Bcamp (BioDeep_00000778082)
代谢物信息卡片
8-bromo-Cyclic AMP
化学式: C10H11BrN5O6P (406.963)
中文名称: 8-溴腺苷-3,5-环单磷酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C2C(C(C(O2)N3C4=NC=NC(=C4N=C3Br)N)O)OP(=O)(O1)O
InChI: InChI=1S/C10H11BrN5O6P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14)/t3-,5-,6-,9-/m1/s1
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:64211
- PubChem: 32014
- ChEMBL: CHEMBL1626177
- MeSH: 8-Bromo Cyclic Adenosine Monophosphate
- CAS: 23583-48-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Huijia Fu, Wang Tan, Zhi Chen, Zi Ye, Yuhan Duan, Jiayu Huang, Hongbo Qi, Xiru Liu. TOP2A deficit-induced abnormal decidualization leads to recurrent implantation failure via the NF-κB signaling pathway.
Reproductive biology and endocrinology : RB&E.
2022 Sep; 20(1):142. doi:
10.1186/s12958-022-01013-1. [PMID: 36138481] - Silvia Cristina Czuchlej, María Clara Volonteri, María Florencia Scaia, Nora Raquel Ceballos. Characterization of StAR protein of Rhinella arenarum (Amphibia, Anura).
General and comparative endocrinology.
2020 09; 295(?):113535. doi:
10.1016/j.ygcen.2020.113535. [PMID: 32535173] - Jordan J S VerPlank, Sudarsanareddy Lokireddy, Jinghui Zhao, Alfred L Goldberg. 26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America.
2019 03; 116(10):4228-4237. doi:
10.1073/pnas.1809254116. [PMID: 30782827] - John T Szilagyi, Gabriella M Composto-Wahler, Laurie B Joseph, Bingbing Wang, Todd Rosen, Jeffrey D Laskin, Lauren M Aleksunes. Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis.
Pharmacological research.
2019 03; 141(?):331-342. doi:
10.1016/j.phrs.2019.01.002. [PMID: 30610963] - Lauro González-Fernández, Beatriz Macías-García, Violeta Calle-Guisado, Luis Jesús García-Marín, María Julia Bragado. Calmodulin inhibitors increase the affinity of Merocyanine 540 for boar sperm membrane under non-capacitating conditions.
The Journal of reproduction and development.
2018 Oct; 64(5):445-449. doi:
10.1262/jrd.2018-021. [PMID: 29887540] - Rajakrishnan Veluthakal, Oleg G Chepurny, Colin A Leech, Frank Schwede, George G Holz, Debbie C Thurmond. Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets.
Diabetes.
2018 10; 67(10):1999-2011. doi:
10.2337/db17-1174. [PMID: 29986926] - Limin Su, Liying Liu, Yingli Jia, Lei Lei, Jiangfeng Liu, Shuai Zhu, Hong Zhou, Ruoyun Chen, Hua Ann Jenny Lu, Baoxue Yang. Ganoderma triterpenes retard renal cyst development by downregulating Ras/MAPK signaling and promoting cell differentiation.
Kidney international.
2017 12; 92(6):1404-1418. doi:
10.1016/j.kint.2017.04.013. [PMID: 28709639] - Xi Qiao, Lihua Wang, Yanhong Wang, Xiaole Su, Yue Qi, Yun Fan, Zhiqiang Peng. Intermedin inhibits unilateral ureteral obstruction-induced oxidative stress via NADPH oxidase Nox4 and cAMP-dependent mechanisms.
Renal failure.
2017 Nov; 39(1):652-659. doi:
10.1080/0886022x.2017.1361839. [PMID: 28805491] - Yu-Feng Song, Christer Hogstrand, Chuan-Chuan Wei, Kun Wu, Ya-Xiong Pan, Zhi Luo. Endoplasmic reticulum (ER) stress and cAMP/PKA pathway mediated Zn-induced hepatic lipolysis.
Environmental pollution (Barking, Essex : 1987).
2017 Sep; 228(?):256-264. doi:
10.1016/j.envpol.2017.05.046. [PMID: 28549333] - Guey-Shyang Hwang, Chih-Chieh Chen, Jou-Chun Chou, Ling-Ling Chang, Shu-Fen Kan, Wei-Ho Lai, Fu-Kong Lieu, Sindy Hu, Paulus S Wang, Shyi-Wu Wang. Stimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats.
Scientific reports.
2017 08; 7(1):9035. doi:
10.1038/s41598-017-07054-6. [PMID: 28831034] - Xiaojiaoyang Li, Zihang Yuan, Runping Liu, Hozeifa M Hassan, Hang Yang, Rong Sun, Luyong Zhang, Zhenzhou Jiang. UDCA and CDCA alleviate 17α-ethinylestradiol-induced cholestasis through PKA-AMPK pathways in rats.
Toxicology and applied pharmacology.
2016 Nov; 311(?):12-25. doi:
10.1016/j.taap.2016.10.011. [PMID: 27743861] - Cuicui Zhuang, Dawei Liu, Xu Yang, Haoran Wang, Lulu Han, Yanfei Li. The immunotoxicity of aluminum trichloride on rat peritoneal macrophages via β2-adrenoceptors/cAMP pathway acted by norepinephrine.
Chemosphere.
2016 Apr; 149(?):34-40. doi:
10.1016/j.chemosphere.2016.01.084. [PMID: 26844663] - Lee B Bockus, Kenneth M Humphries. cAMP-dependent Protein Kinase (PKA) Signaling Is Impaired in the Diabetic Heart.
The Journal of biological chemistry.
2015 Dec; 290(49):29250-8. doi:
10.1074/jbc.m115.681767. [PMID: 26468277] - Xinjun Cindy Zhu, Rafiquel Sarker, John R Horton, Molee Chakraborty, Tian-E Chen, C Ming Tse, Boyoung Cha, Mark Donowitz. Nonsynonymous single nucleotide polymorphisms of NHE3 differentially decrease NHE3 transporter activity.
American journal of physiology. Cell physiology.
2015 May; 308(9):C758-66. doi:
10.1152/ajpcell.00421.2014. [PMID: 25715704] - Hong-Jhih Jhuang, Wei-Hsiang Hsu, Kuan-Ting Lin, Shih-Lan Hsu, Feng-Sheng Wang, Chen-Kung Chou, Kuen-Haur Lee, Ann-Ping Tsou, Jin-Mei Lai, Sheau-Farn Yeh, Chi-Ying F Huang. Gluconeogenesis, lipogenesis, and HBV replication are commonly regulated by PGC-1α-dependent pathway.
Oncotarget.
2015 Apr; 6(10):7788-803. doi:
10.18632/oncotarget.3050. [PMID: 25762623] - Jing Wu, Di Tu, Li-Yun Yuan, Jin-e Yi, Yanan Tian. T-2 toxin regulates steroid hormone secretion of rat ovarian granulosa cells through cAMP-PKA pathway.
Toxicology letters.
2015 Feb; 232(3):573-9. doi:
10.1016/j.toxlet.2014.12.016. [PMID: 25542145] - Dong-Ha Lee, Hyuk-Woo Kwon, Hyun-Hong Kim, Deok Hwi Lim, Gi Suk Nam, Jung-Hae Shin, Yun-Yi Kim, Jong-Lae Kim, Jong-Jin Lee, Ho-Kyun Kwon, Hwa-Jin Park. Cordycepin-enriched WIB801C from Cordyceps militaris inhibits ADP-induced [Ca(2+)] i mobilization and fibrinogen binding via phosphorylation of IP 3R and VASP.
Archives of pharmacal research.
2015 Jan; 38(1):81-97. doi:
10.1007/s12272-014-0436-z. [PMID: 25001901] - Hua-Cheng Liu, Danyan Zhu, Chan Wang, Hongguo Guan, Senlin Li, Cong Hu, Zhichuan Chen, Yuanyuan Hu, Han Lin, Qing-Quan Lian, Ren-Shan Ge. Effects of Etomidate on the Steroidogenesis of Rat Immature Leydig Cells.
PloS one.
2015; 10(11):e0139311. doi:
10.1371/journal.pone.0139311. [PMID: 26555702] - Stefania Averaimo, Marta Gritti, Erica Barini, Laura Gasparini, Michele Mazzanti. CLIC1 functional expression is required for cAMP-induced neurite elongation in post-natal mouse retinal ganglion cells.
Journal of neurochemistry.
2014 Nov; 131(4):444-56. doi:
10.1111/jnc.12832. [PMID: 25060644] - Yasuyo Okada, Jyun-ichi Nishikawa, Masanori Semma, Atsushi Ichikawa. Role of lipid raft components and actin cytoskeleton in fibronectin-binding, surface expression, and de novo synthesis of integrin subunits in PGE2- or 8-Br-cAMP-stimulated mastocytoma P-815 cells.
Biochemical pharmacology.
2014 Apr; 88(3):364-71. doi:
10.1016/j.bcp.2014.01.039. [PMID: 24518258] - Anand Kumar, Lata Rani, Bodhana Dhole. Role of oxygen in the regulation of Leydig tumor derived MA-10 cell steroid production: the effect of cobalt chloride.
Systems biology in reproductive medicine.
2014 Apr; 60(2):112-8. doi:
10.3109/19396368.2013.861034. [PMID: 24328340] - Natalia Maria Ordoñez, Claudius Marondedze, Ludivine Thomas, Stefania Pasqualini, Lana Shabala, Sergey Shabala, Chris Gehring. Cyclic mononucleotides modulate potassium and calcium flux responses to H2O2 in Arabidopsis roots.
FEBS letters.
2014 Mar; 588(6):1008-15. doi:
10.1016/j.febslet.2014.01.062. [PMID: 24530500] - Biao Dong, Honglan Zhou, Conghui Han, Jufang Yao, Longmei Xu, Ming Zhang, Yaowen Fu, Qiang Xia. Ischemia/reperfusion-induced CHOP expression promotes apoptosis and impairs renal function recovery: the role of acidosis and GPR4.
PloS one.
2014; 9(10):e110944. doi:
10.1371/journal.pone.0110944. [PMID: 25343248] - Anita C A Dankers, Maarke J E Roelofs, Aldert H Piersma, Fred C G J Sweep, Frans G M Russel, Martin van den Berg, Majorie B M van Duursen, Rosalinde Masereeuw. Endocrine disruptors differentially target ATP-binding cassette transporters in the blood-testis barrier and affect Leydig cell testosterone secretion in vitro.
Toxicological sciences : an official journal of the Society of Toxicology.
2013 Dec; 136(2):382-91. doi:
10.1093/toxsci/kft198. [PMID: 24014645] - Ana Hurtado de Llera, David Martin-Hidalgo, Joan E Rodriguez-Gil, M Cruz Gil, Luis J Garcia-Marin, M Julia Bragado. AMP-activated kinase, AMPK, is involved in the maintenance of plasma membrane organization in boar spermatozoa.
Biochimica et biophysica acta.
2013 Sep; 1828(9):2143-51. doi:
10.1016/j.bbamem.2013.05.026. [PMID: 23747367] - Keiji Kuroda, Radha Venkatakrishnan, Madhuri S Salker, Emma S Lucas, Fozia Shaheen, Masako Kuroda, Andrew Blanks, Mark Christian, Siobhan Quenby, Jan J Brosens. Induction of 11β-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells.
Molecular endocrinology (Baltimore, Md.).
2013 Feb; 27(2):192-202. doi:
10.1210/me.2012-1247. [PMID: 23275455] - Corina Anders, Nick Ashton, Parisa Ranjzad, Mark R Dilworth, Adrian S Woolf. Ex vivo modeling of chemical synergy in prenatal kidney cystogenesis.
PloS one.
2013; 8(3):e57797. doi:
10.1371/journal.pone.0057797. [PMID: 23554868] - Jeffrey P Smith, Amy L Uhernik, Lun Li, Zejian Liu, Lester R Drewes. Regulation of Mct1 by cAMP-dependent internalization in rat brain endothelial cells.
Brain research.
2012 Oct; 1480(?):1-11. doi:
10.1016/j.brainres.2012.08.026. [PMID: 22925948] - Monika Thumova, Vladimir Pech, Otto Froehlich, Diana Agazatian, Xiaonan Wang, Jill W Verlander, Young Hee Kim, Susan M Wall. Pendrin protein abundance in the kidney is regulated by nitric oxide and cAMP.
American journal of physiology. Renal physiology.
2012 Sep; 303(6):F812-20. doi:
10.1152/ajprenal.00577.2011. [PMID: 22811483] - Shan Qin, Mary Taglienti, Lei Cai, Jing Zhou, Jordan A Kreidberg. c-Met and NF-κB-dependent overexpression of Wnt7a and -7b and Pax2 promotes cystogenesis in polycystic kidney disease.
Journal of the American Society of Nephrology : JASN.
2012 Aug; 23(8):1309-18. doi:
10.1681/asn.2011030277. [PMID: 22677559] - Chiara Ghezzi, Ernest M Wright. Regulation of the human Na+-dependent glucose cotransporter hSGLT2.
American journal of physiology. Cell physiology.
2012 Aug; 303(3):C348-54. doi:
10.1152/ajpcell.00115.2012. [PMID: 22673616] - Zhaopeng Du, Qingshang Yan, Laxiang Wan, Sheldon Weinbaum, Alan M Weinstein, Tong Wang. Regulation of glomerulotubular balance. I. Impact of dopamine on flow-dependent transport.
American journal of physiology. Renal physiology.
2012 Aug; 303(3):F386-95. doi:
10.1152/ajprenal.00531.2011. [PMID: 22552936] - Emilio P Mottillo, Ainsley E Bloch, Todd Leff, James G Granneman. Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
The Journal of biological chemistry.
2012 Jul; 287(30):25038-48. doi:
10.1074/jbc.m112.374041. [PMID: 22685301] - Yu Jin Lee, Mi Ok Kim, Jung Min Ryu, Ho Jae Han. Regulation of SGLT expression and localization through Epac/PKA-dependent caveolin-1 and F-actin activation in renal proximal tubule cells.
Biochimica et biophysica acta.
2012 Apr; 1823(4):971-82. doi:
10.1016/j.bbamcr.2011.12.011. [PMID: 22230192] - Caroline Vanparys, Tine L M Hectors, Ronny Blust, Wim De Coen. Mechanistic profiling of the cAMP-dependent steroidogenic pathway in the H295R endocrine disrupter screening system: new endpoints for toxicity testing.
Toxicology letters.
2012 Jan; 208(2):174-84. doi:
10.1016/j.toxlet.2011.10.014. [PMID: 22079614] - Nidhi Mahajan, Tarundeep Kaur, Veena Puri, S K Singla, Vivekanand Jha, Sanjeev Puri. Calcium ameliorates renal cyst growth in metanephric organ culture: a morphological study.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.
2012; 31(3):285-93. doi:
10.1615/jenvironpatholtoxicoloncol.v31.i3.90. [PMID: 23339702] - Christian Winter, Nicole B Kampik, Luca Vedovelli, Florina Rothenberger, Teodor G Paunescu, Paul A Stehberger, Dennis Brown, Hubert John, Carsten A Wagner. Aldosterone stimulates vacuolar H(+)-ATPase activity in renal acid-secretory intercalated cells mainly via a protein kinase C-dependent pathway.
American journal of physiology. Cell physiology.
2011 Nov; 301(5):C1251-61. doi:
10.1152/ajpcell.00076.2011. [PMID: 21832245] - Jee Yeon Lee, Joel Karwatsky, Loretta Ma, Xiaohui Zha. ABCA1 increases extracellular ATP to mediate cholesterol efflux to ApoA-I.
American journal of physiology. Cell physiology.
2011 Oct; 301(4):C886-94. doi:
10.1152/ajpcell.00042.2011. [PMID: 21697542] - Tae Sik Sung, Jae Pyo Jeon, Byung Joo Kim, Chansik Hong, Sung Young Kim, Jinsung Kim, Ju Hong Jeon, Hyun Jin Kim, Chang Kook Suh, Seon Jeong Kim, Insuk So. Molecular determinants of PKA-dependent inhibition of TRPC5 channel.
American journal of physiology. Cell physiology.
2011 Oct; 301(4):C823-32. doi:
10.1152/ajpcell.00351.2010. [PMID: 21734191] - Sushant Bhatnagar, Angie T Oler, Mary E Rabaglia, Donald S Stapleton, Kathryn L Schueler, Nathan A Truchan, Sara L Worzella, Jonathan P Stoehr, Susanne M Clee, Brian S Yandell, Mark P Keller, Debbie C Thurmond, Alan D Attie. Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion.
PLoS genetics.
2011 Oct; 7(10):e1002323. doi:
10.1371/journal.pgen.1002323. [PMID: 21998599] - Po-Ling Yu, Han-Wei Lin, Shyi-Wu Wang, Paulus S Wang. Effects of nonylphenol on the production of progesterone on the rats granulosa cells.
Journal of cellular biochemistry.
2011 Sep; 112(9):2627-36. doi:
10.1002/jcb.23189. [PMID: 21598305] - Yi-Chen Juan, Chia-Chuan Chang, Wei-Jern Tsai, Yun-Lian Lin, Yi-Shin Hsu, Hui-Kang Liu. Pharmacological evaluation of insulin mimetic novel suppressors of PEPCK gene transcription from Paeoniae Rubra Radix.
Journal of ethnopharmacology.
2011 Sep; 137(1):592-600. doi:
10.1016/j.jep.2011.06.007. [PMID: 21704145] - Xiaolu Tang, Xiaoyan Zhu, Shujuan Liu, Shan Wang, Xin Ni. Isoflavones suppress cyclic adenosine 3',5'-monophosphate regulatory element-mediated transcription in osteoblastic cell line.
The Journal of nutritional biochemistry.
2011 Sep; 22(9):865-73. doi:
10.1016/j.jnutbio.2010.07.011. [PMID: 21056929] - Navdeep Sandhu, Mathilakath M Vijayan. Cadmium-mediated disruption of cortisol biosynthesis involves suppression of corticosteroidogenic genes in rainbow trout.
Aquatic toxicology (Amsterdam, Netherlands).
2011 May; 103(1-2):92-100. doi:
10.1016/j.aquatox.2011.02.011. [PMID: 21396343] - Yukiko Enomoto, Seiji Adachi, Tomoaki Doi, Hideo Natsume, Kenji Kato, Rie Matsushima-Nishiwaki, Shigeru Akamatsu, Haruhiko Tokuda, Shinichi Yoshimura, Takanobu Otsuka, Shinji Ogura, Osamu Kozawa, Toru Iwama. cAMP regulates ADP-induced HSP27 phosphorylation in human platelets.
International journal of molecular medicine.
2011 May; 27(5):695-700. doi:
10.3892/ijmm.2011.637. [PMID: 21373747] - Y X Chen, M Allars, K Maiti, G L Angeli, C Abou-Seif, R Smith, R C Nicholson. Factors affecting cytotrophoblast cell viability and differentiation: Evidence of a link between syncytialisation and apoptosis.
The international journal of biochemistry & cell biology.
2011 May; 43(5):821-8. doi:
10.1016/j.biocel.2011.02.007. [PMID: 21352948] - Srijana Ranjit, Emilie Boutet, Pallavi Gandhi, Matthieu Prot, Yoshikazu Tamori, Anil Chawla, Andrew S Greenberg, Vishwajeet Puri, Michael P Czech. Regulation of fat specific protein 27 by isoproterenol and TNF-α to control lipolysis in murine adipocytes.
Journal of lipid research.
2011 Feb; 52(2):221-36. doi:
10.1194/jlr.m008771. [PMID: 21097823] - Y-C Juan, W-J Tsai, Y-L Lin, G-J Wang, J-J Cheng, H-Y Yang, C-Y Hsu, H-K Liu. The novel anti-hyperglycemic effect of Paeoniae radix via the transcriptional suppression of phosphoenopyruvate carboxykinase (PEPCK).
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2010 Jul; 17(8-9):626-34. doi:
10.1016/j.phymed.2009.12.007. [PMID: 20096551] - Julio C Amezcua-Romero, Omar Pantoja, Rosario Vera-Estrella. Ser123 is essential for the water channel activity of McPIP2;1 from Mesembryanthemum crystallinum.
The Journal of biological chemistry.
2010 May; 285(22):16739-47. doi:
10.1074/jbc.m109.053850. [PMID: 20332086] - Ravikrishna Ramanujam, Naweed I Naqvi. PdeH, a high-affinity cAMP phosphodiesterase, is a key regulator of asexual and pathogenic differentiation in Magnaporthe oryzae.
PLoS pathogens.
2010 May; 6(5):e1000897. doi:
10.1371/journal.ppat.1000897. [PMID: 20463817] - Hideo Natsume, Haruhiko Tokuda, Jun Mizutani, Seiji Adachi, Rie Matsushima-Nishiwaki, Chiho Minamitani, Kenji Kato, Osamu Kozawa, Takanobu Otsuka. Synergistic effect of vasoactive intestinal peptides on TNF-alpha-induced IL-6 synthesis in osteoblasts: amplification of p44/p42 MAP kinase activation.
International journal of molecular medicine.
2010 May; 25(5):813-7. doi:
10.3892/ijmm_00000409. [PMID: 20372827] - Yingqiu Liu, Dequan Zhou, Nada A Abumrad, Xiong Su. ADP-ribosylation factor 6 modulates adrenergic stimulated lipolysis in adipocytes.
American journal of physiology. Cell physiology.
2010 Apr; 298(4):C921-8. doi:
10.1152/ajpcell.00541.2009. [PMID: 20107045] - Teodor G Păunescu, Marija Ljubojevic, Leileata M Russo, Christian Winter, Margaret M McLaughlin, Carsten A Wagner, Sylvie Breton, Dennis Brown. cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells.
American journal of physiology. Renal physiology.
2010 Mar; 298(3):F643-54. doi:
10.1152/ajprenal.00584.2009. [PMID: 20053793] - Juan P Ianowski, Jean-Paul Paluzzi, Victoria A Te Brugge, Ian Orchard. The antidiuretic neurohormone RhoprCAPA-2 downregulates fluid transport across the anterior midgut in the blood-feeding insect Rhodnius prolixus.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 Mar; 298(3):R548-57. doi:
10.1152/ajpregu.00208.2009. [PMID: 20007522] - Qiong Xie, Shui-ping Zhao, Feng Li. D-4F, an apolipoprotein A-I mimetic peptide, promotes cholesterol efflux from macrophages via ATP-binding cassette transporter A1.
The Tohoku journal of experimental medicine.
2010 Mar; 220(3):223-8. doi:
10.1620/tjem.220.223. [PMID: 20208418] - Guey-Shyang Hwang, Szu-Tah Chen, Te-Jung Chen, Shyi-Wu Wang. Effects of hypoxia on testosterone release in rat Leydig cells.
American journal of physiology. Endocrinology and metabolism.
2009 Nov; 297(5):E1039-45. doi:
10.1152/ajpendo.00010.2009. [PMID: 19690072] - Po-Ling Yu, Hsu-Li Chao, Shyi-Wu Wang, Paulus S Wang. Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats.
Journal of cellular biochemistry.
2009 Oct; 108(2):469-75. doi:
10.1002/jcb.22276. [PMID: 19639602] - Megan O Nuwer, Kelly E Picchione, Arin Bhattacharjee. cAMP-dependent kinase does not modulate the Slack sodium-activated potassium channel.
Neuropharmacology.
2009 Sep; 57(3):219-26. doi:
10.1016/j.neuropharm.2009.06.006. [PMID: 19540251] - Long Xu, Ting-Lou, Nonghua Lv, Xuan Zhu, Youxiang Chen, Jing Yang. Emodin augments calcium activated chloride channel in colonic smooth muscle cells by Gi/Go protein.
European journal of pharmacology.
2009 Aug; 615(1-3):171-6. doi:
10.1016/j.ejphar.2009.04.045. [PMID: 19409890] - Xu-Feng Qi, Dong-Heui Kim, Yang-Suk Yoon, Jian-Hong Li, Soon-Bong Song, Dan Jin, Xue-Zhu Huang, Yung-Chien Teng, Kyu-Jae Lee. The adenylyl cyclase-cAMP system suppresses TARC/CCL17 and MDC/CCL22 production through p38 MAPK and NF-kappaB in HaCaT keratinocytes.
Molecular immunology.
2009 Jun; 46(10):1925-34. doi:
10.1016/j.molimm.2009.03.018. [PMID: 19371952] - W Fujimoto, T Miki, T Ogura, M Zhang, Y Seino, L S Satin, H Nakaya, S Seino. Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in mice.
Diabetologia.
2009 May; 52(5):863-72. doi:
10.1007/s00125-009-1306-y. [PMID: 19266181] - Gemma E Rooney, Linda Howard, Timothy O'Brien, Anthony J Windebank, Frank P Barry. Elevation of cAMP in mesenchymal stem cells transiently upregulates neural markers rather than inducing neural differentiation.
Stem cells and development.
2009 Apr; 18(3):387-98. doi:
10.1089/scd.2008.0080. [PMID: 18554089] - Zili Zhai, Avery Solco, Lankun Wu, Eve S Wurtele, Marian L Kohut, Patricia A Murphy, Joan E Cunnick. Echinacea increases arginase activity and has anti-inflammatory properties in RAW 264.7 macrophage cells, indicative of alternative macrophage activation.
Journal of ethnopharmacology.
2009 Feb; 122(1):76-85. doi:
10.1016/j.jep.2008.11.028. [PMID: 19111603] - Jennifer L Seifert, Sonyta Som, Dianna L Hynds. Differential activation of Rac1 and RhoA in neuroblastoma cell fractions.
Neuroscience letters.
2009 Jan; 450(2):176-80. doi:
10.1016/j.neulet.2008.11.025. [PMID: 19027829] - Shyi-Wu Wang, Guey-Shyang Hwang, Te-Jung Chen, Paulus S Wang. Effects of arecoline on testosterone release in rats.
American journal of physiology. Endocrinology and metabolism.
2008 Aug; 295(2):E497-504. doi:
10.1152/ajpendo.00045.2008. [PMID: 18559981] - Krishna Baksi, José J Tavárez-Pagán, Juan A Martínez, Dipak K Banerjee. Unique structural motif supports mannosylphospho dolichol synthase: an important angiogenesis regulator.
Current drug targets.
2008 Apr; 9(4):262-71. doi:
10.2174/138945008783954916. [PMID: 18393820] - V A Te Brugge, I Orchard. Distribution and activity of a Dippu DH31-like peptide in the large milkweed bug Oncopeltus fasciatus.
Peptides.
2008 Feb; 29(2):206-13. doi:
10.1016/j.peptides.2007.10.031. [PMID: 18206263] - Huda Ismail Abdullah, Paulina L Pedraza, John C McGiff, Nicholas R Ferreri. CaR activation increases TNF production by mTAL cells via a Gi-dependent mechanism.
American journal of physiology. Renal physiology.
2008 Feb; 294(2):F345-54. doi:
10.1152/ajprenal.00509.2006. [PMID: 18032544] - Iris Lorenzi, Arnold von Eckardstein, Clara Cavelier, Silvija Radosavljevic, Lucia Rohrer. Apolipoprotein A-I but not high-density lipoproteins are internalised by RAW macrophages: roles of ATP-binding cassette transporter A1 and scavenger receptor BI.
Journal of molecular medicine (Berlin, Germany).
2008 Feb; 86(2):171-83. doi:
10.1007/s00109-007-0267-1. [PMID: 17906976] - Stefan Lorkowski. The ins and outs of lipid efflux.
Journal of molecular medicine (Berlin, Germany).
2008 Feb; 86(2):129-34. doi:
10.1007/s00109-007-0293-z. [PMID: 18084736] - Wenchang Zhang, Haimei Jia. Effect and mechanism of cadmium on the progesterone synthesis of ovaries.
Toxicology.
2007 Oct; 239(3):204-12. doi:
10.1016/j.tox.2007.07.007. [PMID: 17719163] - Mark O Huising, Lieke M van der Aa, Juriaan R Metz, Aurélia de Fátima Mazon, B M Lidy Verburg-van Kemenade, Gert Flik. Corticotropin-releasing factor (CRF) and CRF-binding protein expression in and release from the head kidney of common carp: evolutionary conservation of the adrenal CRF system.
The Journal of endocrinology.
2007 Jun; 193(3):349-57. doi:
10.1677/joe-07-0070. [PMID: 17535873] - Li Cong, Ke Chen, Ji Li, Ping Gao, Qiang Li, Shuhua Mi, Xin Wu, Allan Z Zhao. Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes.
The Biochemical journal.
2007 May; 403(3):519-25. doi:
10.1042/bj20061478. [PMID: 17286556] - Paola Capuano, Desa Bacic, Marcel Roos, Serge M Gisler, Gerti Stange, Jürg Biber, Brigitte Kaissling, Edward J Weinman, Shirish Shenolikar, Carsten A Wagner, Heini Murer. Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice.
American journal of physiology. Cell physiology.
2007 Feb; 292(2):C927-34. doi:
10.1152/ajpcell.00126.2006. [PMID: 16987995] - Yong-Fu Xiao. Cyclic AMP-dependent modulation of cardiac L-type Ca2+ and transient outward K+ channel activities by epoxyeicosatrienoic acids.
Prostaglandins & other lipid mediators.
2007 Jan; 82(1-4):11-8. doi:
10.1016/j.prostaglandins.2006.05.023. [PMID: 17164128] - Naonobu Nishino, Yoshikazu Tamori, Masato Kasuga. Insulin efficiently stores triglycerides in adipocytes by inhibiting lipolysis and repressing PGC-1alpha induction.
The Kobe journal of medical sciences.
2007; 53(3):99-106. doi:
NULL. [PMID: 17684441] - Dennis K Y Yeung, Susan W S Leung, Yan Chun Xu, Paul M Vanhoutte, Ricky Y K Man. Puerarin, an isoflavonoid derived from Radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery.
European journal of pharmacology.
2006 Dec; 552(1-3):105-11. doi:
10.1016/j.ejphar.2006.08.078. [PMID: 17027964] - Brenda S Magenheimer, Patricia L St John, Kathryn S Isom, Dale R Abrahamson, Robert C De Lisle, Darren P Wallace, Robin L Maser, Jared J Grantham, James P Calvet. Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na(+),K(+),2Cl(-) Co-transporter-dependent cystic dilation.
Journal of the American Society of Nephrology : JASN.
2006 Dec; 17(12):3424-37. doi:
10.1681/asn.2006030295. [PMID: 17108316] - Dhvanit I Shah, Manjeet Singh. Possible role of exogenous cAMP to improve vascular endothelial dysfunction in hypertensive rats.
Fundamental & clinical pharmacology.
2006 Dec; 20(6):595-604. doi:
10.1111/j.1472-8206.2006.00449.x. [PMID: 17109653] - Chi-Chuan Yu, Pi-Hsueh S Li. In vivo inhibition of steroidogenic acute regulatory protein expression by dexamethasone parallels induction of the negative transcription factor DAX-1.
Endocrine.
2006 Dec; 30(3):313-23. doi:
10.1007/s12020-006-0010-7. [PMID: 17526944] - Ling-Ling Chang, Alfred Wan-Song Wun, Chien-Te Hung, Shih-Min Hsia, Wenchang Chiang, Paulus S Wang. Effects of crude adlay hull acetone extract on corticosterone release from rat zona fasciculata-reticularis cells.
Naunyn-Schmiedeberg's archives of pharmacology.
2006 Nov; 374(2):141-52. doi:
10.1007/s00210-006-0094-x. [PMID: 17019563] - Otto Fröhlich, Janet D Klein, Pauline M Smith, Jeff M Sands, Robert B Gunn. Regulation of UT-A1-mediated transepithelial urea flux in MDCK cells.
American journal of physiology. Cell physiology.
2006 Oct; 291(4):C600-6. doi:
10.1152/ajpcell.00413.2005. [PMID: 16641165] - Keikantse Matlhagela, Mary Taub. Regulation of the Na-K-ATPase beta(1)-subunit promoter by multiple prostaglandin-responsive elements.
American journal of physiology. Renal physiology.
2006 Sep; 291(3):F635-46. doi:
10.1152/ajprenal.00452.2005. [PMID: 16478973] - Elizabeth A Potter, Gavin Stewart, Craig P Smith. Urea flux across MDCK-mUT-A2 monolayers is acutely sensitive to AVP, cAMP, and [Ca2+]i.
American journal of physiology. Renal physiology.
2006 Jul; 291(1):F122-8. doi:
10.1152/ajprenal.00423.2005. [PMID: 16449356] - Dhvanit I Shah, Manjeet Singh. Activation of protein kinase A improves vascular endothelial dysfunction.
Endothelium : journal of endothelial cell research.
2006 Jul; 13(4):267-77. doi:
10.1080/10623320600904047. [PMID: 16990183] - Brenda Gonzalez, Francisco Paz, Leonor Florán, Jorge Aceves, David Erlij, Benjamín Florán. Adenosine A2A receptor stimulation decreases GAT-1-mediated GABA uptake in the globus pallidus of the rat.
Neuropharmacology.
2006 Jul; 51(1):154-9. doi:
10.1016/j.neuropharm.2006.03.011. [PMID: 16730753] - Maryanne Borsick, Trivikram Rajkhowa, Mary Taub. Evidence for post-transcriptional regulation of Na,K-ATPase by prostaglandin E1.
Biochemical and biophysical research communications.
2006 Jun; 345(2):739-45. doi:
10.1016/j.bbrc.2006.04.158. [PMID: 16701566] - Kelly C Wade, Susan H Guttentag, Linda W Gonzales, Kathryn L Maschhoff, John Gonzales, Venkatadri Kolla, Sunil Singhal, Philip L Ballard. Gene induction during differentiation of human pulmonary type II cells in vitro.
American journal of respiratory cell and molecular biology.
2006 Jun; 34(6):727-37. doi:
10.1165/rcmb.2004-0389oc. [PMID: 16474099] - Anthony D Postle, Linda W Gonzales, Wolfgang Bernhard, Graeme T Clark, Marye H Godinez, Rodolfo I Godinez, Philip L Ballard. Lipidomics of cellular and secreted phospholipids from differentiated human fetal type II alveolar epithelial cells.
Journal of lipid research.
2006 Jun; 47(6):1322-31. doi:
10.1194/jlr.m600054-jlr200. [PMID: 16513897] - Marina Gegelashvili, Anna Rodriguez-Kern, Iryna Pirozhkova, Jian Zhang, Luther Sung, Georgi Gegelashvili. High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes.
Neurochemistry international.
2006 May; 48(6-7):611-5. doi:
10.1016/j.neuint.2005.12.033. [PMID: 16516348] - Gert-Jan Botma, Delfina Vieira, Mirjam Heuveling, Hans Jansen, Adrie J M Verhoeven. Transient induction of a variant hepatic lipase messenger RNA by corticotropic hormone in rat adrenals.
Metabolism: clinical and experimental.
2006 Apr; 55(4):467-77. doi:
10.1016/j.metabol.2005.10.008. [PMID: 16546477] - J Kang, P Chapdelaine, P Y Laberge, M A Fortier. Functional characterization of prostaglandin transporter and terminal prostaglandin synthases during decidualization of human endometrial stromal cells.
Human reproduction (Oxford, England).
2006 Mar; 21(3):592-9. doi:
10.1093/humrep/dei400. [PMID: 16339169] - Cheorl-Ho Kim, Byung-Soo Koo, Kyeong-Ok Kim, June-Ki Kim, Young-Chae Chang, In-Seon Lee. Salviae miltiorrhizae radix increases dopamine release of rat and pheochromocytoma PC12 cells.
Phytotherapy research : PTR.
2006 Mar; 20(3):191-9. doi:
10.1002/ptr.1833. [PMID: 16521109] - Erik G Lund, Laurence B Peterson, Alan D Adams, My-Hanh N Lam, Charlotte A Burton, Jayne Chin, Qiu Guo, Shaei Huang, Melanie Latham, Jacqueline C Lopez, John G Menke, Denise P Milot, Lyndon J Mitnaul, Sandra E Rex-Rabe, Raymond L Rosa, Jenny Y Tian, Samuel D Wright, Carl P Sparrow. Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype.
Biochemical pharmacology.
2006 Feb; 71(4):453-63. doi:
10.1016/j.bcp.2005.11.004. [PMID: 16325781] - Ming-Jae Lo, Mei-Mei Kau, Paulus S Wang. Effect of aging on corticosterone secretion in diestrous rats.
Journal of cellular biochemistry.
2006 Feb; 97(2):351-8. doi:
10.1002/jcb.20576. [PMID: 16187308] - J B Thomas, K M Gilmour. The impact of social status on the erythrocyte beta-adrenergic response in rainbow trout, Oncorhynchus mykiss.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2006 Feb; 143(2):162-72. doi:
10.1016/j.cbpa.2005.11.008. [PMID: 16403476] - Kwang-Hoon Song, John Y L Chiang. Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis.
Hepatology (Baltimore, Md.).
2006 Jan; 43(1):117-25. doi:
10.1002/hep.20919. [PMID: 16323215] - Geoffrey M Coast, Christopher S Garside, Simon G Webster, Kathleen M Schegg, David A Schooley. Mosquito natriuretic peptide identified as a calcitonin-like diuretic hormone in Anopheles gambiae (Giles).
The Journal of experimental biology.
2005 Sep; 208(Pt 17):3281-91. doi:
10.1242/jeb.01760. [PMID: 16109890] - Leonard A Sauer, Robert T Dauchy, David E Blask, Jean A Krause, Leslie K Davidson, Erin M Dauchy. Eicosapentaenoic acid suppresses cell proliferation in MCF-7 human breast cancer xenografts in nude rats via a pertussis toxin-sensitive signal transduction pathway.
The Journal of nutrition.
2005 Sep; 135(9):2124-9. doi:
10.1093/jn/135.9.2124. [PMID: 16140887]
