Toborinone (BioDeep_00000773597)

   


代谢物信息卡片


6-{3-[(3,4-Dimethoxybenzyl)amino]-2-hydroxypropoxy}-2-quinolinol

化学式: C21H24N2O5 (384.1685134)
中文名称: 托波力农
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C(C=C1)CNCC(COC2=CC3=C(C=C2)NC(=O)C=C3)O)OC
InChI: InChI=1S/C21H24N2O5/c1-26-19-7-3-14(9-20(19)27-2)11-22-12-16(24)13-28-17-5-6-18-15(10-17)4-8-21(25)23-18/h3-10,16,22,24H,11-13H2,1-2H3,(H,23,25)

描述信息

C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor
D020011 - Protective Agents > D002316 - Cardiotonic Agents

同义名列表

2 个代谢物同义名

6-{3-[(3,4-Dimethoxybenzyl)amino]-2-hydroxypropoxy}-2-quinolinol; Toborinone



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kyoko Kageyama, Toshiki Mizobe, Shinji Nozuchi, Noriko Hiramatsu, Yasufumi Nakajima, Hiroshi Aoki. Toborinone and olprinone, phosphodiesterase III inhibitors, inhibit human platelet aggregation due to the inhibition of both calcium release from intracellular stores and calcium entry. Journal of anesthesia. 2004; 18(2):107-12. doi: 10.1007/s00540-004-0228-6. [PMID: 15127258]
  • Brinda Tammara, John M Trang, Mami Kitani, Gohachiro Miyamoto, Steven L Bramer. The pharmacokinetics of toborinone in subjects with congestive heart failure and concomitant renal impairment and/or concomitant hepatic impairment. Journal of clinical pharmacology. 2002 Dec; 42(12):1318-25. doi: 10.1177/0091270002042012011. [PMID: 12463726]
  • Brinda Tammara, John M Trang, Gohachiro Miyamoto, Mami Kitani, Jerry Brisson, Steven L Bramer. The effects of concomitant administration of theophylline and toborinone on the pharmacokinetics of both compounds in poor and extensive metabolizers via CYP2D6. Journal of clinical pharmacology. 2002 May; 42(5):492-500. doi: 10.1177/00912700222011544. [PMID: 12017343]
  • M Kitani, G Miyamoto, M Nagasawa, T Yamada, J Matsubara, M Uchida, M Odomi. Biotransformation of the novel inotropic agent toborinone (OPC-18790) in rats and dogs. Evidence for the formation of novel glutathione and two cysteine conjugates. Drug metabolism and disposition: the biological fate of chemicals. 1997 Jun; 25(6):663-74. doi: NULL. [PMID: 9193867]
  • A Ohnishi, T Toyoki, T Ohno, Y Takeshige, T Fujita, K Kodama, M Mishima, A Hirayama, M Kitani, G Miyamoto. Pharmacokinetics and pharmacodynamics of intravenous OPC-18790 in humans: a novel nonglycosidic inotropic agent. Journal of clinical pharmacology. 1994 Feb; 34(2):176-83. doi: 10.1002/j.1552-4604.1994.tb03983.x. [PMID: 8163718]
  • M Kitani, G Miyamoto, M Odomi. Stereoselective high-performance liquid chromatographic assay for the determination of OPC-18790 enantiomers in human plasma and urine. Journal of chromatography. 1993 Oct; 620(1):97-104. doi: 10.1016/0378-4347(93)80056-a. [PMID: 8106598]