(R)-ketorolac (BioDeep_00000776336)
代谢物信息卡片
(R)-ketorolac
化学式: C15H13NO3 (255.0895)
中文名称: (R)-酮咯酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O
InChI: InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/t11-/m1/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Binh Cao Quan Nguyen, Hideaki Takahashi, Yoshihiro Uto, M D Shahinozzaman, Shinkichi Tawata, Hiroshi Maruta. 1,2,3-Triazolyl ester of Ketorolac: A "Click Chemistry"-based highly potent PAK1-blocking cancer-killer.
European journal of medicinal chemistry.
2017 Jan; 126(?):270-276. doi:
10.1016/j.ejmech.2016.11.038. [PMID: 27889630] - A Kulo, M van de Velde, K van Calsteren, A Smits, J de Hoon, R Verbesselt, J Deprest, K Allegaert. Pharmacokinetics of intravenous ketorolac following caesarean delivery.
International journal of obstetric anesthesia.
2012 Oct; 21(4):334-8. doi:
10.1016/j.ijoa.2012.06.001. [PMID: 22901775] - David R Drover, Gregory B Hammer, Brian J Anderson. The pharmacokinetics of ketorolac after single postoperative intranasal administration in adolescent patients.
Anesthesia and analgesia.
2012 Jun; 114(6):1270-6. doi:
10.1213/ane.0b013e31824f92c2. [PMID: 22467894] - Eduardo G Victor, Paulo C L Silveira, Jonathann C Possato, Guilherme L da Rosa, Uillian B Munari, Claudio T de Souza, Ricardo A Pinho, Luciano da Silva, Emilio L Streck, Marcos M S Paula. Pulsed ultrasound associated with gold nanoparticle gel reduces oxidative stress parameters and expression of pro-inflammatory molecules in an animal model of muscle injury.
Journal of nanobiotechnology.
2012 Mar; 10(?):11. doi:
10.1186/1477-3155-10-11. [PMID: 22410000] - Jong Yeon Lee, Young Tae Moon. Evaluation of the optimal frequency of and pretreatment with shock waves in patients with renal stones.
Korean journal of urology.
2011 Nov; 52(11):776-81. doi:
10.4111/kju.2011.52.11.776. [PMID: 22195268] - Arianna Bertocchini, Cristina Lo Zupone, Francesco Callea, Fabrizio Gennari, Annalisa Serra, Lidia Monti, Jean de Ville de Goyet. Unresectable multifocal omental and peritoneal inflammatory myofibroblastic tumor in a child: revisiting the role of adjuvant therapy.
Journal of pediatric surgery.
2011 Apr; 46(4):e17-e21. doi:
10.1016/j.jpedsurg.2011.01.007. [PMID: 21496520] - Jaleh Varshosaz, Valiollah Hajhashemi, Sindokht Soltanzadeh. Lipid nanocapsule-based gels for enhancement of transdermal delivery of ketorolac tromethamine.
Journal of drug delivery.
2011; 2011(?):571272. doi:
10.1155/2011/571272. [PMID: 22175029] - Liliana L Jorge, Caroline C Feres, Vitor Ep Teles. Topical preparations for pain relief: efficacy and patient adherence.
Journal of pain research.
2010 Dec; 4(?):11-24. doi:
10.2147/jpr.s9492. [PMID: 21386951] - M A Radwan, B T AlQuadeib, N M Aloudah, H Y Aboul Enein. Pharmacokinetics of ketorolac loaded to polyethylcyanoacrylate nanoparticles using UPLC MS/MS for its determination in rats.
International journal of pharmaceutics.
2010 Sep; 397(1-2):173-8. doi:
10.1016/j.ijpharm.2010.06.035. [PMID: 20600724] - Doaa Ahmed El-Setouhy, Sahar Mohy Ahmed El-Ashmony. Ketorolac trometamol topical formulations: release behaviour, physical characterization, skin permeation, efficacy and gastric safety.
The Journal of pharmacy and pharmacology.
2010 Jan; 62(1):25-34. doi:
10.1211/jpp.62.01.0002. [PMID: 20722996] - V R Sinha, R V Kumar, G Singh. Ketorolac tromethamine formulations: an overview.
Expert opinion on drug delivery.
2009 Sep; 6(9):961-75. doi:
10.1517/17425240903116006. [PMID: 19663721] - Ericka López-Bojórquez, Gilberto Castañeda-Hernández, Mario González-de la Parra, Salvador Namur. Development and validation of a high-performance thin-layer chromatographic method, with densitometry, for quantitative analysis of ketorolac tromethamine in human plasma.
Journal of AOAC International.
2008 Sep; 91(5):1191-5. doi:
10.1093/jaoac/91.5.1191. [PMID: 18980140] - Juan Francisco Galán-Herrera, Jorge Luis Poo, Jose Alfonso Maya-Barrios, Alberto de Lago, Iván Oliva, Mario González-de la Parra, Patricia Jiménez, Ericka López-Bojórquez, Victoria Burke-Fraga, Salvador Namur. Bioavailability of two sublingual formulations of ketorolac tromethamine 30 mg: a randomized, open-label, single-dose, two-period crossover comparison in healthy Mexican adult volunteers.
Clinical therapeutics.
2008 Sep; 30(9):1667-74. doi:
10.1016/j.clinthera.2008.09.011. [PMID: 18840372] - Munish Ahuja, Avinash S Dhake, Surendra K Sharma, Dipak K Majumdar. Topical ocular delivery of NSAIDs.
The AAPS journal.
2008 Jun; 10(2):229-41. doi:
10.1208/s12248-008-9024-9. [PMID: 18437583] - Afsana Momen, Jian Cui, Patrick McQuillan, Lawrence I Sinoway. Local prostaglandin blockade attenuates muscle mechanoreflex-mediated renal vasoconstriction during muscle stretch in humans.
American journal of physiology. Heart and circulatory physiology.
2008 May; 294(5):H2184-90. doi:
10.1152/ajpheart.00948.2007. [PMID: 18326807] - Antonio Oliva, Fabio De Giorgio, Vincenzo Arena, Nadia Fucci, Vincenzo L Pascali, Pierluigi Navarra. Death due to anaphylactic shock secondary to intravenous self-injection of Toradol: a case report and review of the literature.
Clinical toxicology (Philadelphia, Pa.).
2007 Sep; 45(6):709-13. doi:
10.1080/15563650701397076. [PMID: 17849248] - Manal Eid, Amina El-Brashy, Fatma Aly, Wael Talaat. Spectrofluorometric determination of ketorolac tromethamine via its oxidation with cerium(IV) in pharmaceutical preparations and biological fluids.
Journal of AOAC International.
2007 Jul; 90(4):941-7. doi:
10.1093/jaoac/90.4.941. [PMID: 17760331] - Padmanabhan Santhosh, Nagarajan Senthil Kumar, Murugesan Renukadevi, Anantha Iyengar Gopalan, Thiyagarajan Vasudevan, Kwang-Pill Lee. Enhanced electrochemical detection of ketorolac tromethamine at polypyrrole modified glassy carbon electrode.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2007 Apr; 23(4):475-8. doi:
10.2116/analsci.23.475. [PMID: 17420555] - Chandra Kallanagowdar, Alice LeBreton, Diego H Aviles. Acute renal failure.
Clinical pediatrics.
2006 Oct; 45(8):771-3. doi:
10.1177/0009922806292813. [PMID: 16968965] - Hyungsuk Kim, Hyewon Lee, Janet Rowan, Jaime Brahim, Raymond A Dionne. Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans.
Molecular pain.
2006 Jul; 2(?):24. doi:
10.1186/1744-8069-2-24. [PMID: 16848906] - Li-Kai Wang, Pei-Jung Wang, Chia-Hui Hou, Chin-Chen Chu, Jann-Inn Tzeng, Ja-Ping Shieh, Jhi-Joung Wang. The antinociceptive and anti-inflammatory effects of five depot formulations of ketorolac propyl ester in rats.
Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists.
2005 Jun; 43(2):85-92. doi:
". [PMID: 16060403] - Barbara Ruozi, Giovanni Tosi, Flavio Forni, Maria Angela Vandelli. Ketorolac tromethamine liposomes: encapsulation and release studies.
Journal of liposome research.
2005; 15(3-4):175-85. doi:
10.1080/08982100500364214. [PMID: 16393909] - Christopher J Diblasio, Mark E Snyder, Michael W Kattan, Paul Russo. Ketorolac: safe and effective analgesia for the management of renal cortical tumors with partial nephrectomy.
The Journal of urology.
2004 Mar; 171(3):1062-5. doi:
10.1097/01.ju.0000109961.69936.8e. [PMID: 14767271] - Ichiro Koyama, Tatsuo Kawai, David Andrews, Svetlan Boskovic, Ognjenka Nadazdin, Siew Lin Wee, Hiroshi Sogawa, Dong-Li Wu, R Neal Smith, Robert B Colvin, David H Sachs, A Benedict Cosimi. Thrombophilia associated with anti-CD154 monoclonal antibody treatment and its prophylaxis in nonhuman primates.
Transplantation.
2004 Feb; 77(3):460-2. doi:
10.1097/01.tp.0000110291.29370.c0. [PMID: 14966427] - A Saita, A Bonaccorsi, M Aquilino, F Guzzardi, A Lazzara, M Motta. ESWL: Comparing two analgesic techniques. Our experience.
Urologia internationalis.
2004; 72 Suppl 1(?):46-7. doi:
10.1159/000076592. [PMID: 15133334] - Alan E Jones, John A Watts, Jacob P Debelak, Lisa R Thornton, John G Younger, Jeffrey A Kline. Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat.
American journal of physiology. Lung cellular and molecular physiology.
2003 Jun; 284(6):L1072-81. doi:
10.1152/ajplung.00283.2002. [PMID: 12639842] - Gopi N Devaraj, S R Parakh, Ravi Devraj, S S Apte, B Ramesh Rao, D Rambhau. Release studies on niosomes containing fatty alcohols as bilayer stabilizers instead of cholesterol.
Journal of colloid and interface science.
2002 Jul; 251(2):360-5. doi:
10.1006/jcis.2002.8399. [PMID: 16290741] - Richard M Dsida, Melissa Wheeler, Patrick K Birmingham, Zhao Wang, Corri L Heffner, Charles J Coté, Michael J Avram. Age-stratified pharmacokinetics of ketorolac tromethamine in pediatric surgical patients.
Anesthesia and analgesia.
2002 Feb; 94(2):266-70, table of contents. doi:
10.1097/00000539-200202000-00007. [PMID: 11812682] - J B Marotte, D P Smith. Extravesical ureteral reimplantations for the correction of primary reflux can be done as outpatient procedures.
The Journal of urology.
2001 Jun; 165(6 Pt 2):2228-31. doi:
10.1097/00005392-200106001-00003. [PMID: 11371950] - Z Wang, R M Dsida, M J Avram. Determination of ketorolac in human plasma by reversed-phase high-performance liquid chromatography using solid-phase extraction and ultraviolet detection.
Journal of chromatography. B, Biomedical sciences and applications.
2001 May; 755(1-2):383-6. doi:
10.1016/s0378-4347(01)00134-7. [PMID: 11393731] - G K Chow, M D Fabrizio, T Steer, S R Potter, T W Jarrett, S Gelman, L R Kavoussi. Prospective double-blind study of effect of ketorolac administration after laparoscopic urologic surgery.
Journal of endourology.
2001 Mar; 15(2):171-4. doi:
10.1089/089277901750134502. [PMID: 11325088] - G Della Rocca, M G Costa, K Bruno, C Coccia, L Pompei, P Di Marco, R Pretagostini, M Colonnello, M Rossi, P Pietropaoli, R Cortesini. Pediatric renal transplantation: anesthesia and perioperative complications.
Pediatric surgery international.
2001 Mar; 17(2-3):175-9. doi:
10.1007/s003830000486. [PMID: 11315282]
