Clomipramine HCl (BioDeep_00000776701)
代谢物信息卡片
Clomipramine hydrochloride
化学式: C19H24Cl2N2 (350.13164439999997)
中文名称: 盐酸氯米帕明
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl.Cl
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017367 - Selective Serotonin Reuptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
D049990 - Membrane Transport Modulators
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:3755
- KEGGdrug: D00811
- PubChem: 68539
- ChEMBL: CHEMBL1200710
- MeSH: Clomipramine
- CAS: 17321-77-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Daria A Belinskaia, Natalia N Shestakova. Structure- and Cation-Dependent Mechanism of Interaction of Tricyclic Antidepressants with NMDA Receptor According to Molecular Modeling Data.
Biochemistry. Biokhimiia.
2024 Mar; 89(3):507-522. doi:
10.1134/s0006297924030106. [PMID: 38648769] - Wei Su, Dan Zhao, Hongmei Zhao, Wanhong Zheng, Wangxin Zhang. A 28-Year-Old Man with Obsessive-Compulsive Disorder, Post-Traumatic Stress Disorder, and Dissociative Identity Disorder Responding to Aripiprazole Augmentation of Clomipramine Combined with Psychoeducation and Exposure and Response Prevention.
The American journal of case reports.
2023 Dec; 24(?):e941534. doi:
10.12659/ajcr.941534. [PMID: 38100391] - Paulo Francisco Veiga Bizerra, Fernanda Sayuri Itou da Silva, Eduardo Hideo Gilglioni, Letícia Fernanda Nanami, Eduardo Makiyama Klosowski, Byanca Thais Lima de Souza, Ana Flávia Gatto Raimundo, Karina Borba Paulino Dos Santos, Juliana Moraes Mewes, Renato Polimeni Constantin, Márcio Shigueaki Mito, Emy Luiza Ishii-Iwamoto, Jorgete Constantin, Fábio Ermínio Mingatto, Giovana Natiele Machado Esquissato, Rogério Marchiosi, Wanderley Dantas Dos Santos, Osvaldo Ferrarese-Filho, Rodrigo Polimeni Constantin. The harmful acute effects of clomipramine in the rat liver: impairments in mitochondrial bioenergetics.
Toxicology letters.
2023 May; ?(?):. doi:
10.1016/j.toxlet.2023.05.008. [PMID: 37217012] - Rohini Pungle, Shivraj Hariram Nile, Arun S Kharat. Green synthesis and characterization of Solanum xanthocarpum capped silver nanoparticles and its antimicrobial effect on multidrug-resistant bacterial (MDR) isolates.
Chemical biology & drug design.
2023 03; 101(3):469-478. doi:
10.1111/cbdd.13945. [PMID: 34453485] - A K Sandhu, A M van Schip, L Driessen, W van Dorp. [Pharmacobezoar in a woman with a clomipramine intoxication].
Nederlands tijdschrift voor geneeskunde.
2021 05; 165(?):. doi:
. [PMID: 34346606] - Suwarna Chakraborty, Sunil Jamuna Tripathi, T R Raju, B S Shankaranarayana Rao. Brain stimulation rewarding experience attenuates neonatal clomipramine-induced adulthood anxiety by reversal of pathological changes in the amygdala.
Progress in neuro-psychopharmacology & biological psychiatry.
2020 12; 103(?):110000. doi:
10.1016/j.pnpbp.2020.110000. [PMID: 32512130] - Ibraam E Mikhail, Masoomeh Tehranirokh, Andrew A Gooley, Rosanne M Guijt, Michael C Breadmore. In-Syringe Electrokinetic Protein Removal from Biological Samples prior to Electrospray Ionization Mass Spectrometry.
Angewandte Chemie (International ed. in English).
2020 12; 59(51):23162-23168. doi:
10.1002/anie.202006481. [PMID: 32869436] - B Nobile, M Durand, E Olié, S Guillaume, J P Molès, E Haffen, P Courtet. Clomipramine Could Be Useful in Preventing Neurological Complications of SARS-CoV-2 Infection.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.
2020 09; 15(3):347-348. doi:
10.1007/s11481-020-09939-2. [PMID: 32601885] - Jiani Huang, Fang Wen, Wenjie Huang, Yingfeng Bai, Xiaona Lu, Peng Shu. Identification of hub genes and discovery of promising compounds in gastric cancer based on bioinformatics analysis.
Biomarkers in medicine.
2020 08; 14(12):1069-1084. doi:
10.2217/bmm-2019-0608. [PMID: 32969243] - Ashley M Beaulieu, Edward Tabasky, David N Osser. The psychopharmacology algorithm project at the Harvard South Shore Program: An algorithm for adults with obsessive-compulsive disorder.
Psychiatry research.
2019 11; 281(?):112583. doi:
10.1016/j.psychres.2019.112583. [PMID: 31600606] - Anssi Lipponen, Teemu Natunen, Mika Hujo, Robert Ciszek, Elina Hämäläinen, Jussi Tohka, Mikko Hiltunen, Jussi Paananen, David Poulsen, Emilia Kansanen, Xavier Ekolle Ndode-Ekane, Anna-Liisa Levonen, Asla Pitkänen. In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned.
International journal of molecular sciences.
2019 Oct; 20(21):. doi:
10.3390/ijms20215395. [PMID: 31671916] - Narumi Hashikawa-Hobara, Ami Otsuka, Risa Ishikawa, Naoya Hashikawa. Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Oct; 118(?):109263. doi:
10.1016/j.biopha.2019.109263. [PMID: 31369988] - Hadi Tabani, Ali Shokri, Shakila Tizro, Saeed Nojavan, Pakorn Varanusupakul, Michal Alexovič. Evaluation of dispersive liquid-liquid microextraction by coupling with green-based agarose gel-electromembrane extraction: An efficient method to the tandem extraction of basic drugs from biological fluids.
Talanta.
2019 Jul; 199(?):329-335. doi:
10.1016/j.talanta.2019.02.078. [PMID: 30952267] - Jean Henrique da Silva Rodrigues, Nathielle Miranda, Hélito Volpato, Tânia Ueda-Nakamura, Celso Vataru Nakamura. The antidepressant clomipramine induces programmed cell death in Leishmania amazonensis through a mitochondrial pathway.
Parasitology research.
2019 Mar; 118(3):977-989. doi:
10.1007/s00436-018-06200-x. [PMID: 30694414] - Stephan von Düring, Corinne Challet, Laurent Christin. Endoscopic removal of a gastric pharmacobezoar induced by clomipramine, lorazepam, and domperidone overdose: a case report.
Journal of medical case reports.
2019 Feb; 13(1):45. doi:
10.1186/s13256-019-1984-0. [PMID: 30808405] - Saeed Nojavan, Hossein Shaghaghi, Turaj Rahmani, Ali Shokri, Mahnaz Nasiri-Aghdam. Combination of electromembrane extraction and electro-assisted liquid-liquid microextraction: A tandem sample preparation method.
Journal of chromatography. A.
2018 Aug; 1563(?):20-27. doi:
10.1016/j.chroma.2018.05.068. [PMID: 29880217] - Bernd Reichl, Markus Himmelsbach, Lisa Emhofer, Christian W Klampfl, Wolfgang Buchberger. Uptake and metabolism of the antidepressants sertraline, clomipramine, and trazodone in a garden cress (Lepidium sativum) model.
Electrophoresis.
2018 05; 39(9-10):1301-1308. doi:
10.1002/elps.201700482. [PMID: 29427324] - Ana G Jimenez, Joshua D Winward, Dana M Smith, Christina M Ragan. Effects of short-term clomipramine on anxiety-like behavior, cellular metabolism, and oxidative stress in primary fibroblast cells of male and female rats.
Physiological reports.
2018 05; 6(9):e13615. doi:
10.14814/phy2.13615. [PMID: 29745454] - Irina G Bryndina, Maria N Shalagina, Alexey V Sekunov, Andrei L Zefirov, Alexey M Petrov. Clomipramine counteracts lipid raft disturbance due to short-term muscle disuse.
Neuroscience letters.
2018 01; 664(?):1-6. doi:
10.1016/j.neulet.2017.11.009. [PMID: 29126773] - Carlo Ripoli, Anna Paola Pinna, Faustina Podda, Roberta Zanni, Maria Giada Tronci, Anna Maria Nurchi. Second-generation antipsychotic and diabetes mellitus in children and adolescents.
La Pediatria medica e chirurgica : Medical and surgical pediatrics.
2017 Dec; 39(4):149. doi:
10.4081/pmc.2017.149. [PMID: 29502389] - Fatemeh Hamidi, Mohammad Reza Hadjmohammadi, Ali B G Aghaie. Ultrasound-assisted dispersive magnetic solid phase extraction based on amino-functionalized Fe3O4 adsorbent for recovery of clomipramine from human plasma and its determination by high performance liquid chromatography: Optimization by experimental design.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Sep; 1063(?):18-24. doi:
10.1016/j.jchromb.2017.08.005. [PMID: 28825989] - Jacob T Brown, Mark Schneiderhan, Seenae Eum, Jeffrey R Bishop. Serum clomipramine and desmethylclomipramine levels in a CYP2C19 and CYP2D6 intermediate metabolizer.
Pharmacogenomics.
2017 May; 18(7):601-605. doi:
10.2217/pgs-2017-0015. [PMID: 28470111] - Xing Li, Wen Sun, Jinbo Li, Mengmeng Wang, Hengwei Zhang, Lingpeng Pei, Brendan F Boyce, Zhiyu Wang, Lianping Xing. Clomipramine causes osteoporosis by promoting osteoclastogenesis via E3 ligase Itch, which is prevented by Zoledronic acid.
Scientific reports.
2017 02; 7(?):41358. doi:
10.1038/srep41358. [PMID: 28145497] - Stefania Antoniazzi, Alessandro Tatulli, Felicia S Falvella, Michela Cigliobianco, Riccardo A Paoli, Dario Cattaneo, Stefania Cheli, Francesca F Bernardi, Emilio Clementi, Carlo A Altamura. The combination of pharmacogenetic and pharmacokinetic analyses to optimize clomipramine dosing in major depression: a case report.
Journal of clinical pharmacy and therapeutics.
2017 Feb; 42(1):119-121. doi:
10.1111/jcpt.12478. [PMID: 27800629] - Vera Alves, Carlota Conceição, João Gonçalves, Helena M Teixeira, José S Câmara. Improved Analytical Approach Based on QuECHERS/UHPLC-PDA for Quantification of Fluoxetine, Clomipramine and their Active Metabolites in Human Urine Samples.
Journal of analytical toxicology.
2017 Jan; 41(1):45-53. doi:
10.1093/jat/bkw077. [PMID: 27681341] - Bin Feng, Zhang-Jin Zhang, Rui-Ming Zhu, Guo-Zhen Yuan, Li-Yuan Luo, Grainne M McAlonan, Fang-Zhong Xu, Jiong Chen, Lan-Ying Liu, Yang-Yang Lv, Hei Kiu Wong, Ying Zhang, Li-Xia Zhu. Transcutaneous electrical acupoint stimulation as an adjunct therapy for obsessive-compulsive disorder: A randomized controlled study.
Journal of psychiatric research.
2016 09; 80(?):30-37. doi:
10.1016/j.jpsychires.2016.05.015. [PMID: 27281260] - Katja Biering Leth-Møller, Annette Højmann Hansen, Maia Torstensson, Stig Ejdrup Andersen, Lars Ødum, Gunnar Gislasson, Christian Torp-Pedersen, Ellen Astrid Holm. Antidepressants and the risk of hyponatremia: a Danish register-based population study.
BMJ open.
2016 05; 6(5):e011200. doi:
10.1136/bmjopen-2016-011200. [PMID: 27194321] - Saied Saeed Hosseiny Davarani, Hamid Reza Moazami, Elham Memarian, Saeed Nojavan. Electromembrane extraction through a virtually rotating supported liquid membrane.
Electrophoresis.
2016 Jan; 37(2):339-46. doi:
10.1002/elps.201500296. [PMID: 26462723] - P G J Ter Horst, J H Proost, J P Smit, M T Vries, L T W de Jong-van de Berg, B Wilffert. Pharmacokinetics of clomipramine during pregnancy.
European journal of clinical pharmacology.
2015 Dec; 71(12):1493-500. doi:
10.1007/s00228-015-1944-6. [PMID: 26416100] - Xian-Zhang Hu, Jian-Dong Ma, Ping Huang, Xiao-Wen Shan, Zhao-Hui Zhang, Jian-Hong Zhang, Hua Ouyang, Shao-Jie Kou, Zhi-Rong Li, Shu-Fan Wang, Hong-Zeng Zhao, Hui Wang, Chang-Hong Wang. Highly efficacious cognitive-coping therapy for overt or covert compulsions.
Psychiatry research.
2015 Oct; 229(3):732-8. doi:
10.1016/j.psychres.2015.08.010. [PMID: 26275705] - Vera Alves, João Gonçalves, Carlota Conceição, Helena M Teixeira, José S Câmara. An improved analytical strategy combining microextraction by packed sorbent combined with ultra high pressure liquid chromatography for the determination of fluoxetine, clomipramine and their active metabolites in human urine.
Journal of chromatography. A.
2015 Aug; 1408(?):30-40. doi:
10.1016/j.chroma.2015.07.021. [PMID: 26189207] - Oskar González, Michael van Vliet, Carola W N Damen, Frans M van der Kloet, Rob J Vreeken, Thomas Hankemeier. Matrix Effect Compensation in Small-Molecule Profiling for an LC-TOF Platform Using Multicomponent Postcolumn Infusion.
Analytical chemistry.
2015 Jun; 87(12):5921-9. doi:
10.1021/ac504268y. [PMID: 25965142] - E J J Berm, J Paardekooper, E Brummel-Mulder, E Hak, B Wilffert, J G Maring. A simple dried blood spot method for therapeutic drug monitoring of the tricyclic antidepressants amitriptyline, nortriptyline, imipramine, clomipramine, and their active metabolites using LC-MS/MS.
Talanta.
2015 Mar; 134(?):165-172. doi:
10.1016/j.talanta.2014.10.041. [PMID: 25618654] - Tania Marcourakis, Márcio A Bernik, Francisco Lotufo Neto, Roseli Gedanke Shavitt, Clarice Gorenstein. Clomipramine demethylation rate is important on the outcome of obsessive-compulsive disorder treatment.
International clinical psychopharmacology.
2015 Jan; 30(1):43-8. doi:
10.1097/yic.0000000000000050. [PMID: 25279584] - Ofelia Limón-Morales, Cesar Soria-Fregozo, Marcela Arteaga-Silva, Marisela Hernández González, Gonzalo Vázquez-Palacios, Herlinda Bonilla-Jaime. Hormone replacement with 17β-estradiol plus dihydrotestosterone restores male sexual behavior in rats treated neonatally with clomipramine.
Hormones and behavior.
2014 Nov; 66(5):820-7. doi:
10.1016/j.yhbeh.2014.09.014. [PMID: 25449595] - Walter H Reinhart, Szabina Lubszky, Sandra Thöny, Thomas Schulzki. Interaction of injectable neurotropic drugs with the red cell membrane.
Toxicology in vitro : an international journal published in association with BIBRA.
2014 Oct; 28(7):1274-9. doi:
10.1016/j.tiv.2014.06.008. [PMID: 24997296] - Kosuke Saito, Keiko Maekawa, Masaki Ishikawa, Yuya Senoo, Masayo Urata, Mayumi Murayama, Noriyuki Nakatsu, Hiroshi Yamada, Yoshiro Saito. Glucosylceramide and lysophosphatidylcholines as potential blood biomarkers for drug-induced hepatic phospholipidosis.
Toxicological sciences : an official journal of the Society of Toxicology.
2014 Oct; 141(2):377-86. doi:
10.1093/toxsci/kfu132. [PMID: 24980264] - M Harvey, G Cave, B Ong. Intravenous lipid emulsion-augmented plasma exchange in a rabbit model of clomipramine toxicity; survival, but no sink.
Clinical toxicology (Philadelphia, Pa.).
2014 Jan; 52(1):13-9. doi:
10.3109/15563650.2013.866242. [PMID: 24397752] - Mats B Humble, Kerstin Uvnäs-Moberg, Ingemar Engström, Susanne Bejerot. Plasma oxytocin changes and anti-obsessive response during serotonin reuptake inhibitor treatment: a placebo controlled study.
BMC psychiatry.
2013 Dec; 13(?):344. doi:
10.1186/1471-244x-13-344. [PMID: 24359174] - Dilek Yonar, Nuray Horasan, Dilek Dadayli Paktaş, Zrinka Abramović, Janez Štrancar, M Maral Sünnetçioğlu, Marjeta Sentjurc. Interaction of antidepressant drug, clomipramine, with model and biological stratum corneum membrane as studied by electron paramagnetic resonance.
Journal of pharmaceutical sciences.
2013 Oct; 102(10):3762-72. doi:
10.1002/jps.23687. [PMID: 23925997] - Grant Cave, Martyn Harvey, Tom Shaw, Robert Damitz, Anuj Chauhan. Comparison of intravenous lipid emulsion, bicarbonate, and tailored liposomes in rabbit clomipramine toxicity.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.
2013 Oct; 20(10):1076-9. doi:
10.1111/acem.12224. [PMID: 24127716] - Yongbo Li, Zhujun Zhang. Nepem-211 ion exchange conductive membrane immobilized tris(2,2´-bipyridyl) ruthenium(II) electrogenerated chemiluminescence flow sensor for high-performance liquid chromatography and its application.
Luminescence : the journal of biological and chemical luminescence.
2013 Jul; 28(4):474-81. doi:
10.1002/bio.2479. [PMID: 23401164] - Jan Magdalan, Marcin Zawadzki, Tomasz Słoka, Tomasz Sozański. Suicidal overdose with relapsing clomipramine concentrations due to a large gastric pharmacobezoar.
Forensic science international.
2013 Jun; 229(1-3):e19-22. doi:
10.1016/j.forsciint.2013.03.025. [PMID: 23570967] - Mariana Strauss, M Silvina Lo Presti, Paula Carolina Bazán, Alejandra Baez, Romina Fauro, Blanca Esteves, Olga Sanchez Negrete, David Cremonezzi, Patricia A Paglini-Oliva, H Walter Rivarola. Clomipramine and benznidazole association for the treatment of acute experimental Trypanosoma cruzi infection.
Parasitology international.
2013 Jun; 62(3):293-9. doi:
10.1016/j.parint.2013.02.004. [PMID: 23500720] - Jae-Won Kim, Hyo-Sang Ahn, Ja-Hyun Baik, Bong-June Yoon. Administration of clomipramine to neonatal mice alters stress response behavior and serotonergic gene expressions in adult mice.
Journal of psychopharmacology (Oxford, England).
2013 Feb; 27(2):171-80. doi:
10.1177/0269881112460107. [PMID: 22992375] - Xiaoyan Wang, Chuiyu Zeng, Jingchao Lin, Tianlu Chen, Tie Zhao, Zhiying Jia, Xie Xie, Yunping Qiu, Mingming Su, Tao Jiang, Mingmei Zhou, Aihua Zhao, Wei Jia. Metabonomics approach to assessing the modulatory effects of St John's wort, ginsenosides, and clomipramine in experimental depression.
Journal of proteome research.
2012 Dec; 11(12):6223-30. doi:
10.1021/pr300891v. [PMID: 23110693] - Bonnie A Merchant, Jeffry D Madura. Insights from molecular dynamics: the binding site of cocaine in the dopamine transporter and permeation pathways of substrates in the leucine and dopamine transporters.
Journal of molecular graphics & modelling.
2012 Sep; 38(?):1-12. doi:
10.1016/j.jmgm.2012.05.007. [PMID: 23079638] - Saied Saeed Hosseiny Davarani, Amin Morteza Najarian, Saeed Nojavan, Mohammad-Ali Tabatabaei. Electromembrane extraction combined with gas chromatography for quantification of tricyclic antidepressants in human body fluids.
Analytica chimica acta.
2012 May; 725(?):51-6. doi:
10.1016/j.aca.2012.02.048. [PMID: 22502611] - Peter G J ter Horst, Susanne van der Linde, Jan Pieter Smit, Jan den Boon, Richard A van Lingen, Frank G A Jansman, Lolkje T W De Jong-van den Berg, Bob Wilffert. Clomipramine concentration and withdrawal symptoms in 10 neonates.
British journal of clinical pharmacology.
2012 Feb; 73(2):295-302. doi:
10.1111/j.1365-2125.2011.04072.x. [PMID: 21801198] - Michele Fabrazzo, Francesco Perris, Palmiero Monteleone, Giuseppina Esposito, Francesco Catapano, Mario Maj. Aripiprazole augmentation strategy in clomipramine-resistant depressive patients: an open preliminary study.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2012 Feb; 22(2):132-6. doi:
10.1016/j.euroneuro.2011.06.006. [PMID: 21784621] - M Martínez-Vázquez, R Estrada-Reyes, A G Araujo Escalona, I Ledesma Velázquez, L Martínez-Mota, J Moreno, G Heinze. Antidepressant-like effects of an alkaloid extract of the aerial parts of Annona cherimolia in mice.
Journal of ethnopharmacology.
2012 Jan; 139(1):164-70. doi:
10.1016/j.jep.2011.10.033. [PMID: 22101086] - Donatella Marazziti, Stefano Baroni, Luca Faravelli, Gino Giannaccini, Gabriele Massimetti, Lionella Palego, Mario Catena-Dell'Osso. Plasma clomipramine levels in adult patients with obsessive-compulsive disorder.
International clinical psychopharmacology.
2012 Jan; 27(1):55-60. doi:
10.1097/yic.0b013e32834cde39. [PMID: 21979789] - Mohammad Saraji, Ali Akbar Hajialiakbari Bidgoli, Taghi Khayamian, Ali Moradmand. Combination of corona discharge ion mobility spectrometry with a novel reagent gas and two immiscible organic solvent liquid-liquid-liquid microextraction for analysis of clomipramine in biological samples.
Journal of chromatography. A.
2011 Dec; 1218(48):8600-7. doi:
10.1016/j.chroma.2011.10.026. [PMID: 22041141] - Joachim Cordes, Kai G Kahl, Christian Werner, Uwe Henning, Gunnar Regenbrecht, Rolf Larisch, Christian Schmidt-Kraepelin, Johanna Thünker, Marcus W Agelink, Stefan Löffler, Thomas Hohlfeld, Wolfgang Gaebel, Ansgar Klimke. Clomipramine-induced serum prolactin as a marker for serotonin and dopamine turnover: results of an open label study.
European archives of psychiatry and clinical neuroscience.
2011 Dec; 261(8):567-73. doi:
10.1007/s00406-011-0201-y. [PMID: 21404115] - Shinji Kobuchi, Keizo Fukushima, Hiroaki Aoyama, Tatsuma Matsuda, Yukako Ito, Nobuyuki Sugioka, Kanji Takada. Effect of oxidative stress on the pharmacokinetics of clomipramine in rats treated with ferric-nitrilotriacetate.
Drug metabolism letters.
2011 Dec; 5(4):243-52. doi:
10.2174/187231211798472548. [PMID: 22022866] - A de Vos, J van der Weide, H M Loovers. Association between CYP2C19*17 and metabolism of amitriptyline, citalopram and clomipramine in Dutch hospitalized patients.
The pharmacogenomics journal.
2011 Oct; 11(5):359-67. doi:
10.1038/tpj.2010.39. [PMID: 20531370] - Dilek Yonar, Dilek Dadaylı Paktaş, Nuray Horasan, Janez Strancar, Marjeta Sentjurc, M Maral Sünnetçioğlu. EPR investigation of clomipramine interaction with phosphatidylcholine membranes in presence and absence of cholesterol.
Journal of liposome research.
2011 Sep; 21(3):194-202. doi:
10.3109/08982104.2010.499540. [PMID: 20624028] - Akihiro Takano, Sangram Nag, Balázs Gulyás, Christer Halldin, Lars Farde. NET occupancy by clomipramine and its active metabolite, desmethylclomipramine, in non-human primates in vivo.
Psychopharmacology.
2011 Jul; 216(2):279-86. doi:
10.1007/s00213-011-2212-9. [PMID: 21336575] - A-S Wattiez, F Libert, A-M Privat, S Loiodice, J Fialip, A Eschalier, C Courteix. Evidence for a differential opioidergic involvement in the analgesic effect of antidepressants: prediction for efficacy in animal models of neuropathic pain?.
British journal of pharmacology.
2011 Jun; 163(4):792-803. doi:
10.1111/j.1476-5381.2011.01297.x. [PMID: 21371007] - Daniel S Mills, Sarah E Redgate, Gary M Landsberg. A meta-analysis of studies of treatments for feline urine spraying.
PloS one.
2011 Apr; 6(4):e18448. doi:
10.1371/journal.pone.0018448. [PMID: 21525994] - Shinji Kobuchi, Keizo Fukushima, Masakazu Shibata, Yukako Ito, Nobuyuki Sugioka, Kanji Takada. Pharmacokinetics of clomipramine, an antidepressant, in poloxamer 407-induced hyperlipidaemic model rats.
The Journal of pharmacy and pharmacology.
2011 Apr; 63(4):515-23. doi:
10.1111/j.2042-7158.2010.01245.x. [PMID: 21401603] - Karen Miguita, Quirino Cordeiro, Roseli Gedanke Shavitt, Eurípedes Constantino Miguel, Homero Vallada. Association study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment.
Arquivos de neuro-psiquiatria.
2011; 69(2B):283-7. doi:
10.1590/s0004-282x2011000300003. [PMID: 21625751] - Rodrigo de Souza Balk, Jessika Cristina Bridi, Rafael de Lima Portella, Nelson Rodrigues Carvalho, Fernando Dobrachinski, Michele Hinerasky da Silva, Guilherme Pires Amaral, Glaecir Roseni Mundstock Dias, Nilda de Vargas Barbosa, Felix Alexandre Antunes Soares. Clomipramine treatment and repeated restraint stress alter parameters of oxidative stress in brain regions of male rats.
Neurochemical research.
2010 Nov; 35(11):1761-70. doi:
10.1007/s11064-010-0240-1. [PMID: 20694755] - Izumi Takase, Yoshio Yamamoto, Tokiko Nakagawa, Katsuji Nishi. A fatal case of potential chronic overdoses of prescribed and proprietary remedies.
Human & experimental toxicology.
2010 Aug; 29(8):695-9. doi:
10.1177/0960327109360116. [PMID: 20106941] - Anita Chamba, Michelle J Holder, Ruth F Jarrett, Lesley Shield, Kai M Toellner, Mark T Drayson, Nicholas M Barnes, John Gordon. SLC6A4 expression and anti-proliferative responses to serotonin transporter ligands chlomipramine and fluoxetine in primary B-cell malignancies.
Leukemia research.
2010 Aug; 34(8):1103-6. doi:
10.1016/j.leukres.2010.03.007. [PMID: 20363025] - K Aitchison, K Datla, H Rooprai, J Fernando, D Dexter. Regional distribution of clomipramine and desmethylclomipramine in rat brain and peripheral organs on chronic clomipramine administration.
Journal of psychopharmacology (Oxford, England).
2010 Aug; 24(8):1261-8. doi:
10.1177/0269881109105789. [PMID: 19553387] - H Bonilla-Jaime, S Retana-Márquez, M Arteaga-Silva, M Hernández-González, G Vázquez-Palacios. Circadian activity of corticosterone in an animal model of depression: response to muscarinic cholinergic stimulation.
Physiology & behavior.
2010 Jun; 100(4):311-5. doi:
10.1016/j.physbeh.2010.03.002. [PMID: 20226801] - R P Markus, D G Franco, L A Carvalho, V Gentil, C Gorenstein. Acute increase in urinary 6-sulfatoximelatonin after clomipramine, as a predictive measure for emotional improvement.
Journal of psychopharmacology (Oxford, England).
2010 Jun; 24(6):855-60. doi:
10.1177/0269881109102542. [PMID: 19264813] - Francesco Matrisciano, Antonella M E Modafferi, Giuseppina I Togna, Ylenia Barone, Graziano Pinna, Ferdinando Nicoletti, Sergio Scaccianoce. Repeated anabolic androgenic steroid treatment causes antidepressant-reversible alterations of the hypothalamic-pituitary-adrenal axis, BDNF levels and behavior.
Neuropharmacology.
2010 Jun; 58(7):1078-84. doi:
10.1016/j.neuropharm.2010.01.015. [PMID: 20138062] - Jadwiga Piwowarska, Małgorzata Wrzosek, Maria Radziwoń-Zaleska, Beata Ryszewska-Pokraśniewicz, Michał Skalski, Halina Matsumoto, Agata Biernacka-Bazyluk, Waldemar Szelenberger, Jan Pachecka. Serum cortisol concentration in patients with major depression after treatment with clomipramine.
Pharmacological reports : PR.
2009 Jul; 61(4):604-11. doi:
10.1016/s1734-1140(09)70112-4. [PMID: 19815942] - Chaomei Xiong, Jinlan Ruan, Yaling Cai, Ying Tang. Extraction and determination of some psychotropic drugs in urine samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography.
Journal of pharmaceutical and biomedical analysis.
2009 Feb; 49(2):572-8. doi:
10.1016/j.jpba.2008.11.036. [PMID: 19135820] - P H Kook, A Kranjc, M Dennler, T M Glaus. Pancreatitis associated with clomipramine administration in a dog.
The Journal of small animal practice.
2009 Feb; 50(2):95-8. doi:
10.1111/j.1748-5827.2008.00690.x. [PMID: 19200265] - Martyn Harvey, Grant Cave, Kerry Hoggett. Correlation of plasma and peritoneal diasylate clomipramine concentration with hemodynamic recovery after intralipid infusion in rabbits.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.
2009 Feb; 16(2):151-6. doi:
10.1111/j.1553-2712.2008.00313.x. [PMID: 19133855] - Joachim Cordes, Rolf Larisch, Uwe Henning, Johanna Thünker, Christian Werner, Guillermo Orozco, Fermín Mayoral, Fabio Rivas, Georg Auburger, Marco Tosch, Marcella Rietschel, Wolfgang Gaebel, Hans-Wilhelm Müller, Ansgar Klimke. Abnormal neuroendocrine response to clomipramine in hereditary affective psychosis.
Depression and anxiety.
2009; 26(8):E111-9. doi:
10.1002/da.20405. [PMID: 19288582] - Werner Zitterl, Martin Aigner, Thomas Stompe, Karin Zitterl-Eglseer, Karin Gutierrez-Lobos, Thomas Wenzel, Georg Zettinig, Kurt Hornik, Walter Pirker, Kenneth Thau. Changes in thalamus-hypothalamus serotonin transporter availability during clomipramine administration in patients with obsessive-compulsive disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2008 Dec; 33(13):3126-34. doi:
10.1038/npp.2008.35. [PMID: 18354388] - Qingqiu Mao, Zhen Huang, Siupo Ip, Chuntao Che. Antidepressant-like effect of ethanol extract from Paeonia lactiflora in mice.
Phytotherapy research : PTR.
2008 Nov; 22(11):1496-9. doi:
10.1002/ptr.2519. [PMID: 18570231] - Aroldo Cupello, Fabio Bandini, Claudio Albano, Emilio Favale, Roberta Marchese, Simona Scarrone, Carlo Trompetto. Catatonic features in major depression relieved by electroconvulsive treatment: parallel evaluation of the status of platelet serotonin transporter.
The International journal of neuroscience.
2008 Oct; 118(10):1460-6. doi:
10.1080/00207450701870303. [PMID: 18788029] - François-Ludovic Sauvage, Jean-Michel Gaulier, Gérard Lachâtre, Pierre Marquet. Pitfalls and prevention strategies for liquid chromatography-tandem mass spectrometry in the selected reaction-monitoring mode for drug analysis.
Clinical chemistry.
2008 Sep; 54(9):1519-27. doi:
10.1373/clinchem.2008.105478. [PMID: 18635749] - Vincenzo Micale, Giovanni Scapagnini, Claudia Colombrita, Carmen Mazzola, Daniel L Alkon, Filippo Drago. Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2008 Jun; 18(6):462-71. doi:
10.1016/j.euroneuro.2007.11.006. [PMID: 18222653] - Peter Vestergaard, Lars Rejnmark, Leif Mosekilde. Selective serotonin reuptake inhibitors and other antidepressants and risk of fracture.
Calcified tissue international.
2008 Feb; 82(2):92-101. doi:
10.1007/s00223-007-9099-9. [PMID: 18219438] - Mona M Hanna, Nahed M Eid, Riham F George, Hani M Safwat. Synthesis of some tropane derivatives of anticipated activity on the reuptake of norepinephrine and/or serotonin.
Bioorganic & medicinal chemistry.
2007 Dec; 15(24):7765-72. doi:
10.1016/j.bmc.2007.08.055. [PMID: 17870537] - L Bertilsson. Metabolism of antidepressant and neuroleptic drugs by cytochrome p450s: clinical and interethnic aspects.
Clinical pharmacology and therapeutics.
2007 Nov; 82(5):606-9. doi:
10.1038/sj.clpt.6100358. [PMID: 17898711] - Claudete Alves, Alvaro J Santos-Neto, Christian Fernandes, José C Rodrigues, Fernando M Lanças. Analysis of tricyclic antidepressant drugs in plasma by means of solid-phase microextraction-liquid chromatography-mass spectrometry.
Journal of mass spectrometry : JMS.
2007 Oct; 42(10):1342-7. doi:
10.1002/jms.1288. [PMID: 17902106] - Victoria F Samanidou, Maria K Nika, Ioannis N Papadoyannis. Development of an HPLC method for the monitoring of tricyclic antidepressants in biofluids.
Journal of separation science.
2007 Oct; 30(15):2391-400. doi:
10.1002/jssc.200700142. [PMID: 17625794] - Akira Onishi, Hisashi Yamamoto, Tetsu Akimoto, Osamu Saito, Makoto Inoue, Yasuhiro Ando, Shigeaki Muto, Eiji Kusano. Reversible acute renal failure associated with clomipramine-induced interstitial nephritis.
Clinical and experimental nephrology.
2007 Sep; 11(3):241-243. doi:
10.1007/s10157-007-0485-4. [PMID: 17891354] - Satinder K Singh, Atsuko Yamashita, Eric Gouaux. Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature.
2007 Aug; 448(7156):952-6. doi:
10.1038/nature06038. [PMID: 17687333] - Guo-han Yu, Shao-cai Liang, Qi-zhang Sun. [Study on Modified Xiaoyao Decoction combining Clomipramine treating depression].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2007 Apr; 27(4):318-20. doi:
. [PMID: 17526170] - C Lainesse, D Frank, F Beaudry, M Doucet. Effects of physiological covariables on pharmacokinetic parameters of clomipramine in a large population of cats after a single oral administration.
Journal of veterinary pharmacology and therapeutics.
2007 Apr; 30(2):116-26. doi:
10.1111/j.1365-2885.2007.00826.x. [PMID: 17348896] - Bin Feng, Lanying Liu, Xu Fangzhong, Jiong Chen, Peirong Wang, Wensong Chen, Enyan Yu. Thirty cases of obsession treated by point-stimulation and with small dose of chlorimipramine.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2007 Mar; 27(1):3-6. doi:
". [PMID: 17393613] - M Janeiro, E Camblor, R Fernández, D Núñez. [Narcolepsy and anesthesia].
Revista espanola de anestesiologia y reanimacion.
2007 Mar; 54(3):198-9. doi:
NULL. [PMID: 17436663] - Monika Szewczuk-Bogusławska, Andrzej Kiejna, Magdalena Grzesiak, Jan Aleksander Beszłej, Iwona Chlebowska, Krystyna Orzechowska-Juzwenko, Piotr Milejski. [The influence of clomipramine on CYP2D6 activity].
Psychiatria polska.
2007 Mar; 41(2):243-9. doi:
. [PMID: 17598433] - Martyn Harvey, Grant Cave. Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxicity.
Annals of emergency medicine.
2007 Feb; 49(2):178-85, 185.e1. doi:
10.1016/j.annemergmed.2006.07.016. [PMID: 17098328] - B Pfuhlmann, M Gerlach, R Burger, S Gonska, S Unterecker, B Jabs, P Riederer, J Deckert. Therapeutic drug monitoring of tricyclic antidepressants in everyday clinical practice.
Journal of neural transmission. Supplementum.
2007; ?(72):287-96. doi:
10.1007/978-3-211-73574-9_35. [PMID: 17982905] - Jamshid Ahmadi, Kyle Kampman, Charles Dackis. Outcome predictors in cocaine dependence treatment trials.
The American journal on addictions.
2006 Nov; 15(6):434-9. doi:
10.1080/10550490600998476. [PMID: 17182445] - Diane Frank, Audrey Gauthier, Renée Bergeron. Placebo-controlled double-blind clomipramine trial for the treatment of anxiety or fear in beagles during ground transport.
The Canadian veterinary journal = La revue veterinaire canadienne.
2006 Nov; 47(11):1102-8. doi:
NULL. [PMID: 17147141] - C Lainesse, D Frank, V Meucci, L Intorre, G Soldani, M Doucet. Pharmacokinetics of clomipramine and desmethylclomipramine after single-dose intravenous and oral administrations in cats.
Journal of veterinary pharmacology and therapeutics.
2006 Aug; 29(4):271-8. doi:
10.1111/j.1365-2885.2006.00742.x. [PMID: 16846464] - Maria Radziwoń-Zaleska, Halina Matsumoto, Michał Skalski, Joanna Wilkowska, Piotr Januszko, Daria Matoszko, Anna Dziklińska, Bartłomiej Gmaj, Waldemar Szelenberger. Therapeutic tricyclic antidepressant drug monitoring in younger and older depressive patients.
Pharmacological reports : PR.
2006 Jul; 58(4):501-6. doi:
NULL. [PMID: 16963795] - P L Stephan, M Etzensberger, E Jaquenoud Sirot. [Therapeutic drug monitoring: A pharmacotherapeutic tool in psychiatry].
Praxis.
2006 Apr; 95(17):671-8. doi:
10.1024/0369-8394.95.17.671. [PMID: 16686323] - Ada M Loughhead, Zachary N Stowe, D Jeffrey Newport, James C Ritchie, C Lindsay DeVane, Michael J Owens. Placental passage of tricyclic antidepressants.
Biological psychiatry.
2006 Feb; 59(3):287-90. doi:
10.1016/j.biopsych.2005.06.040. [PMID: 16271264]