Tideglusib (BioDeep_00000771864)
代谢物信息卡片
化学式: C19H14N2O2S (334.0775944)
中文名称: Tideglusib
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)CN2C(=O)N(SC2=O)C3=CC=CC4=CC=CC=C43
InChI: InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:147398
- PubChem: 11313622
- DrugBank: DB12129
- ChEMBL: CHEMBL3545157
- CAS: 865854-05-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- A S Al-Zaidi, N Mohtarrudin, J Chupri, M Hassan. Differential time course of glycogen synthase kinase-3 inhibition in experimental autoimmune encephalomyelitis.
The Malaysian journal of pathology.
2021 Dec; 43(3):413-424. doi:
. [PMID: 34958063] - Pei Liu, Hongbo Liu, Qi Sun, Hao Liang, Chunmei Li, Xiaobing Deng, Ying Liu, Luhua Lai. Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds.
European journal of medicinal chemistry.
2020 Nov; 206(?):112702. doi:
10.1016/j.ejmech.2020.112702. [PMID: 32798789] - Carmen Gil, Tiziana Ginex, Inés Maestro, Vanesa Nozal, Lucía Barrado-Gil, Miguel Ángel Cuesta-Geijo, Jesús Urquiza, David Ramírez, Covadonga Alonso, Nuria E Campillo, Ana Martinez. COVID-19: Drug Targets and Potential Treatments.
Journal of medicinal chemistry.
2020 11; 63(21):12359-12386. doi:
10.1021/acs.jmedchem.0c00606. [PMID: 32511912] - Joseph Horrigan, Tiago Bernardino Gomes, Mike Snape, Nikoletta Nikolenko, Alison McMorn, Stuart Evans, Alex Yaroshinsky, Oscar Della Pasqua, Sean Oosterholt, Hanns Lochmüller. A Phase 2 Study of AMO-02 (Tideglusib) in Congenital and Childhood-Onset Myotonic Dystrophy Type 1 (DM1).
Pediatric neurology.
2020 11; 112(?):84-93. doi:
10.1016/j.pediatrneurol.2020.08.001. [PMID: 32942085] - Neeraj Kumar Saini, P S Suresh, Mahalakhsmi Lella, Ravi Kanth Bhamidipati, Sriram Rajagopal, Ramesh Mullangi. LC-MS/MS determination of tideglusib, a novel GSK-3β inhibitor in mice plasma and its application to a pharmacokinetic study in mice.
Journal of pharmaceutical and biomedical analysis.
2018 Jan; 148(?):100-107. doi:
10.1016/j.jpba.2017.09.022. [PMID: 28982059] - Guido Furlotti, Maria Alessandra Alisi, Nicola Cazzolla, Patrizia Dragone, Lucia Durando, Gabriele Magarò, Francesca Mancini, Giorgina Mangano, Rosella Ombrato, Marco Vitiello, Andrea Armirotti, Valeria Capurro, Massimiliano Lanfranco, Giuliana Ottonello, Maria Summa, Angelo Reggiani. Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders.
Journal of medicinal chemistry.
2015 Nov; 58(22):8920-37. doi:
10.1021/acs.jmedchem.5b01208. [PMID: 26486317] - Eduardo Tolosa, Irene Litvan, Günter U Höglinger, David Burn, Andrew Lees, María V Andrés, Belén Gómez-Carrillo, Teresa León, Teodoro Del Ser. A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy.
Movement disorders : official journal of the Movement Disorder Society.
2014 Apr; 29(4):470-8. doi:
10.1002/mds.25824. [PMID: 24532007] - Teodoro del Ser, Klaus C Steinwachs, Hermann J Gertz, María V Andrés, Belén Gómez-Carrillo, Miguel Medina, Joan A Vericat, Pilar Redondo, David Fleet, Teresa León. Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study.
Journal of Alzheimer's disease : JAD.
2013; 33(1):205-15. doi:
10.3233/jad-2012-120805. [PMID: 22936007]