Tipiracil (BioDeep_00000778428)
代谢物信息卡片
化学式: C9H11ClN4O2 (242.0570496)
中文名称: 替吡嘧啶杂质
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(=N)N(C1)CC2=C(C(=O)NC(=O)N2)Cl
InChI: InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16)
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:90879
- PubChem: 6323266
- DrugBank: DB09343
- DrugBank: DB02631
- ChEMBL: CHEMBL235668
- CAS: 183204-74-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Youngchang Kim, Jacek Wower, Natalia Maltseva, Changsoo Chang, Robert Jedrzejczak, Mateusz Wilamowski, Soowon Kang, Vlad Nicolaescu, Glenn Randall, Karolina Michalska, Andrzej Joachimiak. Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Communications biology.
2021 02; 4(1):193. doi:
10.1038/s42003-021-01735-9
. [PMID: 33564093] - T Yoshino, J M Cleary, E Van Cutsem, R J Mayer, A Ohtsu, E Shinozaki, A Falcone, K Yamazaki, T Nishina, R Garcia-Carbonero, Y Komatsu, H Baba, G Argilés, A Tsuji, A Sobrero, K Yamaguchi, M Peeters, K Muro, A Zaniboni, N Sugimoto, Y Shimada, Y Tsuji, H S Hochster, T Moriwaki, B Tran, T Esaki, C Hamada, T Tanase, F Benedetti, L Makris, F Yamashita, H-J Lenz. Neutropenia and survival outcomes in metastatic colorectal cancer patients treated with trifluridine/tipiracil in the RECOURSE and J003 trials.
Annals of oncology : official journal of the European Society for Medical Oncology.
2020 01; 31(1):88-95. doi:
10.1016/j.annonc.2019.10.005
. [PMID: 31912801] - Geoffroy Desbuissons, Liliane Ngango, Isabelle Brochériou, Philippe Fournier. IgA Nephropathy Associated with Trifluridine/Tipiracil: A Case Report.
Nephron.
2020; 144(10):506-508. doi:
10.1159/000509375
. [PMID: 32799198] - Alexander B Aria, Leon Chen, William F Glass, Amit Lahoti, Susan Y Chon. Leukocytoclastic vasculitis with late-onset Henoch-Schönlein purpura after trifluridine/tipiracil treatment.
Dermatology online journal.
2018 Oct; 24(10):. doi:
NULL
. [PMID: 30677817] - James M Cleary, Lee S Rosen, Kenichiro Yoshida, Drew Rasco, Geoffrey I Shapiro, Weijing Sun. A phase 1 study of the pharmacokinetics of nucleoside analog trifluridine and thymidine phosphorylase inhibitor tipiracil (components of TAS-102) vs trifluridine alone.
Investigational new drugs.
2017 04; 35(2):189-197. doi:
10.1007/s10637-016-0409-9
. [PMID: 28111727] - James J Lee, Jabed Seraj, Kenichiro Yoshida, Hirokazu Mizuguchi, Sandra Strychor, Jillian Fiejdasz, Tyeler Faulkner, Robert A Parise, Patrick Fawcett, Laura Pollice, Scott Mason, Jeremy Hague, Marie Croft, James Nugteren, Charles Tedder, Weijing Sun, Edward Chu, Jan Hendrik Beumer. Human mass balance study of TAS-102 using (14)C analyzed by accelerator mass spectrometry.
Cancer chemotherapy and pharmacology.
2016 Mar; 77(3):515-26. doi:
10.1007/s00280-016-2965-2
. [PMID: 26787503] - Tomohiro Emura, Fumio Nakagawa, Akio Fujioka, Hideyuki Ohshimo, Kenji Kitazato. Thymidine kinase and thymidine phosphorylase level as the main predictive parameter for sensitivity to TAS-102 in a mouse model.
Oncology reports.
2004 Feb; 11(2):381-7. doi:
10.3892/or.11.2.381
. [PMID: 14719072]