Cisatracurium Besylate (BioDeep_00000778230)
代谢物信息卡片
Cisatracurium Besylate
化学式: C65H82N2O18S2 (1242.5003792000002)
中文名称: 顺苯磺阿曲库铵
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C=C6)OC)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)[O-].C1=CC=C(C=C1)S(=O)(=O)[O-]
InChI: InChI=1S/C53H72N2O12.2C6H6O3S/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6
描述信息
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents > D009466 - Neuromuscular Blocking Agents
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C66886 - Nicotinic Antagonist
Cisatracurium besylate (51W89) is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:3721
- KEGGdrug: D00759
- PubChem: 62886
- ChEMBL: CHEMBL1200641
- CAS: 96946-42-8
- medchemexpress: HY-13596
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Ju-Tae Sohn. Malignant Hyperthermia and Cisatracurium During Severe SARS-CoV-2 Infection.
American journal of therapeutics.
2022 Jul; 29(4):490-492. doi:
10.1097/mjt.0000000000001453. [PMID: 35802921] - Ashraf A Dahaba, Zhaoyang Xiao, Xiaoling Zhu, Karl Oettl, Hailong Dong, Lize Xiong, Sieglinde Zelzer, Shuiyu Zhao, Gilbert Reibnegger. Location matters: Overlooked ethnic-geographic effect in China and Austria on propofol/cisatracurium sex differences among a population pharmacokinetic/pharmacodynamic (PopPK/PD) covariate analysis in men, women, and one transgender subject.
Fundamental & clinical pharmacology.
2022 Feb; 36(1):182-198. doi:
10.1111/fcp.12704. [PMID: 34050969] - Panadda Panusitthikorn, Chuthamanee Suthisisang, Viratch Tangsujaritvijit, Wichit Nosoongnoen, Pitchaya Dilokpattanamongkol. Pharmacokinetics and pharmacodynamics studies of a loading dose of cisatracurium in critically ill patients with respiratory failure.
BMC anesthesiology.
2022 01; 22(1):32. doi:
10.1186/s12871-022-01571-2. [PMID: 35065599] - Ling Ai, Yan Fang. General anesthesia with cisatracurium and sevoflurane for a patient with primary carnitine deficiency receiving L-carnitine therapy: A case report.
Medicine.
2021 Sep; 100(38):e27333. doi:
10.1097/md.0000000000027333. [PMID: 34559155] - Swaminathan P Sathyanarayanan, Muhammad Hamza, Khizar Hamid, Dayna Groskreutz. Cisatracurium-Associated Malignant Hyperthermia During Severe Sars-CoV-2 Infection.
American journal of therapeutics.
2021 08; 28(5):e590-e591. doi:
10.1097/mjt.0000000000001437. [PMID: 34387563] - Alison Merkel, Kyle Massey, Cassandra Bellamy, Todd Miano, Barry Fuchs, Christina Candeloro. Predictors of Cisatracurium Continuous Infusion Dose in Acute Respiratory Distress Syndrome.
Journal of pharmacy practice.
2021 Aug; 34(4):600-605. doi:
10.1177/0897190019888103. [PMID: 31736402] - Maria Vargas, Pasquale Buonanno, Andrea Sica, Emanuele Sabatella, Francesco P D'Alessio, Simone Alfieri, Carmine Iacovazzo, Rosa Carrano, Giuseppe Servillo. Effects of Sugammadex Plus Rocuronium vs Neostigmine Plus Cisatracurium During Renal Transplantation on Graft Function: A Retrospective, Case-Control Study.
Transplantation proceedings.
2021 Apr; 53(3):818-824. doi:
10.1016/j.transproceed.2020.09.012. [PMID: 33069485] - Igor Pedrosa Saffier, Rafael P Kayano. Sedation during mechanical ventilation of COVID-19 patients in intensive care units into operating rooms.
Brazilian journal of anesthesiology (Elsevier).
2021 Jan; 71(1):91-92. doi:
10.1016/j.bjane.2020.09.013. [PMID: 33518835] - Mona E El Sharkasy, M Walash, F Belal, M M Salim. Conventional and first derivative synchronous spectrofluorimetric methods for the simultaneous determination of cisatracurium and nalbuphine in biological fluids.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Mar; 228(?):117841. doi:
10.1016/j.saa.2019.117841. [PMID: 31784219] - Mona E El Sharkasy, M Walash, F Belal, M M Salim. First derivative synchronous spectrofluorimetric method for the simultaneous determination of propofol and cisatracurium besylate in biological fluids.
Luminescence : the journal of biological and chemical luminescence.
2020 Mar; 35(2):312-320. doi:
10.1002/bio.3729. [PMID: 31746124] - Xiaocong Huang, Lei Chen, Yujing Cai, Jinfeng Wei, Lina Lin, Jie Sun, Xuemei Peng, Sheng Wang. Abnormal cisatracurium pharmacodynamics and pharmacokinetics among patients with severe aortic regurgitation during anesthetic induction.
BMC anesthesiology.
2020 01; 20(1):21. doi:
10.1186/s12871-020-0935-z. [PMID: 31969113] - Magda M Ayad, F Belal, Mervet M Hosney, Heba Elmansi, Nora Elsayed. Simultaneous HPLC Determination of Cisatracurium and Propofol in Human Plasma via Fluorometric Detection.
Journal of chromatographic science.
2018 Jul; 56(6):524-530. doi:
10.1093/chromsci/bmy027. [PMID: 29635320] - Jianrong Guo, Xiaohong Yuan, Xiaofang Zhou, Xiaoju Jin. Pharmacokinetics and pharmacodynamics of cisatracurium in patients undergoing surgery with two hemodilution methods.
Journal of clinical anesthesia.
2017 May; 38(?):75-80. doi:
10.1016/j.jclinane.2017.01.013. [PMID: 28372687] - Jiayi Liu, Chunying Lu, Qirong Zou, Sheng Wang, Xuemei Peng. Altered pharmacodynamics and pharmacokinetics of cisatracurium in patients with severe mitral valve regurgitation during anaesthetic induction period.
British journal of clinical pharmacology.
2017 02; 83(2):363-369. doi:
10.1111/bcp.13121. [PMID: 27582302] - Jia-Yang Li, Qi-Rong Zou, Xue-Mei Peng. [Pharmacokinetics of a cisatracurium dose according to fat-free mass for anesthesia induction in morbidly obese patients].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2016 Oct; 36(10):1396-1400. doi:
NULL. [PMID: 27777205] - Vito Fanelli, Yasumasa Morita, Paola Cappello, Mirna Ghazarian, Bina Sugumar, Luisa Delsedime, Jane Batt, V Marco Ranieri, Haibo Zhang, Arthur S Slutsky. Neuromuscular Blocking Agent Cisatracurium Attenuates Lung Injury by Inhibition of Nicotinic Acetylcholine Receptor-α1.
Anesthesiology.
2016 Jan; 124(1):132-40. doi:
10.1097/aln.0000000000000907. [PMID: 26540149] - Friederike Haerter, Jeroen Cedric Peter Simons, Urs Foerster, Ingrid Moreno Duarte, Daniel Diaz-Gil, Shweta Ganapati, Katharina Eikermann-Haerter, Cenk Ayata, Ben Zhang, Manfred Blobner, Lyle Isaacs, Matthias Eikermann. Comparative Effectiveness of Calabadion and Sugammadex to Reverse Non-depolarizing Neuromuscular-blocking Agents.
Anesthesiology.
2015 Dec; 123(6):1337-49. doi:
10.1097/aln.0000000000000868. [PMID: 26418697] - T Szakmany, T Woodhouse. Use of cisatracurium in critical care: a review of the literature.
Minerva anestesiologica.
2015 Apr; 81(4):450-60. doi:
. [PMID: 24721895] - Jihong Jiang, Bin Yang, Guangwei Han, Meirong Yang, Shitong Li. Early administration of cisatracurium attenuates sepsis-induced diaphragm dysfunction in rats.
Inflammation.
2015 Feb; 38(1):305-11. doi:
10.1007/s10753-014-0034-8. [PMID: 25266883] - Jieying Gao, Ting Yang, Mao Ye, Xiaoqing Zhang, Gang Tian, Qianna Zhen, Min Ding. High-performance liquid chromatography assay with programmed flow elution for cisatracurium in human plasma: application to pharmacokinetics in infants and children.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Apr; 955-956(?):58-63. doi:
10.1016/j.jchromb.2014.02.023. [PMID: 24631811] - Ulrike Hoffmann, Martina Grosse-Sundrup, Katharina Eikermann-Haerter, Sebastina Zaremba, Cenk Ayata, Ben Zhang, Da Ma, Lyle Isaacs, Matthias Eikermann. Calabadion: A new agent to reverse the effects of benzylisoquinoline and steroidal neuromuscular-blocking agents.
Anesthesiology.
2013 Aug; 119(2):317-25. doi:
10.1097/aln.0b013e3182910213. [PMID: 23549405] - Michele Carron, Stefano Veronese, Walter Gomiero, Mirto Foletto, Donato Nitti, Carlo Ori, Ulderico Freo. Hemodynamic and hormonal stress responses to endotracheal tube and ProSeal Laryngeal Mask Airway™ for laparoscopic gastric banding.
Anesthesiology.
2012 Aug; 117(2):309-20. doi:
10.1097/aln.0b013ef31825b6a80. [PMID: 22614132] - Xin Liu, Peter S Kruger, Michael Weiss, Michael S Roberts. The pharmacokinetics and pharmacodynamics of cisatracurium in critically ill patients with severe sepsis.
British journal of clinical pharmacology.
2012 May; 73(5):741-9. doi:
10.1111/j.1365-2125.2011.04149.x. [PMID: 22114771] - Davinia Withington, Guillaume Ménard, France Varin. Cisatracurium pharmacokinetics and pharmacodynamics during hypothermic cardiopulmonary bypass in infants and children.
Paediatric anaesthesia.
2011 Mar; 21(3):341-6. doi:
10.1111/j.1460-9592.2010.03514.x. [PMID: 21223452] - Laurent Papazian, Jean-Marie Forel, Arnaud Gacouin, Christine Penot-Ragon, Gilles Perrin, Anderson Loundou, Samir Jaber, Jean-Michel Arnal, Didier Perez, Jean-Marie Seghboyan, Jean-Michel Constantin, Pierre Courant, Jean-Yves Lefrant, Claude Guérin, Gwenaël Prat, Sophie Morange, Antoine Roch. Neuromuscular blockers in early acute respiratory distress syndrome.
The New England journal of medicine.
2010 Sep; 363(12):1107-16. doi:
10.1056/nejmoa1005372. [PMID: 20843245] - Hong Wang, Ying Zhang, Shi-Tong Li. The effect of local anesthetics on the inhibition of adult muscle-type nicotinic acetylcholine receptors by nondepolarizing muscle relaxants.
European journal of pharmacology.
2010 Mar; 630(1-3):29-33. doi:
10.1016/j.ejphar.2009.12.028. [PMID: 20045405] - C Chen, N Yamaguchi, F Varin. Studies on the pharmacokinetics of cisatracurium in anesthetized dogs: in vitro-in vivo correlations.
Journal of veterinary pharmacology and therapeutics.
2009 Dec; 32(6):571-6. doi:
10.1111/j.1365-2885.2009.01078.x. [PMID: 20444012] - Man Liu, James P Dilger. Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptor.
Molecular pharmacology.
2009 Jan; 75(1):166-73. doi:
10.1124/mol.108.051060. [PMID: 18842832] - Elaine Campana Sanches Bornia, Erika Bando, Miguel Machinski, Monalisa Wolski Pereira, Wilson Alves-Do-Prado. Presynaptic M1, M2, and A1 receptors play roles in tetanic fade induced by pancuronium or cisatracurium.
Journal of anesthesia.
2009; 23(4):513-9. doi:
10.1007/s00540-009-0790-z. [PMID: 19921360] - C Chen, N Yamaguchi, F Varin. Dose-dependency of pharmacokinetic/pharmacodynamic parameters after intravenous bolus doses of cisatracurium.
British journal of anaesthesia.
2008 Dec; 101(6):788-97. doi:
10.1093/bja/aen308. [PMID: 18974056] - Karynn Imbeault, Davina E Withington, France Varin. Pharmacokinetics and pharmacodynamics of a 0.1 mg/kg dose of cisatracurium besylate in children during N2O/O2/propofol anesthesia.
Anesthesia and analgesia.
2006 Mar; 102(3):738-43. doi:
10.1213/01.ane.0000195342.29133.ce. [PMID: 16492821] - A Sánchez Palacios, M Ortiz Ponce, A Rodríguez Pérez, F Schamann Medina, J A García Marrero. Modification of mediators of immune reaction after general anaesthesia.
Allergologia et immunopathologia.
2004 Nov; 32(6):352-60. doi:
10.1016/s0301-0546(04)79268-x. [PMID: 15617663] - A K Karabulut, R Reisli, I I Uysal, J B Celik, T Ziylan. An investigation of non-depolarizing muscle relaxants on embryonic development in cultured rat embryos.
European journal of anaesthesiology.
2004 Sep; 21(9):715-24. doi:
10.1017/s0265021504009081. [PMID: 15595584] - Siriwan Jirasiritham, Kamthorn Tantivitayatan, Sopon Jirasiritham. A comparison of the efficacy of cisatracurium and atracurium in kidney transplantation operation.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2004 Jan; 87(1):73-9. doi:
. [PMID: 14971538] - Fabienne Tamion, Karine Hamelin, Annie Duflo, Christophe Girault, Jean-Christophe Richard, Guy Bonmarchand. Gastric emptying in mechanically ventilated critically ill patients: effect of neuromuscular blocking agent.
Intensive care medicine.
2003 Oct; 29(10):1717-22. doi:
10.1007/s00134-003-1898-5. [PMID: 12897996] - W J Fawcett, J P Stone. Recurarization in the recovery room following the use of magnesium sulphate.
British journal of anaesthesia.
2003 Sep; 91(3):435-8. doi:
10.1093/bja/aeg179. [PMID: 12925489] - P Carmona García, A Peleteiro Pensado, C Jiménez de La Fuente, S Gago Quiroga, M Zaballos García. [Anesthesia with propofol, remifentanil and cisatracurium in renal transplantation].
Revista espanola de anestesiologia y reanimacion.
2003 Aug; 50(7):356-9. doi:
NULL. [PMID: 14552108] - G Della Rocca, L Pompei, C Coccia, M G Costa, V Cecchini, V Vilardi, P Pietropaoli. Atracurium, cisatracurium, vecuronium and rocuronium in patients with renal failure.
Minerva anestesiologica.
2003 Jul; 69(7-8):605-11, 612, 5. doi:
NULL. [PMID: 14564242] - V Fodale, L B Santamaria. Laudanosine, an atracurium and cisatracurium metabolite.
European journal of anaesthesiology.
2002 Jul; 19(7):466-73. doi:
10.1017/s0265021502000777. [PMID: 12113608] - Salmaan Kanji, Jeffrey F Barletta, James J Janisse, James A Kruse, John W Devlin. Tachyphylaxis associated with continuous cisatracurium versus pancuronium therapy.
Pharmacotherapy.
2002 Jul; 22(7):823-30. doi:
10.1592/phco.22.11.823.33625. [PMID: 12126215] - G Dhonneur, C Cerf, F Lagneau, J Mantz, C Gillotin, P Duvaldestin. The pharmacokinetics of cisatracurium in patients with acute respiratory distress syndrome.
Anesthesia and analgesia.
2001 Aug; 93(2):400-4 , 3rd contents page. doi:
10.1097/00000539-200108000-00033. [PMID: 11473869] - F Sztark, O Cantini, C Bourdallé-Badie, P L Gardien, P Erny. [Recovery of neuromuscular block after continuous infusion of cisatracurium in patients with renal dysfunction].
Annales francaises d'anesthesie et de reanimation.
2001 May; 20(5):446-51. doi:
10.1016/s0750-7658(01)00394-x. [PMID: 11419239] - H J Sparr, T M Beaufort, T Fuchs-Buder. Newer neuromuscular blocking agents: how do they compare with established agents?.
Drugs.
2001; 61(7):919-42. doi:
10.2165/00003495-200161070-00003. [PMID: 11434449] - G Briassoulis, T Hatzis, P Mammi, A Alikatora. Persistent anaphylactic reaction after induction with thiopentone and cisatracurium.
Paediatric anaesthesia.
2000; 10(4):429-34. doi:
10.1046/j.1460-9592.2000.00527.x. [PMID: 10886702] - A A Dahaba, F von Klobucar, P H Rehak, W F List. Total intravenous anesthesia with remifentanil, propofol and cisatracurium in end-stage renal failure.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
1999 Jul; 46(7):696-700. doi:
10.1007/bf03013962. [PMID: 10442969] - D P Atherton, J M Hunter. Clinical pharmacokinetics of the newer neuromuscular blocking drugs.
Clinical pharmacokinetics.
1999 Mar; 36(3):169-89. doi:
10.2165/00003088-199936030-00001. [PMID: 10223167] - A Baraka, A Soueidi, C Berzina. Cisatracurium in a patient with atypical plasma cholinesterase.
British journal of anaesthesia.
1999 Feb; 82(2):301. doi:
10.1093/bja/82.2.301. [PMID: 10365019] - D F Kisor, V D Schmith. Clinical pharmacokinetics of cisatracurium besilate.
Clinical pharmacokinetics.
1999 Jan; 36(1):27-40. doi:
10.2165/00003088-199936010-00003. [PMID: 9989341] - T V Tran, P Fiset, F Varin. Pharmacokinetics and pharmacodynamics of cisatracurium after a short infusion in patients under propofol anesthesia.
Anesthesia and analgesia.
1998 Nov; 87(5):1158-63. doi:
10.1097/00000539-199811000-00034. [PMID: 9806701] - A W Doenicke, E Czeslick, J Moss, R Hoernecke. Onset time, endotracheal intubating conditions, and plasma histamine after cisatracurium and vecuronium administration.
Anesthesia and analgesia.
1998 Aug; 87(2):434-8. doi:
10.1097/00000539-199808000-00038. [PMID: 9706946] - J Soukup, E Czeslick, S Bunk, T Clausen, M Menzel, J Radke. [Cisatracurium in patients with compromised kidney function. Pharmacodynamic and intubation conditions under isoflurane-nitrous oxide anesthesia].
Der Anaesthesist.
1998 Aug; 47(8):669-76. doi:
10.1007/s001010050612. [PMID: 9770090] - J R Ortiz, J A Percaz, F Carrascosa. [Cisatracurium].
Revista espanola de anestesiologia y reanimacion.
1998 Jun; 45(6):242-7. doi:
. [PMID: 9719722] - S Muravchick. The effects of aging on anesthetic pharmacology.
Acta anaesthesiologica Belgica.
1998; 49(2):79-84. doi:
NULL. [PMID: 9675376] - J J Savarese, C A Lien, M R Belmont, W B Wastila. [The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and mivacurium].
Der Anaesthesist.
1997 Oct; 46(10):840-9. doi:
10.1007/s001010050477. [PMID: 9424966] - V D Schmith, J Fiedler-Kelly, L Phillips, T H Grasela. Dose proportionality of cisatracurium.
Journal of clinical pharmacology.
1997 Jul; 37(7):625-9. doi:
10.1002/j.1552-4604.1997.tb04345.x. [PMID: 9243356] - J Soukup, A Doenicke, R Hoernecke, J qass. [Cisatracurium--is the stereoisomer an "ideal" relaxant? Histamine liberation and tryptase determination after bolus administration of cistracurium: a comparison with vecuronium].
Der Anaesthesist.
1997 Jun; 46(6):486-91. doi:
10.1007/s001010050428. [PMID: 9297379] - A Doenicke, J Soukup, R Hoernecke, J Moss. The lack of histamine release with cisatracurium: a double-blind comparison with vecuronium.
Anesthesia and analgesia.
1997 Mar; 84(3):623-8. doi:
10.1097/00000539-199703000-00030. [PMID: 9052314] - V D Schmith, J Fiedler-Kelly, L Phillips, T H Grasela. Prospective use of population pharmacokinetics/pharmacodynamics in the development of cisatracurium.
Pharmaceutical research.
1997 Jan; 14(1):91-7. doi:
10.1023/a:1012015719694. [PMID: 9034227] - D F Kisor, V D Schmith, W A Wargin, C A Lien, E Ornstein, D R Cook. Importance of the organ-independent elimination of cisatracurium.
Anesthesia and analgesia.
1996 Nov; 83(5):1065-71. doi:
10.1097/00000539-199611000-00029. [PMID: 8895287] - J Y Lepage, J M Malinovsky, M Malinge, T Lechevalier, C Dupuch, A Cozian, M Pinaud, R Souron. Pharmacodynamic dose-response and safety study of cisatracurium (51W89) in adult surgical patients during N2O-O2-opioid anesthesia.
Anesthesia and analgesia.
1996 Oct; 83(4):823-9. doi:
10.1097/00000539-199610000-00030. [PMID: 8831329]