SEA-0400 (BioDeep_00000771993)
代谢物信息卡片
2-(4-((2,5-Difluorobenzyl)oxy)phenoxy)-5-ethoxyaniline
化学式: C21H19F2NO3 (371.13329280000005)
中文名称: 2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC1=CC(=C(C=C1)OC2=CC=C(C=C2)OCC3=C(C=CC(=C3)F)F)N
InChI: InChI=1S/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shogo Hamaguchi, Kohei Abe, Momoka Komatsu, Jun Kainuma, Iyuki Namekata, Hikaru Tanaka. Positive Lusitropic Effect of Quercetin on Isolated Ventricular Myocardia from Normal and Streptozotocin-Induced Diabetic Mice.
Biological & pharmaceutical bulletin.
2021; 44(12):1894-1897. doi:
10.1248/bpb.b21-00580. [PMID: 34853274] - Wakana Shoda, Naohiro Nomura, Fumiaki Ando, Hideaki Tagashira, Takahiro Iwamoto, Akihito Ohta, Kiyoshi Isobe, Takayasu Mori, Koichiro Susa, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida. Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia.
PloS one.
2020; 15(6):e0235360. doi:
10.1371/journal.pone.0235360. [PMID: 32603346] - Uwe Primessnig, Patrick Schönleitner, Alexander Höll, Susanne Pfeiffer, Taja Bracic, Thomas Rau, Martin Kapl, Tatjana Stojakovic, Toma Glasnov, Kirsten Leineweber, Paulina Wakula, Gudrun Antoons, Burkert Pieske, Frank R Heinzel. Novel pathomechanisms of cardiomyocyte dysfunction in a model of heart failure with preserved ejection fraction.
European journal of heart failure.
2016 08; 18(8):987-97. doi:
10.1002/ejhf.524. [PMID: 27135883] - Michael P Rassner, Andreas Moser, Marie Follo, Kevin Joseph, Vera van Velthoven-Wurster, Thomas J Feuerstein. Neocortical GABA release at high intracellular sodium and low extracellular calcium: an anti-seizure mechanism.
Journal of neurochemistry.
2016 Apr; 137(2):177-89. doi:
10.1111/jnc.13555. [PMID: 26821584] - Midori Sasaki Yatabe, Junichi Yatabe, Kozue Takano, Hironobu Sanada, Junko Kimura, Tsuyoshi Watanabe. Effects of renal Na+/Ca2+ exchanger 1 inhibitor (SEA0400) treatment on electrolytes, renal function and hemodynamics in rats.
Clinical and experimental nephrology.
2015 Aug; 19(4):585-90. doi:
10.1007/s10157-014-1053-3. [PMID: 25410661] - Yusuke Gotoh, Satomi Kita, Makoto Fujii, Hideaki Tagashira, Ichiro Horie, Yuji Arai, Shinichi Uchida, Takahiro Iwamoto. Genetic knockout and pharmacologic inhibition of NCX2 cause natriuresis and hypercalciuria.
Biochemical and biophysical research communications.
2015 Jan; 456(2):670-5. doi:
10.1016/j.bbrc.2014.12.016. [PMID: 25498502] - Nobutaka Morimoto, Satomi Kita, Masamitsu Shimazawa, Hiroko Namimatsu, Kazuhiro Tsuruma, Kazuhide Hayakawa, Kenichi Mishima, Nobuaki Egashira, Takuya Iyoda, Ichiro Horie, Yusuke Gotoh, Katsunori Iwasaki, Michihiro Fujiwara, Toshio Matsuda, Akemichi Baba, Issei Komuro, Kyoji Horie, Junji Takeda, Takahiro Iwamoto, Hideaki Hara. Preferential involvement of Na⁺/Ca²⁺ exchanger type-1 in the brain damage caused by transient focal cerebral ischemia in mice.
Biochemical and biophysical research communications.
2012 Dec; 429(3-4):186-90. doi:
10.1016/j.bbrc.2012.10.114. [PMID: 23137542] - Yukio Ago, Toshiyuki Kawasaki, Tetsuaki Nashida, Yuki Ota, Yana Cong, Mari Kitamoto, Teisuke Takahashi, Kazuhiro Takuma, Toshio Matsuda. SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease.
Neuropharmacology.
2011 Dec; 61(8):1441-51. doi:
10.1016/j.neuropharm.2011.08.041. [PMID: 21903118] - Péter Birinyi, András Tóth, István Jóna, Károly Acsai, János Almássy, Norbert Nagy, János Prorok, Iuliana Gherasim, Zoltán Papp, Zita Hertelendi, Norbert Szentandrássy, Tamás Bányász, Ferenc Fülöp, Julius Gy Papp, András Varró, Péter P Nánási, János Magyar. The Na+/Ca2+ exchange blocker SEA0400 fails to enhance cytosolic Ca2+ transient and contractility in canine ventricular cardiomyocytes.
Cardiovascular research.
2008 Jun; 78(3):476-84. doi:
10.1093/cvr/cvn031. [PMID: 18252759] - Vladimir V Matchkov, Helena Gustafsson, Awahan Rahman, Donna M Briggs Boedtkjer, Sarah Gorintin, Anne Kirstine Hansen, Elena V Bouzinova, Helle A Praetorius, Christian Aalkjaer, Holger Nilsson. Interaction between Na+/K+-pump and Na+/Ca2+-exchanger modulates intercellular communication.
Circulation research.
2007 Apr; 100(7):1026-35. doi:
10.1161/01.res.0000262659.09293.56. [PMID: 17347477] - Takahiro Iwamoto, Satomi Kita. [Na+/Ca2+ exchanger (NCX1) and cardiovascular disease].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2007 Apr; 129(4):262-5. doi:
10.1254/fpj.129.262. [PMID: 17435337] - Ayako Takeuchi, Shuji Tatsumi, Nobuaki Sarai, Keisuke Terashima, Satoshi Matsuoka, Akinori Noma. Ionic mechanisms of cardiac cell swelling induced by blocking Na+/K+ pump as revealed by experiments and simulation.
The Journal of general physiology.
2006 Nov; 128(5):495-507. doi:
10.1085/jgp.200609646. [PMID: 17074975] - T Iwamoto, S Kita. Hypertension, Na+/Ca2+ exchanger, and Na+, K+-ATPase.
Kidney international.
2006 Jun; 69(12):2148-54. doi:
10.1038/sj.ki.5000421. [PMID: 16641927] - Takahiro Iwamoto. [Na+/Ca2+ exchanger(NCX1) and salt-sensitive hypertension].
Nihon rinsho. Japanese journal of clinical medicine.
2006 Jan; 64(1):167-76. doi:
. [PMID: 16408465] - Toshio Matsuda, Yutaka Koyama, Akemichi Baba. Functional proteins involved in regulation of intracellular Ca(2+) for drug development: pharmacology of SEA0400, a specific inhibitor of the Na(+)-Ca(2+) exchanger.
Journal of pharmacological sciences.
2005 Mar; 97(3):339-43. doi:
10.1254/jphs.fmj04007x2. [PMID: 15764845] - Yutaka Koyama, Shigeo Matsui, Soichi Itoh, Masakazu Osakada, Akemichi Baba, Toshio Matsuda. The selective Na+-Ca2+ exchange inhibitor attenuates brain edema after radiofrequency lesion in rats.
European journal of pharmacology.
2004 Apr; 489(3):193-6. doi:
10.1016/j.ejphar.2004.03.018. [PMID: 15087242] - Takahiro Iwamoto, Satomi Kita. Development and application of Na+/Ca2+ exchange inhibitors.
Molecular and cellular biochemistry.
2004 Apr; 259(1-2):157-61. doi:
10.1023/b:mcbi.0000021367.42752.54. [PMID: 15124919] - Takahiro Iwamoto, Satomi Kita, Akira Uehara, Issei Imanaga, Toshio Matsuda, Akemichi Baba, Takeshi Katsuragi. Molecular determinants of Na+/Ca2+ exchange (NCX1) inhibition by SEA0400.
The Journal of biological chemistry.
2004 Feb; 279(9):7544-53. doi:
10.1074/jbc.m310491200. [PMID: 14660663] - Masaya Ogata, Takahiro Iwamoto, Naoko Tazawa, Mitsunori Nishikawa, Junji Yamashita, Masanori Takaoka, Yasuo Matsumura. A novel and selective Na+/Ca2+ exchange inhibitor, SEA0400, improves ischemia/reperfusion-induced renal injury.
European journal of pharmacology.
2003 Oct; 478(2-3):187-98. doi:
10.1016/j.ejphar.2003.08.082. [PMID: 14575804] - Takahiro Iwamoto, Satomi Kita, Munekazu Shigekawa. [Functional analysis of Na+/Ca2+ exchanger using novel drugs and genetically engineered mice].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2002 Nov; 120(1):91P-93P. doi:
NULL. [PMID: 12491791]