Cerivastatin sodium (BioDeep_00000777712)

   


代谢物信息卡片


Cerivastatin sodium

化学式: C26H33FNNaO5 (481.2240340000001)
中文名称: 头孢伐他汀钠
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C1=C(C(=C(C(=N1)C(C)C)COC)C2=CC=C(C=C2)F)C=CC(CC(CC(=O)[O-])O)O.[Na+]
InChI: /q

描述信息

D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D004791 - Enzyme Inhibitors > D019161 - Hydroxymethylglutaryl-CoA Reductase Inhibitors
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
C471 - Enzyme Inhibitor > C1655 - HMG-CoA Reductase Inhibitor
D009676 - Noxae > D000963 - Antimetabolites
Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect[1][2].

同义名列表

2 个代谢物同义名

Cerivastatin sodium; Cerivastatin (sodium)



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

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Plant Reactome(0)

INOH(0)

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COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Sarah A Long, Shan Huang, Anusha Kambala, Ling Ren, Jennifer Wilson, Michael Goetz, Xiaojiang Hao, Xiaosheng Yang, Ekaterina I Goncharova, Libin Jia, Amy LeBlanc, Chand Khanna, Curtis J Henrich, John A Beutler. Identification of potential modulators of osteosarcoma metastasis by high-throughput cellular screening of natural products. Chemical biology & drug design. 2021 01; 97(1):77-86. doi: 10.1111/cbdd.13762. [PMID: 32666679]
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  • Yan Wang, Jun Zhang, Yanrong Ma, Xiangxin Song, Suli Li, Xianqin Zhan, Lan Wu. Different lipid profiles, insulin sensitivity, and insulin resistance among Han, Uygur, and Kazak men with normal glucose tolerance in Xinjiang, China. Lipids in health and disease. 2018 Sep; 17(1):209. doi: 10.1186/s12944-018-0863-9. [PMID: 30193578]
  • Akiko Matsubara, Shingo Oda, Sho Akai, Koichi Tsuneyama, Tsuyoshi Yokoi. Establishment of a drug-induced rhabdomyolysis mouse model by co-administration of ciprofloxacin and atorvastatin. Toxicology letters. 2018 Jul; 291(?):184-193. doi: 10.1016/j.toxlet.2018.04.016. [PMID: 29679711]
  • Hisakuni Obayashi, Naoko Kobayashi, Yoshikazu Nezu, Takashi Yamoto, Mitsuyuki Shirai, Fumitoshi Asai. Plasma 2-hydroxyglutarate, a promising prognostic biomarker candidate for skeletal muscle injury in Fischer 344 rats. The Journal of toxicological sciences. 2018; 43(10):601-610. doi: 10.2131/jts.43.601. [PMID: 30298848]
  • Hisakuni Obayashi, Naoko Kobayashi, Yoshikazu Nezu, Takashi Yamoto, Mitsuyuki Shirai, Fumitoshi Asai. Plasma 2-hydroxyglutarate and hexanoylcarnitine levels are potential biomarkers for skeletal muscle toxicity in male Fischer 344 rats. The Journal of toxicological sciences. 2017; 42(4):385-396. doi: 10.2131/jts.42.385. [PMID: 28717097]
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  • K M Burgazli, K L Bui, M Mericliler, A T Albayrak, M Parahuleva, A Erdogan. The effects of different types of statins on proliferation and migration of HGF-induced Human Umbilical Vein Endothelial Cells (HUVECs). European review for medical and pharmacological sciences. 2013 Nov; 17(21):2874-83. doi: . [PMID: 24254555]
  • Mark J Cziraky, Vincent J Willey, James M McKenney, Siddhesh A Kamat, Maxine D Fisher, John R Guyton, Terry A Jacobson, Michael H Davidson. Risk of hospitalized rhabdomyolysis associated with lipid-lowering drugs in a real-world clinical setting. Journal of clinical lipidology. 2013 Mar; 7(2):102-8. doi: 10.1016/j.jacl.2012.06.006. [PMID: 23415428]
  • Alejandro Álvarez-Prats, Octavio Hernández-Perera, Pilar Díaz-Herrera, Álvaro C Ucero, Aránzazu Anabitarte-Prieto, Antonio Losada-Cabrera, Alberto Ortiz, José C Rodríguez-Pérez. Combination therapy with an angiotensin II receptor blocker and an HMG-CoA reductase inhibitor in experimental subtotal nephrectomy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 Jul; 27(7):2720-33. doi: 10.1093/ndt/gfr671. [PMID: 22302208]
  • Masaki Kobayashi, Kazuhiro Hidaka, Ikumi Chisaki, Natsuko Takahashi, Jiro Ogura, Shirou Itagaki, Takeshi Hirano, Hiroaki Yamaguchi, Ken Iseki. [Effects of acidification and alkalinization agents on statins-induced muscle toxicity]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2012; 132(5):609-15. doi: 10.1248/yakushi.132.609. [PMID: 22687697]
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  • Nelly Aranibar, Jeffrey D Vassallo, John Rathmacher, Steve Stryker, Yingru Zhang, Jun Dai, Evan B Janovitz, Don Robertson, Michael Reily, Linda Lowe-Krentz, Lois Lehman-McKeeman. Identification of 1- and 3-methylhistidine as biomarkers of skeletal muscle toxicity by nuclear magnetic resonance-based metabolic profiling. Analytical biochemistry. 2011 Mar; 410(1):84-91. doi: 10.1016/j.ab.2010.11.023. [PMID: 21094120]
  • Jeffrey D Vassallo, Evan B Janovitz, Debra M Wescott, Chris Chadwick, Linda J Lowe-Krentz, Lois D Lehman-McKeeman. Biomarkers of drug-induced skeletal muscle injury in the rat: troponin I and myoglobin. Toxicological sciences : an official journal of the Society of Toxicology. 2009 Oct; 111(2):402-12. doi: 10.1093/toxsci/kfp166. [PMID: 19628585]
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  • Louise A Donnelly, Colin N A Palmer, Adrian L Whitley, Chim Choy Lang, Alex S F Doney, Andrew D Morris, Peter T Donnan. Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study. Pharmacogenetics and genomics. 2008 Apr; 18(4):279-87. doi: 10.1097/fpc.0b013e3282f60aad. [PMID: 18334912]
  • Chelsie Estey, Xi Chen, Thomas W Moon. 3-Hydroxy-3-methylglutaryl coenzyme A reductase in rainbow trout: effects of fasting and statin drugs on activities and mRNA transcripts. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2008 Apr; 147(3):386-98. doi: 10.1016/j.cbpc.2008.01.008. [PMID: 18280795]
  • Tomoyuki Nishimoto, Eiichiro Ishikawa, Hisashi Anayama, Hitomi Hamajyo, Hirofumi Nagai, Masao Hirakata, Ryuichi Tozawa. Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs. Toxicology and applied pharmacology. 2007 Aug; 223(1):39-45. doi: 10.1016/j.taap.2007.05.005. [PMID: 17599378]
  • H Scharnagl, T Stojakovic, K Winkler, S Rosinger, W März, B O Boehm. The HMG-CoA reductase inhibitor cerivastatin lowers advanced glycation end products in patients with type 2 diabetes. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2007 Jun; 115(6):372-5. doi: 10.1055/s-2007-973830. [PMID: 17701882]
  • F E Cohen-Boulakia, K Tarhzaoui, P E Valensi, R A Lestrade, J P Albertini, A Behar. Effect of cerivastatin on peripheral capillary permeability to albumin and peripheral nerve function in diabetic rats. Diabetes & metabolism. 2007 Jun; 33(3):189-96. doi: 10.1016/j.diabet.2006.11.012. [PMID: 17379559]
  • Faikah Gueler, Joon-Keun Park, Song Rong, Torsten Kirsch, Carsten Lindschau, Wen Zheng, Marlies Elger, Anette Fiebeler, Danilo Fliser, Friedrich C Luft, Hermann Haller. Statins attenuate ischemia-reperfusion injury by inducing heme oxygenase-1 in infiltrating macrophages. The American journal of pathology. 2007 Apr; 170(4):1192-9. doi: 10.2353/ajpath.2007.060782. [PMID: 17392159]
  • Gerd Schmitz, Anna Schmitz-Madry, Peter Ugocsai. Pharmacogenetics and pharmacogenomics of cholesterol-lowering therapy. Current opinion in lipidology. 2007 Apr; 18(2):164-73. doi: 10.1097/mol.0b013e3280555083. [PMID: 17353665]
  • Marie-Louise Koepke, Manfred Weber, Eckhard Schulze-Lohoff, Bogdan Beirowski, Stephan Segerer, Oliver Gross. Nephroprotective effect of the HMG-CoA-reductase inhibitor cerivastatin in a mouse model of progressive renal fibrosis in Alport syndrome. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2007 Apr; 22(4):1062-9. doi: 10.1093/ndt/gfl810. [PMID: 17287218]
  • Barbara J Meyer, Tone Hammervold, Arild Chr Rustan, Peter R C Howe. Dose-dependent effects of docosahexaenoic acid supplementation on blood lipids in statin-treated hyperlipidaemic subjects. Lipids. 2007 Mar; 42(2):109-15. doi: 10.1007/s11745-006-3014-4. [PMID: 17393216]
  • Atsushi Takagi, Yukio Tsurumi, Naoko Ishizuka, Hisako Omori, Kotaro Arai, Nobuhisa Hagiwara, Hiroshi Kasanuki. Single administration of cerivastatin, an HMG-CoA reductase inhibitor, improves the coronary flow velocity reserve: a transthoracic Doppler echocardiography study. Heart and vessels. 2006 Sep; 21(5):298-301. doi: 10.1007/s00380-006-0905-5. [PMID: 17151817]
  • Masaki Kobayashi, Yukio Otsuka, Shirou Itagaki, Takeshi Hirano, Ken Iseki. Inhibitory effects of statins on human monocarboxylate transporter 4. International journal of pharmaceutics. 2006 Jul; 317(1):19-25. doi: 10.1016/j.ijpharm.2006.02.043. [PMID: 16621368]
  • Masato Eto, Lisa Rathgeb, Francesco Cosentino, Toshiyuki Kozai, Thomas F Lüscher. Statins blunt thrombin-induced down-regulation of endothelial nitric oxide synthase expression in human endothelial cells. Journal of cardiovascular pharmacology. 2006 May; 47(5):663-7. doi: 10.1097/01.fjc.0000211754.54691.f3. [PMID: 16775505]
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  • Jennifer L Seachrist, Cho-Ming Loi, Mark G Evans, Kay A Criswell, Charles E Rothwell. Roles of exercise and pharmacokinetics in cerivastatin-induced skeletal muscle toxicity. Toxicological sciences : an official journal of the Society of Toxicology. 2005 Dec; 88(2):551-61. doi: 10.1093/toxsci/kfi305. [PMID: 16141437]
  • J A Paniagua, J López-Miranda, P Pérez-Martínez, C Marín, J M Vida, F Fuentes, R A Fernández de la Puebla, F Pérez-Jiménez. Oxidized-LDL levels are changed during short-term serum glucose variations and lowered with statin treatment in early Type 2 diabetes: a study of endothelial function and microalbuminuria. Diabetic medicine : a journal of the British Diabetic Association. 2005 Dec; 22(12):1647-56. doi: 10.1111/j.1464-5491.2005.01703.x. [PMID: 16401307]
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  • Birgit Jaschke, Cornelia Michaelis, Stefan Milz, Michael Vogeser, Thomas Mund, Ludger Hengst, Adnan Kastrati, Albert Schömig, Rainer Wessely. Local statin therapy differentially interferes with smooth muscle and endothelial cell proliferation and reduces neointima on a drug-eluting stent platform. Cardiovascular research. 2005 Dec; 68(3):483-92. doi: 10.1016/j.cardiores.2005.06.029. [PMID: 16111664]
  • Timothy E Johnson, Xiaohua Zhang, Shu Shi, Diane R Umbenhauer. Statins and PPARalpha agonists induce myotoxicity in differentiated rat skeletal muscle cultures but do not exhibit synergy with co-treatment. Toxicology and applied pharmacology. 2005 Nov; 208(3):210-21. doi: 10.1016/j.taap.2005.03.004. [PMID: 16239165]
  • J-M Corpataux, J Naik, K E Porter, N J M London. The effect of six different statins on the proliferation, migration, and invasion of human smooth muscle cells. The Journal of surgical research. 2005 Nov; 129(1):52-6. doi: 10.1016/j.jss.2005.05.016. [PMID: 16087194]
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  • Yoshihisa Shitara, Masaru Hirano, Hitoshi Sato, Yuichi Sugiyama. Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. The Journal of pharmacology and experimental therapeutics. 2004 Oct; 311(1):228-36. doi: 10.1124/jpet.104.068536. [PMID: 15194707]
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