Meperidine Hydrochloride (BioDeep_00000779282)
代谢物信息卡片
Meperidine Hydrochloride
化学式: C15H22ClNO2 (283.1339)
中文名称: 吡利啶
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)C1(CCN(CC1)C)C2=CC=CC=C2.Cl
InChI: 1H
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:31984
- KEGGdrug: D01383
- PubChem: 5750
- ChEMBL: CHEMBL1701
- MeSH: Meperidine
- CAS: 50-13-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jiangjing Wang, Shunyi Wei, Yingfang Ao, Yuping Yang. [Comparison of the early analgesic efficacy of three different drugs after anterior cruciate ligament reconstruction].
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Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2022 Mar; 35(3):511-516. doi:
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Talanta.
2022 Mar; 239(?):123131. doi:
10.1016/j.talanta.2021.123131. [PMID: 34920261] - Amanda L Hanafi, Rachel A Reed, Heather N Trenholme, Daniel M Sakai, Clare A Ryan, Michele Barletta, Jane E Quandt, Heather K Knych. Pharmacokinetics and pharmacodynamics of meperidine after intramuscular and subcutaneous administration in horses.
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2021 Feb; 50(2):410-417. doi:
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BMC veterinary research.
2020 Oct; 16(1):368. doi:
10.1186/s12917-020-02564-4. [PMID: 32998730] - Aykut Kul, Murat Ozdemir, Olcay Sagirli. Determination of pethidine of abuse and relevant metabolite norpethidine in urine by ultra-performance liquid chromatography-tandem mass spectrometry.
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2020 Jul; 186(?):113320. doi:
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BMC veterinary research.
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PloS one.
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Drug testing and analysis.
2013 Apr; 5(4):213-21. doi:
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Regional anesthesia and pain medicine.
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Glycoconjugate journal.
2004; 20(9):563-77. doi:
10.1023/b:glyc.0000043293.46845.07. [PMID: 15454695] - Shivkumar H Jha, Jyothi A Reddy, Jatin K Dave. Dapsone-induced acute pancreatitis.
The Annals of pharmacotherapy.
2003 Oct; 37(10):1438-40. doi:
10.1345/aph.1c482. [PMID: 14519046] - C Kastner, A Tagg. Improving the effectiveness of the emergency management of renal colic in a district general hospital: a completed audit cycle.
Emergency medicine journal : EMJ.
2003 Sep; 20(5):449-50. doi:
10.1136/emj.20.5.449. [PMID: 12954686] - Sven Björkman. Reduction and lumping of physiologically based pharmacokinetic models: prediction of the disposition of fentanyl and pethidine in humans by successively simplified models.
Journal of pharmacokinetics and pharmacodynamics.
2003 Aug; 30(4):285-307. doi:
10.1023/a:1026194618660. [PMID: 14650375] - Akira Ishii, Miwa Tanaka, Rina Kurihara, Kanako Watanabe-Suzuki, Takeshi Kumazawa, Hiroshi Seno, Osamu Suzuki, Yoshinao Katsumata. Sensitive determination of pethidine in body fluids by gas chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Jul; 792(1):117-21. doi:
10.1016/s1570-0232(03)00132-6. [PMID: 12829004] - Matilda Lampinen, Ulf Bondesson, Elisabeth Fredriksson, Mikael Hedeland. Validation of a method for quantification of ketobemidone in human plasma with liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Jun; 789(2):347-54. doi:
10.1016/s1570-0232(03)00138-7. [PMID: 12742125] - Anthony G Doufas, Chun-Ming Lin, Mohammad-Irfan Suleman, Edwin B Liem, Rainer Lenhardt, Nobutada Morioka, Ozan Akça, Yunus M Shah, Andrew R Bjorksten, Daniel I Sessler. Dexmedetomidine and meperidine additively reduce the shivering threshold in humans.
Stroke.
2003 May; 34(5):1218-23. doi:
10.1161/01.str.0000068787.76670.a4. [PMID: 12690216] - Garrick P Hubbard, Kelly R Wolfe. Meperidine misuse in a patient with sphincter of Oddi dysfunction.
The Annals of pharmacotherapy.
2003 Apr; 37(4):534-7. doi:
10.1345/aph.1c108. [PMID: 12659611] - Barbara Potocka. [Selected psychoactive drugs--clinical problems and medical-legal aspects].
Annales Academiae Medicae Stetinensis.
2003; 49(?):145-59. doi:
NULL. [PMID: 15552845] - Ayman Al-Shurbaji, Leif Tokics. The pharmacokinetics of ketobemidone in critically ill patients.
British journal of clinical pharmacology.
2002 Dec; 54(6):583-6. doi:
10.1046/j.1365-2125.2002.t01-2-01689.x. [PMID: 12492604] - Celalettin Vatansev, Metin Belviranli, Faruk Aksoy, Sema Tuncer, Mustafa Sahin, Omer Karahan. The effects of different hernia repair methods on postoperative pain medication and CRP levels.
Surgical laparoscopy, endoscopy & percutaneous techniques.
2002 Aug; 12(4):243-6. doi:
10.1097/00129689-200208000-00008. [PMID: 12193818] - A I Muñoz Ruiz, E Guerrero Vega, G Maldonado Castro, P de Diego Pozas, F Marcos Sánchez, A Durán Pérez-Navarro. [Severe hyponatremia as the initial manifestation of hypopituitarism].
Anales de medicina interna (Madrid, Spain : 1984).
2002 Jun; 19(6):323-4. doi:
NULL. [PMID: 12152396] - Marcia Stevens, Rosemary Esler, Gregg Asher. Transdermal fentanyl for the management of acute pancreatitis pain.
Applied nursing research : ANR.
2002 May; 15(2):102-10. doi:
10.1053/apnr.2002.29532. [PMID: 11994827] - Xiao-ling Lei, Jun-de Wang. [Solid-phase microextraction for the analysis of drugs and biological samples].
Se pu = Chinese journal of chromatography.
2002 May; 20(3):210-5. doi:
NULL. [PMID: 12541938] - Tung Si Ho, Stig Pedersen-Bjergaard, Knut E Rasmussen. Liquid-phase microextraction of protein-bound drugs under non-equilibrium conditions.
The Analyst.
2002 May; 127(5):608-13. doi:
10.1039/b110105f. [PMID: 12081037] - O Eray, Y Cete, C Oktay, B Karsli, S Akça, N Cete, F Ersoy. Intravenous single-dose tramadol versus meperidine for pain relief in renal colic.
European journal of anaesthesiology.
2002 May; 19(5):368-70. doi:
10.1017/s0265021502000595. [PMID: 12095018] - Ingela Sundström, Mikael Hedeland, Ulf Bondesson, Per E Andrén. Identification of glucuronide conjugates of ketobemidone and its phase I metabolites in human urine utilizing accurate mass and tandem time-of-flight mass spectrometry.
Journal of mass spectrometry : JMS.
2002 Apr; 37(4):414-20. doi:
10.1002/jms.298. [PMID: 11948848] - Ayman Al-Shurbaji, Juliette Säwe. The pharmacokinetics of ketobemidone are not affected by CYP2D6 or CYP2C19 phenotype.
European journal of clinical pharmacology.
2002 Feb; 57(12):877-81. doi:
10.1007/s00228-001-0413-6. [PMID: 11936707] - Joel C Glasson, William T Sawyer, Celeste M Lindley, Brian Ginsberg. Patient-specific factors affecting patient-controlled analgesia dosing.
Journal of pain & palliative care pharmacotherapy.
2002; 16(2):5-21. doi:
10.1080/j354v16n02_02. [PMID: 14650457] - P M Taylor, S A Robertson, M J Dixon, M Ruprah, J W Sear, B D Lascelles, C Waters, M Bloomfield. Morphine, pethidine and buprenorphine disposition in the cat.
Journal of veterinary pharmacology and therapeutics.
2001 Dec; 24(6):391-8. doi:
10.1046/j.1365-2885.2001.368goblin.x. [PMID: 11903869] - D Szkutnik, S Dyderski, K Majcher. Determination of pethidine in rabbit plasma by capillary gas chromatography.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2001 Dec; 14(4):317-21. doi:
10.1016/s0928-0987(01)00200-7. [PMID: 11684406] - I Sundström, U Bondesson, M Hedeland. Identification of phase I and phase II metabolites of ketobemidone in patient urine using liquid chromatography-electrospray tandem mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Nov; 763(1-2):121-31. doi:
10.1016/s0378-4347(01)00375-9. [PMID: 11710570] - P Xiang, M Shen, J Bu, Z Huang. The stability of tetramine, morphine and meperidine in formalin solution.
Forensic science international.
2001 Nov; 122(2-3):159-62. doi:
10.1016/s0379-0738(01)00491-1. [PMID: 11672971] - M Mokhtarani, A N Mahgoub, N Morioka, A G Doufas, M Dae, T E Shaughnessy, A R Bjorksten, D I Sessler. Buspirone and meperidine synergistically reduce the shivering threshold.
Anesthesia and analgesia.
2001 Nov; 93(5):1233-9. doi:
10.1097/00000539-200111000-00038. [PMID: 11682404] - P P Chen, E W Cheam, M Ma, K K Lam, W D Ngan Kee, T Gin. Patient-controlled pethidine after major upper abdominal surgery: comparison of the epidural and intravenous routes.
Anaesthesia.
2001 Nov; 56(11):1106-12. doi:
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Annals of internal medicine.
2001 Oct; 135(8 Pt 2):703-10. doi:
10.7326/0003-4819-135-8_part_2-200110161-00009. [PMID: 11601953] - L G Hall, L J Oyen, M J Murray. Analgesic agents. Pharmacology and application in critical care.
Critical care clinics.
2001 Oct; 17(4):899-923, viii. doi:
10.1016/s0749-0704(05)70186-x. [PMID: 11762267] - J O Svensson, J Säwe, A AL-Shurbaji. Determination of ketobemidone and its metabolites in plasma and urine using solid-phase extraction and liquid chromatography-mass spectrometry.
Therapeutic drug monitoring.
2001 Aug; 23(4):399-405. doi:
10.1097/00007691-200108000-00013. [PMID: 11477323] - A Ishii, R Kurihara, K Watanabe-Suzuki, T Kumazawa, H Seno, H Matsushima, O Suzuki, Y Katsumata. Sensitive determination of pethidine in body fluids by surface ionization organic mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Jul; 758(1):117-21. doi:
10.1016/s0378-4347(01)00049-4. [PMID: 11482730] - C Birch, C Hogan, G Mahoney. Co-administration of drugs and blood products.
Anaesthesia and intensive care.
2001 Apr; 29(2):137-40. doi:
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Postgraduate medicine.
2001 Mar; 109(3):31-2. doi:
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