Rosiglitazone maleate (BioDeep_00000776057)
代谢物信息卡片
Rosiglitazone maleate
化学式: C22H23N3O7S (473.1257)
中文名称: 马来酸罗格列酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3.C(=CC(=O)O)C(=O)O
InChI: 2-1-
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C98241 - Thiazolidinedione Antidiabetic Agent
C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer
D007004 - Hypoglycemic Agents
Rosiglitazone maleate (BRL 49653C) is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone maleate is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).
同义名列表
3 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:8892
- KEGGdrug: D00596
- PubChem: 5281055
- ChEMBL: CHEMBL843
- MeSH: Rosiglitazone
- CAS: 155141-29-0
- medchemexpress: HY-14600
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- G De Soricellis, F Rinaldi, S Tengattini, C Temporini, S Negri, D Capelli, R Montanari, H Cena, S Salerno, G Massolini, F Guzzo, E Calleri. Development of an analytical platform for the affinity screening of natural extracts by SEC-MS towards PPARα and PPARγ receptors.
Analytica chimica acta.
2024 Jun; 1309(?):342666. doi:
10.1016/j.aca.2024.342666. [PMID: 38772654] - Yunxiao Zhang, Maoqi Luo, Yaxin Jia, Tingting Gao, Li Deng, Tao Gong, Zhirong Zhang, Xi Cao, Yao Fu. Adipocyte-targeted delivery of rosiglitazone with localized photothermal therapy for the treatment of diet-induced obesity in mice.
Acta biomaterialia.
2024 Jun; 181(?):317-332. doi:
10.1016/j.actbio.2024.04.029. [PMID: 38643815] - Wenli Cui, Jing Yang, Chuanyun Tu, Ziting Zhang, Huifang Zhao, Yan Qiao, Yanqiu Li, Wulin Yang, Kah-Leong Lim, Quanhong Ma, Chengwu Zhang, Li Lu. Seipin deficiency-induced lipid dysregulation leads to hypomyelination-associated cognitive deficits via compromising oligodendrocyte precursor cell differentiation.
Cell death & disease.
2024 May; 15(5):350. doi:
10.1038/s41419-024-06737-z. [PMID: 38773070] - Chintha Lankatillake, Tien Huynh, Daniel A Dias. Abrus precatorius Leaf Extract Stimulates Insulin-mediated Muscle Glucose Uptake: In vitro Studies and Phytochemical Analysis.
Planta medica.
2024 May; 90(5):388-396. doi:
10.1055/a-2281-0988. [PMID: 38490239] - Wenli Cui, Hong Chen, Lingfeng Lei, Wenru Wang, Kah-Leong Lim, Chengwu Zhang, Li Lu. Seipin Deficiency Leads to Energy Dyshomeostasis via Inducing Hypothalamic Neuroinflammation and Aberrant Expression of Neuropeptides.
Neuromolecular medicine.
2024 May; 26(1):18. doi:
10.1007/s12017-024-08788-z. [PMID: 38691185] - Weisi Lai, Ling Yu, Yali Deng. PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Communications biology.
2024 Apr; 7(1):429. doi:
10.1038/s42003-024-06063-2. [PMID: 38594496] - Jiajia Liao, Lingyun Fu, Shidie Tai, Yini Xu, Shengquan Wang, Linlin Guo, Die Guo, Youqi Du, Jinggang He, Hong Yang, Xiaoxia Hu, Ling Tao, Xiangchun Shen. Essential oil from Fructus Alpiniae zerumbet ameliorates vascular endothelial cell senescence in diabetes by regulating PPAR-γ signalling: A 4D label-free quantitative proteomics and network pharmacology study.
Journal of ethnopharmacology.
2024 Mar; 321(?):117550. doi:
10.1016/j.jep.2023.117550. [PMID: 38065350] - Xinyi Zhang, Yuan Gao, Keyun Tang, Zongyu Li, Alexandra A Halberstam, Liqun Zhou, Rachel J Perry. Thiazolidinedione enhances the efficacy of anti-PD-1 monoclonal antibody in murine melanoma.
American journal of physiology. Endocrinology and metabolism.
2024 Mar; 326(3):E341-E350. doi:
10.1152/ajpendo.00346.2023. [PMID: 38294697] - Lim Shern Kwok, Shim Siang Yian, Layla Qasim Ismael, Yvonne Tee Get Bee, Gam Lay Harn, Khoo Boon Yin. Vimentin protein is a factor for decreasing breast cancer cell proliferation co-culture with human bone marrow-derived mesenchymal stem cells pre-treated with thiazolidinedione solutions.
Molecular biology reports.
2024 Feb; 51(1):317. doi:
10.1007/s11033-024-09269-z. [PMID: 38381204] - I-Ta Lee, Chien-Chung Yang, Chuen-Mao Yang. Harnessing peroxisome proliferator-activated receptor γ agonists to induce Heme Oxygenase-1: a promising approach for pulmonary inflammatory disorders.
Cell communication and signaling : CCS.
2024 02; 22(1):125. doi:
10.1186/s12964-024-01501-4. [PMID: 38360670] - Mi-Jeong Lee, Vishwajeet Puri, Susan K Fried. Metabolic and structural remodeling during browning of primary human adipocytes derived from omental and subcutaneous depots.
Obesity (Silver Spring, Md.).
2024 Jan; 32(1):70-79. doi:
10.1002/oby.23912. [PMID: 37929774] - Yongju Ye, Weimei Zhou, Yuefang Ren, Jiali Lu, Aixue Chen, Ruiying Jin, Feilan Xuan. The ameliorating effects of Guizhi Fuling Wan combined with rosiglitazone in a rat ovarian model of polycystic ovary syndrome by the PI3K/AKT/NF-κB and Nrf2/HO-1 pathways.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2023 Dec; 39(1):2254848. doi:
10.1080/09513590.2023.2254848. [PMID: 37706434] - Hee-Sung Chae, Charles L Cantrell, Ikhlas A Khan, Robert L Jarret, Shabana I Khan. Capsiate-Rich Fraction of Capsicum annuum Induces Muscular Glucose Uptake, Ameliorates Rosiglitazone-Induced Adipogenesis, and Exhibits Activation of NRs Regulating Multiple Signaling Pathways.
Journal of agricultural and food chemistry.
2023 Nov; 71(47):18395-18404. doi:
10.1021/acs.jafc.3c06148. [PMID: 37972244] - Leandro Gastón Parra, Luciana Cecilia Erjavec, Cecilia Irene Casali, Andrea Zerpa Velazquez, Karen Weber, Clara Patricia Setton-Avruj, María Del Carmen Fernández Tome. Cytosolic phospholipase A2 regulates lipid homeostasis under osmotic stress through PPARγ.
The FEBS journal.
2023 Nov; ?(?):. doi:
10.1111/febs.16998. [PMID: 37947039] - Johanna M Melin, Maria Forslund, Simon J Alesi, Terhi Piltonen, Daniela Romualdi, Poli M Spritzer, Chau Thien Tay, Alexia S Pena, Selma F Witchel, Aya Mousa, Helena J Teede. Effects of different insulin sensitisers in the management of polycystic ovary syndrome: A systematic review and meta-analysis.
Clinical endocrinology.
2023 Nov; ?(?):. doi:
10.1111/cen.14983. [PMID: 37933831] - Can Zhao, Jian-Zhong Zhu, Cui-Rong Song, Hui-Jie Ruan, Jian-Hui Liu, Yuan-Yuan Liu, Yue-Lin Sui. Effects of Moringa Oleifera Leaf Extract Plus Rosiglitazone on Serum Leptin and Glucose and Lipid Metabolism in Type 2 Diabetic Rats.
Alternative therapies in health and medicine.
2023 Sep; ?(?):. doi:
. [PMID: 37678870] - Yue Dai, Yuting Chen, Dexiameng Mo, Rui Jin, Yi Huang, Le Zhang, Cuntai Zhang, Hongyu Gao, Qi Yan. Inhibition of ACSL4 ameliorates tubular ferroptotic cell death and protects against fibrotic kidney disease.
Communications biology.
2023 09; 6(1):907. doi:
10.1038/s42003-023-05272-5. [PMID: 37670055] - Yunjin J Yum, Jin Yoo, Kyuhoon Bang, Ji Eun Jun, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung, You-Cheol Hwang. Peroxisome proliferator-activated receptor γ activation ameliorates liver fibrosis-differential action of transcription factor EB and autophagy on hepatocytes and stellate cells.
Hepatology communications.
2023 06; 7(6):. doi:
10.1097/hc9.0000000000000154. [PMID: 37204406] - Elvis Ticiani, Yong Pu, Madison White, Victoria Adomshick, Almudena Veiga-Lopez. Organotin mixtures reveal interactions that modulate adipogenic differentiation in 3T3-L1 preadipocytes.
Archives of toxicology.
2023 06; 97(6):1649-1658. doi:
10.1007/s00204-023-03512-5. [PMID: 37142754] - Hee-Sung Chae, Olivia Dale, Tahir M Mir, Mohammad K Ashfaq, Bharathi Avula, Larry A Walker, Ikhlas A Khan, Shabana I Khan. Juniper Berries Regulate Diabetes and Obesity Markers Through Modulating PPARα, PPARγ, and LXR: In Vitro and In Vivo Effects.
Journal of medicinal food.
2023 May; 26(5):307-318. doi:
10.1089/jmf.2022.0146. [PMID: 37186895] - Yuefang Ren, Yongju Ye, Feilan Xuan, Aixue Chen, Ruiying Jin, Weimei Zhou, Jiali Lu. The effect of sitagliptin combined with rosiglitazone on autophagy and inflammation in polycystic ovary syndrome by regulating PI3K/AKT/mTOR and TLR4/NF-κB pathway.
Reproductive biology.
2023 Apr; 23(2):100763. doi:
10.1016/j.repbio.2023.100763. [PMID: 37075562] - Y Xie, H F Berntsen, K E Zimmer, E Ropstad, S Verhaegen, L Connolly. Luteolin protects against adipogenic and lipogenic potency induced by human relevant mixtures of persistent organic pollutants (POPs) in the 3T3-L1 model.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2023 Mar; 173(?):113608. doi:
10.1016/j.fct.2023.113608. [PMID: 36639049] - Petra Kotzbeck, Ulrike Taschler, Christoph Haudum, Ines Foessl, Gabriele Schoiswohl, Beate Boulgaropoulos, Kaddour Bounab, Johanna Einsiedler, Laura Pajed, Anna Tilp, Anna Schwarz, Thomas O Eichmann, Barbara Obermayer-Pietsch, Antonio Giordano, Saverio Cinti, Rudolf Zechner, Thomas R Pieber. Rosiglitazone Reverses Inflammation in Epididymal White Adipose Tissue in Hormone-Sensitive Lipase-Knockout Mice.
Journal of lipid research.
2023 01; 64(1):100305. doi:
10.1016/j.jlr.2022.100305. [PMID: 36273647] - Manoj K Singh, Rohit Yadav, Akash Kumar Bhaskar, Shantanu Sengupta, Chetana Sachidanandan. A diet-independent zebrafish model for NAFLD recapitulates patient lipid profiles and offers a system for small molecule screening.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2023 01; 1868(1):159246. doi:
10.1016/j.bbalip.2022.159246. [PMID: 36202338] - Xueting Xing, Mengzhu Kong, Qiaoyu Hou, Jiaqi Li, Wen Qian, Xijing Chen, Hanhan Li, Changqing Yang. Effects of ginkgo leaf tablet on the pharmacokinetics of rosiglitazone in rats and its potential mechanism.
Pharmaceutical biology.
2022 Dec; 60(1):1190-1197. doi:
10.1080/13880209.2022.2087688. [PMID: 35758248] - Zongjin Yue, Ruyin Liu, Lu Yu, Xinli Wang, Xiangyang Xu. [Achyranthes bidentata polysaccharide inhibits the adipogenic differentiation of rat bone marrow mesenchymal stem cells by blocking the PPARγ/TRPV4 pathway].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2022 Dec; 38(12):1111-1117. doi:
". [PMID: 36585234] - Xiu-Ying Jiang, Ping-Sun Yang, Ou Xiao, Kang Yu, Shu-Yi Wang, Shuang-Jian Yang, Shi-You Zhou. Effects of PPAR-γ and RXR-α on mouse meibomian gland epithelial cells during inflammation induced by latanoprost.
Experimental eye research.
2022 11; 224(?):109251. doi:
10.1016/j.exer.2022.109251. [PMID: 36150542] - Lena Neuper, Daniel Kummer, Désirée Forstner, Jacqueline Guettler, Nassim Ghaffari-Tabrizi-Wizsy, Cornelius Fischer, Herbert Juch, Olivia Nonn, Martin Gauster. Candesartan Does Not Activate PPARγ and Its Target Genes in Early Gestation Trophoblasts.
International journal of molecular sciences.
2022 Oct; 23(20):. doi:
10.3390/ijms232012326. [PMID: 36293183] - Siyu Liu, Yanping Tang, Lei Liu, Lei Yang, Peicai Li, Xi Liu, Hong Yin. Proteomic analysis reveals that ACSL4 activation during reflux esophagitis contributes to ferroptosis-mediated esophageal mucosal damage.
European journal of pharmacology.
2022 Sep; 931(?):175175. doi:
10.1016/j.ejphar.2022.175175. [PMID: 35921957] - Faizul Azam, Martiniano Bello. Microsecond MD Simulations to Explore the Structural and Energetic Differences between the Human RXRα-PPARγ vs. RXRα-PPARγ-DNA.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27185778. [PMID: 36144514] - Takehiro Yamamoto, Zhicheng Diao, Masaru Murakami, Fumie Shimokawa, Tohru Matsui, Masayuki Funaba. Factors affecting the induction of uncoupling protein 1 in C2C12 myogenic cells.
Cytokine.
2022 09; 157(?):155936. doi:
10.1016/j.cyto.2022.155936. [PMID: 35738051] - Ya-Han Liu, Yan Liu, Xu Zhang, Li Fang, Bei-Lei Zhao, Nan-Ping Wang. Activation of the endocannabinoid system mediates cardiac hypertrophy induced by rosiglitazone.
Acta pharmacologica Sinica.
2022 Sep; 43(9):2302-2312. doi:
10.1038/s41401-022-00858-x. [PMID: 35190698] - Hui Wang, Zhongju Xu, Qi Wang, Shi Shu. Danshao Shugan Granule therapy for non-alcoholic fatty liver disease.
Lipids in health and disease.
2022 Aug; 21(1):76. doi:
10.1186/s12944-022-01689-9. [PMID: 35999630] - Ui-Hyun Park, Jin-Taek Hwang, HyeSook Youn, Eun-Joo Kim, Soo-Jong Um. Kaempferol antagonizes adipogenesis by repressing histone H3K4 methylation at PPARγ target genes.
Biochemical and biophysical research communications.
2022 08; 617(Pt 1):48-54. doi:
10.1016/j.bbrc.2022.05.098. [PMID: 35679710] - Xue Wang, Qiang Ma, Lingyun Chen, Hongxia Wu, Li-Qiao Chen, Fang Qiao, Yuan Luo, Mei-Ling Zhang, Zhen-Yu Du. Peroxisome proliferator-activated receptor gamma is essential for stress adaptation by maintaining lipid homeostasis in female fish.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2022 07; 1867(7):159162. doi:
10.1016/j.bbalip.2022.159162. [PMID: 35427795] - Junxia Feng, Meizhi Lu, Wenhao Li, Jingchun Li, Ping Meng, Zukai Li, Xuejuan Gao, Yunfang Zhang. PPARγ alleviates peritoneal fibrosis progression along with promoting GLUT1 expression and suppressing peritoneal mesothelial cell proliferation.
Molecular and cellular biochemistry.
2022 Jul; 477(7):1959-1971. doi:
10.1007/s11010-022-04419-y. [PMID: 35380292] - Qidong Ren, Xinni Xie, Chuanfang Zhao, Qing Wen, Ruiying Pan, Yuguo Du. 2,2',4,4'-Tetrabromodiphenyl Ether (PBDE 47) Selectively Stimulates Proatherogenic PPARγ Signatures in Human THP-1 Macrophages to Contribute to Foam Cell Formation.
Chemical research in toxicology.
2022 06; 35(6):1023-1035. doi:
10.1021/acs.chemrestox.2c00043. [PMID: 35575305] - Claes Fryklund, Björn Morén, Mathis Neuhaus, Vipul Periwal, Karin G Stenkula. Rosiglitazone treatment enhances intracellular actin dynamics and glucose transport in hypertrophic adipocytes.
Life sciences.
2022 Jun; 299(?):120537. doi:
10.1016/j.lfs.2022.120537. [PMID: 35398016] - Jae Eun Park, Jaemin Son, Youngwan Seo, Ji Sook Han. HM-Chromanone Ameliorates Hyperglycemia and Dyslipidemia in Type 2 Diabetic Mice.
Nutrients.
2022 May; 14(9):. doi:
10.3390/nu14091951. [PMID: 35565920] - Kusuma Kumari Garikapati, Ravi Kiran Ammu V V V, Praveen Thaggikuppe Krishnamurthy, Narenderan S T, Babu B, Krishnaveni Nagappan. Quantification of rosiglitazone in rat plasma and tissues via LC-MS/MS: Method development, validation, and application in pharmacokinetic and tissue distribution studies.
Biomedical chromatography : BMC.
2022 May; 36(5):e5326. doi:
10.1002/bmc.5326. [PMID: 34993979] - Yue Wang, Menghan Zhang, Ran Bi, Yali Su, Fei Quan, Yanting Lin, Chongxiu Yue, Xinmeng Cui, Qixiang Zhao, Siliang Liu, Yong Yang, Dayong Zhang, Qiuhua Cao, Xinghua Gao. ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury.
Redox biology.
2022 05; 51(?):102262. doi:
10.1016/j.redox.2022.102262. [PMID: 35180475] - Qiaoyu Hou, Yanzhi Liu, Xueting Xing, Shuo Li, Jiaqi Li, Wen Qian, Changqing Yang, Hanhan Li. Effects of the total flavonoid extracts and the monomers of Daphne genkwa on CYP2C8 activity.
Xenobiotica; the fate of foreign compounds in biological systems.
2022 Apr; 52(4):353-359. doi:
10.1080/00498254.2022.2083531. [PMID: 35621148] - Moza Mohamed Al-Ali, Amir Ali Khan, Abeer Maher Fayyad, Sallam Hasan Abdallah, Muhammad Nasir Khan Khattak. Transcriptomic profiling of the telomerase transformed Mesenchymal stromal cells derived adipocytes in response to rosiglitazone.
BMC genomic data.
2022 03; 23(1):17. doi:
10.1186/s12863-022-01027-z. [PMID: 35264099] - Francesco Nicoli, Mariela P Cabral-Piccin, Laura Papagno, Eleonora Gallerani, Mathieu Fusaro, Victor Folcher, Marion Dubois, Emmanuel Clave, Hélène Vallet, Justin J Frere, Emma Gostick, Sian Llewellyn-Lacey, David A Price, Antoine Toubert, Loïc Dupré, Jacques Boddaert, Antonella Caputo, Riccardo Gavioli, Victor Appay. Altered Basal Lipid Metabolism Underlies the Functional Impairment of Naive CD8+ T Cells in Elderly Humans.
Journal of immunology (Baltimore, Md. : 1950).
2022 02; 208(3):562-570. doi:
10.4049/jimmunol.2100194. [PMID: 35031578] - Seyed Mohamad Sadegh Modaresi, Wei Wei, Marques Emily, Nicholas A DaSilva, Angela L Slitt. Per- and polyfluoroalkyl substances (PFAS) augment adipogenesis and shift the proteome in murine 3T3-L1 adipocytes.
Toxicology.
2022 01; 465(?):153044. doi:
10.1016/j.tox.2021.153044. [PMID: 34800597] - Minh Anh Thu Phan, Michele C Madigan, Fiona Stapleton, Mark Willcox, Blanka Golebiowski. Human meibomian gland epithelial cell culture models: Current progress, challenges, and future directions.
The ocular surface.
2022 01; 23(?):96-113. doi:
10.1016/j.jtos.2021.11.012. [PMID: 34843998] - Dan Luo, Xiaokang Dong, Jie Huang, Chengcheng Huang, Guowei Fang, Yanqin Huang. Pueraria lobata root polysaccharide alleviates glucose and lipid metabolic dysfunction in diabetic db/db mice.
Pharmaceutical biology.
2021 Dec; 59(1):382-390. doi:
10.1080/13880209.2021.1898648. [PMID: 33794128] - Yiming Ma, Xinyi Du, Dandan Zhao, Kegong Tang, Xiaona Wang, Shaoting Guo, Xiaobei Li, Song Mei, Na Sun, Jiaqi Liu, Chengyu Jiang. 18:0 Lyso PC, a natural product with potential PPAR-γ agonistic activity, plays hypoglycemic effect with lower liver toxicity and cardiotoxicity in db/db mice.
Biochemical and biophysical research communications.
2021 11; 579(?):168-174. doi:
10.1016/j.bbrc.2021.09.059. [PMID: 34607170] - Meng-Ting Chen, Jun-Shang Huang, Ding-Ding Gao, Ying-Xia Li, He-Yao Wang. Combined treatment with FABP4 inhibitor ameliorates rosiglitazone-induced liver steatosis in obese diabetic db/db mice.
Basic & clinical pharmacology & toxicology.
2021 Sep; 129(3):173-182. doi:
10.1111/bcpt.13621. [PMID: 34128319] - Minh Anh Thu Phan, Michele C Madigan, Mark Willcox, Fiona Stapleton, Blanka Golebiowski. Semi-quantification of lipids in human meibomian gland epithelial cells using dual staining microplate assays.
Experimental eye research.
2021 09; 210(?):108719. doi:
10.1016/j.exer.2021.108719. [PMID: 34364889] - Li Feng, Shaoyong Lu, Zhen Zheng, Yingyi Chen, Yuanyuan Zhao, Kun Song, Hongjuan Xue, Lihua Jin, Yong Li, Cheng Huang, Yi-Ming Li, Jian Zhang. Identification of an allosteric hotspot for additive activation of PPARγ in antidiabetic effects.
Science bulletin.
2021 08; 66(15):1559-1570. doi:
10.1016/j.scib.2021.01.023. [PMID: 36654285] - Hannah E Wilson, David A Stanton, Stephanie Rellick, Werner Geldenhuys, Emidio E Pistilli. Breast cancer-associated skeletal muscle mitochondrial dysfunction and lipid accumulation is reversed by PPARG.
American journal of physiology. Cell physiology.
2021 04; 320(4):C577-C590. doi:
10.1152/ajpcell.00264.2020. [PMID: 33439777] - Ronghe Chen, Shanshan Huang, Tongtong Lin, Haosong Ma, Wenjun Shan, Fei Duan, Jing Lv, Jinde Zhang, Lei Ren, Liming Nie. Photoacoustic molecular imaging-escorted adipose photodynamic-browning synergy for fighting obesity with virus-like complexes.
Nature nanotechnology.
2021 04; 16(4):455-465. doi:
10.1038/s41565-020-00844-6. [PMID: 33526836] - Jillian F Ziemanski, Landon Wilson, Stephen Barnes, Kelly K Nichols. Saturation of cholesteryl esters produced by human meibomian gland epithelial cells after treatment with rosiglitazone.
The ocular surface.
2021 04; 20(?):39-47. doi:
10.1016/j.jtos.2020.11.011. [PMID: 33248214] - Ziba Majidi, Shaghayegh Hosseinkhani, Nasrin Amiri-Dashatan, Solaleh Emamgholipour, Sara Tutunchi, Javad Hashemi, Fatemeh Ghorbani, Mehdi Koushki. Effect of rosiglitazone on circulating malondialdehyde (MDA) level in diabetes based on a systematic review and meta-analysis of eight clinical trials.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research.
2021 03; 69(3):697-703. doi:
10.1136/jim-2020-001588. [PMID: 33408159] - Mallikarjuna B G, Uma V Manjappara. Obestatin and Rosiglitazone Differentially Modulate Lipid Metabolism Through Peroxisome Proliferator-activated Receptor-γ (PPARγ) in Pre-adipose and Mature 3T3-L1 Cells.
Cell biochemistry and biophysics.
2021 Mar; 79(1):73-85. doi:
10.1007/s12013-020-00958-7. [PMID: 33432549] - Yi-Fan Dang, Shao-Hui Yang, Xiao-Ning Jiang, Fu-Lian Gong, Xiao-Xia Yang, Yan-Na Cheng, Xiu-Li Guo. Combination treatment strategies with a focus on rosiglitazone and adriamycin for insulin resistant liver cancer.
Journal of drug targeting.
2021 03; 29(3):336-348. doi:
10.1080/1061186x.2020.1844216. [PMID: 33115283] - Dong-Yan Guan, Hui-Wen Sun, Ji-Ting Wang, Zhen Wang, Yang Li, Hao-Jun Han, Xiang Li, Ting-Ting Fang. Rosiglitazone promotes glucose metabolism of GIFT tilapia based on the PI3K/Akt signaling pathway.
Physiological reports.
2021 03; 9(5):e14765. doi:
10.14814/phy2.14765. [PMID: 33650786] - Yousef Baghcheghi, Farimah Beheshti, Hossein Salmani, Mahmoud Hosseini. Brain‑derived neurotrophic factor and nitric oxide contribute to protective effects of rosiglitazone on learning and memory in hypothyroid rats.
Acta neurobiologiae experimentalis.
2021; 81(3):218-232. doi:
10.21307/ane-2021-021. [PMID: 34672293] - Hongyan Lu, Xifeng Sun, Min Jia, Fa Sun, Jianguo Zhu, Xiaolong Chen, Kun Chen, Kehua Jiang. Rosiglitazone Suppresses Renal Crystal Deposition by Ameliorating Tubular Injury Resulted from Oxidative Stress and Inflammatory Response via Promoting the Nrf2/HO-1 Pathway and Shifting Macrophage Polarization.
Oxidative medicine and cellular longevity.
2021; 2021(?):5527137. doi:
10.1155/2021/5527137. [PMID: 34691355] - Mette Simone Aae Madsen, Rikke Veggerby Grønlund, John Eid, Mikkel Christensen-Dalsgaard, Morten Sommer, Kristoffer Rigbolt, Martin Rønn Madsen, Jacob Jelsing, Niels Vrang, Henrik H Hansen, Martin Mikkelsen. Characterization of local gut microbiome and intestinal transcriptome responses to rosiglitazone treatment in diabetic db/db mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jan; 133(?):110966. doi:
10.1016/j.biopha.2020.110966. [PMID: 33171401] - Ken Korzekwa. Case Study 5: Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast.
Methods in molecular biology (Clifton, N.J.).
2021; 2342(?):685-693. doi:
10.1007/978-1-0716-1554-6_24. [PMID: 34272712] - Longlong Gong, Huan Jin, Yonghua Li, Yingyao Quan, Jichun Yang, Qing Tang, Zhengzhi Zou. Rosiglitazone ameliorates skeletal muscle insulin resistance by decreasing free fatty acids release from adipocytes.
Biochemical and biophysical research communications.
2020 12; 533(4):1122-1128. doi:
10.1016/j.bbrc.2020.09.144. [PMID: 33036752] - Suping Ren, Yongyong Hou, Zhuo Zuo, Zhiyuan Liu, Huihui Wang, Yuanyuan Xu, Masayuki Yamamoto, Qiang Zhang, Jingqi Fu, Jingbo Pi. Protracted rosiglitazone treatment exacerbates inflammation in white adipose tissues of adipocyte-specific Nfe2l1 knockout mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 Dec; 146(?):111836. doi:
10.1016/j.fct.2020.111836. [PMID: 33137425] - Yixin Xu, Xuehan Li, Yan Cheng, Mingan Yang, Rurong Wang. Inhibition of ACSL4 attenuates ferroptotic damage after pulmonary ischemia-reperfusion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 12; 34(12):16262-16275. doi:
10.1096/fj.202001758r. [PMID: 33070393] - Carli Weyers, Laura M K Dingle, Brendan S Wilhelmi, Adrienne L Edkins, Clinton G L Veale. Use of a non-hepatic cell line highlights limitations associated with cell-based assessment of metabolically induced toxicity.
Drug and chemical toxicology.
2020 Nov; 43(6):656-662. doi:
10.1080/01480545.2019.1585869. [PMID: 30880486] - Mingyang Li, Jingwen Hu, Lihua Yao, Minzhi Gao. Decreased ANGPTL4 impairs endometrial angiogenesis during peri-implantation period in patients with recurrent implantation failure.
Journal of cellular and molecular medicine.
2020 09; 24(18):10730-10743. doi:
10.1111/jcmm.15696. [PMID: 32745373] - Xiaolong Wang, Song He, Zhe Zhou, Xiaochen Bo, Dongmei Qi, Xianjun Fu, Zhenguo Wang, Jing Yang, Shengqi Wang. LINCS dataset-based repositioning of rosiglitazone as a potential anti-human adenovirus drug.
Antiviral research.
2020 07; 179(?):104789. doi:
10.1016/j.antiviral.2020.104789. [PMID: 32353383] - Anirban Kundu, Hyeyoung Nam, Sandeep Shelar, Darshan S Chandrashekar, Garrett Brinkley, Suman Karki, Tanecia Mitchell, Carolina B Livi, Phillip Buckhaults, Richard Kirkman, Yawen Tang, Glenn C Rowe, Shi Wei, Sooryanarayana Varambally, Sunil Sudarshan. PRDM16 suppresses HIF-targeted gene expression in kidney cancer.
The Journal of experimental medicine.
2020 06; 217(6):. doi:
10.1084/jem.20191005. [PMID: 32251515] - Lingling Zhang, Ping Wu, Luyan Zhang, Nagaraja SreeHarsha, Anurag Mishra, Xinyou Su. Ameliorative effect of rosiglitazone, a peroxisome proliferator gamma agonist on adriamycin-induced cardio toxicity via suppressing oxidative stress and apoptosis.
IUBMB life.
2020 04; 72(4):607-615. doi:
10.1002/iub.2190. [PMID: 31660680] - Mohd Ashraf Ganie, Aafia Rashid, Mona Sood, Nighat Yaseen Sofi, Ishfaq A Wani, Sobia Nisar, Tabasum Parvaiz Butt, Nandita Gupta, Dilafroze Bhat, Naseer Choh, Shariq Rashid Masoodi. Coadministration of metformin or spironolactone enhances efficacy of rosiglitazone in management of PCOS.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2020 Apr; 36(4):308-312. doi:
10.1080/09513590.2019.1675044. [PMID: 31701799] - Aifeng Lin, Robert D Inman, Catherine J Streutker, Zhenbo Zhang, Kenneth P H Pritzker, Hing Wo Tsui, Florence W L Tsui. Lipocalin 2 links inflammation and ankylosis in the clinical overlap of inflammatory bowel disease (IBD) and ankylosing spondylitis (AS).
Arthritis research & therapy.
2020 03; 22(1):51. doi:
10.1186/s13075-020-02149-4. [PMID: 32188494] - Abhinav Sharma, Neha J Pagidipati, Robert M Califf, Darren K McGuire, Jennifer B Green, Dave Demets, Jyothis Thomas George, Hertzel C Gerstein, Todd Hobbs, Rury R Holman, Francesca C Lawson, Lawrence A Leiter, Marc A Pfeffer, Jane Reusch, Jeffrey S Riesmeyer, Matthew T Roe, Yves Rosenberg, Robert Temple, Stephen Wiviott, John McMurray, Christopher Granger. Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus: Lessons Learned and Future Directions.
Circulation.
2020 03; 141(10):843-862. doi:
10.1161/circulationaha.119.041022. [PMID: 31992065] - Shuang Zhang, Miao Yu, Fangling Guo, Xiaoxiao Yang, Yuanli Chen, Chuanrui Ma, Qi Li, Zhuo Wei, Xiaoju Li, Hua Wang, Huaqing Hu, Yujue Zhang, Derun Kong, Qing Robert Miao, Wenquan Hu, David P Hajjar, Yan Zhu, Jihong Han, Yajun Duan. Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ12,14 -PGJ2 and Nogo.
British journal of pharmacology.
2020 03; 177(5):1041-1060. doi:
10.1111/bph.14886. [PMID: 31658492] - Taisuke Konno, Kenroh Sasaki, Kyoko Kobayashi, Toshihiro Murata. Indirubin promotes adipocyte differentiation and reduces lipid accumulation in 3T3‑L1 cells via peroxisome proliferator‑activated receptor γ activation.
Molecular medicine reports.
2020 03; 21(3):1552-1560. doi:
10.3892/mmr.2020.10946. [PMID: 32016452] - Yukimasa Takeda, Ping Dai. A developed serum-free medium and an optimized chemical cocktail for direct conversion of human dermal fibroblasts into brown adipocytes.
Scientific reports.
2020 02; 10(1):3775. doi:
10.1038/s41598-020-60769-x. [PMID: 32111895] - Laale F Alawi, Sana E Emberesh, Brenda A Owuor, Harshita Chodavarapu, Rucha Fadnavis, Salim S El-Amouri, Khalid M Elased. Effect of hyperglycemia and rosiglitazone on renal and urinary neprilysin in db/db diabetic mice.
Physiological reports.
2020 02; 8(3):e14364. doi:
10.14814/phy2.14364. [PMID: 32026607] - Petter Bjornstad, Kara Hughan, Megan M Kelsey, Amy S Shah, Jane Lynch, Edward Nehus, Mark Mitsnefes, Todd Jenkins, Peixin Xu, Changchun Xie, Thomas Inge, Kristen Nadeau. Effect of Surgical Versus Medical Therapy on Diabetic Kidney Disease Over 5 Years in Severely Obese Adolescents With Type 2 Diabetes.
Diabetes care.
2020 01; 43(1):187-195. doi:
10.2337/dc19-0708. [PMID: 31685489] - Yujing Li, Jing Tan, Qiuyi Wang, Changling Duan, Yuanyuan Hu, Wei Huang. Comparing the individual effects of metformin and rosiglitazone and their combination in obese women with polycystic ovary syndrome: a randomized controlled trial.
Fertility and sterility.
2020 01; 113(1):197-204. doi:
10.1016/j.fertnstert.2019.09.011. [PMID: 31718828] - Xin Wang, Jin Deng, Chongxiang Xiong, Haishan Chen, Qin Zhou, Yue Xia, Xiaofei Shao, Hequn Zou. Treatment with a PPAR-γ Agonist Protects Against Hyperuricemic Nephropathy in a Rat Model.
Drug design, development and therapy.
2020; 14(?):2221-2233. doi:
10.2147/dddt.s247091. [PMID: 32606592] - Shuping Wei, Chaoli Xu, Yidan Zhang, Zhongqing Shi, Min Wu, Bin Yang. Ultrasound Assisted a Peroxisome Proliferator-Activated Receptor (PPAR)γ Agonist-Loaded Nanoparticle-Microbubble Complex to Attenuate Renal Interstitial Fibrosis.
International journal of nanomedicine.
2020; 15(?):7315-7327. doi:
10.2147/ijn.s262052. [PMID: 33061383] - S-M Zhang, X-F Cai, Y-L Ma, Q Lu. Effect of rosiglitazone on myocardial injury in septic rats through NF-κB pathway.
European review for medical and pharmacological sciences.
2020 01; 24(1):452-460. doi:
10.26355/eurrev_202001_19945. [PMID: 31957860] - Konrad A Szychowski, Jan Gmiński. The Elastin-Derived Peptide VGVAPG Does Not Activate the Inflammatory Process in Mouse Cortical Astrocytes In Vitro.
Neurotoxicity research.
2020 Jan; 37(1):136-145. doi:
10.1007/s12640-019-00114-x. [PMID: 31691186] - Belén Palomares, Francisco Ruiz-Pino, Martin Garrido-Rodriguez, M Eugenia Prados, Miguel A Sánchez-Garrido, Inmaculada Velasco, María J Vazquez, Xavier Nadal, Carlos Ferreiro-Vera, Rosario Morrugares, Giovanni Appendino, Marco A Calzado, Manuel Tena-Sempere, Eduardo Muñoz. Tetrahydrocannabinolic acid A (THCA-A) reduces adiposity and prevents metabolic disease caused by diet-induced obesity.
Biochemical pharmacology.
2020 01; 171(?):113693. doi:
10.1016/j.bcp.2019.113693. [PMID: 31706843] - Motohiko Ukiya, Daisuke Sato, Hirokazu Kimura, Mamoru Koketsu, Nyunt Phay, Atsuyoshi Nishina. (-)-O-Methylcubebin from Vitex trifolia Enhanced Adipogenesis in 3T3-L1 Cells via the Inhibition of ERK1/2 and p38MAPK Phosphorylation.
Molecules (Basel, Switzerland).
2019 Dec; 25(1):. doi:
10.3390/molecules25010073. [PMID: 31878261] - Alexander D Graham, Rajesh Pandey, Viktoriya S Tsancheva, Alessia Candeo, Stanley W Botchway, Alasdair J Allan, Lydia Teboul, Kamel Madi, Tahkur S Babra, Louisa A K Zolkiewski, Xuan Xue, Liz Bentley, Joan Gannon, Sam N Olof, Roger D Cox. The development of a high throughput drug-responsive model of white adipose tissue comprising adipogenic 3T3-L1 cells in a 3D matrix.
Biofabrication.
2019 12; 12(1):015018. doi:
10.1088/1758-5090/ab56fe. [PMID: 31715591] - A Sikora-Wiorkowska, A Smolen, G Czechowska, K Wiorkowski, A Korolczuk. The role of PPAR gamma agonists - rosiglitazone and 15-deoxy-Δ12,14-prostaglandin J2 in experimental cyclosporine A hepatotoxicity.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2019 Dec; 70(6):. doi:
10.26402/jpp.2019.6.07. [PMID: 32084649] - Samanta C Funes, Mariana Ríos, Felipe Gómez-Santander, Ayleen Fernández-Fierro, María J Altamirano-Lagos, Daniela Rivera-Perez, Raul Pulgar-Sepúlveda, Evelyn L Jara, Diego Rebolledo-Zelada, Alejandra Villarroel, Juan C Roa, Juan P Mackern-Oberti, Alexis M Kalergis. Tolerogenic dendritic cell transfer ameliorates systemic lupus erythematosus in mice.
Immunology.
2019 12; 158(4):322-339. doi:
10.1111/imm.13119. [PMID: 31509246] - Zhuo Wei, Dan Zhao, Ye Zhang, Yuanli Chen, Shuang Zhang, Qi Li, Peng Zeng, Xiaoju Li, Wenwen Zhang, Yajun Duan, Jihong Han, Xiaoxiao Yang. Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-κB-TNF-α signaling pathway in a PPARγ-dependent manner.
Biochemical and biophysical research communications.
2019 11; 519(4):854-860. doi:
10.1016/j.bbrc.2019.09.084. [PMID: 31561855] - Qinglang Li, Ying Xiao, Guihua Lu, Dongmei Xie, Yuansheng Zhai, Juhong Zhang, Jie Li, Xiuren Gao. Inhibition of perivascular mast cell activation is involved in the atheroprotective effect of rosiglitazone in apolipoprotein E-deficient mice.
Biochemical and biophysical research communications.
2019 11; 519(2):261-266. doi:
10.1016/j.bbrc.2019.08.146. [PMID: 31493866] - Hui Luo, Qi-Qi Li, Ni Wu, Yu-Ge Shen, Wei-Ting Liao, Yun Yang, E Dong, Gui-Min Zhang, Bin-Rui Liu, Xiao-Zhu Yue, Xiao-Qiang Tang, Han-Shuo Yang. Chronological in vivo imaging reveals endothelial inflammation prior to neutrophils accumulation and lipid deposition in HCD-fed zebrafish.
Atherosclerosis.
2019 11; 290(?):125-135. doi:
10.1016/j.atherosclerosis.2019.09.017. [PMID: 31614249] - Yang Li, Dongcheng Feng, Zhanyu Wang, Yan Zhao, Ruimin Sun, Donghai Tian, Deshun Liu, Feng Zhang, Shili Ning, Jihong Yao, Xiaofeng Tian. Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion.
Cell death and differentiation.
2019 Nov; 26(11):2284-2299. doi:
10.1038/s41418-019-0299-4. [PMID: 30737476] - Tomohiro Matsumoto, Satomi Kiuchi, Takatoshi Murase. Synergistic activation of thermogenic adipocytes by a combination of PPARγ activation, SMAD3 inhibition and adrenergic receptor activation ameliorates metabolic abnormalities in rodents.
Diabetologia.
2019 10; 62(10):1915-1927. doi:
10.1007/s00125-019-4938-6. [PMID: 31317231] - Andressa Manfredini, Larissa Constantino, Milton Castro Pinto, Monique Michels, Henrique Burger, Luiza W Kist, Milena Carvalho Silva, Lara Mezzari Gomes, Diogo Dominguini, Amanda Steckert, Carmen Simioni, Mauricio Bogo, Emílio Streck, Tatiana Barichello, João de Quevedo, Mervyn Singer, Cristiane Ritter, Felipe Dal-Pizzol. Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model.
Clinical science (London, England : 1979).
2019 09; 133(18):1993-2004. doi:
10.1042/cs20190351. [PMID: 31527095] - David M Nathan, Peter H Bennett, Jill P Crandall, Sharon L Edelstein, Ronald B Goldberg, Steven E Kahn, William C Knowler, Kieren J Mather, Sunder Mudaliar, Trevor J Orchard, Marinella Temprosa, Neil H White. Does diabetes prevention translate into reduced long-term vascular complications of diabetes?.
Diabetologia.
2019 08; 62(8):1319-1328. doi:
10.1007/s00125-019-4928-8. [PMID: 31270584] - Ilia Goltsman, Emad E Khoury, Doron Aronson, Omri Nativ, Giora Z Feuerstein, Joseph Winaver, Zaid Abassi. Rosiglitazone treatment restores renal responsiveness to atrial natriuretic peptide in rats with congestive heart failure.
Journal of cellular and molecular medicine.
2019 07; 23(7):4779-4794. doi:
10.1111/jcmm.14366. [PMID: 31087547] - Aya Manabe, Chisa Furukawa, Hajime Hasegawa, Toshiyuki Matsunaga, Satoshi Endo, Akira Ikari. Upregulation of transient receptor potential melastatin 6 channel expression by rosiglitazone and all-trans-retinoic acid in erlotinib-treated renal tubular epithelial cells.
Journal of cellular physiology.
2019 06; 234(6):8951-8962. doi:
10.1002/jcp.27565. [PMID: 30461012] - Radha Gopal, Angelico Mendy, Michael A Marinelli, Lacee J Richwalls, Philip J Seger, Shivani Patel, Kevin J McHugh, Helen E Rich, Jennifer A Grousd, Erick Forno, John F Alcorn. Peroxisome Proliferator-Activated Receptor Gamma (PPAR) Suppresses Inflammation and Bacterial Clearance during Influenza-Bacterial Super-Infection.
Viruses.
2019 06; 11(6):. doi:
10.3390/v11060505. [PMID: 31159430] - Jin Deng, Yue Xia, Qin Zhou, Xin Wang, Chongxiang Xiong, Xiaofei Shao, Mengjiao Shao, Hequn Zou. Protective effect of rosiglitazone on chronic renal allograft dysfunction in rats.
Transplant immunology.
2019 06; 54(?):20-28. doi:
10.1016/j.trim.2019.01.002. [PMID: 30682409]
