Niraparib (BioDeep_00000773714)
代谢物信息卡片
化学式: C19H20N4O (320.163703)
中文名称: 尼拉帕尼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
InChI: InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01X - Other antineoplastic agents > L01XK - Poly (adp-ribose) polymerase (parp) inhibitors
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C62554 - Poly (ADP-Ribose) Polymerase Inhibitor
D000970 - Antineoplastic Agents > D000067856 - Poly(ADP-ribose) Polymerase Inhibitors
D004791 - Enzyme Inhibitors
C471 - Enzyme Inhibitor
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:176844
- KEGGdrug: D10140
- PubChem: 24958200
- DrugBank: DB11793
- ChEMBL: CHEMBL1094636
- CAS: 1038915-60-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Margarida L F Martins, Nancy H C Loos, Sümeyra Mucuk, Danielle de Jong, Maria C Lebre, Hilde Rosing, Matthijs Tibben, Jos H Beijnen, Alfred H Schinkel. P-Glycoprotein (ABCB1/MDR1) Controls Brain Penetration and Intestinal Disposition of the PARP1/2 Inhibitor Niraparib.
Molecular pharmaceutics.
2021 12; 18(12):4371-4384. doi:
10.1021/acs.molpharmaceut.1c00553. [PMID: 34730366] - Hélène Lazareth, Nicolas Delanoy, Raphaël Cohen, Emilie Boissier, Hamza Ayari, Pierre Combe, Céline Crespel, Elise Mercadier-Riaz, Alexandre Karras, Marie Courbebaisse, Eric Thervet, Nicolas Pallet. Nephrotoxicity Associated With Niraparib.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2020 12; 76(6):898-900. doi:
10.1053/j.ajkd.2020.05.021. [PMID: 32679152] - Kathleen Moore, John K Chan, Angeles Alvarez Secord, Manish R Patel, Timothy Callahan, Wei Guo, Zhi-Yi Zhang. Effect of niraparib on cardiac repolarization in patients with platinum-sensitive, recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer.
Cancer chemotherapy and pharmacology.
2019 04; 83(4):717-726. doi:
10.1007/s00280-019-03774-w. [PMID: 30680521] - Na Gan, Qiaomei Sun, Peixiao Tang, Di Wu, Tonghui Xie, Yongkui Zhang, Hui Li. Determination of interactions between human serum albumin and niraparib through multi-spectroscopic and computational methods.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 Jan; 206(?):126-134. doi:
10.1016/j.saa.2018.07.100. [PMID: 30096696] - Kathleen Moore, Zhi-Yi Zhang, Shefali Agarwal, Howard Burris, Manish R Patel, Vikram Kansra. The effect of food on the pharmacokinetics of niraparib, a poly(ADP-ribose) polymerase (PARP) inhibitor, in patients with recurrent ovarian cancer.
Cancer chemotherapy and pharmacology.
2018 03; 81(3):497-503. doi:
10.1007/s00280-017-3512-5. [PMID: 29322231] - Laurence Booth, Jane L Roberts, Rumeesa Rais, Andrew Poklepovic, Paul Dent. Valproate augments Niraparib killing of tumor cells.
Cancer biology & therapy.
2018; 19(9):797-808. doi:
10.1080/15384047.2018.1472190. [PMID: 29923797] - L van Andel, H Rosing, Z Zhang, L Hughes, V Kansra, M Sanghvi, M M Tibben, A Gebretensae, J H M Schellens, J H Beijnen. Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a 14C-microtracer and therapeutic dose in cancer patients.
Cancer chemotherapy and pharmacology.
2018 01; 81(1):39-46. doi:
10.1007/s00280-017-3455-x. [PMID: 29043410] - Lotte van Andel, Z Zhang, S Lu, V Kansra, S Agarwal, L Hughes, M M Tibben, A Gebretensae, L Lucas, M J X Hillebrand, H Rosing, J H M Schellens, J H Beijnen. Human mass balance study and metabolite profiling of 14C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer.
Investigational new drugs.
2017 12; 35(6):751-765. doi:
10.1007/s10637-017-0451-2. [PMID: 28303528] - L van Andel, Z Zhang, S Lu, V Kansra, S Agarwal, L Hughes, M M Tibben, A Gebretensae, H Rosing, J H M Schellens, J H Beijnen. Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Jan; 1040(?):14-21. doi:
10.1016/j.jchromb.2016.11.020. [PMID: 27898364]