Clobenztropine (BioDeep_00000773333)
代谢物信息卡片
化学式: C21H24ClNO (341.1546324)
中文名称: 氯苯托品
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=C(C=C4)Cl
InChI: InChI=1S/C21H24ClNO/c1-23-18-11-12-19(23)14-20(13-18)24-21(15-5-3-2-4-6-15)16-7-9-17(22)10-8-16/h2-10,18-21H,11-14H2,1H3
描述信息
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ahmed A Othman, Shariq A Syed, Amy H Newman, Natalie D Eddington. Transport, metabolism, and in vivo population pharmacokinetics of the chloro benztropine analogs, a class of compounds extensively evaluated in animal models of drug abuse.
The Journal of pharmacology and experimental therapeutics.
2007 Jan; 320(1):344-53. doi:
10.1124/jpet.106.111245. [PMID: 17003230] - A H Newman, M J Robarge, I M Howard, S L Wittkopp, C George, T Kopajtic, S Izenwasser, J L Katz. Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes.
Journal of medicinal chemistry.
2001 Feb; 44(4):633-40. doi:
10.1021/jm000417f. [PMID: 11170654] - B T Hoffman, T Kopajtic, J L Katz, A H Newman. 2D QSAR modeling and preliminary database searching for dopamine transporter inhibitors using genetic algorithm variable selection of Molconn Z descriptors.
Journal of medicinal chemistry.
2000 Nov; 43(22):4151-9. doi:
10.1021/jm990472s. [PMID: 11063611] - A H Newman, S Izenwasser, M J Robarge, R H Kline. CoMFA study of novel phenyl ring-substituted 3alpha-(diphenylmethoxy)tropane analogues at the dopamine transporter.
Journal of medicinal chemistry.
1999 Sep; 42(18):3502-9. doi:
10.1021/jm980701v. [PMID: 10479283] - R H Kline, S Izenwasser, J L Katz, D B Joseph, W D Bowen, A H Newman. 3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile.
Journal of medicinal chemistry.
1997 Mar; 40(6):851-7. doi:
10.1021/jm950782k. [PMID: 9083473] - M L Gantzer, C M Grisham. Characterization of Mg2+-ATPase from sheep kidney medulla: purification.
Archives of biochemistry and biophysics.
1979 Nov; 198(1):263-7. doi:
10.1016/0003-9861(79)90418-1. [PMID: 159664] - A H Beckett, R Achari. Plasma concentrations and excretion of zipeprol in man under acidic urine conditions.
The Journal of pharmacy and pharmacology.
1977 Oct; 29(10):589-92. doi:
10.1111/j.2042-7158.1977.tb11411.x. [PMID: 21236] - B Hultberg, A Lundblad, P K Masson, P A Ockerman. Specificity studies on alpha-mannosidases using oligosaccharides from mannosidosis urine as substrates.
Biochimica et biophysica acta.
1975 Nov; 410(1):156-63. doi:
10.1016/0005-2744(75)90216-8. [PMID: 70]