Tedizolid Phosphate (BioDeep_00000776152)
代谢物信息卡片
化学式: C17H16FN6O6P (450.0852938)
中文名称: 磷酸泰地唑胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1N=C(N=N1)C2=NC=C(C=C2)C3=C(C=C(C=C3)N4CC(OC4=O)COP(=O)(O)O)F
InChI: InChI=1S/C17H16FN6O6P/c1-23-21-16(20-22-23)15-5-2-10(7-19-15)13-4-3-11(6-14(13)18)24-8-12(30-17(24)25)9-29-31(26,27)28/h2-7,12H,8-9H2,1H3,(H2,26,27,28)/t12-/m1/s1
描述信息
A four-component ring assembly consisting of 5-(phosphooxymethyl)-1,3-oxazolidin-2-one, fluorobenzene, pyridine and 2-methyltetrazole rings joined in sequence. The prodrug of tedizolid, used for the treatment of acute bacterial skin infections caused by certain susceptible bacteria, including Staphylococcus aureus (including methicillin-resistant strains (MRSA) and methicillin-susceptible strains), various Streptococcus species, and Enterococcus faecalis.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:83326
- KEGGdrug: D09686
- PubChem: 11476460
- DrugBank: DB09042
- ChEMBL: CHEMBL2105669
- CAS: 856867-55-5
- MetaboLights: MTBLC83326
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Antonio C Arrieta, Jocelyn Y Ang, Claudia Espinosa, Oleksandr Fofanov, Camilla Tøndel, Margaret Z Chou, Carisa S De Anda, Jason Y Kim, Dan Li, Philip Sabato, Pamela S Sears, John S Bradley. Pharmacokinetics and Safety of Single-dose Tedizolid Phosphate in Children 2 to <12 Years of Age.
The Pediatric infectious disease journal.
2021 04; 40(4):317-323. doi:
10.1097/inf.0000000000003030. [PMID: 33710976] - A Young J Park, Joshua Wang, Jordanna Jayne, Lynn Fukushima, Adupa P Rao, David Z D'Argenio, Paul M Beringer. Pharmacokinetics of Tedizolid in Plasma and Sputum of Adults with Cystic Fibrosis.
Antimicrobial agents and chemotherapy.
2018 09; 62(9):. doi:
10.1128/aac.00550-18. [PMID: 29914949] - Shawn D Flanagan, Sonia L Minassian, Philippe Prokocimer. Pharmacokinetics, Safety, and Tolerability of Tedizolid Phosphate in Elderly Subjects.
Clinical pharmacology in drug development.
2018 09; 7(7):788-794. doi:
10.1002/cpdd.426. [PMID: 29319932] - Yun Kim, Anhye Kim, SeungHwan Lee, Sung-Hak Choi, Dae Young Lee, Ji-Su Song, Howard Lee, In-Jin Jang, Kyung-Sang Yu. Pharmacokinetics, Safety, and Tolerability of Tedizolid Phosphate After Single-dose Administration in Healthy Korean Male Subjects.
Clinical therapeutics.
2017 Sep; 39(9):1849-1857. doi:
10.1016/j.clinthera.2017.08.002. [PMID: 28865799] - Muzaffar Iqbal. A highly sensitive and efficient UPLC-MS/MS assay for rapid analysis of tedizolid (a novel oxazolidinone antibiotic) in plasma sample.
Biomedical chromatography : BMC.
2016 Nov; 30(11):1750-1756. doi:
10.1002/bmc.3749. [PMID: 27105920] - Kyung-Hwa Park, Kerryl E Greenwood-Quaintance, Jayawant Mandrekar, Robin Patel. Activity of Tedizolid in Methicillin-Resistant Staphylococcus aureus Experimental Foreign Body-Associated Osteomyelitis.
Antimicrobial agents and chemotherapy.
2016 11; 60(11):6568-6572. doi:
10.1128/aac.01248-16. [PMID: 27550347] - Norihito Kaku, Yoshitomo Morinaga, Kazuaki Takeda, Kosuke Kosai, Naoki Uno, Hiroo Hasegawa, Taiga Miyazaki, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara. Antimicrobial and immunomodulatory effects of tedizolid against methicillin-resistant Staphylococcus aureus in a murine model of hematogenous pulmonary infection.
International journal of medical microbiology : IJMM.
2016 Sep; 306(6):421-8. doi:
10.1016/j.ijmm.2016.05.010. [PMID: 27259840] - Thomas P Lodise, Monique R Bidell, Shawn D Flanagan, Evan J Zasowski, Sonia L Minassian, Philippe Prokocimer. Characterization of the haematological profile of 21 days of tedizolid in healthy subjects.
The Journal of antimicrobial chemotherapy.
2016 09; 71(9):2553-8. doi:
10.1093/jac/dkw206. [PMID: 27317442] - John S Bradley, Shawn D Flanagan, Antonio C Arrieta, Richard Jacobs, Edmund Capparelli, Philippe Prokocimer. Pharmacokinetics, Safety and Tolerability of Single Oral or Intravenous Administration of 200 mg Tedizolid Phosphate in Adolescents.
The Pediatric infectious disease journal.
2016 06; 35(6):628-33. doi:
10.1097/inf.0000000000001096. [PMID: 26910588] - Michael J Schlosser, Hiromi Hosako, Ann Radovsky, Mark T Butt, Dragomir Draganov, Jenifer Vija, Frederick Oleson. Lack of neuropathological changes in rats administered tedizolid phosphate for nine months.
Antimicrobial agents and chemotherapy.
2015 Jan; 59(1):475-81. doi:
10.1128/aac.03950-14. [PMID: 25385101] - Ye Hui, Lü Xiaoju. Tedizolid for treatment of acute bacterial skin and skin structure infections.
Expert review of anti-infective therapy.
2015; 13(9):1051-60. doi:
10.1586/14787210.2015.1073107. [PMID: 26211946] - Liana C Chan, Li Basuino, Etyene C Dip, Henry F Chambers. Comparative efficacies of tedizolid phosphate, vancomycin, and daptomycin in a rabbit model of methicillin-resistant Staphylococcus aureus endocarditis.
Antimicrobial agents and chemotherapy.
2015; 59(6):3252-6. doi:
10.1128/aac.04376-14. [PMID: 25801564] - S Flanagan, S L Minassian, D Morris, R Ponnuraj, T C Marbury, H W Alcorn, E Fang, P Prokocimer. Pharmacokinetics of tedizolid in subjects with renal or hepatic impairment.
Antimicrobial agents and chemotherapy.
2014 Nov; 58(11):6471-6. doi:
10.1128/aac.03431-14. [PMID: 25136024] - Shawn Flanagan, Edward Fang, Kelly A Muñoz, Sonia L Minassian, Philippe G Prokocimer. Single- and multiple-dose pharmacokinetics and absolute bioavailability of tedizolid.
Pharmacotherapy.
2014 Sep; 34(9):891-900. doi:
10.1002/phar.1458. [PMID: 24989138] - Voon Ong, Shawn Flanagan, Edward Fang, Howard J Dreskin, Jeffrey B Locke, Kenneth Bartizal, Philippe Prokocimer. Absorption, distribution, metabolism, and excretion of the novel antibacterial prodrug tedizolid phosphate.
Drug metabolism and disposition: the biological fate of chemicals.
2014 Aug; 42(8):1275-84. doi:
10.1124/dmd.113.056697. [PMID: 24875463] - Shawn D Flanagan, Paul A Bien, Kelly A Muñoz, Sonia L Minassian, Philippe G Prokocimer. Pharmacokinetics of tedizolid following oral administration: single and multiple dose, effect of food, and comparison of two solid forms of the prodrug.
Pharmacotherapy.
2014 Mar; 34(3):240-50. doi:
10.1002/phar.1337. [PMID: 23926058] - Arnold Louie, Weiguo Liu, Robert Kulawy, G L Drusano. In vivo pharmacodynamics of torezolid phosphate (TR-701), a new oxazolidinone antibiotic, against methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains in a mouse thigh infection model.
Antimicrobial agents and chemotherapy.
2011 Jul; 55(7):3453-60. doi:
10.1128/aac.01565-10. [PMID: 21502615] - Nelly Alejandra Espinoza-González, Oliverio Welsh, Noemi Waksman de Torres, Norma Cavazos-Rocha, Jorge Ocampo-Candiani, Salvador Said-Fernandez, Gerardo Lozano-Garza, Sung-Hak Choi, Lucio Vera-Cabrera. Efficacy of DA-7218, a new oxazolidinone prodrug, in the treatment of experimental actinomycetoma produced by Nocardia brasiliensis.
Molecules (Basel, Switzerland).
2008 Jan; 13(1):31-40. doi:
10.3390/molecules13010031. [PMID: 18259127] - Soo K Bae, Si H Yang, Karen N Shin, Jae K Rhee, Moohi Yoo, Myung G Lee. Pharmacokinetics of DA-7218, a new oxazolidinone, and its active metabolite, DA-7157, after intravenous and oral administration of DA-7218 and DA-7157 to rats.
The Journal of pharmacy and pharmacology.
2007 Jul; 59(7):955-63. doi:
10.1211/jpp.59.7.0007. [PMID: 17637190]