangfeng Zhou, Shanchun Xu, Jue Tu, Yueqin Cai, Jingyan Liu, Zhaowei Cai, Dejun Wang. Smilax glabra Roxb. flavonoids protect against pathological cardiac hypertrophy by inhibiting the Raf/MEK/ERK pathway: In vivo and in vitro studies.
Journal of ethnopharmacology.
2022 Jun; 292(?):115213. doi:
10.1016/j.jep.2022.115213. [PMID: 35331878] - Anouar Feriani, Meriam Tir, Waleed Aldahmash, Kais Mnafgui, Alimi Hichem, Ana María Gómez-Caravaca, María Del Mar Contreras, Amani Taamalli, Saleh Alwasel, Antonio Segura-Carretero, Nizar Tlili, Abdel Halim Harrath. In vivo evaluation and molecular docking studies of Schinus molle L. fruit extract protective effect against isoproterenol-induced infarction in rats.
Environmental science and pollution research international.
2022 Jun; ?(?):. doi:
10.1007/s11356-022-21422-4. [PMID: 35729379] - Asmaa A Khalifa, Nahed H El Sokkary, Samar S Elblehi, Mohamed A Diab, Mennatallah A Ali. Potential cardioprotective effect of octreotide via NOXs mitigation, mitochondrial biogenesis and MAPK/Erk1/2/STAT3/NF-kβ pathway attenuation in isoproterenol-induced myocardial infarction in rats.
European journal of pharmacology.
2022 Jun; 925(?):174978. doi:
10.1016/j.ejphar.2022.174978. [PMID: 35500641] - Stanely Mainzen Prince Ponnian. Preventive effects of (-) epicatechin on tachycardia, cardiac hypertrophy, and nuclear factor- κB inflammatory signaling pathway in isoproterenol-induced myocardial infarcted rats.
European journal of pharmacology.
2022 Jun; 924(?):174909. doi:
10.1016/j.ejphar.2022.174909. [PMID: 35346644] - M Lupu, D-V Tudor, V-A Toma, A Florea, A Lupsor, R Moldovan, B Stancu, N Decea, A G Filip. Iron chelation effects on lipid peroxidation, inflammation and ventricular performance in a rat model of isoproterenol induced acute myocardial stress.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2022 Jun; 73(3):. doi:
10.26402/jpp.2022.3.04. [PMID: 36302532] - Preethi S, Hitesh Kumar, Ramesh C, Sowmya B A, Niveditha K, Ramkishan Ajmeer, Vikas Jain. Protective Effects of Sauropus Androgynus Leaf Extract against Isoproterenol Induced Cardiotoxicity.
Cardiovascular toxicology.
2022 06; 22(6):579-591. doi:
10.1007/s12012-022-09739-5. [PMID: 35428918] - Rajendran HarishKumar, Chinnadurai Immanuel Selvaraj. Nuciferine from Nelumbo nucifera Gaertn. attenuates isoproterenol-induced myocardial infarction in Wistar rats.
Biotechnology and applied biochemistry.
2022 Jun; 69(3):1176-1189. doi:
10.1002/bab.2194. [PMID: 33998037] - Samaneh Sadat Alavi, Siyavash Joukar, Farzaneh Rostamzadeh, Hamid Najafipour, Fatemeh Darvishzadeh-Mahani, Abbas Mortezaeizade. Exercise Training Attenuates Cardiac Vulnerability and Promotes Cardiac Resistance to Isoproterenol-Induced Injury Following Hookah Smoke Inhalation in Male Rats: Role of Klotho and Sirtuins.
Cardiovascular toxicology.
2022 06; 22(6):501-514. doi:
10.1007/s12012-022-09733-x. [PMID: 35316495] - Fatima Saqib, Muqeet Wahid, Arwa Abdulkreem Al-Huqail, Hanadi Talal Ahmedah, Nicusor Bigiu, Marius Irimie, Marius Moga, Romina Alina Marc Vlaic, Oana Lelia Pop, Liana Maria Chicea. Metabolomics based mechanistic insights to vasorelaxant and cardioprotective effect of ethanolic extract of Citrullus lanatus (Thunb.) Matsum. & Nakai. seeds in isoproterenol induced myocardial infraction.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jun; 100(?):154069. doi:
10.1016/j.phymed.2022.154069. [PMID: 35364560] - Yosuke Masubuchi, Jinhui Ma, Tomohiro Suzuki, Itaru Kojima, Takeshi Inagaki, Hiroshi Shibata. T1R3 homomeric sweet taste receptor negatively regulates insulin-induced glucose transport through Gαs-mediated microtubules disassembly in 3T3-L1 adipocytes.
Endocrine journal.
2022 May; 69(5):487-493. doi:
10.1507/endocrj.ej21-0661. [PMID: 34803124] - Shriyansh Srivastava, Shubham Yadav, Gaaminepreet Singh, Shamsher Singh Bajwa. Wnt/β-catenin antagonist pyrvinium rescues high dose isoproterenol induced cardiotoxicity in rats: Biochemical and immunohistological evidences.
Chemico-biological interactions.
2022 May; 358(?):109902. doi:
10.1016/j.cbi.2022.109902. [PMID: 35305975] - Dimitrios Tsikas, Björn Redfors. Pilot Study on Acute Effects of Pharmacological Intraperitoneal L-Homoarginine on Homeostasis of Lysine and Other Amino Acids in a Rat Model of Isoprenaline-Induced Takotsubo Cardiomyopathy.
International journal of molecular sciences.
2022 Apr; 23(9):. doi:
10.3390/ijms23094734. [PMID: 35563125] - Philipp Palombo, Alexander Bürkle, Maria Moreno-Villanueva. Culture medium-dependent isoproterenol stability and its impact on DNA strand breaks formation and repair.
Chemico-biological interactions.
2022 Apr; 357(?):109877. doi:
10.1016/j.cbi.2022.109877. [PMID: 35276129] - Shubham Yadav, Shriyansh Srivastava, Gaaminepreet Singh. Platelet-rich plasma exhibits anti-inflammatory effect and attenuates cardiomyocyte damage by reducing NF-κB and enhancing VEGF expression in isoproterenol induced cardiotoxicity model.
Environmental toxicology.
2022 Apr; 37(4):936-953. doi:
10.1002/tox.23456. [PMID: 35014750] - T Mohan Manu, T Anand, G R Sharath Babu, Mahantesh M Patil, Farhath Khanum. Bacopa monniera extract mitigates isoproterenol-induced cardiac stress via Nrf2/Keap1/NQO1 mediated pathway.
Archives of physiology and biochemistry.
2022 Apr; 128(2):341-351. doi:
10.1080/13813455.2019.1683583. [PMID: 31755309] - Muqeet Wahid, Fatima Saqib, Liana Chicea, Hanadi Talal Ahmedah, Bayan Hussein Sajer, Romina Alina Marc Vlaic, Oana Lelia Pop, Marius Moga, Claudia Gavris. Metabolomics analysis delineates the therapeutic effects of hydroethanolic extract of Cucumis sativus L. seeds on hypertension and isoproterenol-induced myocardial infarction.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Apr; 148(?):112704. doi:
10.1016/j.biopha.2022.112704. [PMID: 35180666] - Azar Hosseini, Arezoo Rajabian, Mohammad-Ali Sobhanifar, Mohaddeseh Sadat Alavi, Zahra Taghipour, Maede Hasanpour, Mehrdad Iranshahi, Samaneh Boroumand-Noughabi, Maciej Banach, Amirhossein Sahebkar. Attenuation of isoprenaline-induced myocardial infarction by Rheum turkestanicum.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Apr; 148(?):112775. doi:
10.1016/j.biopha.2022.112775. [PMID: 35240528] - Taohua Lan, Qiaohuang Zeng, Wei Jiang, Tong Liu, Wenjing Xu, Ping Yao, Weihui Lu. Metabolism disorder promotes isoproterenol-induced myocardial injury in mice with high temperature and high humidity and high-fat diet.
BMC cardiovascular disorders.
2022 03; 22(1):133. doi:
10.1186/s12872-022-02583-z. [PMID: 35350989] - Agné Kulyté, Veroniqa Lundbäck, Peter Arner, Rona J Strawbridge, Ingrid Dahlman. Shared genetic loci for body fat storage and adipocyte lipolysis in humans.
Scientific reports.
2022 03; 12(1):3666. doi:
10.1038/s41598-022-07291-4. [PMID: 35256633] - Shanna Hamilton, Radmila Terentyeva, Vladimir Bogdanov, Tae Yun Kim, Fruzsina Perger, Jiajie Yan, Xun Ai, Cynthia A Carnes, Andriy E Belevych, Christopher H George, Jonathan P Davis, Sandor Gyorke, Bum-Rak Choi, Dmitry Terentyev. Ero1α-Dependent ERp44 Dissociation From RyR2 Contributes to Cardiac Arrhythmia.
Circulation research.
2022 03; 130(5):711-724. doi:
10.1161/circresaha.121.320531. [PMID: 35086342] - Marwa Medhet, Wesam M El-Bakly, Amira M Badr, Azza Awad, Ebtehal El-Demerdash. Thymoquinone attenuates isoproterenol-induced myocardial infarction by inhibiting cytochrome C and matrix metalloproteinase-9 expression.
Clinical and experimental pharmacology & physiology.
2022 03; 49(3):391-405. doi:
10.1111/1440-1681.13614. [PMID: 34767666] - Tausif Alam, Mohd Asif Ansari, Sanjula Baboota, Javed Ali. Nanostructured lipid carriers of isradipine for effective management of hypertension and isoproterenol induced myocardial infarction.
Drug delivery and translational research.
2022 03; 12(3):577-588. doi:
10.1007/s13346-021-00958-x. [PMID: 33782898] - Tatsuya Kokawa, Hiroyuki Yamamoto, Mitsuaki Itoh, Akira Shimane, Hiroya Kawai, Tomofumi Takaya. Fever-Related Ventricular Fibrillation - Potential Adverse Effect of SARS-CoV-2 Vaccination in Patients With Brugada Syndrome.
Circulation journal : official journal of the Japanese Circulation Society.
2022 Feb; 86(3):474. doi:
10.1253/circj.cj-21-0750. [PMID: 34615807] - Jie Li, Xiaohe Chen, Xiang Li, Jiayang Tang, Yan Li, Bin Liu, Shuzhen Guo. Cryptochlorogenic acid and its metabolites ameliorate myocardial hypertrophy through a HIF1α-related pathway.
Food & function.
2022 Feb; 13(4):2269-2282. doi:
10.1039/d1fo03838a. [PMID: 35141734] - Minru Liao, Qiang Xie, Yuqian Zhao, Chengcan Yang, Congcong Lin, Guan Wang, Bo Liu, Lingjuan Zhu. Main active components of Si-Miao-Yong-An decoction (SMYAD) attenuate autophagy and apoptosis via the PDE5A-AKT and TLR4-NOX4 pathways in isoproterenol (ISO)-induced heart failure models.
Pharmacological research.
2022 02; 176(?):106077. doi:
10.1016/j.phrs.2022.106077. [PMID: 35026404] - Cícera Edna Barbosa David, Aline Maria Brito Lucas, Pedro Lourenzo Oliveira Cunha, Yuana Ivia Ponte Viana, Marcos Yukio Yoshinaga, Sayuri Miyamoto, Adriano Brito Chaves Filho, Anna Lídia Nunes Varela, Alicia Juliana Kowaltowski, Heberty Tarso Facundo. Calorie restriction changes lipidomic profiles and maintains mitochondrial function and redox balance during isoproterenol-induced cardiac hypertrophy.
Journal of physiology and biochemistry.
2022 Feb; 78(1):283-294. doi:
10.1007/s13105-021-00863-4. [PMID: 35023023] - Emanuel Tenório Paulino, Amanda Karine Barros Ferreira Rodrigues, Maria Luiza Dal Pont Machado, Kelly Rayane Vital de Oliveira, Alessando César Bernardino, Lucindo José Quintans-Júnior, Aldeídia Pereira Oliveira, Êurica Adélia Nogueira Ribeiro. Alpha-terpineol prevents myocardial damage against isoproterenol-MI induced in Wistar-Kyoto rats: new possible to promote cardiovascular integrity.
Life sciences.
2022 Feb; 290(?):120087. doi:
10.1016/j.lfs.2021.120087. [PMID: 34740575] - Irfan Cinar, Muhammed Yayla, Taha Tavaci, Erdem Toktay, Rustem Anil Ugan, Pınar Bayram, Hamza Halici. In Vivo and In Vitro Cardioprotective Effect of Gossypin Against Isoproterenol-Induced Myocardial Infarction Injury.
Cardiovascular toxicology.
2022 01; 22(1):52-62. doi:
10.1007/s12012-021-09698-3. [PMID: 34599475] - Runhong Mu, Siping Ye, Rui Lin, Yupeng Li, Xiao Guo, Liping An. Effects of Peroxiredoxin 6 and Its Mutants on the Isoproterenol Induced Myocardial Injury in H9C2 Cells and Rats.
Oxidative medicine and cellular longevity.
2022; 2022(?):2576310. doi:
10.1155/2022/2576310. [PMID: 35378825] - Dareuosh Shackebaei, Mahvash Hesari, Soudabeh Ramezani-Aliakbari, Zohreh Hoseinkhani, Fatemeh Ramezani-Aliakbari. Gallic acid protects against isoproterenol-induced cardiotoxicity in rats.
Human & experimental toxicology.
2022 Jan; 41(?):9603271211064532. doi:
10.1177/09603271211064532. [PMID: 35193428]