Osanetant (BioDeep_00000772293)

   


代谢物信息卡片


Osanetant

化学式: C35H41Cl2N3O2 (605.2576)
中文名称: 奥沙奈坦
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5
InChI: InChI=1S/C35H41Cl2N3O2/c1-27(41)38(2)35(29-13-7-4-8-14-29)19-23-39(24-20-35)21-9-17-34(30-15-16-31(36)32(37)25-30)18-10-22-40(26-34)33(42)28-11-5-3-6-12-28/h3-8,11-16,25H,9-10,17-24,26H2,1-2H3/t34-/m0/s1

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia[1].

同义名列表

2 个代谢物同义名

Osanetant; SR142801



数据库引用编号

5 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表


文献列表

  • Hamid R Hoveyda, Graeme L Fraser, Marie-Odile Roy, Guillaume Dutheuil, Frédéric Batt, Mohamed El Bousmaqui, Julien Korac, François Lenoir, Alexey Lapin, Sophie Noël, Sébastien Blanc. Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I). Journal of medicinal chemistry. 2015 Apr; 58(7):3060-82. doi: 10.1021/jm5017413. [PMID: 25738882]
  • Hamid R Hoveyda, Marie-Odile Roy, Sebastien Blanc, Sophie Noël, Joseph M Salvino, Mark A Ator, Graeme Fraser. Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor. Bioorganic & medicinal chemistry letters. 2011 Apr; 21(7):1991-6. doi: 10.1016/j.bmcl.2011.02.033. [PMID: 21376585]
  • G Kronenberg, P Berger, R F Tauber, B Bandelow, V Henkel, I Heuser. Randomized, double-blind study of SR142801 (Osanetant). A novel neurokinin-3 (NK3) receptor antagonist in panic disorder with pre- and posttreatment cholecystokinin tetrapeptide (CCK-4) challenges. Pharmacopsychiatry. 2005 Jan; 38(1):24-9. doi: 10.1055/s-2005-837768. [PMID: 15706463]
  • Júlia M M Santos, Maria Aparecida K F Tatsuo, Regina Maria M Turchetti-Maia, Marcela C G Lisboa, Janetti N de Francischi. Leukocyte recruitment to peritoneal cavity of rats following formalin injection: role of tachykinin receptors. Journal of pharmacological sciences. 2004 Apr; 94(4):384-92. doi: 10.1254/jphs.94.384. [PMID: 15107578]
  • Andrew D Grant, Roksana Akhtar, Norma P Gerard, Susan D Brain. Neurokinin B induces oedema formation in mouse lung via tachykinin receptor-independent mechanisms. The Journal of physiology. 2002 Sep; 543(Pt 3):1007-14. doi: 10.1113/jphysiol.2002.018846. [PMID: 12231654]
  • S Daoui, B D'Agostino, L Gallelli, X Emonds Alt, F Rossi, C Advenier. Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation. The European respiratory journal. 2002 Aug; 20(2):268-73. doi: 10.1183/09031936.02.00250902. [PMID: 12212954]
  • H M Sarau, J A Feild, R S Ames, J J Foley, P Nuthulaganti, D B Schmidt, P T Buckley, N A Elshourbagy, M E Brawner, M A Luttmann, G A Giardina, D W Hay. Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor. European journal of pharmacology. 2001 Feb; 413(2-3):143-50. doi: 10.1016/s0014-2999(01)00732-4. [PMID: 11226387]
  • J Gay, J Fioramonti, R Garcia-Villar, X Emonds-Alt, L Bueno. Involvement of tachykinin receptors in sensitisation to cow's milk proteins in guinea pigs. Gut. 1999 Apr; 44(4):497-503. doi: 10.1136/gut.44.4.497. [PMID: 10075956]
  • S Daoui, C Cognon, E Naline, X Emonds-Alt, C Advenier. Involvement of tachykinin NK3 receptors in citric acid-induced cough and bronchial responses in guinea pigs. American journal of respiratory and critical care medicine. 1998 Jul; 158(1):42-8. doi: 10.1164/ajrccm.158.1.9705052. [PMID: 9655705]
  • S Daoui, Y Y Cui, V Lagente, X Emonds-Alt, C Advenier. A tachykinin NK3 receptor antagonist, SR 142801 (osanetant), prevents substance P-induced bronchial hyperreactivity in guinea-pigs. Pulmonary pharmacology & therapeutics. 1997 Oct; 10(5-6):261-70. doi: 10.1006/pupt.1998.0104. [PMID: 9778489]
  • H M Sarau, D E Griswold, W Potts, J J Foley, D B Schmidt, E F Webb, L D Martin, M E Brawner, N A Elshourbagy, A D Medhurst, G A Giardina, D W Hay. Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. The Journal of pharmacology and experimental therapeutics. 1997 Jun; 281(3):1303-11. doi: NULL. [PMID: 9190866]
  • X K Nguyen-Le, Q T Nguyen, F Gobeil, L H Pheng, X Emonds-Alt, J C Brelière, D Regoli. Pharmacological characterization of SR 142801: a new non-peptide antagonist of the neurokinin NK-3 receptor. Pharmacology. 1996 May; 52(5):283-91. doi: 10.1159/000139393. [PMID: 8807672]