Pemirolast potassium (BioDeep_00000777699)

   


代谢物信息卡片


Pemirolast potassium

化学式: C10H7KN6O (266.0318392)
中文名称: 吡嘧司特钾
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC=CN2C1=NC=C(C2=O)C3=NN=N[N-]3.[K+]
InChI: +1

描述信息

C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C29714 - Mast Cell Stabilizer
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
Pemirolast potassium (TWT-8152) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. Target: Histamine H1 Receptor Pemirolast potassium (TWT-8152) is a new oral, nonbronchodilator antiallergy medication that is being evaluated for the therapy of asthma [1]. Pemirolast potassium (TWT-8152) inhibits chemical mediator release from tissue mast cells and is also shown to inhibit the release of peptides including substance P, Pemirolast potassium (TWT-8152) reduces kaolin intake by inhibition of substance P release in rats [2]. Pemirolast potassium (TWT-8152) potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats [3]. Pemirolast potassium (TWT-8152) potassium is used for the treatment of allergic conjunctivitis and prophylaxis for pulmonary hypersensitivity reactions to drugs such as paclitaxel [4].

同义名列表

4 个代谢物同义名

Pemirolast potassium; TWT-8152; BMY 26517; Pemirolast (potassium)



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文献列表

  • Tomohito Gohda, Chisei Ra, Chieko Hamada, Toshinao Tsuge, Hiroshi Kawachi, Yasuhiko Tomino. Suppressive activity of pemirolast potassium, an antiallergic drug, on glomerulonephritis. Studies in glomerulonephritis model rats and in patients with chronic glomerulonephritis concurrently affected by allergic rhinitis. Arzneimittel-Forschung. 2008; 58(1):18-23. doi: 10.1055/s-0031-1296461. [PMID: 18368946]
  • Hideaki Yahata, Mami Saito, Toshiaki Sendo, Yoshinori Itoh, Mayako Uchida, Toshio Hirakawa, Hitoo Nakano, Ryozo Oishi. Prophylactic effect of pemirolast, an antiallergic agent, against hypersensitivity reactions to paclitaxel in patients with ovarian cancer. International journal of cancer. 2006 May; 118(10):2636-8. doi: 10.1002/ijc.21680. [PMID: 16353140]
  • Mayumi Kunitomo, Hirokuni Otsuka. Comparison of antigen-induced leukotriene and histamine release from nasal scrapings in allergic rhinitis. Rhinology. 2005 Sep; 43(3):199-204. doi: NULL. [PMID: 16218513]
  • Yoshinori Itoh, Toshiaki Sendo, Toshio Hirakawa, Shinya Takasaki, Takeshi Goromaru, Hitoo Nakano, Ryozo Oishi. Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats. Neuropharmacology. 2004 May; 46(6):888-94. doi: 10.1016/j.neuropharm.2003.11.018. [PMID: 15033348]
  • T Hasegawa, K Takagi, M Nadai, Y Ogura, T Nabeshima. Kinetic interaction between theophylline and a newly developed anti-allergic drug, pemirolast potassium. European journal of clinical pharmacology. 1994; 46(1):55-8. doi: 10.1007/bf00195916. [PMID: 8005187]
  • Y Yanagihara, H Kasai, S Matsui, K Ninomiya. Immunopharmacological studies on TBX, a new antiallergic drug (3). Inhibitory effects on histamine release from lung fragments and bronchoconstriction in guinea pigs. Japanese journal of pharmacology. 1989 Sep; 51(1):83-92. doi: 10.1254/jjp.51.83. [PMID: 2478743]
  • H Cheng, K A Pittman, K A Dandekar. Liquid chromatographic determination of 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one in human plasma with fluorescence detection. Journal of pharmaceutical sciences. 1987 Dec; 76(12):918-9. doi: 10.1002/jps.2600761216. [PMID: 2894450]