Lomitapide Mesylate (BioDeep_00000772289)
代谢物信息卡片
Lomitapide Mesylate
化学式: C40H41F6N3O5S (789.2670968)
中文名称: 甲磺酸洛美他派
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CS(=O)(=O)O.C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F
InChI: 1H3,(H,2,3,4)
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:72299
- KEGGdrug: D09638
- PubChem: 11274333
- ChEMBL: CHEMBL2105662
- CAS: 2059395-52-5
- CAS: 202914-84-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Vishal Patel, Amit Joharapurkar, Samadhan Kshirsagar, Maulik Patel, Hiren Patel, Hardikkumar Savsani, Mukul Jain. Microsomal triglyceride transfer protein inhibitor lomitapide-induced liver toxicity is ameliorated by Triiodothyronine treatment following improved bile homeostasis and β-oxidation.
Toxicology and applied pharmacology.
2022 01; 434(?):115825. doi:
10.1016/j.taap.2021.115825. [PMID: 34902352] - Antonina Giammanco, Angelo B Cefalù, Davide Noto, Maurizio R Averna. Therapeutic Options for Homozygous Familial Hypercholesterolemia: The Role of Lomitapide.
Current medicinal chemistry.
2020; 27(23):3773-3783. doi:
10.2174/0929867326666190121120735. [PMID: 30663562] - Atsushi Nohara, Yoshihiko Otsubo, Koji Yanagi, Masayuki Yoshida, Katsunori Ikewaki, Mariko Harada-Shiba, Agnieszka Jurecka. Safety and Efficacy of Lomitapide in Japanese Patients with Homozygous Familial Hypercholesterolemia (HoFH): Results from the AEGR-733-301 Long-Term Extension Study.
Journal of atherosclerosis and thrombosis.
2019 Apr; 26(4):368-377. doi:
10.5551/jat.45708. [PMID: 30259883] - Noriko Kameyama, Chizuko Maruyama, Fuyuha Kitagawa, Kazunobu Nishii, Kaori Uenomachi, Yayoi Katayama, Hiromi Koga, Naoko Chikamoto, Yuko Kuwata, Junko Torigoe, Masako Arimoto, Toshiaki Tokumaru, Katsunori Ikewaki, Atsushi Nohara, Yoshihiko Otsubo, Koji Yanagi, Masayuki Yoshida, Mariko Harada-Shiba. Dietary Intake during 56 Weeks of a Low-Fat Diet for Lomitapide Treatment in Japanese Patients with Homozygous Familial Hypercholesterolemia.
Journal of atherosclerosis and thrombosis.
2019 Jan; 26(1):72-83. doi:
10.5551/jat.44107. [PMID: 29899183] - Ezim Ajufo, Daniel J Rader. New Therapeutic Approaches for Familial Hypercholesterolemia.
Annual review of medicine.
2018 01; 69(?):113-131. doi:
10.1146/annurev-med-051215-030943. [PMID: 29414257] - Robert Leipold, Frederick Raal, Jack Ishak, Kees Hovingh, Helen Phillips. The effect of lomitapide on cardiovascular outcome measures in homozygous familial hypercholesterolemia: A modelling analysis.
European journal of preventive cardiology.
2017 11; 24(17):1843-1850. doi:
10.1177/2047487317730473. [PMID: 28925748] - Amanda J Brahm, Robert A Hegele. Lomitapide for the treatment of hypertriglyceridemia.
Expert opinion on investigational drugs.
2016 Dec; 25(12):1457-1463. doi:
10.1080/13543784.2016.1254187. [PMID: 27785928] - Peter P Toth. Novel Therapies for Low-Density Lipoprotein Cholesterol Reduction.
The American journal of cardiology.
2016 Sep; 118(6 Suppl):19A-32A. doi:
10.1016/j.amjcard.2016.05.028. [PMID: 27620356] - Dirk J Blom, Zahi A Fayad, John J P Kastelein, Dominique Larrey, Lukas Makris, Charles Schwamlein, LeAnne Bloeden, James Underberg. LOWER, a registry of lomitapide-treated patients with homozygous familial hypercholesterolemia: Rationale and design.
Journal of clinical lipidology.
2016 Mar; 10(2):273-82. doi:
10.1016/j.jacl.2015.11.011. [PMID: 27055957] - Jeanine Roeters van Lennep, Maurizio Averna, Rodrigo Alonso. Treating homozygous familial hypercholesterolemia in a real-world setting: Experiences with lomitapide.
Journal of clinical lipidology.
2015 Jul; 9(4):607-17. doi:
10.1016/j.jacl.2015.05.001. [PMID: 26228681] - NULL. Iomitapide (Lojuxta). Use only in homozygous familial hypercholesterolaemia, with caution.
Prescrire international.
2015 Jul; 24(162):176-8. doi:
NULL. [PMID: 26240881] - Amanda J Brahm, Robert A Hegele. Chylomicronaemia--current diagnosis and future therapies.
Nature reviews. Endocrinology.
2015 Jun; 11(6):352-62. doi:
10.1038/nrendo.2015.26. [PMID: 25732519] - Ioanna Gouni-Berthold, Heiner K Berthold. Mipomersen and lomitapide: Two new drugs for the treatment of homozygous familial hypercholesterolemia.
Atherosclerosis. Supplements.
2015 May; 18(?):28-34. doi:
10.1016/j.atherosclerosissup.2015.02.005. [PMID: 25936301] - Amanda J Hooper, John R Burnett, Gerald F Watts. Contemporary aspects of the biology and therapeutic regulation of the microsomal triglyceride transfer protein.
Circulation research.
2015 Jan; 116(1):193-205. doi:
10.1161/circresaha.116.304637. [PMID: 25552696] - Gautam Das, Alan Rees. Microsomal triglyceride transfer protein inhibition: a novel treatment for lowering plasma cholesterol.
Current opinion in lipidology.
2014 Dec; 25(6):471-3. doi:
10.1097/mol.0000000000000134. [PMID: 25370457] - Kyle A Davis, Marta A Miyares. Lomitapide: A novel agent for the treatment of homozygous familial hypercholesterolemia.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2014 Jun; 71(12):1001-8. doi:
10.2146/ajhp130592. [PMID: 24865757] - Sony Tuteja, Danielle Duffy, Richard L Dunbar, Rajesh Movva, Ram Gadi, LeAnne T Bloedon, Marina Cuchel. Pharmacokinetic interactions of the microsomal triglyceride transfer protein inhibitor, lomitapide, with drugs commonly used in the management of hypercholesterolemia.
Pharmacotherapy.
2014 Mar; 34(3):227-39. doi:
10.1002/phar.1351. [PMID: 24734312] - Alpo Vuorio, Matti J Tikkanen, Petri T Kovanen. Inhibition of hepatic microsomal triglyceride transfer protein - a novel therapeutic option for treatment of homozygous familial hypercholesterolemia.
Vascular health and risk management.
2014; 10(?):263-70. doi:
10.2147/vhrm.s36641. [PMID: 24851052] - Amirhossein Sahebkar, Gerald F Watts. New therapies targeting apoB metabolism for high-risk patients with inherited dyslipidaemias: what can the clinician expect?.
Cardiovascular drugs and therapy.
2013 Dec; 27(6):559-67. doi:
10.1007/s10557-013-6479-4. [PMID: 23913122] - Borje Darpo, Georg Ferber, Meijian Zhou, Mark Sumeray, Philip Sager. Lomitapide at supratherapeutic plasma levels does not prolong the Qtc interval--results from a TQT study with moxifloxacin and ketoconazole.
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.
2013 Nov; 18(6):577-89. doi:
10.1111/anec.12103. [PMID: 24118671] - Caroline M Perry. Lomitapide: a review of its use in adults with homozygous familial hypercholesterolemia.
American journal of cardiovascular drugs : drugs, devices, and other interventions.
2013 Aug; 13(4):285-96. doi:
10.1007/s40256-013-0030-7. [PMID: 23720215] - Vipin Dhote, Amit Joharapurkar, Samadhan Kshirsagar, Nirav Dhanesha, Vishal Patel, Avnish Patel, Saurin Raval, Mukul Jain. Inhibition of microsomal triglyceride transfer protein improves insulin sensitivity and reduces atherogenic risk in Zucker fatty rats.
Clinical and experimental pharmacology & physiology.
2011 May; 38(5):338-44. doi:
10.1111/j.1440-1681.2011.05513.x. [PMID: 21401695] - Richard Češka, Tomáš Štulc, Lucie Votavová, Lucie Schwarzová, Martina Vaclová, Tomáš Freiberger. [Hyperlipoproteinemia and dyslipidemia as rare diseases. Diagnostics and treatment].
Vnitrni lekarstvi.
Fall 201; 62(11):887-894. doi:
NULL. [PMID: 28128575] - Toshiyuki Funatsu, Hirotoshi Kakuta, Toshiyuki Takasu, Keiji Miyata. Atorvastatin increases hepatic fatty acid beta-oxidation in sucrose-fed rats: comparison with an MTP inhibitor.
European journal of pharmacology.
2002 Nov; 455(2-3):161-7. doi:
10.1016/s0014-2999(02)02611-0. [PMID: 12445582]
