5-Amino-6-(5'-phosphoribitylamino)uracil (BioDeep_00000007784)

 

Secondary id: BioDeep_00001869446

human metabolite Endogenous


代谢物信息卡片


{[(2R,3S,4S)-5-[(5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino]-2,3,4-trihydroxypentyl]oxy}phosphonic acid

化学式: C9H17N4O9P (356.07331220000003)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 1.32%

分子结构信息

SMILES: C(C(C(C(COP(=O)(O)O)O)O)O)NC1=C(C(=O)NC(=O)N1)N
InChI: InChI=1S/C9H17N4O9P/c10-5-7(12-9(18)13-8(5)17)11-1-3(14)6(16)4(15)2-22-23(19,20)21/h3-4,6,14-16H,1-2,10H2,(H2,19,20,21)(H3,11,12,13,17,18)/t3-,4+,6-/m0/s1

描述信息

5-Amino-6-(5-phosphoribitylamino)uracil belongs to the class of organic compounds known as monosaccharide phosphates. These are monosaccharides comprising a phosphated group linked to the carbohydrate unit. 5-Amino-6-(5-phosphoribitylamino)uracil is an extremely weak basic (essentially neutral) compound (based on its pKa). 5-Amino-6-(5-phosphoribitylamino)uracil has been detected, but not quantified in, several different foods, such as sapodilla, kumquats, sacred lotus, Persian limes, and Cascade huckleberries. This could make 5-amino-6-(5-phosphoribitylamino)uracil a potential biomarker for the consumption of these foods. 5-Amino-6-(5-phosphoribitylamino)uracil is an intermediate in riboflavin metabolism. 5-Amino-6-(5-phosphoribitylamino)uracil is the third to last step in the synthesis of 7-hydroxy-6-methyl-8-ribityl lumazine and is converted from 5-amino-6-(5-phosphoribosylamino)uracil via the enzyme 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193). It is then converted into 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine via a hydrolase enzyme (EC 3.1.3.- ).
5-amino-6-(5-phospho-d-ribitylamino)uracil is a member of the class of compounds known as monosaccharide phosphates. Monosaccharide phosphates are monosaccharides comprising a phosphated group linked to the carbohydrate unit. 5-amino-6-(5-phospho-d-ribitylamino)uracil is slightly soluble (in water) and a moderately acidic compound (based on its pKa). 5-amino-6-(5-phospho-d-ribitylamino)uracil can be found in a number of food items such as star fruit, chinese cabbage, mamey sapote, and sapodilla, which makes 5-amino-6-(5-phospho-d-ribitylamino)uracil a potential biomarker for the consumption of these food products. 5-amino-6-(5-phospho-d-ribitylamino)uracil exists in E.coli (prokaryote) and yeast (eukaryote).

同义名列表

12 个代谢物同义名

{[(2R,3S,4S)-5-[(5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino]-2,3,4-trihydroxypentyl]oxy}phosphonic acid; [(2R,3S,4S)-5-[(5-amino-2,6-dioxo-1,3-dihydropyrimidin-4-yl)amino]-2,3,4-trihydroxypentyl]oxyphosphonic acid; 5-Amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione-5’-phosphate; 5-Amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione-5-phosphate; 5-Amino-2,6-dioxy-4-(5’-phospho-D-ribitylamino)pyrimidine; 5-Amino-2,6-dioxy-4-(5-phospho-D-ribitylamino)pyrimidine; 5-Amino-2,6-dioxy-4-(5-phosphoribitylamino)pyrimidine; 5-Amino-6-(5’-phospho-D-ribitylamino)uracil; 5-Amino-6-(5-phospho-D-ribitylamino)uracil; 5-Amino-6-(5’-phosphoribitylamino)uracil; 5-Amino-6-(5-phosphoribitylamino)uracil; 5-amino-6-(5-phosphoribitylamino)uracil



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

229 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(225)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(3)

  • Flavin Biosynthesis: 5-Amino-6-(5'-phosphoribosylamino)uracil + Hydrogen Ion + NADPH ⟶ 5-Amino-6-(5'-phosphoribitylamino)uracil + NADP
  • Flavin Biosynthesis: Adenosine triphosphate + Riboflavin ⟶ Adenosine diphosphate + Flavin Mononucleotide + Hydrogen Ion
  • Riboflavin Metabolism: FAD + Water ⟶ Adenosine monophosphate + Flavin Mononucleotide

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • M Sano. Subcellular localizations of guanylate cyclase and 3',5'-cyclic nucleotide phosphodiesterase in sea urchin sperm. Biochimica et biophysica acta. 1976 Apr; 428(2):525-31. doi: 10.1016/0304-4165(76)90061-1. [PMID: 6049]